LOCUS       NM_008368               2712 bp    mRNA    linear   ROD 29-OCT-2024
DEFINITION  Mus musculus interleukin 2 receptor, beta chain (Il2rb), mRNA.
ACCESSION   NM_008368
VERSION     NM_008368.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2712)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2712)
  AUTHORS   Zhang,Y., Zhao,Z., Huang,L.A., Liu,Y., Yao,J., Sun,C., Li,Y.,
            Zhang,Z., Ye,Y., Yuan,F., Nguyen,T.K., Garlapati,N.R., Wu,A.,
            Egranov,S.D., Caudle,A.S., Sahin,A.A., Lim,B., Beretta,L.,
            Calin,G.A., Yu,D., Hung,M.C., Curran,M.A., Rezvani,K., Gan,B.,
            Tan,Z., Han,L., Lin,C. and Yang,L.
  TITLE     Molecular mechanisms of snoRNA-IL-15 crosstalk in adipocyte
            lipolysis and NK cell rejuvenation
  JOURNAL   Cell Metab 35 (8), 1457-1473 (2023)
   PUBMED   37329887
REFERENCE   3  (bases 1 to 2712)
  AUTHORS   Wong,H.S., Park,K., Gola,A., Baptista,A.P., Miller,C.H., Deep,D.,
            Lou,M., Boyd,L.F., Rudensky,A.Y., Savage,P.A., Altan-Bonnet,G.,
            Tsang,J.S. and Germain,R.N.
  TITLE     A local regulatory T cell feedback circuit maintains immune
            homeostasis by pruning self-activated T cells
  JOURNAL   Cell 184 (15), 3981-3997 (2021)
   PUBMED   34157301
REFERENCE   4  (bases 1 to 2712)
  AUTHORS   Won,H.Y., Kim,H.K., Crossman,A., Awasthi,P., Gress,R.E. and
            Park,J.H.
  TITLE     The Timing and Abundance of IL-2Rbeta (CD122) Expression Control
            Thymic iNKT Cell Generation and NKT1 Subset Differentiation
  JOURNAL   Front Immunol 12, 642856 (2021)
   PUBMED   34054809
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2712)
  AUTHORS   Lou,W., Yan,J. and Wang,W.
  TITLE     Downregulation of miR-497-5p Improves Sepsis-Induced Acute Lung
            Injury by Targeting IL2RB
  JOURNAL   Biomed Res Int 2021, 6624702 (2021)
   PUBMED   33954185
  REMARK    GeneRIF: Downregulation of miR-497-5p Improves Sepsis-Induced Acute
            Lung Injury by Targeting IL2RB.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2712)
  AUTHORS   Casey,L.S., Lichtman,A.H. and Boothby,M.
  TITLE     IL-4 induces IL-2 receptor p75 beta-chain gene expression and
            IL-2-dependent proliferation in mouse T lymphocytes
  JOURNAL   J Immunol 148 (11), 3418-3426 (1992)
   PUBMED   1588041
REFERENCE   7  (bases 1 to 2712)
  AUTHORS   Berberich,I. and Schimpl,A.
  TITLE     Regulation of immunoglobulin gene expression in normal lymphocytes.
            II. Mechanisms of down-regulation of immunoglobulin secretion after
            engagement of the B cell antigen receptor
  JOURNAL   Eur J Immunol 22 (2), 525-529 (1992)
   PUBMED   1537386
REFERENCE   8  (bases 1 to 2712)
  AUTHORS   Campbell,H.D., Webb,G.C., Kono,T., Taniguchi,T., Ford,J.H. and
            Young,I.G.
  TITLE     Assignment of the interleukin-2 receptor beta chain gene (Il-2rb)
            to band E on mouse chromosome 15
  JOURNAL   Genomics 12 (1), 179-180 (1992)
   PUBMED   1733860
REFERENCE   9  (bases 1 to 2712)
  AUTHORS   Montgomery,R.A. and Dallman,M.J.
