LOCUS       NM_133775               2538 bp    mRNA    linear   ROD 11-FEB-2025
DEFINITION  Mus musculus interleukin 33 (Il33), transcript variant 2, mRNA.
ACCESSION   NM_133775
VERSION     NM_133775.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2538)
  AUTHORS   Hu,Y., Feng,Z., An,G., Lv,Z., Wang,J., Cui,Y., Corrigan,C.J.,
            Wang,W., Li,Q. and Ying,S.
  TITLE     Edwardsiella tarda induces airways inflammation and production of
            autoantibodies against lung tissues through regulation of the
            IL-33-ST2 axis
  JOURNAL   Immunology 173 (3), 575-589 (2024)
   PUBMED   39126327
  REMARK    GeneRIF: Edwardsiella tarda induces airways inflammation and
            production of autoantibodies against lung tissues through
            regulation of the IL-33-ST2 axis.
REFERENCE   2  (bases 1 to 2538)
  AUTHORS   Wu,F., Zhang,S., Zhuang,R., Hu,C. and Zhu,K.
  TITLE     Blocking IL-33 decelerates cartilage degeneration in knee
            osteoarthritis through mice model
  JOURNAL   PLoS One 19 (8), e0301199 (2024)
   PUBMED   39172956
  REMARK    GeneRIF: Blocking IL-33 decelerates cartilage degeneration in knee
            osteoarthritis through mice model.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2538)
  AUTHORS   Xu,R., Pan,Y., Zheng,K., Chen,M., Yin,C., Hu,Q., Wang,J., Yu,Q.,
            Li,P., Tai,Y., Fang,J., Liu,B., Fang,J., Tian,G. and Liu,B.
  TITLE     IL-33/ST2 induces macrophage-dependent ROS production and TRPA1
            activation that mediate pain-like responses by skin incision in
            mice
  JOURNAL   Theranostics 14 (13), 5281-5302 (2024)
   PUBMED   39267790
  REMARK    GeneRIF: IL-33/ST2 induces macrophage-dependent ROS production and
            TRPA1 activation that mediate pain-like responses by skin incision
            in mice.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2538)
  AUTHORS   Bisen,S., Verma,S.K., Mukhopadhyay,C.S. and Singh,N.K.
  TITLE     A neutrophil elastase-generated mature form of IL-33 is a potent
            regulator of endothelial cell activation and proliferative
            retinopathy
  JOURNAL   Exp Mol Med 56 (8), 1703-1716 (2024)
   PUBMED   39085349
REFERENCE   5  (bases 1 to 2538)
  AUTHORS   Braun,H., Afonina,I.S., Mueller,C. and Beyaert,R.
  TITLE     Dichotomous function of IL-33 in health and disease: From biology
            to clinical implications
  JOURNAL   Biochem Pharmacol 148, 238-252 (2018)
   PUBMED   29309756
  REMARK    Review article
REFERENCE   6  (bases 1 to 2538)
  AUTHORS   Cayrol,C. and Girard,J.P.
  TITLE     Interleukin-33 (IL-33): A nuclear cytokine from the IL-1 family
  JOURNAL   Immunol Rev 281 (1), 154-168 (2018)
   PUBMED   29247993
  REMARK    Review article
REFERENCE   7  (bases 1 to 2538)
  AUTHORS   Carriere,V., Roussel,L., Ortega,N., Lacorre,D.A., Americh,L.,
            Aguilar,L., Bouche,G. and Girard,J.P.
  TITLE     IL-33, the IL-1-like cytokine ligand for ST2 receptor, is a
            chromatin-associated nuclear factor in vivo
  JOURNAL   Proc Natl Acad Sci U S A 104 (1), 282-287 (2007)
   PUBMED   17185418
  REMARK    GeneRIF: IL-33 is a dual function protein that may function as both
            a proinflammatory cytokine and an intracellular nuclear factor with
            transcriptional regulatory properties.
REFERENCE   8  (bases 1 to 2538)
  AUTHORS   Schmitz,J., Owyang,A., Oldham,E., Song,Y., Murphy,E.,
            McClanahan,T.K., Zurawski,G., Moshrefi,M., Qin,J., Li,X.,
            Gorman,D.M., Bazan,J.F. and Kastelein,R.A.
  TITLE     IL-33, an interleukin-1-like cytokine that signals via the IL-1
            receptor-related protein ST2 and induces T helper type 2-associated
            cytokines
  JOURNAL   Immunity 23 (5), 479-490 (2005)
   PUBMED   16286016
  REMARK    GeneRIF: IL-33, which mediates its biological effects via IL-1
            receptor ST 2, activates NF-kappaB and MAP kinases, and drives
            production of T(H)2-associated cytokines from in vitro polarized
            T(H)2 cells
REFERENCE   9  (bases 1 to 2538)
  AUTHORS   Kuninger,D., Kuzmickas,R., Peng,B., Pintar,J.E. and Rotwein,P.
