LOCUS       NM_010556                849 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus interleukin 3 (Il3), mRNA.
ACCESSION   NM_010556
VERSION     NM_010556.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 849)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 849)
  AUTHORS   Ullrich,K.A., Derdau,J., Baltes,C., Battistella,A., Rosso,G.,
            Uderhardt,S., Schulze,L.L., Liu,L.J., Dedden,M., Spocinska,M.,
            Kainka,L., Kubankova,M., Muller,T.M., Schmidt,N.M., Becker,E., Ben
            Brahim,O., Atreya,I., Finotto,S., Prots,I., Wirtz,S., Weigmann,B.,
            Lopez-Posadas,R., Atreya,R., Ekici,A.B., Lautenschlager,F.,
            Guck,J., Neurath,M.F. and Zundler,S.
  TITLE     IL-3 receptor signalling suppresses chronic intestinal inflammation
            by controlling mechanobiology and tissue egress of regulatory T
            cells
  JOURNAL   Gut 72 (11), 2081-2094 (2023)
   PUBMED   37541770
REFERENCE   3  (bases 1 to 849)
  AUTHORS   Palani,S., Uddin,M.B., McKelvey,M., Shao,S. and Sun,K.
  TITLE     Immune predisposition drives susceptibility to pneumococcal
            pneumonia after mild influenza A virus infection in mice
  JOURNAL   Front Immunol 14, 1272920 (2023)
   PUBMED   37771584
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 849)
  AUTHORS   Benard,A., Mittelstadt,A., Klosch,B., Glanz,K., Muller,J.,
            Schoen,J., Nuse,B., Brunner,M., Naschberger,E., Sturzl,M.,
            Mattner,J., Munoz,L.E., Sohn,K., Grutzmann,R. and Weber,G.F.
  TITLE     IL-3 orchestrates ulcerative colitis pathogenesis by controlling
            the development and the recruitment of splenic reservoir
            neutrophils
  JOURNAL   Cell Rep 42 (6), 112637 (2023)
   PUBMED   37300834
  REMARK    GeneRIF: IL-3 orchestrates ulcerative colitis pathogenesis by
            controlling the development and the recruitment of splenic
            reservoir neutrophils.
REFERENCE   5  (bases 1 to 849)
  AUTHORS   Hachem,C.E., Marschall,P., Hener,P., Karnam,A., Bonam,S.R.,
            Meyer,P., Flatter,E., Birling,M.C., Bayry,J. and Li,M.
  TITLE     IL-3 produced by T cells is crucial for basophil extravasation in
            hapten-induced allergic contact dermatitis
  JOURNAL   Front Immunol 14, 1151468 (2023)
   PUBMED   37180157
  REMARK    GeneRIF: IL-3 produced by T cells is crucial for basophil
            extravasation in hapten-induced allergic contact dermatitis.
            Erratum:[Front Immunol. 2023 Jul 18;14:1254157. doi:
            10.3389/fimmu.2023.1254157.. PMID: 37533860]
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 849)
  AUTHORS   Laneuville,P., Sun,G., Timm,M. and Vekemans,M.
  TITLE     Clonal evolution in a myeloid cell line transformed to
            interleukin-3 independent growth by retroviral transduction and
            expression of p210bcr/abl
  JOURNAL   Blood 80 (7), 1788-1797 (1992)
   PUBMED   1327283
REFERENCE   7  (bases 1 to 849)
  AUTHORS   Kaupmann,K., Simon-Chazottes,D., Guenet,J.L. and Jockusch,H.
  TITLE     Wobbler, a mutation affecting motoneuron survival and gonadal
            functions in the mouse, maps to proximal chromosome 11
  JOURNAL   Genomics 13 (1), 39-43 (1992)
   PUBMED   1349581
REFERENCE   8  (bases 1 to 849)
  AUTHORS   Takahashi,Y., Shimizu,A., Sakai,T., Endo,Y., Osawa,N., Shisa,H. and
            Honjo,T.
  TITLE     Mapping of the nu gene using congenic nude strains and in situ
            hybridization
  JOURNAL   J Exp Med 175 (3), 873-876 (1992)
   PUBMED   1346798
REFERENCE   9  (bases 1 to 849)
  AUTHORS   Colombo,M.P., Martinotti,A., Howard,T.A., Schneider,C.,
            D'Eustachio,P. and Seldin,M.F.
  TITLE     Localization of growth arrest-specific genes on mouse chromosomes
            1, 7, 8, 11, 13, and 16
  JOURNAL   Mamm Genome 2 (2), 130-134 (1992)
   PUBMED   1347472
REFERENCE   10 (bases 1 to 849)
  AUTHORS   Danciger,M., Kozak,C.A., Adamson,M.C. and Farber,D.B.