  TITLE     Analysis of cytokine gene expression during fetal thymic ontogeny
            using the polymerase chain reaction
  JOURNAL   J Immunol 147 (2), 554-560 (1991)
   PUBMED   1649220
REFERENCE   10 (bases 1 to 2712)
  AUTHORS   Kono,T., Doi,T., Yamada,G., Hatakeyama,M., Minamoto,S., Tsudo,M.,
            Miyasaka,M., Miyata,T. and Taniguchi,T.
  TITLE     Murine interleukin 2 receptor beta chain: dysregulated gene
            expression in lymphoma line EL-4 caused by a promoter insertion
  JOURNAL   Proc Natl Acad Sci U S A 87 (5), 1806-1810 (1990)
   PUBMED   2155425
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK017288.1 and BQ033566.1.
            
            On Mar 4, 2010 this sequence version replaced NM_008368.3.
            
            Summary:  The interleukin 2 receptor is composed of alpha and beta
            subunits. The beta subunit encoded by this gene is very homologous
            to the human beta subunit and also shows structural similarity to
            other cytokine receptors. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK017288.1, BC026869.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2692              AK017288.1         1-2692
            2693-2712           BQ033566.1         1-20                c
FEATURES             Location/Qualifiers
     source          1..2712
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 37.52 cM"
     gene            1..2712
                     /gene="Il2rb"
                     /gene_synonym="CD122; IL-15Rbeta; Il-2/15Rbeta; Il-2Rbeta;
                     IL15Rbeta; p70"
                     /note="interleukin 2 receptor, beta chain"
                     /db_xref="GeneID:16185"
                     /db_xref="MGI:MGI:96550"
     exon            1..119
                     /gene="Il2rb"
                     /gene_synonym="CD122; IL-15Rbeta; Il-2/15Rbeta; Il-2Rbeta;
                     IL15Rbeta; p70"
                     /inference="alignment:Splign:2.1.0"
     exon            120..237
                     /gene="Il2rb"
                     /gene_synonym="CD122; IL-15Rbeta; Il-2/15Rbeta; Il-2Rbeta;
                     IL15Rbeta; p70"
                     /inference="alignment:Splign:2.1.0"
     CDS             150..1769
                     /gene="Il2rb"
                     /gene_synonym="CD122; IL-15Rbeta; Il-2/15Rbeta; Il-2Rbeta;
                     IL15Rbeta; p70"
                     /note="IL-2 receptor beta chain; IL-2/15 receptor-beta;
                     interleukin-2 receptor subunit beta; IL-2RB; p70-75; IL-2R
                     subunit beta; IL-2 receptor subunit beta; high affinity
                     IL-2 receptor subunit beta; IL-15 receptor beta chain"
                     /codon_start=1
                     /product="interleukin-2 receptor subunit beta precursor"
                     /protein_id="NP_032394.1"
                     /db_xref="CCDS:CCDS27616.1"
                     /db_xref="GeneID:16185"
                     /db_xref="MGI:MGI:96550"
                     /translation="MATIALPWSLSLYVFLLLLATPWASAAVKNCSHLECFYNSRANV
                     SCMWSHEEALNVTTCHVHAKSNLRHWNKTCELTLVRQASWACNLILGSFPESQSLTSV
