LOCUS       NM_016671               2671 bp    mRNA    linear   ROD 11-NOV-2023
DEFINITION  Mus musculus interleukin 27 receptor, alpha (Il27ra), mRNA.
ACCESSION   NM_016671
VERSION     NM_016671.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2671)
  AUTHORS   Zhang Y, Gao S, Yao S, Weng D, Wang Y, Huang Q, Zhang X, Wang H and
            Xu W.
  TITLE     IL-27 mediates immune response of pneumococcal vaccine SPY1 through
            Th17 and memory CD4+T cells
  JOURNAL   iScience 26 (8), 107464 (2023)
   PUBMED   37588169
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2671)
  AUTHORS   Ahmadi F, Junghus F, Ashworth C, Lappalainen A, Morbe U, Kotarsky K
            and Agace WW.
  TITLE     cDC1-derived IL-27 regulates small intestinal CD4+ T cell
            homeostasis in mice
  JOURNAL   J Exp Med 220 (3) (2023)
   PUBMED   36515659
REFERENCE   3  (bases 1 to 2671)
  AUTHORS   Aghayev T, Mazitova AM, Fang JR, Peshkova IO, Rausch M, Hung M,
            White KF, Masia R, Titerina EK, Fatkhullina AR, Cousineau I,
            Turcotte S, Zhigarev D, Marchenko A, Khoziainova S, Makhov P, Tan
            YF, Kossenkov AV, Wiest DL, Stagg J, Wang XW, Campbell KS, Dzutsev
            AK, Trinchieri G, Hill JA, Grivennikov SI and Koltsova EK.
  TITLE     IL27 Signaling Serves as an Immunologic Checkpoint for Innate
            Cytotoxic Cells to Promote Hepatocellular Carcinoma
  JOURNAL   Cancer Discov 12 (8), 1960-1983 (2022)
   PUBMED   35723626
REFERENCE   4  (bases 1 to 2671)
  AUTHORS   Dahlgren MW, Plumb AW, Niss K, Lahl K, Brunak S and
            Johansson-Lindbom B.
  TITLE     Type I Interferons Promote Germinal Centers Through B Cell
            Intrinsic Signaling and Dendritic Cell Dependent Th1 and Tfh Cell
            Lineages
  JOURNAL   Front Immunol 13, 932388 (2022)
   PUBMED   35911733
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2671)
  AUTHORS   Sharma A, Noon JB, Kontodimas K, Garo LP, Platten J, Quinton LJ,
            Urban JF Jr, Reinhardt C and Bosmann M.
  TITLE     IL-27 Enhances gammadelta T Cell-Mediated Innate Resistance to
            Primary Hookworm Infection in the Lungs
  JOURNAL   J Immunol 208 (8), 2008-2018 (2022)
   PUBMED   35354611
REFERENCE   6  (bases 1 to 2671)
  AUTHORS   Villarino A, Hibbert L, Lieberman L, Wilson E, Mak T, Yoshida H,
            Kastelein RA, Saris C and Hunter CA.
  TITLE     The IL-27R (WSX-1) is required to suppress T cell hyperactivity
            during infection
  JOURNAL   Immunity 19 (5), 645-655 (2003)
   PUBMED   14614852
REFERENCE   7  (bases 1 to 2671)
  AUTHORS   Zhang JH, He H, Borzychowski AM, Takeda K, Akira S and Croy BA.
  TITLE     Analysis of cytokine regulators inducing interferon production by
            mouse uterine natural killer cells
  JOURNAL   Biol Reprod 69 (2), 404-411 (2003)
   PUBMED   12646495
REFERENCE   8  (bases 1 to 2671)
  AUTHORS   Yoshida H, Hamano S, Senaldi G, Covey T, Faggioni R, Mu S, Xia M,
            Wakeham AC, Nishina H, Potter J, Saris CJ and Mak TW.
  TITLE     WSX-1 is required for the initiation of Th1 responses and
            resistance to L. major infection
  JOURNAL   Immunity 15 (4), 569-578 (2001)
   PUBMED   11672539
REFERENCE   9  (bases 1 to 2671)
  AUTHORS   Chen Q, Ghilardi N, Wang H, Baker T, Xie MH, Gurney A, Grewal IS
            and de Sauvage FJ.
  TITLE     Development of Th1-type immune responses requires the type I
            cytokine receptor TCCR
  JOURNAL   Nature 407 (6806), 916-920 (2000)
   PUBMED   11057672
REFERENCE   10 (bases 1 to 2671)
  AUTHORS   Sprecher CA, Grant FJ, Baumgartner JW, Presnell SR, Schrader SK,
            Yamagiwa T, Whitmore TE, O'Hara PJ and Foster DF.
