LOCUS       NM_013563               1663 bp    mRNA    linear   ROD 11-MAR-2025
DEFINITION  Mus musculus interleukin 2 receptor, gamma chain (Il2rg),
            transcript variant a, mRNA.
ACCESSION   NM_013563
VERSION     NM_013563.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1663)
  AUTHORS   Burrows,K., Ngai,L., Chiaranunt,P., Watt,J., Popple,S., Forde,B.,
            Denha,S., Olyntho,V.M., Tai,S.L., Cao,E.Y., Tejeda-Garibay,S.,
            Koenig,J.F.E., Mayer-Barber,K.D., Streutker,C.J., Hoyer,K.K.,
            Osborne,L.C., Liu,J., O'Mahony,L. and Mortha,A.
  TITLE     A gut commensal protozoan determines respiratory disease outcomes
            by shaping pulmonary immunity
  JOURNAL   Cell 188 (2), 316-330 (2025)
   PUBMED   39706191
REFERENCE   2  (bases 1 to 1663)
  AUTHORS   Brandao,W., Jain,N., Yin,Z., Kleemann,K.L., Carpenter,M., Bao,X.,
            Serrano,J.R., Tycksen,E., Durao,A., Barry,J.L., Baufeld,C.,
            Guneykaya,D., Zhang,X., Litvinchuk,A., Jiang,H., Rosenzweig,N.,
            Pitts,K.M., Aronchik,M., Yahya,T., Cao,T., Takahashi,M.K.,
            Krishnan,R., Davtyan,H., Ulrich,J.D., Blurton-Jones,M., Ilin,I.,
            Weiner,H.L., Holtzman,D.M. and Butovsky,O.
  TITLE     Inhaled xenon modulates microglia and ameliorates disease in mouse
            models of amyloidosis and tauopathy
  JOURNAL   Sci Transl Med 17 (781), eadk3690 (2025)
   PUBMED   39813317
REFERENCE   3  (bases 1 to 1663)
  AUTHORS   Kazemi,M.H., Momeni-Varposhti,Z., Li,X., Hurrell,B.P., Sakano,Y.,
            Shen,S., Shafiei-Jahani,P., Sakano,K. and Akbari,O.
  TITLE     FOXO1 pathway activation by VISTA immune checkpoint restrains
            pulmonary ILC2 functions
  JOURNAL   J Clin Invest 135 (4), e184932 (2025)
   PUBMED   39745792
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1663)
  AUTHORS   Chiu,R.K., Droll,A., Cooper,D.L., Dougherty,S.T., Dirks,J.F. and
            Dougherty,G.J.
  TITLE     Molecular mechanisms regulating the hyaluronan binding activity of
            the adhesion protein CD44
  JOURNAL   J Neurooncol 26 (3), 231-239 (1995)
   PUBMED   8750189
REFERENCE   5  (bases 1 to 1663)
  AUTHORS   He,Y.W. and Malek,T.R.
  TITLE     The IL-2 receptor gamma c chain does not function as a subunit
            shared by the IL-4 and IL-13 receptors. Implication for the
            structure of the IL-4 receptor
  JOURNAL   J Immunol 155 (1), 9-12 (1995)
   PUBMED   7602126
REFERENCE   6  (bases 1 to 1663)
  AUTHORS   He,Y.W., Adkins,B., Furse,R.K. and Malek,T.R.
  TITLE     Expression and function of the gamma c subunit of the IL-2, IL-4,
            and IL-7 receptors. Distinct interaction of gamma c in the IL-4
            receptor
  JOURNAL   J Immunol 154 (4), 1596-1605 (1995)
   PUBMED   7530740
REFERENCE   7  (bases 1 to 1663)
  AUTHORS   DiSanto,J.P., Certain,S., Wilson,A., MacDonald,H.R., Avner,P.,
            Fischer,A. and de Saint Basile,G.
  TITLE     The murine interleukin-2 receptor gamma chain gene: organization,
            chromosomal localization and expression in the adult thymus
  JOURNAL   Eur J Immunol 24 (12), 3014-3018 (1994)
   PUBMED   7805729
REFERENCE   8  (bases 1 to 1663)
  AUTHORS   Cao,X., Kozak,C.A., Liu,Y.J., Noguchi,M., O'Connell,E. and
            Leonard,W.J.