  TITLE     Gene discovery by microarray: identification of novel genes induced
            during growth factor-mediated muscle cell survival and
            differentiation
  JOURNAL   Genomics 84 (5), 876-889 (2004)
   PUBMED   15475267
REFERENCE   10 (bases 1 to 2538)
  AUTHORS   Baekkevold,E.S., Roussigne,M., Yamanaka,T., Johansen,F.E.,
            Jahnsen,F.L., Amalric,F., Brandtzaeg,P., Erard,M., Haraldsen,G. and
            Girard,J.P.
  TITLE     Molecular characterization of NF-HEV, a nuclear factor
            preferentially expressed in human high endothelial venules
  JOURNAL   Am J Pathol 163 (1), 69-79 (2003)
   PUBMED   12819012
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC157785.2, AK163464.1 and AC111048.8.
            
            On Feb 10, 2018 this sequence version replaced NM_133775.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC003847.1, AK163464.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849376
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1                 AC157785.2         125380-125380
            2-1431              AK163464.1         2-1431
            1432-1432           AC111048.8         99697-99697
            1433-2517           AK163464.1         1433-2517
            2518-2538           AC111048.8         100783-100803
FEATURES             Location/Qualifiers
     source          1..2538
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 24.56 cM"
     gene            1..2538
                     /gene="Il33"
                     /gene_synonym="9230117N10Rik; Il-33; Il1f11; NF-HEV"
                     /note="interleukin 33"
                     /db_xref="GeneID:77125"
                     /db_xref="MGI:MGI:1924375"
     exon            1..49
                     /gene="Il33"
                     /gene_synonym="9230117N10Rik; Il-33; Il1f11; NF-HEV"
                     /inference="alignment:Splign:2.1.0"
     exon            50..157
                     /gene="Il33"
                     /gene_synonym="9230117N10Rik; Il-33; Il1f11; NF-HEV"
                     /inference="alignment:Splign:2.1.0"
     CDS             61..861
                     /gene="Il33"
                     /gene_synonym="9230117N10Rik; Il-33; Il1f11; NF-HEV"
                     /note="isoform 1 is encoded by transcript variant 2;
                     nuclear factor from high endothelial venules"
                     /codon_start=1
                     /product="interleukin-33 isoform 1"
                     /protein_id="NP_598536.2"
                     /db_xref="CCDS:CCDS29740.1"
                     /db_xref="GeneID:77125"
                     /db_xref="MGI:MGI:1924375"
                     /translation="MRPRMKYSNSKISPAKFSSTAGEALVPPCKIRRSQQKTKEFCHV
                     YCMRLRSGLTIRKETSYFRKEPTKRYSLKSGTKHEENFSAYPRDSRKRSLLGSIQAFA
                     ASVDTLSIQGTSLLTQSPASLSTYNDQSVSFVLENGCYVINVDDSGKDQEQDQVLLRY
                     YESPCPASQSGDGVDGKKLMVNMSPIKDTDIWLHANDKDYSVELQRGDVSPPEQAFFV
                     LHKKSSDFVSFECKNLPGTYIGVKDNQLALVEEKDESCNNIMFKLSKI"
     exon            158..283
                     /gene="Il33"
                     /gene_synonym="9230117N10Rik; Il-33; Il1f11; NF-HEV"
                     /inference="alignment:Splign:2.1.0"
     exon            284..394
                     /gene="Il33"
                     /gene_synonym="9230117N10Rik; Il-33; Il1f11; NF-HEV"
                     /inference="alignment:Splign:2.1.0"
     exon            395..520
                     /gene="Il33"
                     /gene_synonym="9230117N10Rik; Il-33; Il1f11; NF-HEV"
                     /inference="alignment:Splign:2.1.0"
     exon            521..571
                     /gene="Il33"
                     /gene_synonym="9230117N10Rik; Il-33; Il1f11; NF-HEV"
                     /inference="alignment:Splign:2.1.0"
     exon            572..669
                     /gene="Il33"