  TITLE     Cloning and characterization of a novel class I cytokine receptor
  JOURNAL   Biochem Biophys Res Commun 246 (1), 82-90 (1998)
   PUBMED   9600072
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK133753.1, BC032878.1 and BF019826.1.
            
            [WARNING] On Nov 22, 2023 this sequence was replaced by
            NM_016671.4.
            
            On Mar 27, 2008 this sequence version replaced NM_016671.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC032878.1, AK133753.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1700              AK133753.1         16-1715
            1701-1849           BC032878.1         1701-1849
            1850-2650           AK133753.1         1866-2666
            2651-2671           BF019826.1         1-21                c
FEATURES             Location/Qualifiers
     source          1..2671
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 40.26 cM"
     gene            1..2671
                     /gene="Il27ra"
                     /gene_synonym="CRL1; IL-27R; Tccr; WSX-1; Wsx1; zcytor1"
                     /note="interleukin 27 receptor, alpha"
                     /db_xref="GeneID:50931"
                     /db_xref="MGI:MGI:1355318"
     exon            1..126
                     /gene="Il27ra"
                     /gene_synonym="CRL1; IL-27R; Tccr; WSX-1; Wsx1; zcytor1"
                     /inference="alignment:Splign:2.1.0"
     exon            127..244
                     /gene="Il27ra"
                     /gene_synonym="CRL1; IL-27R; Tccr; WSX-1; Wsx1; zcytor1"
                     /inference="alignment:Splign:2.1.0"
     exon            245..402
                     /gene="Il27ra"
                     /gene_synonym="CRL1; IL-27R; Tccr; WSX-1; Wsx1; zcytor1"
                     /inference="alignment:Splign:2.1.0"
     exon            403..560
                     /gene="Il27ra"
                     /gene_synonym="CRL1; IL-27R; Tccr; WSX-1; Wsx1; zcytor1"
                     /inference="alignment:Splign:2.1.0"
     exon            561..717
                     /gene="Il27ra"
                     /gene_synonym="CRL1; IL-27R; Tccr; WSX-1; Wsx1; zcytor1"
                     /inference="alignment:Splign:2.1.0"
     exon            718..791
                     /gene="Il27ra"
                     /gene_synonym="CRL1; IL-27R; Tccr; WSX-1; Wsx1; zcytor1"
                     /inference="alignment:Splign:2.1.0"
     exon            792..975
                     /gene="Il27ra"
                     /gene_synonym="CRL1; IL-27R; Tccr; WSX-1; Wsx1; zcytor1"
                     /inference="alignment:Splign:2.1.0"
     exon            976..1164
                     /gene="Il27ra"
                     /gene_synonym="CRL1; IL-27R; Tccr; WSX-1; Wsx1; zcytor1"
                     /inference="alignment:Splign:2.1.0"
     exon            1165..1266
                     /gene="Il27ra"
                     /gene_synonym="CRL1; IL-27R; Tccr; WSX-1; Wsx1; zcytor1"
                     /inference="alignment:Splign:2.1.0"
     exon            1267..1425
                     /gene="Il27ra"
                     /gene_synonym="CRL1; IL-27R; Tccr; WSX-1; Wsx1; zcytor1"
                     /inference="alignment:Splign:2.1.0"
     exon            1426..1551
                     /gene="Il27ra"
                     /gene_synonym="CRL1; IL-27R; Tccr; WSX-1; Wsx1; zcytor1"
                     /inference="alignment:Splign:2.1.0"
     exon            1552..1642
                     /gene="Il27ra"
                     /gene_synonym="CRL1; IL-27R; Tccr; WSX-1; Wsx1; zcytor1"
                     /inference="alignment:Splign:2.1.0"
     exon            1643..1751
                     /gene="Il27ra"
                     /gene_synonym="CRL1; IL-27R; Tccr; WSX-1; Wsx1; zcytor1"