  TITLE     Characterization of cDNAs encoding the murine interleukin 2
            receptor (IL-2R) gamma chain: chromosomal mapping and tissue
            specificity of IL-2R gamma chain expression
  JOURNAL   Proc Natl Acad Sci U S A 90 (18), 8464-8468 (1993)
   PUBMED   8378320
REFERENCE   9  (bases 1 to 1663)
  AUTHORS   Kobayashi,N., Nakagawa,S., Minami,Y., Taniguchi,T. and Kono,T.
  TITLE     Cloning and sequencing of the cDNA encoding a mouse IL-2 receptor
            gamma
  JOURNAL   Gene 130 (2), 303-304 (1993)
   PUBMED   8359699
REFERENCE   10 (bases 1 to 1663)
  AUTHORS   Kumaki,S., Kondo,M., Takeshita,T., Asao,H., Nakamura,M. and
            Sugamura,K.
  TITLE     Cloning of the mouse interleukin 2 receptor gamma chain:
            demonstration of functional differences between the mouse and human
            receptors
  JOURNAL   Biochem Biophys Res Commun 193 (1), 356-363 (1993)
   PUBMED   8503926
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL683892.12 and AK143669.1.
            
            On May 9, 2015 this sequence version replaced NM_013563.3.
            
            Summary: This gene encodes a transmembrane protein that is a common
            subunit of several interleukin receptor complexes. These receptors
            are comprised of alpha and beta subunits in addition to this gamma
            subunit. Signalling through this pathway in important in immune
            cell differentiation and function. Alternative splicing results in
            multiple transcript variants. [provided by RefSeq, May 2015].
            
            Transcript Variant: This variant (a) represents the longer
            transcript and encodes the longer isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK143669.1, BC014720.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849383, SAMN00849388
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: downstream AUG is associated
                                                with N-terminal localization
                                                signal
            RefSeq Select criteria           :: based on conservation,
                                                expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-66                AL683892.12        7756-7821           c
            67-1663             AK143669.1         1-1597
FEATURES             Location/Qualifiers
     source          1..1663
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 43.9 cM"
     gene            1..1663
                     /gene="Il2rg"
                     /gene_synonym="CD132; gamma(c); gc; p64; [g]c"
                     /note="interleukin 2 receptor, gamma chain"
                     /db_xref="GeneID:16186"
                     /db_xref="MGI:MGI:96551"
     exon            1..201
                     /gene="Il2rg"
                     /gene_synonym="CD132; gamma(c); gc; p64; [g]c"
                     /inference="alignment:Splign:2.1.0"
     CDS             87..1196
                     /gene="Il2rg"
                     /gene_synonym="CD132; gamma(c); gc; p64; [g]c"
                     /note="isoform a precursor is encoded by transcript
                     variant a; cytokine receptor common subunit gamma; IL-2R
                     subunit gamma; IL-2 receptor subunit gamma; interleukin-2
                     receptor subunit gamma; gamma C receptor; common gamma
                     chain"
                     /codon_start=1
                     /product="cytokine receptor common subunit gamma isoform a
                     precursor"
                     /protein_id="NP_038591.1"
                     /db_xref="CCDS:CCDS30312.1"
                     /db_xref="GeneID:16186"
                     /db_xref="MGI:MGI:96551"
                     /translation="MLKLLLSPRSFLVLQLLLLRAGWSSKVLMSSANEDIKADLILTS
                     TAPEHLSAPTLPLPEVQCFVFNIEYMNCTWNSSSEPQATNLTLHYRYKVSDNNTFQEC
                     SHYLFSKEITSGCQIQKEDIQLYQTFVVQLQDPQKPQRRAVQKLNLQNLVIPRAPENL
                     TLSNLSESQLELRWKSRHIKERCLQYLVQYRSNRDRSWTELIVNHEPRFSLPSVDELK
                     RYTFRVRSRYNPICGSSQQWSKWSQPVHWGSHTVEENPSLFALEAVLIPVGTMGLIIT
                     LIFVYCWLERMPPIPPIKNLEDLVTEYQGNFSAWSGVSKGLTESLQPDYSERFCHVSE
