LOCUS       NM_027163                790 bp    mRNA    linear   ROD 21-AUG-2024
DEFINITION  Mus musculus interleukin 36B (Il36b), mRNA.
ACCESSION   NM_027163 XM_130058 XM_913174 XM_973310
VERSION     NM_027163.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 790)
  AUTHORS   Zhu,J., Xu,Y., Li,Z., Liu,S., Fu,W. and Wei,Y.
  TITLE     Interleukin-36beta exacerbates DSS-induce acute colitis via
            inhibiting Foxp3+ regulatory T cell response and increasing Th2
            cell response
  JOURNAL   Int Immunopharmacol 108, 108762 (2022)
   PUBMED   35436743
  REMARK    GeneRIF: Interleukin-36beta exacerbates DSS-induce acute colitis
            via inhibiting Foxp3(+) regulatory T cell response and increasing
            Th2 cell response.
REFERENCE   2  (bases 1 to 790)
  AUTHORS   Ge,Y., Huang,M., Dong,N. and Yao,Y.M.
  TITLE     Effect of Interleukin-36beta on Activating Autophagy of CD4+CD25+
            Regulatory T cells and Its Immune Regulation in Sepsis
  JOURNAL   J Infect Dis 222 (9), 1517-1530 (2020)
   PUBMED   32421784
  REMARK    GeneRIF: Effect of Interleukin-36beta on Activating Autophagy of
            CD4+CD25+ Regulatory T cells and Its Immune Regulation in Sepsis.
REFERENCE   3  (bases 1 to 790)
  AUTHORS   Zaladonis,A., Zhang,X., Manupipatpong,K.K., Kalaiselvan,S.,
            Alvarez,P. and Jensen,L.E.
  TITLE     Interleukin-36 (IL-36) system in the 1-fluoro-2,4-dinitrobenzene
            (DNFB) mouse model of allergic contact dermatitis
  JOURNAL   Allergy 75 (8), 2078-2081 (2020)
   PUBMED   32145081
REFERENCE   4  (bases 1 to 790)
  AUTHORS   Wang,P., Gamero,A.M. and Jensen,L.E.
  TITLE     IL-36 promotes anti-viral immunity by boosting sensitivity to
            IFN-alpha/beta in IRF1 dependent and independent manners
  JOURNAL   Nat Commun 10 (1), 4700 (2019)
   PUBMED   31619669
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 790)
  AUTHORS   Mao,D., Hu,C., Zhang,J., Feng,C., Zhang,Z., Wang,J., Man,Z.,
            Zhu,Z., Wang,Y., Zhao,H., Zhu,X., Ouyang,J., Dong,X. and Zhao,X.
  TITLE     Long Noncoding RNA GM16343 Promotes IL-36beta to Regulate Tumor
            Microenvironment by CD8+T cells
  JOURNAL   Technol Cancer Res Treat 18, 1533033819883633 (2019)
   PUBMED   31684829
  REMARK    GeneRIF: Interleukin 36beta may enhance antitumor immune response
            of CD8(+)T cells by regulating GM16343.
REFERENCE   6  (bases 1 to 790)
  AUTHORS   Towne,J.E., Renshaw,B.R., Douangpanya,J., Lipsky,B.P., Shen,M.,
            Gabel,C.A. and Sims,J.E.
  TITLE     Interleukin-36 (IL-36) ligands require processing for full agonist
            (IL-36alpha, IL-36beta, and IL-36gamma) or antagonist (IL-36Ra)
            activity
  JOURNAL   J Biol Chem 286 (49), 42594-42602 (2011)
   PUBMED   21965679
  REMARK    GeneRIF: Interleukin-36 (IL-36) ligands require processing for full
            agonist (IL-36alpha, IL-36beta, and IL-36gamma) or antagonist
            (IL-36Ra) activity
REFERENCE   7  (bases 1 to 790)
  AUTHORS   Vigne,S., Palmer,G., Lamacchia,C., Martin,P., Talabot-Ayer,D.,
            Rodriguez,E., Ronchi,F., Sallusto,F., Dinh,H., Sims,J.E. and
            Gabay,C.
  TITLE     IL-36R ligands are potent regulators of dendritic and T cells
  JOURNAL   Blood 118 (22), 5813-5823 (2011)
   PUBMED   21860022
  REMARK    GeneRIF: A critical role of IL-36R ligands in the interface between
            innate and adaptive immunity, leading to the stimulation of T
            helper responses.
REFERENCE   8  (bases 1 to 790)
  AUTHORS   Egawa,G., Osawa,M., Uemura,A., Miyachi,Y. and Nishikawa,S.