                     DLLDINVVCWEEKGWRRVKTCDFHPFDNLRLVAPHSLQVLHIDTQRCNISWKVSQVSH
                     YIEPYLEFEARRRLLGHSWEDASVLSLKQRQQWLFLEMLIPSTSYEVQVRVKAQRNNT
                     GTWSPWSQPLTFRTRPADPMKEILPMSWLRYLLLVLGCFSGFFSCVYILVKCRYLGPW
                     LKTVLKCHIPDPSEFFSQLSSQHGGDLQKWLSSPVPLSFFSPSGPAPEISPLEVLDGD
                     SKAVQLLLLQKDSAPLPSPSGHSQASCFTNQGYFFFHLPNALEIESCQVYFTYDPCVE
                     EEVEEDGSRLPEGSPHPPLLPLAGEQDDYCAFPPRDDLLLFSPSLSTPNTAYGGSRAP
                     EERSPLSLHEGLPSLASRDLMGLQRPLERMPEGDGEGLSANSSGEQASVPEGNLHGQD
                     QDRGQGPILTLNTDAYLSLQELQAQDSVHLI"
     exon            238..352
                     /gene="Il2rb"
                     /gene_synonym="CD122; IL-15Rbeta; Il-2/15Rbeta; Il-2Rbeta;
                     IL15Rbeta; p70"
                     /inference="alignment:Splign:2.1.0"
     exon            353..434
                     /gene="Il2rb"
                     /gene_synonym="CD122; IL-15Rbeta; Il-2/15Rbeta; Il-2Rbeta;
                     IL15Rbeta; p70"
                     /inference="alignment:Splign:2.1.0"
     exon            435..540
                     /gene="Il2rb"
                     /gene_synonym="CD122; IL-15Rbeta; Il-2/15Rbeta; Il-2Rbeta;
                     IL15Rbeta; p70"
                     /inference="alignment:Splign:2.1.0"
     exon            541..689
                     /gene="Il2rb"
                     /gene_synonym="CD122; IL-15Rbeta; Il-2/15Rbeta; Il-2Rbeta;
                     IL15Rbeta; p70"
                     /inference="alignment:Splign:2.1.0"
     exon            690..855
                     /gene="Il2rb"
                     /gene_synonym="CD122; IL-15Rbeta; Il-2/15Rbeta; Il-2Rbeta;
                     IL15Rbeta; p70"
                     /inference="alignment:Splign:2.1.0"
     exon            856..976
                     /gene="Il2rb"
                     /gene_synonym="CD122; IL-15Rbeta; Il-2/15Rbeta; Il-2Rbeta;
                     IL15Rbeta; p70"
                     /inference="alignment:Splign:2.1.0"
     exon            977..1061
                     /gene="Il2rb"
                     /gene_synonym="CD122; IL-15Rbeta; Il-2/15Rbeta; Il-2Rbeta;
                     IL15Rbeta; p70"
                     /inference="alignment:Splign:2.1.0"
     exon            1062..2697
                     /gene="Il2rb"
                     /gene_synonym="CD122; IL-15Rbeta; Il-2/15Rbeta; Il-2Rbeta;
                     IL15Rbeta; p70"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2677..2682
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Il2rb"
                     /gene_synonym="CD122; IL-15Rbeta; Il-2/15Rbeta; Il-2Rbeta;
                     IL15Rbeta; p70"
                     /note="hexamer: AAGAAA"
     polyA_site      2697
                     /gene="Il2rb"
                     /gene_synonym="CD122; IL-15Rbeta; Il-2/15Rbeta; Il-2Rbeta;
                     IL15Rbeta; p70"
                     /note="major polyA site"
ORIGIN      
        1 agtctgttgc tggcctagct gttgtctgct acctaagctg cggagcagga gatggccgtg
       61 gacccaacct ccagcaggac tgcagggaac atctcgacac aactccatgt tgcagccagg
      121 gtttgcatcc tcagctcctc tcagctgtga tggctaccat agctcttccc tggagcctgt
