LOCUS       NM_029594               1239 bp    mRNA    linear   ROD 30-JUN-2024
DEFINITION  Mus musculus interleukin 31 (Il31), transcript variant 1, mRNA.
ACCESSION   NM_029594 XM_006530498 XM_132344 XM_915437
VERSION     NM_029594.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1239)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1239)
  AUTHORS   Fassett,M.S., Braz,J.M., Castellanos,C.A., Salvatierra,J.J.,
            Sadeghi,M., Yu,X., Schroeder,A.W., Caston,J., Munoz-Sandoval,P.,
            Roy,S., Lazarevsky,S., Mar,D.J., Zhou,C.J., Shin,J.S., Basbaum,A.I.
            and Ansel,K.M.
  TITLE     IL-31-dependent neurogenic inflammation restrains cutaneous type 2
            immune response in allergic dermatitis
  JOURNAL   Sci Immunol 8 (88), eabi6887 (2023)
   PUBMED   37831760
  REMARK    GeneRIF: IL-31-dependent neurogenic inflammation restrains
            cutaneous type 2 immune response in allergic dermatitis.
REFERENCE   3  (bases 1 to 1239)
  AUTHORS   Kawano,M., Takagi,R., Tokano,M. and Matsushita,S.
  TITLE     Adenosine induces IL-31 secretion by T-helper 2 cells: Implication
            for the effect of adenosine on atopic dermatitis and its
            therapeutic strategy
  JOURNAL   Biochem Biophys Res Commun 645, 47-54 (2023)
   PUBMED   36680936
  REMARK    GeneRIF: Adenosine induces IL-31 secretion by T-helper 2 cells:
            Implication for the effect of adenosine on atopic dermatitis and
            its therapeutic strategy.
REFERENCE   4  (bases 1 to 1239)
  AUTHORS   Kamikaseda,Y., Uruno,T., Kunimura,K., Harada,A., Saiki,K.,
            Oisaki,K., Sakata,D., Nakahara,T., Kido-Nakahara,M., Kanai,M.,
            Nakamura,S., Ohkawa,Y., Furue,M. and Fukui,Y.
  TITLE     Targeted inhibition of EPAS1-driven IL-31 production by a
            small-molecule compound
  JOURNAL   J Allergy Clin Immunol 148 (2), 633-638 (2021)
   PUBMED   33819507
  REMARK    GeneRIF: Targeted inhibition of EPAS1-driven IL-31 production by a
            small-molecule compound.
REFERENCE   5  (bases 1 to 1239)
  AUTHORS   Xu,J., Zanvit,P., Hu,L., Tseng,P.Y., Liu,N., Wang,F., Liu,O.,
            Zhang,D., Jin,W., Guo,N., Han,Y., Yin,J., Cain,A., Hoon,M.A.,
            Wang,S. and Chen,W.
  TITLE     The Cytokine TGF-beta Induces Interleukin-31 Expression from Dermal
            Dendritic Cells to Activate Sensory Neurons and Stimulate Wound
            Itching
  JOURNAL   Immunity 53 (2), 371-383 (2020)
   PUBMED   32673566
  REMARK    GeneRIF: The Cytokine TGF-beta Induces Interleukin-31 Expression
            from Dermal Dendritic Cells to Activate Sensory Neurons and
            Stimulate Wound Itching.
REFERENCE   6  (bases 1 to 1239)
  AUTHORS   Jerome-Majewska,L.A., Achkar,T., Luo,L., Lupu,F. and Lacy,E.
  TITLE     The trafficking protein Tmed2/p24beta(1) is required for
            morphogenesis of the mouse embryo and placenta
  JOURNAL   Dev Biol 341 (1), 154-166 (2010)
   PUBMED   20178780
REFERENCE   7  (bases 1 to 1239)
  AUTHORS   Perrigoue,J.G., Zaph,C., Guild,K., Du,Y. and Artis,D.
  TITLE     IL-31-IL-31R interactions limit the magnitude of Th2
            cytokine-dependent immunity and inflammation following intestinal
            helminth infection
  JOURNAL   J Immunol 182 (10), 6088-6094 (2009)
   PUBMED   19414760
  REMARK    GeneRIF: these data provide the first evidence of a function for
            IL-31-IL-31R interactions in limiting the magnitude of type 2
            inflammatory responses within the intestine.
REFERENCE   8  (bases 1 to 1239)
  AUTHORS   Grimstad,O., Sawanobori,Y., Vestergaard,C., Bilsborough,J.,
            Olsen,U.B., Gronhoj-Larsen,C. and Matsushima,K.
  TITLE     Anti-interleukin-31-antibodies ameliorate scratching behaviour in
            NC/Nga mice: a model of atopic dermatitis
  JOURNAL   Exp Dermatol 18 (1), 35-43 (2009)
   PUBMED   19054054
  REMARK    GeneRIF: -31 antibody reduces scratching behaviour in an atopic
            dermatitis-like murine model during the onset of clinical skin
            manifestations
REFERENCE   9  (bases 1 to 1239)
  AUTHORS   Perrigoue,J.G., Li,J., Zaph,C., Goldschmidt,M., Scott,P., de
            Sauvage,F.J., Pearce,E.J., Ghilardi,N. and Artis,D.
  TITLE     IL-31-IL-31R interactions negatively regulate type 2 inflammation
            in the lung
  JOURNAL   J Exp Med 204 (3), 481-487 (2007)
   PUBMED   17353366
  REMARK    GeneRIF: IL-31 interaction with IL-31 receptor (IL-31R) is
            identified in an acute model of T helper cell type 2 inflammation
            in the lung.