                     IPPKGGALGEGPGGSPCSLHSPYWPPPCYSLKPEA"
     exon            202..355
                     /gene="Il2rg"
                     /gene_synonym="CD132; gamma(c); gc; p64; [g]c"
                     /inference="alignment:Splign:2.1.0"
     exon            356..540
                     /gene="Il2rg"
                     /gene_synonym="CD132; gamma(c); gc; p64; [g]c"
                     /inference="alignment:Splign:2.1.0"
     exon            541..683
                     /gene="Il2rg"
                     /gene_synonym="CD132; gamma(c); gc; p64; [g]c"
                     /inference="alignment:Splign:2.1.0"
     exon            684..846
                     /gene="Il2rg"
                     /gene_synonym="CD132; gamma(c); gc; p64; [g]c"
                     /inference="alignment:Splign:2.1.0"
     exon            847..943
                     /gene="Il2rg"
                     /gene_synonym="CD132; gamma(c); gc; p64; [g]c"
                     /inference="alignment:Splign:2.1.0"
     exon            944..1010
                     /gene="Il2rg"
                     /gene_synonym="CD132; gamma(c); gc; p64; [g]c"
                     /inference="alignment:Splign:2.1.0"
     exon            1011..1663
                     /gene="Il2rg"
                     /gene_synonym="CD132; gamma(c); gc; p64; [g]c"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1636..1641
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Il2rg"
                     /gene_synonym="CD132; gamma(c); gc; p64; [g]c"
                     /note="hexamer: AAGAAA"
     regulatory      1640..1645
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Il2rg"
                     /gene_synonym="CD132; gamma(c); gc; p64; [g]c"
                     /note="hexamer: AATAAA"
     polyA_site      1654
                     /gene="Il2rg"
                     /gene_synonym="CD132; gamma(c); gc; p64; [g]c"
                     /note="major polyA site"
     polyA_site      1663
                     /gene="Il2rg"
                     /gene_synonym="CD132; gamma(c); gc; p64; [g]c"
                     /note="major polyA site"
ORIGIN      
        1 aggaaatgta tgggtgggga gggcttgtgg gagagtggtt cagggttctg acacagacta
       61 cacccagaga aagaagagca agcaccatgt tgaaactatt attgtcacct agatccttct
      121 tagtccttca gctgctcctg ctgagggcag ggtggagctc caaggtcctc atgtccagtg
      181 cgaatgaaga catcaaagct gatttgatcc tgacttctac agcccctgaa cacctcagtg
      241 ctcctactct gccccttcca gaggttcagt gctttgtgtt caacatagag tacatgaatt
      301 gcacttggaa tagcagttct gagcctcagg caaccaacct cacgctgcac tataggtaca
      361 aggtatctga taataataca ttccaggagt gcagtcacta tttgttctcc aaagagatta
      421 cttctggctg tcagatacaa aaagaagata tccagctcta ccagacattt gttgtccagc
      481 tccaggaccc ccagaaaccc cagaggcgag ctgtacagaa gctaaaccta cagaatcttg
      541 tgatcccacg ggctccagaa aatctaacac tcagcaatct gagtgaatcc cagctagagc
      601 tgagatggaa aagcagacat attaaagaac gctgtttaca atacttggtg cagtaccgga
      661 gcaacagaga tcgaagctgg acggaactaa tagtgaatca tgaacctaga ttctccctgc
      721 ctagtgtgga tgagctgaaa cggtacacat ttcgggttcg gagccgctat aacccaatct
      781 gtggaagttc tcaacagtgg agtaaatgga gccagcctgt ccactggggg agtcatactg
      841 tagaggagaa tccttccttg tttgcactgg aagctgtgct tatccctgtt ggcaccatgg
      901 ggttgattat taccctgatc tttgtgtact gttggttgga acgaatgcct ccaattcccc
      961 ccatcaagaa tctagaggat ctggttactg aataccaagg gaacttttcg gcctggagtg
     1021 gtgtgtctaa agggctgact gagagtctgc agccagacta cagtgaacgg ttctgccacg
     1081 tcagcgagat tccccccaaa ggaggggccc taggagaggg gcctggaggt tctccttgca
     1141 gcctgcatag cccttactgg cctcccccat gttattctct gaagccggaa gcctgaacat
     1201 caatcctttg atggaacctc aaagtcctat agtcctaagt gacgctaacc tcccctactc
     1261 accttggcaa tctggatcca atgctcactg ccttcccttg gggctaagtt tcgatttcct
     1321 gtcccatgta actgcttttc tgttccatat gccctacttg agagtgtccc ttgccctctt
     1381 tccctgcaca agccctccca tgcccagcct aacacctttc cactttcttt gaagagagtc
     1441 ttaccctgta gcccagggtg gctgggagct cactatgtag gccaggttgg cctccaactc
     1501 acaggctatc ctcccacctc tgcctcataa gagttggggt tactggcatg caccaccaca
     1561 cccagcatgg tccttctctt ttataggatt ctccctccct ttttctacct atgattcaac
     1621 tgtttccaaa tcaacaagaa ataaagtttt taaccaatga tca
//
