LOCUS       NM_008367               4428 bp    mRNA    linear   ROD 12-NOV-2024
DEFINITION  Mus musculus interleukin 2 receptor, alpha chain (Il2ra), mRNA.
ACCESSION   NM_008367 XM_993137
VERSION     NM_008367.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4428)
  AUTHORS   Wong,V.A., Dinh,K.N., Chen,G. and Wrenshall,L.E.
  TITLE     IL-2Ralpha KO mice exhibit maternal microchimerism and reveal
            nuclear localization of IL-2Ralpha in lymphoid and non-lymphoid
            cells
  JOURNAL   Front Immunol 15, 1369818 (2024)
   PUBMED   38812502
  REMARK    GeneRIF: IL-2Ralpha KO mice exhibit maternal microchimerism and
            reveal nuclear localization of IL-2Ralpha in lymphoid and
            non-lymphoid cells.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4428)
  AUTHORS   Sommer,C., Cohen,J.N., Dehmel,S., Neuhaus,V., Schaudien,D.,
            Braun,A., Sewald,K. and Rosenblum,M.D.
  TITLE     Interleukin-2-induced skin inflammation
  JOURNAL   Eur J Immunol 54 (4), e2350580 (2024)
   PUBMED   38430129
REFERENCE   3  (bases 1 to 4428)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 4428)
  AUTHORS   Spolski,R., Li,P., Chandra,V., Shin,B., Goel,S., Sakamoto,K.,
            Liu,C., Oh,J., Ren,M., Enomoto,Y., West,E.E., Christensen,S.M.,
            Wan,E.C.K., Ge,M., Lin,J.X., Yan,B., Kazemian,M., Yu,Z.X.,
            Nagao,K., Vijayanand,P., Rothenberg,E.V. and Leonard,W.J.
  TITLE     Distinct use of super-enhancer elements controls cell type-specific
            CD25 transcription and function
  JOURNAL   Sci Immunol 8 (89), eadi8217 (2023)
   PUBMED   37922339
  REMARK    GeneRIF: Distinct use of super-enhancer elements controls cell
            type-specific CD25 transcription and function.
REFERENCE   5  (bases 1 to 4428)
  AUTHORS   Abu-Romman,A., Scholand,K.K., Pal-Ghosh,S., Yu,Z., Kelagere,Y.,
            Yazdanpanah,G., Kao,W.W., Coulson-Thomas,V.J., Stepp,M.A. and de
            Paiva,C.S.
  TITLE     Conditional deletion of CD25 in the corneal epithelium reveals sex
            differences in barrier disruption
  JOURNAL   Ocul Surf 30, 57-72 (2023)
   PUBMED   37516317
  REMARK    GeneRIF: Conditional deletion of CD25 in the corneal epithelium
            reveals sex differences in barrier disruption.
REFERENCE   6  (bases 1 to 4428)
  AUTHORS   Morse,H.C. 3rd.
  TITLE     Genetic nomenclature for loci controlling surface antigens of mouse
            hemopoietic cells
  JOURNAL   J Immunol 149 (10), 3129-3134 (1992)
   PUBMED   1431091
  REMARK    Review article
            Erratum:[J Immunol 1993 Mar 15;150(6):2563]
REFERENCE   7  (bases 1 to 4428)
  AUTHORS   Matesanz,F., Alcina,A. and Pellicer,A.
  TITLE     A new cDNA sequence for the murine interleukin-2 gene
  JOURNAL   Biochim Biophys Acta 1132 (3), 335-336 (1992)
   PUBMED   1420317
REFERENCE   8  (bases 1 to 4428)
  AUTHORS   Ruhl,S., Begley,C.G., Bickel,M. and Pluznik,D.H.
  TITLE     Transient expression of the IL-2 receptor alpha-chain in
            IL-6-induced myeloid cells is regulated by autocrine production of
            prostaglandin E2
  JOURNAL   Exp Hematol 20 (5), 619-625 (1992)
   PUBMED   1587308
REFERENCE   9  (bases 1 to 4428)
  AUTHORS   Kato,T., Inoue,T., Yamamoto,K., Tamura,T. and Nariuchi,H.