      181 ccctctacgt cttcctcctg ctcctggcta caccttgggc atctgcagca gtgaaaaact
      241 gttcccatct tgaatgcttc tacaactcaa gagccaatgt ctcttgcatg tggagccatg
      301 aagaggctct gaatgtcaca acctgccacg tccatgccaa gtcgaacctg cgacactgga
      361 acaaaacctg tgagctaact cttgtgaggc aggcatcctg ggcctgcaac ctgatcctcg
      421 ggtcgttccc agagtcccag tcactgacct ccgtggacct ccttgacata aatgtggtgt
      481 gctgggaaga gaagggttgg cgtagggtaa agacctgcga cttccatccc tttgacaacc
      541 ttcgcctggt ggcccctcat tccctccaag ttctgcacat tgatacccag agatgtaaca
      601 taagctggaa ggtctcccag gtctctcact acattgaacc atacttggaa tttgaggccc
      661 gtagacgtct tctgggccac agctgggagg atgcatccgt attaagcctc aagcagagac
      721 agcagtggct cttcttggag atgctgatcc ctagtacctc atatgaggtc caggtgaggg
      781 tcaaagctca acgaaacaat accgggacct ggagtccctg gagccagccc ctgacctttc
      841 ggacaaggcc agcagatccc atgaaggaga tcctccccat gtcatggctc agataccttc
      901 tgctggtcct tggttgtttt tctggcttct tctcctgcgt ctacattttg gtcaagtgcc
      961 ggtaccttgg gccatggctg aagacagttc tcaagtgcca catcccagat ccttctgagt
     1021 tcttctccca gctgagctcc cagcatgggg gagaccttca gaaatggctc tcctcgcctg
     1081 tccccttgtc cttcttcagc cccagtggcc ctgcccctga gatctctccg ctggaagtgc
     1141 tcgacggaga ttccaaggcc gtgcagctgc tcctgttaca gaaggactct gcccctttac
     1201 cctcgcccag cggccactca caggccagct gcttcaccaa ccagggctac ttcttcttcc
     1261 atctgcccaa tgccttggag atcgaatcct gccaggtgta cttcacctat gacccctgtg
     1321 tggaagagga ggtggaggag gatgggtcaa ggctgcccga gggatctccc cacccacctc
     1381 tgctgcctct ggctggagaa caggatgact actgtgcctt cccgcccagg gatgacctgc
     1441 tgctcttctc cccgagcctc agcaccccca acactgccta tgggggcagc agagcccctg
     1501 aagaaagatc tccactctcc ctgcatgagg gacttccctc cctagcatcc cgtgacctga
     1561 tgggcttaca gcgccctctg gagcggatgc cggaaggtga tggagagggg ctgtctgcca
     1621 atagctctgg ggagcaggcc agtgtcccag aaggcaacct tcatgggcaa gatcaggaca
     1681 gaggccaggg ccccatcctg accctgaaca ccgatgccta tctgtctctt caagaactac
     1741 aggcccaaga ttcagtccac ctaatatagc aggtggccag gactgggatc cagctgcctg
     1801 gatcaggtca ggcttgagga agactgctta agaggtctct tgaggacagt ccactgctga
     1861 ggactgtcct ggctatccct gccccccccc tccaaactta atcatccact tctgaactcc
     1921 atttgctact tcctggtcta accagggttt ggtggagggt ggggagtggg ggagcggtgg
     1981 tcagctccac tgccctattt agtcatgagg tcactagctt cctgtacctg cctccttccc
     2041 tcctgcttgc cttcacaggg cagctagaac ttgcttcccc caatacaaac ataaccttgc
     2101 tcctcattta tccctgagct tgctggggct ccttacttcc ctctgcccca tttcctgtct
     2161 caactcttgc cctgccagca cggctgtgga acagctgtcc tcaggttgtg atgtggctgt
     2221 acactgtctt aaaatcagag cagctttgac aacccaaacg aagaggtcct gataagactg
     2281 aatgcagcct gttgactatg gagggtccct cgtagaagga ggggttggga agggtcatca
     2341 gtcatcacct gagatcgtag ccactctcct gcaccccatc ctcagctatt ctgctcctgg
     2401 agcatgagtt attttatgtg ttcttgggcg atgctggtct atgtaagggg tgggggcgcg
     2461 gggttgattg aagtgagggc tccttctatg ttgctttggg gaccttgtct attctggggt
     2521 gggtttttct gtgaagcagc ttctttgggg taacctagcc cccttgtcag taagcctaag
     2581 agagtcaaag gaccaccgag ctggacttga gtgtacgcct acttttgatg caacatctgg
     2641 gaaaagtact ttttttgtta atgtatcctt gaagctaaga aaagcttaca ccacaaaaaa
     2701 aaaaaaaaaa aa
//
