LOCUS       NM_145636               1103 bp    mRNA    linear   ROD 11-MAR-2025
DEFINITION  Mus musculus interleukin 27 (Il27), mRNA.
ACCESSION   NM_145636
VERSION     NM_145636.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1103)
  AUTHORS   Jiang,T., Zou,A., Song,W., Zheng,J., Lai,L., Wang,Q. and Cui,B.
  TITLE     Interleukin-27 signaling resists obesity by promoting the
            accumulation of Treg cells in visceral adipose tissue
  JOURNAL   Biochem Biophys Res Commun 733, 150690 (2024)
   PUBMED   39276693
  REMARK    GeneRIF: Interleukin-27 signaling resists obesity by promoting the
            accumulation of Treg cells in visceral adipose tissue.
REFERENCE   2  (bases 1 to 1103)
  AUTHORS   Chudnovskiy,A., Castro,T.B.R., Nakandakari-Higa,S., Cui,A.,
            Lin,C.H., Sade-Feldman,M., Phillips,B.K., Pae,J., Mesin,L.,
            Bortolatto,J., Schweitzer,L.D., Pasqual,G., Lu,L.F., Hacohen,N. and
            Victora,G.D.
  TITLE     Proximity-dependent labeling identifies dendritic cells that drive
            the tumor-specific CD4+ T cell response
  JOURNAL   Sci Immunol 9 (100), eadq8843 (2024)
   PUBMED   39365874
REFERENCE   3  (bases 1 to 1103)
  AUTHORS   Zhao,S.J., Hu,X.H., Lin,X.X., Zhang,Y.J., Wang,J., Wang,H.,
            Gong,G.S., Mor,G. and Liao,A.H.
  TITLE     IL-27/Blimp-1 axis regulates the differentiation and function of
            Tim-3+ Tregs during early pregnancy
  JOURNAL   JCI Insight 9 (16), e179233 (2024)
   PUBMED   39171524
  REMARK    GeneRIF: IL-27/Blimp-1 axis regulates the differentiation and
            function of Tim-3+ Tregs during early pregnancy.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1103)
  AUTHORS   Aldridge,D.L., Moodley,D., Park,J., Phan,A.T., Rausch,M.,
            White,K.F., Ren,Y., Golin,K., Radaelli,E., Kedl,R., Holland,P.M.,
            Hill,J. and Hunter,C.A.
  TITLE     Endogenous IL-27 during toxoplasmosis limits early monocyte
            responses and their inflammatory activation by pathological T cells
  JOURNAL   mBio 15 (3), e0008324 (2024)
   PUBMED   38376210
  REMARK    GeneRIF: Endogenous IL-27 during toxoplasmosis limits early
            monocyte responses and their inflammatory activation by
            pathological T cells.
REFERENCE   5  (bases 1 to 1103)
  AUTHORS   Bradford,S.D., Ryan,K.J., Divens,A.M., Povroznik,J.M., Bonigala,S.
            and Robinson,C.M.
  TITLE     IL-27 alters inflammatory cytokine expression and limits protective
            immunity against Mycobacterium tuberculosis in a neonatal BCG
            vaccination model
  JOURNAL   Front Immunol 15, 1217098 (2024)
   PUBMED   38390338
  REMARK    GeneRIF: IL-27 alters inflammatory cytokine expression and limits
            protective immunity against Mycobacterium tuberculosis in a
            neonatal BCG vaccination model.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1103)
  AUTHORS   Yoshimoto,T., Okada,K., Morishima,N., Kamiya,S., Owaki,T.,
            Asakawa,M., Iwakura,Y., Fukai,F. and Mizuguchi,J.
  TITLE     Induction of IgG2a class switching in B cells by IL-27
  JOURNAL   J Immunol 173 (4), 2479-2485 (2004)
   PUBMED   15294962
REFERENCE   7  (bases 1 to 1103)
  AUTHORS   Murakami,M., Kamimura,D. and Hirano,T.
  TITLE     New IL-6 (gp130) family cytokine members, CLC/NNT1/BSF3 and IL-27
  JOURNAL   Growth Factors 22 (2), 75-77 (2004)
   PUBMED   15253382
  REMARK    GeneRIF: IL-6 (gp130) family cytokine members include CLC/NNT1/BSF3
            and IL-27 [review]
            Review article
REFERENCE   8  (bases 1 to 1103)
  AUTHORS   Lucas,S., Ghilardi,N., Li,J. and de Sauvage,F.J.
  TITLE     IL-27 regulates IL-12 responsiveness of naive CD4+ T cells through
            Stat1-dependent and -independent mechanisms
  JOURNAL   Proc Natl Acad Sci U S A 100 (25), 15047-15052 (2003)
   PUBMED   14657353
  REMARK    GeneRIF: IL-27 regulates IL-12 responsiveness of naive CD4+ T cells
            through Stat1-dependent and -independent mechanisms
REFERENCE   9  (bases 1 to 1103)
  AUTHORS   Zhang,J.H., He,H., Borzychowski,A.M., Takeda,K., Akira,S. and
            Croy,B.A.