  TITLE     Induction of IL-2 receptor expression and proliferation of T cell
            clones by a novel cytokine(s)
  JOURNAL   Cell Immunol 142 (1), 79-93 (1992)
   PUBMED   1586961
REFERENCE   10 (bases 1 to 4428)
  AUTHORS   Threadgill,D.S. and Womack,J.E.
  TITLE     Mapping HSA10 homologous loci in cattle
  JOURNAL   Cytogenet Cell Genet 57 (2-3), 123-126 (1991)
   PUBMED   1655359
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY200401.1, AK037369.1 and AL831794.6.
            
            On Jul 21, 2009 this sequence version replaced NM_008367.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK088594.1, AK037369.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-15                BY200401.1         1-15
            16-1122             AK037369.1         2-1108
            1123-4428           AL831794.6         53354-56659         c
FEATURES             Location/Qualifiers
     source          1..4428
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 8.91 cM"
     gene            1..4428
                     /gene="Il2ra"
                     /gene_synonym="CD25; Il2r; Ly-43"
                     /note="interleukin 2 receptor, alpha chain"
                     /db_xref="GeneID:16184"
                     /db_xref="MGI:MGI:96549"
     exon            1..273
                     /gene="Il2ra"
                     /gene_synonym="CD25; Il2r; Ly-43"
                     /inference="alignment:Splign:2.1.0"
     CDS             210..1016
                     /gene="Il2ra"
                     /gene_synonym="CD25; Il2r; Ly-43"
                     /note="interleukin-2 receptor subunit alpha; IL2-RA;
                     IL-2-RA; IL-2R subunit alpha; IL-2 receptor subunit alpha;
                     IL-2R alpha chain; p55 chain"
                     /codon_start=1
                     /product="interleukin-2 receptor subunit alpha precursor"
                     /protein_id="NP_032393.3"
                     /db_xref="CCDS:CCDS15685.1"
                     /db_xref="GeneID:16184"
                     /db_xref="MGI:MGI:96549"
                     /translation="MEPRLLMLGFLSLTIVPSCRAELCLYDPPEVPNATFKALSYKNG
                     TILNCECKRGFRRLKELVYMRCLGNSWSSNCQCTSNSHDKSRKQVTAQLEHQKEQQTT
                     TDMQKPTQSMHQENLTGHCREPPPWKHEDSKRIYHFVEGQSVHYECIPGYKALQRGPA
                     ISICKMKCGKTGWTQPQLTCVDEREHHRFLASEESQGSRNSSPESETSCPITTTDFPQ
                     PTETTAMTETFVLTMEYKVAVASCLFLLISILLLSGLTWQHRWRKSRRTI"
     exon            274..450
                     /gene="Il2ra"
                     /gene_synonym="CD25; Il2r; Ly-43"
                     /inference="alignment:Splign:2.1.0"
     exon            451..564
                     /gene="Il2ra"
                     /gene_synonym="CD25; Il2r; Ly-43"
                     /inference="alignment:Splign:2.1.0"
     exon            565..780
                     /gene="Il2ra"
                     /gene_synonym="CD25; Il2r; Ly-43"
                     /inference="alignment:Splign:2.1.0"
     exon            781..852
                     /gene="Il2ra"
                     /gene_synonym="CD25; Il2r; Ly-43"
                     /inference="alignment:Splign:2.1.0"
     exon            853..924
                     /gene="Il2ra"
                     /gene_synonym="CD25; Il2r; Ly-43"
                     /inference="alignment:Splign:2.1.0"
     exon            925..991
                     /gene="Il2ra"