  TITLE     Chromosomal localization of the murine genes for the alpha- and
            beta-subunits of calcium/calmodulin-dependent protein kinase II
  JOURNAL   Mamm Genome 3 (2), 122-125 (1992)
   PUBMED   1319776
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK153634.1.
            
            On Apr 9, 2007 this sequence version replaced NM_010556.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK153634.1, CJ137533.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-849               AK153634.1         2-850
FEATURES             Location/Qualifiers
     source          1..849
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 32.13 cM"
     gene            1..849
                     /gene="Il3"
                     /gene_synonym="BPA; Csfmu; HCGF; Il-3; MCGF; PSF"
                     /note="interleukin 3"
                     /db_xref="GeneID:16187"
                     /db_xref="MGI:MGI:96552"
     exon            1..194
                     /gene="Il3"
                     /gene_synonym="BPA; Csfmu; HCGF; Il-3; MCGF; PSF"
                     /inference="alignment:Splign:2.1.0"
     CDS             30..530
                     /gene="Il3"
                     /gene_synonym="BPA; Csfmu; HCGF; Il-3; MCGF; PSF"
                     /note="mast cell growth factor; P-cell-stimulating factor;
                     hematopoietic growth factor; multipotential
                     colony-stimulating factor"
                     /codon_start=1
                     /product="interleukin-3 precursor"
                     /protein_id="NP_034686.2"
                     /db_xref="CCDS:CCDS24693.1"
                     /db_xref="GeneID:16187"
                     /db_xref="MGI:MGI:96552"
                     /translation="MVLASSTTSIHTMLLLLLMLFHLGLQASISGRDTHRLTRTLNCS
                     SIVKEIIGKLPEPELKTDDEGPSLRNKSFRRVNLSKFVESQGEVDPEDRYVIKSNLQK
                     LNCCLPTSANDSALPGVFIRDLDDFRKKLRFYMVHLNDLETVLTSRPPQPASGSVSPN
                     RGTVEC"
     exon            195..236
                     /gene="Il3"
                     /gene_synonym="BPA; Csfmu; HCGF; Il-3; MCGF; PSF"
                     /inference="alignment:Splign:2.1.0"
     exon            237..332
                     /gene="Il3"
                     /gene_synonym="BPA; Csfmu; HCGF; Il-3; MCGF; PSF"
                     /inference="alignment:Splign:2.1.0"
     exon            333..374
                     /gene="Il3"
                     /gene_synonym="BPA; Csfmu; HCGF; Il-3; MCGF; PSF"
                     /inference="alignment:Splign:2.1.0"
     exon            375..849
                     /gene="Il3"
                     /gene_synonym="BPA; Csfmu; HCGF; Il-3; MCGF; PSF"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      849
                     /gene="Il3"
                     /gene_synonym="BPA; Csfmu; HCGF; Il-3; MCGF; PSF"
                     /note="putative"
ORIGIN      
        1 agaacccctt ggaggaccag aacgagacaa tggttcttgc cagctctacc accagcatcc
       61 acaccatgct gctcctgctc ctgatgctct tccacctggg actccaagct tcaatcagtg
      121 gccgggatac ccaccgttta accagaacgt tgaattgcag ctctattgtc aaggagatta
      181 tagggaagct cccagaacct gaactcaaaa ctgatgatga aggaccctct ctgaggaata
      241 agagctttcg gagagtaaac ctgtccaaat tcgtggaaag ccaaggagaa gtggatcctg
      301 aggacagata cgttatcaag tccaatcttc agaaacttaa ctgttgcctg cctacatctg
      361 cgaatgactc tgcgctgcca ggggtcttca ttcgagatct ggatgacttt cggaagaaac
      421 tgagattcta catggtccac cttaacgatc tggagacagt gctaacctct agaccacctc
      481 agcccgcatc tggctccgtc tctcctaacc gtggaaccgt ggaatgttaa aacagcaggc
      541 agagcaccta aagtctgaat gttcctcatg gcccatggtc aaaaggattt tacattcctt
      601 tatgccatca aatgtcttat caatttatct actttctgaa atttacaact ctcctttggc
      661 tttacctaat tatgttccta ttttattcca ttaaggctat ttatttatgt atttatgtat
      721 ttatttattt attgccttct gtgatgtgag tatatctgtt ttagctgagg aggagtttct
      781 ccaaagaaaa ttccaaggaa gactggggcc atgttcattt gtcccttgtg gaaataaata
      841 actttgaac
//