                     /inference="alignment:Splign:2.1.0"
     exon            1752..2658
                     /gene="Il27ra"
                     /gene_synonym="CRL1; IL-27R; Tccr; WSX-1; Wsx1; zcytor1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2633..2638
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Il27ra"
                     /gene_synonym="CRL1; IL-27R; Tccr; WSX-1; Wsx1; zcytor1"
                     /note="putative"
ORIGIN      
        1 gtaagcccca agcctggtgg tgtcacttgt ccctgggagc catgaaccgg ctccgggttg
       61 cacgcctcac gccgttggag cttctgctgt cgctgatgtc gctgctgctc gggacgcggc
      121 cccacggcag tccaggtcca ctgcagtgct acagcgtcgg tcccctggga atcctgaact
      181 gctcctggga acctttgggc gacctggaga ctccacctgt gctgtatcac cagagtcaga
      241 aataccatcc caatagagtc tgggaggtga aggtgccttc caaacagagt tgggtgacca
      301 ttccccggga acagttcacc atggctgaca aactcctcat ctgggggaca caaaagggac
      361 ggcctctgtg gtcctctgtc tctgtgaacc tggagaccca aatgaagcca gacacacccc
      421 agatcttctc tcaagtggat atttctgagg aagcaaccct ggaggccact gtgcagtggg
      481 cgccgcccgt gtggccaccg cagaaagttc tcatctgtca gttccggtac aaggaatgcc
      541 aggctgaaac atggacccgg ctggagcccc agctgaagac agatgggctg actcctgttg
      601 agatgcagaa cctggaacct ggcacctgct accaggtgtc tggccgctgc caggtggaga
      661 acggatatcc atggggcgag tggagttcgc ccctgtcctt ccagacgcca ttcttagatc
      721 ctgaagatgt gtgggtatcg gggaccgtct gtgaaacttc tggcaaacgg gcagccctgc
      781 ttgtctggaa ggacccaaga ccttgtgtgc aggtgactta cacagtctgg tttggggctg
      841 gagatattac tacaactcaa gaagaggtcc cgtgctgcaa gtcccctgtc cctgcatgga
      901 tggagtgggc tgtggtctct cctggcaaca gcaccagctg ggtgcctccc accaacctgt
      961 ctctggtgtg cttggctcca gaatctgccc cctgtgacgt gggagtgagc agtgctgatg
     1021 ggagcccagg gataaaggtg acctggaaac aagggaccag gaaaccgttg gagtatgtgg
     1081 tggactgggc tcaagatggt gacagcctgg acaagctcaa ctggacccgt ctcccccctg
     1141 gaaacctcag cacattgtta ccaggggagt tcaaaggagg ggtcccctat cgaattacag
     1201 tgactgcagt atattctgga ggattagctg ctgcaccctc agtttgggga ttcagagagg
     1261 agttagtacc ccttgctggg ccagcagttt ggcgacttcc agatgacccc ccagggacac
     1321 ctgttgtagc ctggggagaa gtaccaagac accagctcag aggccaggct actcactaca
     1381 ccttctgcat acagagcaga ggcctctcca ctgtctgcag gaacgtgagc agtcaaaccc
     1441 agactgccac tctgcccaac cttcacttgg gttccttcaa gctgtgggtg acggtgtcca
     1501 ccgttgcagg acagggccca cctggtccca acctttcact tcacctacca gataatagga
     1561 tcaggtggaa agctctgccc tggtttctgt ccctgtgggg tttgcttctg atgggctgtg
     1621 gcctgagcct ggccagtacc aggtgcctac aggccaggtg cttacactgg cggcacaagt
     1681 tgcttcccca gtggatctgg gagagggttc ctgatcctgc caacagcaat tctgggcaac
     1741 cttacatcaa ggaggtgagc ctgccccaac cgcccaagga cggacccatc ctggaggtgg
     1801 aggaagtgga gctacagcct gttgtggagt cccctaaagc ctctgcccca atttactctg
     1861 ggtatgagaa acacttcctg cccacaccag aggagctggg ccttctagtc tgatctgctt
     1921 acggctaggg gctgtacccc tatcttgggc tagacgtttt tgtattttta gatttttgag
     1981 acaggatctc actatggctg gcctggaact tgatataaca accaggctgg cctggaactc
     2041 accaagactc acctggtttt gccttccaag gactgagaag aaatgagtgt gccgcctccc
     2101 gcccaaccag cttttgcttt ccttgcctct gggtcttggg catctgtttg ttactgcaga
     2161 agaatcagtg agctcacagc ctcaacccca tcgttgttat ttcctccttg tgtcacaggc
     2221 ttgctaggta gccaaggctg gcctcgaact tgtgatcctc cctgctgcag catccccaga
     2281 gctgggatta caggtgtgcg tcacttcatc gagtcataac ttttgattct agtaagaata
     2341 actaccaggc aggctatgag gtggtgactc gaaagacaca ttcaagggcc tgaagtggtt
     2401 aagagcctgt gttttcttgc agtagaccaa agtttggttc cctgcccttg caaaggacac
     2461 acgttcagtt tccagcaccc acagggcagc tcagaatcac ctgtaactcc aggtccaagg
     2521 aatccaatgc cctcttctgg cttctgtgag ccctgcacac acatggttac ttatgcaccg
     2581 aaaaacacac gcataaaata aaaataaata aataaataaa aataaattaa taaataaatc
     2641 ttttttttct taaagccaaa aaaaaaaaaa a
//