REFERENCE   10 (bases 1 to 1239)
  AUTHORS   Dillon,S.R., Sprecher,C., Hammond,A., Bilsborough,J.,
            Rosenfeld-Franklin,M., Presnell,S.R., Haugen,H.S., Maurer,M.,
            Harder,B., Johnston,J., Bort,S., Mudri,S., Kuijper,J.L.,
            Bukowski,T., Shea,P., Dong,D.L., Dasovich,M., Grant,F.J.,
            Lockwood,L., Levin,S.D., LeCiel,C., Waggie,K., Day,H., Topouzis,S.,
            Kramer,J., Kuestner,R., Chen,Z., Foster,D., Parrish-Novak,J. and
            Gross,J.A.
  TITLE     Interleukin 31, a cytokine produced by activated T cells, induces
            dermatitis in mice
  JOURNAL   Nat Immunol 5 (7), 752-760 (2004)
   PUBMED   15184896
  REMARK    GeneRIF: IL-31 may be involved in promoting the dermatitis and
            epithelial responses that characterize allergic and non-allergic
            diseases
            Erratum:[Nat Immunol. 2005 Jan;6(1):114]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC157931.11.
            
            On or before Jun 4, 2020 this sequence version replaced
            XM_006530498.2, NM_029594.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189685.67808.1,
                                           SRR5189673.12372.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-275               AC157931.11        102774-103048       c
            276-496             AC157931.11        102459-102679       c
            497-648             AC157931.11        102127-102278       c
            649-1239            AC157931.11        100577-101167       c
FEATURES             Location/Qualifiers
     source          1..1239
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 63.0 cM"
     gene            1..1239
                     /gene="Il31"
                     /gene_synonym="1700013B14Rik"
                     /note="interleukin 31"
                     /db_xref="GeneID:76399"
                     /db_xref="MGI:MGI:1923649"
     exon            1..275
                     /gene="Il31"
                     /gene_synonym="1700013B14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            276..496
                     /gene="Il31"
                     /gene_synonym="1700013B14Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             481..972
                     /gene="Il31"
                     /gene_synonym="1700013B14Rik"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; IL-31"
                     /codon_start=1
                     /product="interleukin-31 isoform 1 precursor"
                     /protein_id="NP_083870.1"
                     /db_xref="CCDS:CCDS51645.1"
                     /db_xref="GeneID:76399"
                     /db_xref="MGI:MGI:1923649"
                     /translation="MIFHTGTTKPTLVLLCCIGTWLATCSLSFGAPISKEDLRTTIDL
                     LKQESQDLYNNYSIKQASGMSADESIQLPCFSLDREALTNISVIIAHLEKVKVLSENT
                     VDTSWVIRWLTNISCFNPLNLNISVPGNTDESYDCKVFVLTVLKQFSNCMAELQAKDN
                     TTC"
     exon            497..648
                     /gene="Il31"
                     /gene_synonym="1700013B14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            649..1239
                     /gene="Il31"
                     /gene_synonym="1700013B14Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1215..1220
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Il31"
                     /gene_synonym="1700013B14Rik"
                     /note="hexamer: AATAAA"
     polyA_site      1239
                     /gene="Il31"
                     /gene_synonym="1700013B14Rik"
                     /note="major polyA site"
ORIGIN      
        1 gagaacgcaa ggacaagggc aggccctgga gcacagatgc cttctcctta tgccttccct
       61 gtgttcacta gagccatccc cctgcctccg gaattcccac agatggatcg ctctgtggct
      121 tcttaaaact tccctgcagg gcactgaccc tcagcccctc taagtcactt cttccccagt
      181 gattgtactt ttcaatcggg cttcaaactt tcctctcatt aaatcagcaa gcactttcca
      241 agaaaagaga gatgctcaag atgccttcct gtgtgccctg ctttccccag gccgagccga
      301 ggctggcaac cttttgaaaa tgttttctgg agaaaagctg agcaatggtt ttgccatggg
      361 cgggcctttg atctgcttcc tcatgacaac cctttatata ttgcctggtg gccatggcga
      421 acacaccagg ctccagagac cacaggcaaa gcgggccttc ctcactctct taccgtcgcc
      481 atgatcttcc acacaggaac aacgaagcct accctggtgc tgctttgctg tataggaacc
      541 tggctggcca cctgcagctt gtccttcggt gccccaatat cgaaggaaga cttaagaact
      601 acaattgacc tcttgaaaca agagtctcag gatctttata acaactatag cataaagcag
      661 gcatctggga tgtcagcaga cgaatcaata cagctgccgt gtttcagcct ggaccgggaa
      721 gcattaacca acatctcggt catcatagca catctggaga aagtcaaagt gttgagcgag
      781 aacacagtag atacttcttg ggtgataaga tggctaacaa acatcagctg tttcaaccca
      841 ctgaatttaa acatttctgt gcctggaaat actgatgaat cctatgattg taaagtgttc
      901 gtgcttacgg ttttaaagca gttctcaaac tgcatggcag aactgcaggc taaggacaat
      961 actacatgct gagtgatggg gggggggggg tgcagtgtcc tcagcagtgc ctgtccttcg
     1021 agggctgagc ttgcaaccca ggacttaact ccaaagggac tgtgcggtca ttactagtca
     1081 tgttatttat gtttttattt tgtccactga aatcttgttc tgctaccctg tagggactgg
     1141 aagtggcagc tatatttatt tatttatgta ctgagtttgt taacgctcca tggaggagcc
     1201 ttcagagtct atttaataaa ttatattgac atgatcaca
//
