LOCUS       NP_062324                156 aa            linear   ROD 04-DEC-2024
DEFINITION  interleukin-36 receptor antagonist protein [Mus musculus].
ACCESSION   NP_062324
VERSION     NP_062324.2
DBSOURCE    REFSEQ: accession NM_019451.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 156)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (residues 1 to 156)
  AUTHORS   Hasegawa,Y., Iwata,Y., Fukushima,H., Tanaka,Y., Watanabe,S.,
            Saito,K., Ito,H., Sugiura,M., Akiyama,M. and Sugiura,K.
  TITLE     Neutrophil extracellular traps are involved in enhanced contact
            hypersensitivity response in IL-36 receptor antagonist-deficient
            mice
  JOURNAL   Sci Rep 12 (1), 13384 (2022)
   PUBMED   35927298
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 156)
  AUTHORS   Yang,W., Dong,H.P., Wang,P., Xu,Z.G., Xian,J., Chen,J., Wu,H.,
            Lou,Y., Lin,D. and Zhong,B.
  TITLE     IL-36gamma and IL-36Ra Reciprocally Regulate Colon Inflammation and
            Tumorigenesis by Modulating the Cell-Matrix Adhesion Network and
            Wnt Signaling
  JOURNAL   Adv Sci (Weinh) 9 (10), e2103035 (2022)
   PUBMED   35119210
REFERENCE   4  (residues 1 to 156)
  AUTHORS   Tanaka,Y., Iwata,Y., Saito,K., Fukushima,H., Watanabe,S.,
            Hasegawa,Y., Akiyama,M. and Sugiura,K.
  TITLE     Cutaneous ischemia-reperfusion injury is exacerbated by IL-36
            receptor antagonist deficiency
  JOURNAL   J Eur Acad Dermatol Venereol 36 (2), 295-304 (2022)
   PUBMED   34699104
  REMARK    GeneRIF: Cutaneous ischemia-reperfusion injury is exacerbated by
            IL-36 receptor antagonist deficiency.
REFERENCE   5  (residues 1 to 156)
  AUTHORS   Wang,P., Yang,W., Guo,H., Dong,H.P., Guo,Y.Y., Gan,H., Wang,Z.,
            Cheng,Y., Deng,Y., Xie,S., Yang,X., Lin,D. and Zhong,B.
  TITLE     IL-36gamma and IL-36Ra Reciprocally Regulate NSCLC Progression by
            Modulating GSH Homeostasis and Oxidative Stress-Induced Cell Death
  JOURNAL   Adv Sci (Weinh) 8 (19), e2101501 (2021)
   PUBMED   34369094
REFERENCE   6  (residues 1 to 156)
  AUTHORS   Debets,R., Timans,J.C., Homey,B., Zurawski,S., Sana,T.R., Lo,S.,
            Wagner,J., Edwards,G., Clifford,T., Menon,S., Bazan,J.F. and
            Kastelein,R.A.
  TITLE     Two novel IL-1 family members, IL-1 delta and IL-1 epsilon,
            function as an antagonist and agonist of NF-kappa B activation
            through the orphan IL-1 receptor-related protein 2
  JOURNAL   J Immunol 167 (3), 1440-1446 (2001)
   PUBMED   11466363
REFERENCE   7  (residues 1 to 156)
  AUTHORS   Barton,J.L., Herbst,R., Bosisio,D., Higgins,L. and Nicklin,M.J.
  TITLE     A tissue specific IL-1 receptor antagonist homolog from the IL-1
            cluster lacks IL-1, IL-1ra, IL-18 and IL-18 antagonist activities
  JOURNAL   Eur J Immunol 30 (11), 3299-3308 (2000)
   PUBMED   11093146
REFERENCE   8  (residues 1 to 156)
  AUTHORS   Kumar,S., McDonnell,P.C., Lehr,R., Tierney,L., Tzimas,M.N.,
            Griswold,D.E., Capper,E.A., Tal-Singer,R., Wells,G.I., Doyle,M.L.
            and Young,P.R.
  TITLE     Identification and initial characterization of four novel members
            of the interleukin-1 family
  JOURNAL   J Biol Chem 275 (14), 10308-10314 (2000)
   PUBMED   10744718
REFERENCE   9  (residues 1 to 156)
  AUTHORS   Smith,D.E., Renshaw,B.R., Ketchem,R.R., Kubin,M., Garka,K.E. and
            Sims,J.E.
  TITLE     Four new members expand the interleukin-1 superfamily
  JOURNAL   J Biol Chem 275 (2), 1169-1175 (2000)
   PUBMED   10625660
REFERENCE   10 (residues 1 to 156)
  AUTHORS   Mulero,J.J., Pace,A.M., Nelken,S.T., Loeb,D.B., Correa,T.R.,
            Drmanac,R. and Ford,J.E.
  TITLE     IL1HY1: A novel interleukin-1 receptor antagonist gene
  JOURNAL   Biochem Biophys Res Commun 263 (3), 702-706 (1999)
   PUBMED   10512743
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK009741.1, AI413231.1 and CJ067640.1.
            
            On Mar 27, 2009 this sequence version replaced NP_062324.1.
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Variants 1, 2 and 3 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ250429.1, AF200495.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849376, SAMN00849383
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..156
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 16.31 cM"
     Protein         1..156
                     /product="interleukin-36 receptor antagonist protein"
                     /note="interleukin 1 receptor antagonist homolog 1;
                     interleukin-1 family member 5; IL-1F5; IL-1L1; IL-1HY1;
                     IL-1 delta; interleukin-1 HY1; interleukin-1 delta;
                     interleukin-1 homolog 3; interleukin-1-like protein 1;
                     interleukin 1 family, member 5 (delta)"
                     /calculated_mol_wt=17005
     Region          6..155
                     /region_name="beta-trefoil_IL36RA"
                     /note="beta-trefoil domain found in interleukin-36
                     receptor antagonist protein (IL-36RA) and similar
                     proteins; cd23303"
                     /db_xref="CDD:466785"
     CDS             1..156
                     /gene="Il36rn"
                     /gene_synonym="Fil1delta; If36rn; Il-1h3; IL-36Ra; Il1f5;
                     Il1hy1"
                     /coded_by="NM_019451.2:229..699"
                     /db_xref="CCDS:CCDS50519.1"
                     /db_xref="GeneID:54450"
                     /db_xref="MGI:MGI:1859325"
ORIGIN      
        1 mmvlsgalcf rmkdsalkvl ylhnnqllag glhaekvikg eeisvvpnra ldaslspvil
       61 gvqggsqcls cgtekgpilk lepvnimely lgakesksft fyrrdmglts sfesaaypgw
      121 flctspeadq pvrltqiped pawdapitdf yfqqcd
//
