LOCUS       NM_139299               3680 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus interleukin 31 receptor A (Il31ra), mRNA.
ACCESSION   NM_139299
VERSION     NM_139299.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3680)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3680)
  AUTHORS   Akkenepally,S.V., Yombo,D.J.K., Yerubandi,S., Reddy,G.B.,
            Deshpande,D.A., McCormack,F.X. and Madala,S.K.
  TITLE     Interleukin 31 receptor alpha promotes smooth muscle cell
            contraction and airway hyperresponsiveness in asthma
  JOURNAL   Nat Commun 14 (1), 8207 (2023)
   PUBMED   38081868
  REMARK    GeneRIF: Interleukin 31 receptor alpha promotes smooth muscle cell
            contraction and airway hyperresponsiveness in asthma.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3680)
  AUTHORS   Fassett,M.S., Braz,J.M., Castellanos,C.A., Salvatierra,J.J.,
            Sadeghi,M., Yu,X., Schroeder,A.W., Caston,J., Munoz-Sandoval,P.,
            Roy,S., Lazarevsky,S., Mar,D.J., Zhou,C.J., Shin,J.S., Basbaum,A.I.
            and Ansel,K.M.
  TITLE     IL-31-dependent neurogenic inflammation restrains cutaneous type 2
            immune response in allergic dermatitis
  JOURNAL   Sci Immunol 8 (88), eabi6887 (2023)
   PUBMED   37831760
REFERENCE   4  (bases 1 to 3680)
  AUTHORS   Arai,I. and Saito,S.
  TITLE     Interleukin-31 Receptor A Expression in the Dorsal Root Ganglion of
            Mice with Atopic Dermatitis
  JOURNAL   Int J Mol Sci 24 (2), 1047 (2023)
   PUBMED   36674561
  REMARK    GeneRIF: Interleukin-31 Receptor A Expression in the Dorsal Root
            Ganglion of Mice with Atopic Dermatitis.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3680)
  AUTHORS   Yombo,D.J.K., Odayar,V., Gupta,N., Jegga,A.G. and Madala,S.K.
  TITLE     The Protective Effects of IL-31RA Deficiency During
            Bleomycin-Induced Pulmonary Fibrosis
  JOURNAL   Front Immunol 12, 645717 (2021)
   PUBMED   33815402
  REMARK    GeneRIF: The Protective Effects of IL-31RA Deficiency During
            Bleomycin-Induced Pulmonary Fibrosis.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3680)
  AUTHORS   Dillon,S.R., Sprecher,C., Hammond,A., Bilsborough,J.,
            Rosenfeld-Franklin,M., Presnell,S.R., Haugen,H.S., Maurer,M.,
            Harder,B., Johnston,J., Bort,S., Mudri,S., Kuijper,J.L.,
            Bukowski,T., Shea,P., Dong,D.L., Dasovich,M., Grant,F.J.,
            Lockwood,L., Levin,S.D., LeCiel,C., Waggie,K., Day,H., Topouzis,S.,
            Kramer,J., Kuestner,R., Chen,Z., Foster,D., Parrish-Novak,J. and
            Gross,J.A.
  TITLE     Interleukin 31, a cytokine produced by activated T cells, induces
            dermatitis in mice
  JOURNAL   Nat Immunol 5 (7), 752-760 (2004)
   PUBMED   15184896
  REMARK    Erratum:[Nat Immunol. 2005 Jan;6(1):114]
REFERENCE   7  (bases 1 to 3680)
  AUTHORS   Judd,L.M., Alderman,B.M., Howlett,M., Shulkes,A., Dow,C.,
            Moverley,J., Grail,D., Jenkins,B.J., Ernst,M. and Giraud,A.S.
  TITLE     Gastric cancer development in mice lacking the SHP2 binding site on
            the IL-6 family co-receptor gp130
  JOURNAL   Gastroenterology 126 (1), 196-207 (2004)
   PUBMED   14699500
  REMARK    GeneRIF: Gp130(757F/F) mice rapidly develop distal stomach tumors,
            with loss of SHP2/Erk/AP-1 transcriptional regulation exemplified
            by decreased TFF1 expression and increased STAT1/3 regulated genes
            such as Reg I.
REFERENCE   8  (bases 1 to 3680)
  AUTHORS   Diveu,C., Lelievre,E., Perret,D., Lak-Hal,A.H., Froger,J.,
            Guillet,C., Chevalier,S., Rousseau,F., Wesa,A., Preisser,L.,
            Chabbert,M., Gauchat,J.F., Galy,A., Gascan,H. and Morel,A.
