LOCUS       NM_001135100            1747 bp    mRNA    linear   ROD 25-FEB-2025
DEFINITION  Mus musculus interleukin 34 (Il34), transcript variant 1, mRNA.
ACCESSION   NM_001135100
VERSION     NM_001135100.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1747)
  AUTHORS   Lehtonen,H., Jokela,H., Hofmann,J., Tola,L., Mehmood,A.,
            Ginhoux,F., Becher,B., Greter,M., Yegutkin,G.G., Salmi,M., Gerke,H.
            and Rantakari,P.
  TITLE     Early precursor-derived pituitary gland tissue-resident macrophages
            play a pivotal role in modulating hormonal balance
  JOURNAL   Cell Rep 44 (2), 115227 (2025)
   PUBMED   39841599
  REMARK    Publication Status: Available-Online prior to print
REFERENCE   2  (bases 1 to 1747)
  AUTHORS   Ho,A., Ngala,B., Yamada,C., Garcia,C., Duarte,C., Akkaoui,J.,
            Ciolac,D., Nusbaum,A., Kochen,W., Efremova,D., Groppa,S.,
            Nathanson,L., Bissel,S., Oblak,A., Kacena,M.A. and Movila,A.
  TITLE     IL-34 exacerbates pathogenic features of Alzheimer's disease and
            calvaria osteolysis in triple transgenic (3x-Tg) female mice
  JOURNAL   Biomed Pharmacother 166, 115435 (2023)
   PUBMED   37666180
  REMARK    GeneRIF: IL-34 exacerbates pathogenic features of Alzheimer's
            disease and calvaria osteolysis in triple transgenic (3x-Tg) female
            mice.
REFERENCE   3  (bases 1 to 1747)
  AUTHORS   Zhuang,L., Zong,X., Yang,Q., Fan,Q. and Tao,R.
  TITLE     Interleukin-34-NF-kappaB signaling aggravates myocardial
            ischemic/reperfusion injury by facilitating macrophage recruitment
            and polarization
  JOURNAL   EBioMedicine 95, 104744 (2023)
   PUBMED   37556943
  REMARK    GeneRIF: Interleukin-34-NF-kappaB signaling aggravates myocardial
            ischemic/reperfusion injury by facilitating macrophage recruitment
            and polarization.
REFERENCE   4  (bases 1 to 1747)
  AUTHORS   Chae,D.S., Han,S., Lee,M.K. and Kim,S.W.
  TITLE     BMP-2 Genome-Edited Human MSCs Protect against Cartilage
            Degeneration via Suppression of IL-34 in Collagen-Induced Arthritis
  JOURNAL   Int J Mol Sci 24 (9), 8223 (2023)
   PUBMED   37175932
  REMARK    GeneRIF: BMP-2 Genome-Edited Human MSCs Protect against Cartilage
            Degeneration via Suppression of IL-34 in Collagen-Induced
            Arthritis.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1747)
  AUTHORS   Su,Y., Cao,Y., Liu,C., Xu,Q., Li,N., Lan,M., Li,L., Wang,K.,
            Zhang,Z. and Meng,Q.
  TITLE     Inactivating IL34 promotes regenerating muscle stem cell expansion
            and attenuates Duchenne muscular dystrophy in mouse models
  JOURNAL   Theranostics 13 (8), 2588-2604 (2023)
   PUBMED   37215564
  REMARK    GeneRIF: Inactivating IL34 promotes regenerating muscle stem cell
            expansion and attenuates Duchenne muscular dystrophy in mouse
            models.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1747)
  AUTHORS   Chen,Z., Buki,K., Vaaraniemi,J., Gu,G. and Vaananen,H.K.
  TITLE     The critical role of IL-34 in osteoclastogenesis
  JOURNAL   PLoS One 6 (4), e18689 (2011)
   PUBMED   21494622
  REMARK    GeneRIF: This study was to explore the biological function,
            specifically osteoclastogenesis and bone metabolism, of il-34.