                     /gene_synonym="9230117N10Rik; Il-33; Il1f11; NF-HEV"
                     /inference="alignment:Splign:2.1.0"
     exon            670..2538
                     /gene="Il33"
                     /gene_synonym="9230117N10Rik; Il-33; Il1f11; NF-HEV"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2503..2508
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Il33"
                     /gene_synonym="9230117N10Rik; Il-33; Il1f11; NF-HEV"
                     /note="hexamer: AATAAA"
     polyA_site      2524
                     /gene="Il33"
                     /gene_synonym="9230117N10Rik; Il-33; Il1f11; NF-HEV"
                     /note="major polyA site"
ORIGIN      
        1 aagaggaact gcagctgcag aagggagaaa tcacggcaga atcatcgaga aacctgaaaa
       61 atgagaccta gaatgaagta ttccaactcc aagatttccc cggcaaagtt cagcagcacc
      121 gcaggcgaag ccctggtccc gccttgcaaa ataagaagat cccaacagaa gaccaaagaa
      181 ttctgccatg tctactgcat gagactccgt tctggcctca ccataagaaa ggagactagt
      241 tattttagga aagaacccac gaaaagatat tcactaaaat cgggtaccaa gcatgaagag
      301 aacttctctg cctatccacg ggattctagg aagagatcct tgcttggcag tatccaagca
      361 tttgctgcgt ctgttgacac attgagcatc caaggaactt cacttttaac acagtctcct
      421 gcctccctga gtacatacaa tgaccaatct gttagttttg ttttggagaa tggatgttat
      481 gtgatcaatg ttgacgactc tggaaaagac caagagcaag accaggtgct actacgctac
      541 tatgagtctc cctgtcctgc aagtcaatca ggcgacggtg tggatgggaa gaagctgatg
      601 gtgaacatga gtcccatcaa agacacagac atctggctgc atgccaacga caaggactac
      661 tccgtggagc ttcaaagggg tgacgtctcg cctccggaac aggccttctt cgtccttcac
      721 aaaaagtcct cggactttgt ttcatttgaa tgcaagaatc ttcctggcac ttacatagga
      781 gtaaaagata accagctggc tctagtggag gagaaagatg agagctgcaa caatattatg
      841 tttaagctct cgaaaatcta atgcagtaaa acgcctgtgc gttctgggtt gaatgactta
      901 atgcttccaa ctgaagaaag ggtaacagag agaaagaaag ccattcttgg cttacgatgt
      961 tgtggaatgt tattatgtag aaaacttctt ttatttcctt ttcttcagct acatgttcaa
     1021 tagactcaca gatatatgac ttacggcgtt ggtaaagaaa ctgaaggaga ttcagccttg
     1081 ctctttcctt ttctctgcct tgagtcctgt atgaaatcac actcacggac ttcagaagag
     1141 caggcaccac agtgcatggt ttgctttaga gagggtccat ttcaaaaacc ttcataaaaa
     1201 caatgcaaaa caagaaaaca accgaacaaa aaaaccacct atttcctggt tctaaacaaa
     1261 tgattgtaat actagagcag ttagtgggag gaccagctag ggggaggatc acctagggga
     1321 ggaccagcta gggggaggac cagctgctgc aaagactgac tgtttctcac ttataataaa
     1381 atgccaaatg cctccgcaga tgccccaggc aaccctcaga tcagcccttt ctgtgaagag
     1441 tggcgttacc tgtgcttgtt tccttcttaa acttccaatt tttctctttt aacacattta
     1501 acatttaact ttaagcaagc cagcttacat taggaagtga aagacatttt agttcccacc
     1561 cgtgattgaa atcattgact atatctaaca agcttaaagt ctcctgtaag aactgatcag
     1621 gatatacact aggacatgcc aatagaatgg gatctcatgg tgcagtctga agccctccaa
     1681 ctggagagac gctaacatca tccttctcgc tgatttccaa ggagctatga ctttggatgc
     1741 atgcatctgc ttggatgaga tgtctcggct gcttgctttc cttatgcaca cgttctgttc
     1801 agcttcacag cagcaatgct cacggtggaa tagcttagct tagcttctgc cccttctttg
     1861 gttcttttga ccaccatatc cgtaacggct ctcctactcc ctcagctttc tttctctttg
     1921 ctctgacgtc tatatgccaa cacacttatt ccactgtctt taccctgcac tgcagaattt
     1981 tacatctacc tactggttac caggttgtcc cctgaacaac cttcctttgt gttttactgt
     2041 tattaaagta gtaatatttg tattcaacca tgtagtaata ttttaagcca ctaaaggaat
     2101 agttttactt atttagacaa cagcaatttc tactacattt ttataagctt aaaacttaca
     2161 tgttttaaaa cttaaaacga taaagacaat aacaacattg atggagtatg atatgacagt
     2221 tcagaaaggg ttagctctta tcttccagtc gaggaaacct attgtataca atagctggag
     2281 gaatgtatga tcaaagaggc cgggaaccgc cgtgtaggat cgtacggctg taacaggtat
     2341 aattgtttca ttaatttgtc acagtcttac tgtagaggaa tgtaaaggcg gaatctgcgt
     2401 cattcctctg gaaaccacag tgttgactct gtgaatctgt acgatatctt taaagtagta
     2461 actacgtagt caaatgtgtt cttgacgttg ttcataactt tgaataaacc atttttcaaa
     2521 accacgtgtg accacaaa
//