                     /gene_synonym="CD25; Il2r; Ly-43"
                     /inference="alignment:Splign:2.1.0"
     exon            992..4428
                     /gene="Il2ra"
                     /gene_synonym="CD25; Il2r; Ly-43"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2226..2231
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Il2ra"
                     /gene_synonym="CD25; Il2r; Ly-43"
                     /note="hexamer: AGTAAA"
     polyA_site      2254
                     /gene="Il2ra"
                     /gene_synonym="CD25; Il2r; Ly-43"
                     /note="major polyA site"
     regulatory      3392..3397
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Il2ra"
                     /gene_synonym="CD25; Il2r; Ly-43"
                     /note="hexamer: AATAAA"
     polyA_site      3414
                     /gene="Il2ra"
                     /gene_synonym="CD25; Il2r; Ly-43"
     regulatory      4407..4412
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Il2ra"
                     /gene_synonym="CD25; Il2r; Ly-43"
                     /note="hexamer: AATAAA"
     polyA_site      4424
                     /gene="Il2ra"
                     /gene_synonym="CD25; Il2r; Ly-43"
ORIGIN      
        1 aagttcctgc tgagcagatc agcctaatgc ttaaatagaa caactcctgg ctgtcattga
       61 cattgtctaa aagccaagat gacagactga gaggcctgag cccttgttct ggcattctcc
      121 caggaagatg cagtaaaggg gttgacccaa tatactgcag agaatttcat ccagttccct
      181 cctccatcct gatcccatgt gccaggaaga tggagccacg cttgctgatg ttggggtttc
      241 tctcattaac catagtaccc agttgtcggg cagaactgtg tctgtatgac ccacccgagg
      301 tccccaatgc cacattcaaa gccctctcct acaagaacgg caccatccta aactgtgaat
      361 gcaagagagg tttccgaaga ctaaaggaat tggtctatat gcgttgctta ggaaactcct
      421 ggagcagcaa ctgccagtgc accagcaact cccatgacaa atcgagaaag caagttacag
      481 ctcaacttga acaccagaaa gagcaacaaa ccacaacaga catgcagaag ccaacacagt
      541 ctatgcacca agagaacctt acaggtcact gcagggagcc acctccttgg aaacatgaag
      601 attccaagag aatctatcat ttcgtggaag gacagagtgt tcactacgag tgtattccgg
      661 gatacaaggc tctacagaga ggtcctgcta ttagcatctg caagatgaag tgtgggaaaa
      721 cggggtggac tcagccccag ctcacatgtg tagatgaaag agaacaccac cgatttctgg
      781 ctagtgagga atctcaagga agcagaaatt cttctcccga gagtgagact tcctgcccca
      841 taaccaccac agacttccca caacccacag aaacaactgc aatgacggag acatttgtgc
      901 tcacaatgga gtataaggta gcagtggcca gctgcctctt cctgctcatc agcatcctcc
      961 tcctgagcgg gctcacctgg caacacagat ggaggaagag cagaagaacc atctagcaag
     1021 ctagaaaagt cagagcccag gcaagcggat gggaatcaca aagctcaagc caaatctgag
     1081 acgccaagca ttcacctaac ggctgtttcc ttctgatccc tgggtttcta gaacattctg
     1141 aagtcacagg acataacagc aactctatca ctaaactgga ctttgccatt gaagaatagg
     1201 atctaaccac ttcagcacag cagttctaaa gctttaatgg gagagagggc ccaacagtgc
     1261 tctgtgtgtt ttgtttttgt gtatatctgt tgatgggagc tgagatggtg tggtcacttt
     1321 tcatgtaaca tatagtatag aaaaagtagc tttaggttga cttcattgtt acaacccagt
     1381 ttggaaagcc caagtaaaac tcagcactaa tgtaaataat tcctcctcct cctcctctct
     1441 cttttcatcc tccgctccat cttcctcttc ttcctcctcc ttttccacct cctctgtccc
     1501 tacccacccc cacccatcca ctttccttct tcctttctgc tctcacaagc tcatcctagc
     1561 tacacgtgca tggctggctc ctttttcaac ctctgtttgc ctaactggct cttctgattt
     1621 catcacttac tgatcagcct ttaaaactct gagctggcaa agatgactct atctatgttc
     1681 ttggctcagt cccagaagga aacccccttt tcatgaagct tcagttttga catcctgaag