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 1747)
  AUTHORS   Chihara,T., Suzu,S., Hassan,R., Chutiwitoonchai,N., Hiyoshi,M.,
            Motoyoshi,K., Kimura,F. and Okada,S.
  TITLE     IL-34 and M-CSF share the receptor Fms but are not identical in
            biological activity and signal activation
  JOURNAL   Cell Death Differ 17 (12), 1917-1927 (2010)
   PUBMED   20489731
REFERENCE   8  (bases 1 to 1747)
  AUTHORS   Wei,S., Nandi,S., Chitu,V., Yeung,Y.G., Yu,W., Huang,M.,
            Williams,L.T., Lin,H. and Stanley,E.R.
  TITLE     Functional overlap but differential expression of CSF-1 and IL-34
            in their CSF-1 receptor-mediated regulation of myeloid cells
  JOURNAL   J Leukoc Biol 88 (3), 495-505 (2010)
   PUBMED   20504948
  REMARK    GeneRIF: The different spatiotemporal expression of IL-34 and CSF-1
            allows for complementary activation of the CSF-1R in developing and
            adult tissues.
REFERENCE   9  (bases 1 to 1747)
  AUTHORS   Baud'huin,M., Renault,R., Charrier,C., Riet,A., Moreau,A.,
            Brion,R., Gouin,F., Duplomb,L. and Heymann,D.
  TITLE     Interleukin-34 is expressed by giant cell tumours of bone and plays
            a key role in RANKL-induced osteoclastogenesis
  JOURNAL   J Pathol 221 (1), 77-86 (2010)
   PUBMED   20191615
REFERENCE   10 (bases 1 to 1747)
  AUTHORS   Lin,H., Lee,E., Hestir,K., Leo,C., Huang,M., Bosch,E.,
            Halenbeck,R., Wu,G., Zhou,A., Behrens,D., Hollenbaugh,D.,
            Linnemann,T., Qin,M., Wong,J., Chu,K., Doberstein,S.K. and
            Williams,L.T.
  TITLE     Discovery of a cytokine and its receptor by functional screening of
            the extracellular proteome
  JOURNAL   Science 320 (5877), 807-811 (2008)
   PUBMED   18467591
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY148512.1, AK008082.1 and AW743837.1.
            
            On Nov 3, 2013 this sequence version replaced NM_001135100.1.
            
            Transcript Variant: This variant (1) encodes the longer protein
            (isoform 1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC016254.1, SRR7652917.590638.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-52                BY148512.1         4-55
            53-985              AK008082.1         1-933
            986-1463            AK008082.1         1052-1529
            1464-1747           AW743837.1         1-284               c
FEATURES             Location/Qualifiers
     source          1..1747
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 57.68 cM"
     gene            1..1747
                     /gene="Il34"
                     /gene_synonym="2010004A03Rik"
                     /note="interleukin 34"
                     /db_xref="GeneID:76527"
                     /db_xref="MGI:MGI:1923777"
     exon            1..191
                     /gene="Il34"
                     /gene_synonym="2010004A03Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            192..611
                     /gene="Il34"
                     /gene_synonym="2010004A03Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             584..1291
                     /gene="Il34"
                     /gene_synonym="2010004A03Rik"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1"
                     /codon_start=1
                     /product="interleukin-34 isoform 1 precursor"
                     /protein_id="NP_001128572.1"
                     /db_xref="CCDS:CCDS52669.1"
                     /db_xref="GeneID:76527"
                     /db_xref="MGI:MGI:1923777"
                     /translation="MPWGLAWLYCLGILLDVALGNENLEIWTLTQDKECDLTGYLRGK