  TITLE     GPL, a novel cytokine receptor related to GP130 and leukemia
            inhibitory factor receptor
  JOURNAL   J Biol Chem 278 (50), 49850-49859 (2003)
   PUBMED   14504285
REFERENCE   9  (bases 1 to 3680)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   10 (bases 1 to 3680)
  AUTHORS   Ghilardi,N., Li,J., Hongo,J.A., Yi,S., Gurney,A. and de
            Sauvage,F.J.
  TITLE     A novel type I cytokine receptor is expressed on monocytes, signals
            proliferation, and activates STAT-3 and STAT-5
  JOURNAL   J Biol Chem 277 (19), 16831-16836 (2002)
   PUBMED   11877449
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AB083111.1, BC145083.1, AC159196.2, AK030512.1 and BC066164.1.
            
            On Mar 17, 2009 this sequence version replaced NM_139299.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB083111.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-377               AB083111.1         1-377
            378-594             BC145083.1         204-420
            595-758             AC159196.2         14470-14633
            759-901             AC159196.2         16551-16693
            902-2910            AB083111.1         901-2909
            2911-3661           AK030512.1         1480-2230
            3662-3680           BC066164.1         2002-2020
FEATURES             Location/Qualifiers
     source          1..3680
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 63.75 cM"
     gene            1..3680
                     /gene="Il31ra"
                     /gene_synonym="CRL3; GLM-R; Glmr; GPL; NR10"
                     /note="interleukin 31 receptor A"
                     /db_xref="GeneID:218624"
                     /db_xref="MGI:MGI:2180511"
     exon            1..25
                     /gene="Il31ra"
                     /gene_synonym="CRL3; GLM-R; Glmr; GPL; NR10"
                     /inference="alignment:Splign:2.1.0"
     exon            26..189
                     /gene="Il31ra"
                     /gene_synonym="CRL3; GLM-R; Glmr; GPL; NR10"
                     /inference="alignment:Splign:2.1.0"
     exon            190..397
                     /gene="Il31ra"
                     /gene_synonym="CRL3; GLM-R; Glmr; GPL; NR10"
                     /inference="alignment:Splign:2.1.0"
     exon            398..476
                     /gene="Il31ra"
                     /gene_synonym="CRL3; GLM-R; Glmr; GPL; NR10"
                     /inference="alignment:Splign:2.1.0"
     CDS             422..2572
                     /gene="Il31ra"
                     /gene_synonym="CRL3; GLM-R; Glmr; GPL; NR10"
                     /note="gp130-like monocyte receptor; interleukin-31
                     receptor subunit alpha; interleukin 31RA; class I cytokine
                     receptor; mGLM-R; IL-31RA; zcytoR17; IL-31R-alpha;
                     gp130-like receptor; IL-31R subunit alpha; novel cytokine
                     receptor 10; IL-31 receptor subunit alpha; cytokine
                     receptor NR10; interleukin-31 receptor subunit alpha short
                     peptide"
                     /codon_start=1
                     /product="interleukin-31 receptor subunit alpha precursor"
                     /protein_id="NP_647460.2"
                     /db_xref="CCDS:CCDS36781.1"
                     /db_xref="GeneID:218624"
                     /db_xref="MGI:MGI:2180511"
                     /translation="MWTLALWAFSFLCKFSLAVLPTKPENISCVFYFDRNLTCTWRPE
                     KETNDTSYIVTLTYSYGKSNYSDNATEASYSFPRSCAMPPDICSVEVQAQNGDGKVKS
                     DITYWHLISIAKTEPPIILSVNPICNRMFQIQWKPREKTRGFPLVCMLRFRTVNSSHW
                     TEVNFENCKQVCNLTGLQAFTEYVLALRFRFNDSRYWSKWSKEETRVTMEEVPHVLDL
                     WRILEPADMNGDRKVRLLWKKARGAPVLEKTFGYHIQYFAENSTNLTEINNITTQQYE