     1741 aacagaaact gtggcagaac aatcttcaga taacatcaaa acaaagtgga gaagccacgg
     1801 gaactgtgga gctctggtat tcagaagcct gtgtctaggg tctgcgccag gagcagaagg
     1861 ctgaaggaag tcccaggacg tggacttaga tgctttccca gcaggccact ctaagcgctg
     1921 gtttctttgg gacagctgtc aattgtacgc tcaatttagc ctgcactaat ctgatgctta
     1981 caggtgaaca ctcaaggcac aggtatggac ttggtacata ccgtgaaaac actggaaaga
     2041 aaagaatact ttcaagttta cagaaggaag gaaggaaaaa ggaagcagag gtggtgatta
     2101 tacaaaagat tagctgtaga ctggatatcc caggcatcct cggataatgc ccccgcccca
     2161 gcaccctgat ccaggtcacc aaagccttgt gagatcagac tgcagagcca gtctgtctct
     2221 gagtcagtaa atgtagaatt tggatttctc acaagttcct ggcggtgtct tttttttttt
     2281 taatattttt tattaggtat tttcctcatt tacatttcca atgctatccc aaaagtcccc
     2341 cataccctcc cccacactcc cctacccacc cactcccact ttttggccct ggtgttcccc
     2401 tgtactgggg catataaagt ttgcaagtcc tggtggtgtc tttatgctga tctctagccc
     2461 acactttgtg aggcactggg ctatcccagt gtgctctcct cttccacaga taccaaaagc
     2521 acctgggttt gatgctcaga cttctgagca cgttcttgtt caatctcttg cgtaagattt
     2581 cctctcagat gagttgagtc agattctcat gtttaacagt gttttagggg attcacagaa
     2641 gcccaaacta tcagttttca tttctgaaaa ggctggaaaa ttttatgaaa aactttcaaa
     2701 ggtcagacag agccattttg agtcttttat gtgaccaagt atgaaccaga tctttcctat
     2761 ctatggtctc ccctttccaa aatatatctt ttgtggggac acggcaagga ggaaagttaa
     2821 atagaatctc aagctactaa ttttagaaaa gaaaaaaata ttaaactctt actaaagagc
     2881 tgtgggtagt ggtacacacc tgtaagccca gctctcagga gactgaggca ggaggattgc
     2941 agtgagtcag agatcagctt cacctacaag caaaaccctg ccttacccct caacctttcc
     3001 ataaaaacag tcttacttgt gtaaaattaa tttttaatac atatttgtgc acgatgtgtg
     3061 tgcctggtgc ccagggaagc caaaaaaata tgttcaatgt ccctggaata ggtggttatg
     3121 agctgccatg gaggtgatgg gatttaaacc cctgttctct gaaaaagcag ctagttctct
     3181 taaccactga gccatctcta cagccccatt aaattgaatt ttattgtcat tactcaatat
     3241 gggagatggg gtaatgataa caattttttt tttataatac taagatgttt agctatttta
     3301 ctctccttca caagtgtaga gtagaatttt ctagaagcta catgcatgat attatcgctc
     3361 tggtgttaac acataatgga tttatcttgt taataaaaga attagtaaat aatattttaa
     3421 attttttctt tgttttagtt ttaagatgat taatatctat agatactagt gtacattaag
     3481 aaagcctttg ggatcctcaa tcattttgca tggttttagt aattttttaa taacataaag
     3541 aaggtctgac agattatgct aaagagctat tgtggtatgg attagaaatg gcccccacag
     3601 gctcctgtgt tcaaacatca gctagcagtg ctgctttggg ttttggaacc tttaagaggt
     3661 ggggccttgc ttaaggagat aggtcactgg aggtgaacca gacttgcttc cagtctccct
     3721 ctctgctgtc ccaggaagcc atcatatgag gagtttcaca acatacttct gctgccacag
     3781 agtccctcca gtaaggcacg tactggccac tgtgtagtgt accctctaaa actgagctag
     3841 agctcccctc tcctccctac actatctctg ttgatgcttt gtcacggtga tgaagaacat
     3901 aagtaaggca aagacaagac atagtttgga gactcacgtg agcatctcag ccagactcag
     3961 gcacagctgc gatgtgggaa ttatcaagca tgagatgcaa agcaatggaa aatgaatcgt
     4021 tatgacagaa gcctacatct agtcttccct tcttcccatt agtaataata gcccgtgttt
     4081 tagaagaaca catctttttg gtgttctagg tagcttatat tgcaaatgtg gcacaatcta
     4141 agagaaatct gggatgaggg aacctcagtg aaagattctc cttgatcaga ttgtcccact
     4201 gatgattgat atgggaaggc ccaacccact gtgaaaggca ccacccattg gcaggatgac
     4261 tggggttata gaagcaaaca ggctgagcat gagccagtga gcaagccagt aagcagtggc
     4321 ttctctttgg aagaagcatg gctttcttcc gtggcttctg tttgatctct ctcaatgata
     4381 gattgtgacc tagaagtata agctaaaata aaccatttct tacccata
//