                     LQYKNRLQYMKHYFPINYRIAVPYEGVLRVANITRLQKAHVSERELRYLWVLVSLNAT
                     ESVMDVLLEGHPSWKYLQEVQTLLENVQRSLMDVEIGPHVEAVLSLLSTPGLSLKLVR
                     PKALLDNCFRVMELLYCSCCKQSPILKWQDCELPRLHPHSPGSLMQCTATNVYPLSRQ
                     TPTSLPGSPSSSHGSLP"
     exon            612..745
                     /gene="Il34"
                     /gene_synonym="2010004A03Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            746..823
                     /gene="Il34"
                     /gene_synonym="2010004A03Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            824..985
                     /gene="Il34"
                     /gene_synonym="2010004A03Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            986..1121
                     /gene="Il34"
                     /gene_synonym="2010004A03Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1122..1741
                     /gene="Il34"
                     /gene_synonym="2010004A03Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1710..1715
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Il34"
                     /gene_synonym="2010004A03Rik"
                     /note="hexamer: ATTAAA"
     polyA_site      1741
                     /gene="Il34"
                     /gene_synonym="2010004A03Rik"
                     /note="major polyA site"
ORIGIN      
        1 tctagaaaca aatctgagct gctgtagcgt gtgtcccccg ccctccgaga agactgtagg
       61 ctgaacacac aacagcctgt cccacacagc atttactgcc acagccccca aggcacctgc
      121 tccaggcctt gagctgctca aagcttccgg cgacggcgac tgtagaagcc cacatcctgg
      181 caggtgagca gagctagact tcacgctgag cagctgcagc cgaagaaacc agagaaagcg
      241 ccacccagcc ccagattcca agaggcctgc ctgctgggga ctcccttctc ttcttcctcc
      301 tcctcctctt cctcctcctg agaccctcaa agtcactgtc tcacaccagt tcctgagctg
      361 caatgggact ggcagccact gccccctggc tgtcctccgc cctgccaagc agatagggcg
      421 gtagctaccc caggagtatc tgccccctct cagcctggac cagccctttc tggacttggt
      481 ggccaccttt gctgacctaa ggccatgtag tccctggctc aggcctctgg acacacttct
      541 ggggacagtg cctctgctct cagggggcac ccagtgcacc accatgccct ggggactcgc
      601 ctggctatac tgtcttggga tcctacttga cgtggctttg ggaaacgaga atttggagat
      661 atggactctg acccaagata aggagtgtga ccttacaggc taccttcggg gcaagctgca
      721 gtacaagaac cggcttcagt acatgaaaca ttacttcccc atcaactaca ggattgctgt
      781 gccttatgag ggggtactca gagtggccaa catcacaagg ctgcagaagg ctcacgtgag
      841 tgagcgagag cttcggtacc tgtgggtctt ggtgagtctc aatgccactg agtctgtgat
      901 ggatgtactt ctcgagggcc acccgtcctg gaagtatcta caggaggttc agacattgct
      961 ggagaacgta cagcggagcc tcatggatgt ggagattggc cctcacgtgg aagctgtgtt
     1021 atctcttctg agtactccag gcctaagcct gaagctggtg cggcccaaag ccttgctgga
     1081 caactgcttc cgggtcatgg aactgctgta ctgttcttgc tgtaaacaaa gccccatctt
     1141 aaaatggcag gactgcgagc tgcccaggct ccatccccac agtccggggt ccttgatgca
     1201 atgtacagct acaaatgtgt accctttgtc tcggcagacc cccacctccc tgcccggatc
     1261 cccaagctca agccatggct cgttgccctg agcaatctat gtattgaccc tgggtcgggc
     1321 cactggatgc atttcagaaa ctggcctgga tctgagacct tcctggatgg tgggtaggta
     1381 gcccctttag gaaaggcctt cagggaaagg cctcctgcct tctcttccac acccaggctt
     1441 cctgccttct ggtggtatca cggagcctca ggggagggat gtggagggga gggctggttg
     1501 ctatccctta cagccacctc tgcttgtggc ccggtccgaa atctgcaaac actgttgccc
     1561 cacaggcggg tggccaagaa cgacggggtg cctcctagga tcccaggact tactggggct
     1621 tttcagttgt gctgactgtg gggtgctggg ccgaggacca accaaatgcc gtatcttgcc
     1681 atgacgatgc tcttctggtt cctttttcta ttaaatggcc atttatttgg tttggcttgc
     1741 aaaaaaa
//