  TITLE     Transient expression of ephrin b2 in perinatal skin is required for
            maintenance of keratinocyte homeostasis
  JOURNAL   J Invest Dermatol 129 (10), 2386-2395 (2009)
   PUBMED   19571816
REFERENCE   9  (bases 1 to 790)
  AUTHORS   Wang,P., Meinhardt,B., Andre,R., Renshaw,B.R., Kimber,I.,
            Rothwell,N.J. and Pinteaux,E.
  TITLE     The interleukin-1-related cytokine IL-1F8 is expressed in glial
            cells, but fails to induce IL-1beta signalling responses
  JOURNAL   Cytokine 29 (6), 245-250 (2005)
   PUBMED   15749024
  REMARK    GeneRIF: The interleukin-1-related cytokine IL-1F8 is expressed in
            glial cells, but fails to induce any of the classical IL-1
            responses in glial cells.
REFERENCE   10 (bases 1 to 790)
  AUTHORS   Taylor,S.L., Renshaw,B.R., Garka,K.E., Smith,D.E. and Sims,J.E.
  TITLE     Genomic organization of the interleukin-1 locus
  JOURNAL   Genomics 79 (5), 726-733 (2002)
   PUBMED   11991723
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC119517.1.
            
            On Jul 25, 2007 this sequence version replaced NM_027163.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC119517.1, AK009787.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849376, SAMN00849382
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..790
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 16.21 cM"
     gene            1..790
                     /gene="Il36b"
                     /gene_synonym="2310043N20Rik; If36b; Il1f8"
                     /note="interleukin 36B"
                     /db_xref="GeneID:69677"
                     /db_xref="MGI:MGI:1916927"
     exon            1..62
                     /gene="Il36b"
                     /gene_synonym="2310043N20Rik; If36b; Il1f8"
                     /inference="alignment:Splign:2.1.0"
     exon            63..156
                     /gene="Il36b"
                     /gene_synonym="2310043N20Rik; If36b; Il1f8"
                     /inference="alignment:Splign:2.1.0"
     CDS             66..617
                     /gene="Il36b"
                     /gene_synonym="2310043N20Rik; If36b; Il1f8"
                     /note="IL-1F8; interleukin 1 family, member 8"
                     /codon_start=1
                     /product="interleukin-36 beta"
                     /protein_id="NP_081439.1"
                     /db_xref="CCDS:CCDS38063.1"
                     /db_xref="GeneID:69677"
                     /db_xref="MGI:MGI:1916927"
                     /translation="MMAFPPQSCVHVLPPKSIQMWEPNHNTMHGSSQSPRNYRVHDSQ
                     QMVWVLTGNTLTAVPASNNVKPVILSLIACRDTEFQDVKKGNLVFLGIKNRNLCFCCV
                     EMEGKPTLQLKEVDIMNLYKERKAQKAFLFYHGIEGSTSVFQSVLYPGWFIATSSIER
                     QTIILTHQRGKLVNTNFYIESEK"
     exon            157..264
                     /gene="Il36b"
                     /gene_synonym="2310043N20Rik; If36b; Il1f8"
                     /inference="alignment:Splign:2.1.0"
     exon            265..404
                     /gene="Il36b"
                     /gene_synonym="2310043N20Rik; If36b; Il1f8"
                     /inference="alignment:Splign:2.1.0"
     exon            405..790
                     /gene="Il36b"
                     /gene_synonym="2310043N20Rik; If36b; Il1f8"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gactggcctc attgcctgct gtcataactt cgatcccaga gacaagactt ctttggacca
       61 aggcaatgat ggctttccct ccacaatctt gtgtacatgt tcttcctcca aagagtattc
      121 aaatgtggga accgaatcat aacactatgc atggatcctc acaatctccc agaaactaca
      181 gggttcatga ctcacaacag atggtatggg tcctgactgg aaatacttta acagcagttc
      241 ctgctagcaa caatgtcaag cctgtcattc ttagcttgat agcatgtaga gacacggaat
      301 tccaagatgt aaagaaaggt aatctagttt tcctgggaat caagaacaga aatctctgct
      361 tctgctgtgt tgagatggag ggcaaaccaa ctttgcagct taaggaagta gacatcatga
      421 atttgtacaa agagagaaaa gcacaaaaag cctttctgtt ctatcatggc atagagggct
      481 ccacttctgt ctttcagtca gtcctctatc ctggctggtt tatagccacc tcttccatag
      541 aaagacagac aatcatcctc acacatcagc ggggtaaatt ggttaacact aacttctaca
      601 tagagtctga gaagtaaatc caacatgggt catatgtggc cagctccagg ccacagaatc
      661 aaactgttga agaatcttct acttgaaaac atagcaagcc tcttagaaga ccaccatgcc
      721 atgtcttcac cagacatcca tgtctaaaat gccactcatt tgaatatcat tccagcatga
      781 agcccatgaa
//