                     LLLMSQAHSVSVTSFNSLGKSQEAILRIPDVHEKTFQYIKSMKAYIAEPLLVVNWQSS
                     IPAVDTWIVEWLPEAAMSKFPALSWESVSQVTNWTIEQDKLKPFTCYNISVYPVLGHR
                     VGEPYSIQAYAKEGTPLKGPETRVENIGLRTATITWKEIPKSARNGFINNYTVFYQAE
                     GGKELSKTVNSHALQCDLESLTRRTSYTVWVMASTRAGGTNGVRINFKTLSISVFEIV
                     LLTSLVGGGLLLLSIKTVTFGLRKPNRLTPLCCPDVPNPAESSLATWLGDGFKKSNMK
                     ETGNSGDTEDVVLKPCPVPADLIDKLVVNFENFLEVVLTEEAGKGQASILGGEANEYV
                     TSPSRPDGPPGKSFKEPSVLTEVASEDSHSTCSRMADEAYSELARQPSSSCQSPGLSP
                     PREDQAQNPYLKNSVTTREFLVHENIPEHSKGEV"
     exon            477..594
                     /gene="Il31ra"
                     /gene_synonym="CRL3; GLM-R; Glmr; GPL; NR10"
                     /inference="alignment:Splign:2.1.0"
     exon            595..758
                     /gene="Il31ra"
                     /gene_synonym="CRL3; GLM-R; Glmr; GPL; NR10"
                     /inference="alignment:Splign:2.1.0"
     exon            759..901
                     /gene="Il31ra"
                     /gene_synonym="CRL3; GLM-R; Glmr; GPL; NR10"
                     /inference="alignment:Splign:2.1.0"
     exon            902..1055
                     /gene="Il31ra"
                     /gene_synonym="CRL3; GLM-R; Glmr; GPL; NR10"
                     /inference="alignment:Splign:2.1.0"
     exon            1056..1135
                     /gene="Il31ra"
                     /gene_synonym="CRL3; GLM-R; Glmr; GPL; NR10"
                     /inference="alignment:Splign:2.1.0"
     exon            1136..1352
                     /gene="Il31ra"
                     /gene_synonym="CRL3; GLM-R; Glmr; GPL; NR10"
                     /inference="alignment:Splign:2.1.0"
     exon            1353..1538
                     /gene="Il31ra"
                     /gene_synonym="CRL3; GLM-R; Glmr; GPL; NR10"
                     /inference="alignment:Splign:2.1.0"
     exon            1539..1640
                     /gene="Il31ra"
                     /gene_synonym="CRL3; GLM-R; Glmr; GPL; NR10"
                     /inference="alignment:Splign:2.1.0"
     exon            1641..1787
                     /gene="Il31ra"
                     /gene_synonym="CRL3; GLM-R; Glmr; GPL; NR10"
                     /inference="alignment:Splign:2.1.0"
     exon            1788..1928
                     /gene="Il31ra"
                     /gene_synonym="CRL3; GLM-R; Glmr; GPL; NR10"
                     /inference="alignment:Splign:2.1.0"
     exon            1929..2022
                     /gene="Il31ra"
                     /gene_synonym="CRL3; GLM-R; Glmr; GPL; NR10"
                     /inference="alignment:Splign:2.1.0"
     exon            2023..2104
                     /gene="Il31ra"
                     /gene_synonym="CRL3; GLM-R; Glmr; GPL; NR10"
                     /inference="alignment:Splign:2.1.0"
     exon            2105..3680
                     /gene="Il31ra"
                     /gene_synonym="CRL3; GLM-R; Glmr; GPL; NR10"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ttagtgccgt tctgtgatca gcctggactt cccgaatata aacttgaaac ttgagtggtt
       61 ctcttgagtt gtttatggcc tctcagatga cgactctccc tttaaagctg agtggtgtaa
      121 gagaagcaga cgatcaccta tttaattgtg ccattacagt aaatgcaact catttctcag
      181 cgtcagtgga agccactgtc cggctcttgg aagtcaaagc tgagctcttc tacactcagt
      241 gcacaatgct gaattaatcc aagaaatcca gctgtggctg tctcagtttc tagaaagtca
      301 ctctctccaa ctgtgactgc tccaactttg cctccgggtg ggctgtatgg tgctgtgaac
      361 catttaaagc ttctttttaa accttcatga ataacagcct ctgggtgtga acgctggaat
      421 aatgtggacc ttggcactgt gggcattctc tttcctctgc aaattcagcc tggcagtcct
      481 gccgactaag ccagagaaca tttcctgcgt cttttacttc gacagaaatc tgacttgcac
      541 ttggagacca gagaaggaaa ccaatgatac cagctacatt gtgactttga cttactccta
      601 tggaaaaagc aattatagtg acaatgctac agaggcttca tattcttttc cccgttcctg
      661 tgcaatgccc ccagacatct gcagtgttga agtacaagct caaaatggag atggtaaagt
      721 taaatctgac atcacatatt ggcatttaat ctccatagca aaaaccgaac cacctataat
      781 tttaagtgtg aatccaattt gtaatagaat gttccagata caatggaaac cgcgtgaaaa
      841 gactcgtggg tttcctttag tatgcatgct tcggttcaga actgtcaaca gtagccactg
      901 gacggaagtc aattttgaaa actgtaaaca ggtctgcaac ctcacaggac ttcaggcttt
      961 cacagaatat gtcctggctc tacgattcag gttcaatgac tcaagatatt ggagcaagtg
     1021 gagcaaagaa gaaaccagag tgactatgga ggaagttcca catgtcctgg acctgtggag
     1081 aattctggaa ccagcagaca tgaacggaga caggaaggtg cgattgttgt ggaagaaggc
     1141 aagaggagcc cccgtcttgg agaaaacatt tggctaccac atacagtact ttgcagagaa
     1201 cagcactaac ctcacagaga taaacaacat caccacccag cagtatgaac tgcttctgat
     1261 gagccaggca cactctgtgt ccgtgacttc ttttaattct cttggcaagt cccaagaggc
     1321 catcctgagg atcccagatg tccatgagaa gaccttccag tacattaaga gcatgaaggc
     1381 ctacatagcc gagcccctgt tggtggtgaa ctggcaaagc tccattcctg cggtggacac
     1441 ttggatagtg gagtggctcc cagaagctgc catgtcgaag ttccctgccc tttcctggga
     1501 atctgtgtct caggtcacga actggaccat cgagcaagat aaactaaaac ctttcacatg
     1561 ctataatata tcagtgtatc cagtgttggg acaccgagtt ggagagccgt attcaatcca
     1621 agcttatgcc aaagaaggaa ctccattaaa aggtcctgag accagggtgg agaacatcgg
     1681 tctgaggaca gccacgatca catggaagga gattcctaag agtgctagga atggatttat
     1741 caacaattac actgtatttt accaagctga aggtggaaaa gaactctcca agactgttaa
     1801 ctctcatgcc ctgcagtgtg acctggagtc tctgacacga aggacctctt atactgtttg
     1861 ggtcatggcc agcaccagag ctggaggtac caacggggtg agaataaact tcaagacatt
     1921 gtcaatcagt gtgtttgaaa ttgtccttct aacatctcta gttggaggag gccttcttct
     1981 acttagcatc aaaacagtga cttttggcct cagaaagcca aaccggttga ctcccctgtg
     2041 ttgtcctgat gttcccaacc ctgctgaaag tagtttagcc acatggctcg gagatggttt
     2101 caagaagtca aatatgaagg agactggaaa ctctggggac acagaagacg tggtcctaaa
     2161 accatgtccc gtccccgcgg atctcattga caagctggta gtgaactttg agaattttct
     2221 ggaagtagtt ttgacagagg aagctggaaa gggtcaggcg agcattttgg gaggagaagc
     2281 gaatgagtat gtgacctccc cgtctaggcc cgacggtccc ccagggaaaa gttttaaaga
     2341 gccctccgtt ttaactgagg ttgcttctga agactcccac agcacgtgtt ccagaatggc
     2401 ggacgaggcg tactcagaat tggccaggca gccttcgtct tcctgtcaga gtccagggct
     2461 atcgcctccc cgtgaagacc aagctcagaa tccatatttg aaaaattcag tgacaaccag
     2521 ggaatttctt gtgcatgaga atatcccaga gcacagcaaa ggagaagtct gagtgctgct
     2581 atggcatgaa gtcctcagaa actgagtgga tctcttccct agaaaagaca ccgagacttc
     2641 cagaaaccgc ctttgacccc tccctgttca gttggctgct gcgctgccgg gaaattggtg
     2701 acacagatgt ggacttaggc caggaagaat ggagtccttt acagggcaaa ggaagttact
     2761 ttctcctgtg tgctctcaca gaggcccctt gaaatgatgg cctcaagaga agggccaagc
     2821 ttcggggctt aaaggacgcg cccaggtgga tgtgtcagat cttatcccag gaaccaagct
     2881 gtcctggcta ttgctgaagc taccctcagg atccaggaca gctgtcttgt tggcacttga
     2941 ctctggcagg aacctgatct ctactcttct tctccctgtc tccggacact ttctctcctt
     3001 catgcagaga ccaggactag agcggattcc tcatggtatg ccaggctcct cagtccttgc
     3061 tcgggctcag gatcttcaac aatgcctttt ctgggacact ccatcaccca cttatattta
     3121 ttttttgcaa cattgtggat tgaacccagg gacttggtta tgcgcggtaa gtgtgctacc
     3181 catctcactc accccaagtt tattacgcat tgactgctgc taaatcaaga aactccagaa
     3241 acctccagta agacactgcc atgggctgtg ggctaggtag caggtcagcc tgctttgtag
     3301 gccatttcct ctgtcttgtg ctatacctgg taggagaagg caccaaacag gtgctcggtg
     3361 gcttttgttc agagacacat acttggggcc caggggtgct ttctgagcag accctgatag
     3421 ggcctcttcc cagccaccct gagtgaggcc tggtgagagg cagcacttag caaccatatt
     3481 tctgccttat gaggacttct gccccttggc tgtagccaag cacagagctt gtgacaagaa
     3541 ggtgcctttg gcagaaatgc ccatcacggg atctatttgc ttaggcttgg ggaactgcgt
     3601 ggcttgtaca cagtgggcca ccctctggcc cctttgtctt gctctcaagc ctgggaagtg
     3661 actttaaaaa aaaaaaaaaa
//