  TITLE     Analysis of cytokine regulators inducing interferon production by
            mouse uterine natural killer cells
  JOURNAL   Biol Reprod 69 (2), 404-411 (2003)
   PUBMED   12646495
REFERENCE   10 (bases 1 to 1103)
  AUTHORS   Takeda,A., Hamano,S., Yamanaka,A., Hanada,T., Ishibashi,T.,
            Mak,T.W., Yoshimura,A. and Yoshida,H.
  TITLE     Cutting edge: role of IL-27/WSX-1 signaling for induction of T-bet
            through activation of STAT1 during initial Th1 commitment
  JOURNAL   J Immunol 170 (10), 4886-4890 (2003)
   PUBMED   12734330
  REMARK    GeneRIF: The IL-27/WSX-1 signaling system is a key commitment step
            at which naive Th precursor cells commence differentiation into Th1
            cells.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC125169.4, AK153466.1 and AI662173.1.
            
            On Feb 15, 2019 this sequence version replaced NM_145636.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK152114.1, AK153466.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849383
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-90                AC125169.4         73287-73376
            91-1102             AK153466.1         1-1012
            1103-1103           AI662173.1         7-7                 c
FEATURES             Location/Qualifiers
     source          1..1103
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 69.18 cM"
     gene            1..1103
                     /gene="Il27"
                     /gene_synonym="IL-27; IL-27-A; IL-27p28; IL27-A; Il30;
                     p28"
                     /note="interleukin 27"
                     /db_xref="GeneID:246779"
                     /db_xref="MGI:MGI:2384409"
     exon            1..143
                     /gene="Il27"
                     /gene_synonym="IL-27; IL-27-A; IL-27p28; IL27-A; Il30;
                     p28"
                     /inference="alignment:Splign:2.1.0"
     CDS             113..817
                     /gene="Il27"
                     /gene_synonym="IL-27; IL-27-A; IL-27p28; IL27-A; Il30;
                     p28"
                     /note="IL-27 p28 subunit; interleukin-27 subunit alpha;
                     interleukin 30; IL-27 subunit alpha"
                     /codon_start=1
                     /product="interleukin-27 subunit alpha precursor"
                     /protein_id="NP_663611.1"
                     /db_xref="CCDS:CCDS21835.1"
                     /db_xref="GeneID:246779"
                     /db_xref="MGI:MGI:2384409"
                     /translation="MGQVTGDLGWRLSLLLLPLLLVQAGSWGFPTDPLSLQELRREFT
                     VSLYLARKLLSEVQGYVHSFAESRLPGVNLDLLPLGYHLPNVSLTFQAWHHLSDSERL
                     CFLATTLRPFPAMLGGLGTQGTWTSSEREQLWAMRLDLRDLHRHLRFQVLAAGFKCSK
                     EEEDKEEEEEEEEEEKKLPLGALGGPNQVSSQVSWPQLLYTYQLLHSLELVLSRAVRD
                     LLLLSLPRRPGSAWDS"
     exon            144..304
                     /gene="Il27"
                     /gene_synonym="IL-27; IL-27-A; IL-27p28; IL27-A; Il30;
                     p28"
                     /inference="alignment:Splign:2.1.0"
     exon            305..403
                     /gene="Il27"
                     /gene_synonym="IL-27; IL-27-A; IL-27p28; IL27-A; Il30;
                     p28"
                     /inference="alignment:Splign:2.1.0"
     exon            404..562
                     /gene="Il27"
                     /gene_synonym="IL-27; IL-27-A; IL-27p28; IL27-A; Il30;
                     p28"
                     /inference="alignment:Splign:2.1.0"
     exon            563..1103
                     /gene="Il27"
                     /gene_synonym="IL-27; IL-27-A; IL-27p28; IL27-A; Il30;
                     p28"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1084..1089
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Il27"
                     /gene_synonym="IL-27; IL-27-A; IL-27p28; IL27-A; Il30;
                     p28"
                     /note="hexamer: AATAAA"
     polyA_site      1103
                     /gene="Il27"
                     /gene_synonym="IL-27; IL-27-A; IL-27p28; IL27-A; Il30;
                     p28"
                     /note="major polyA site"
ORIGIN      
        1 agtgaacaca aagctgaaag tacaagtagg acagaaagtg aaactgggcg cagcccccag
       61 tataagaccc ccctacccag gagatggctg cacacagagg ctgggccctg acatgggcca
      121 ggtgacagga gaccttggct ggcggctcag cctgttgctg ctacccttgc ttctggtaca
      181 agctggttcc tgggggttcc caacagaccc cctgagcctt caagagctgc gcagggaatt
      241 cacagtcagc ctgtaccttg ccaggaagct gctctctgag gttcagggct atgtccacag
      301 ctttgctgaa tctcgattgc caggagtgaa cctggacctc ctgcccctgg gataccatct
      361 tcccaatgtt tccctgactt tccaggcatg gcatcacctc tctgactctg agagactctg
      421 cttcctcgct accacacttc ggcccttccc tgccatgctg ggagggctgg ggacccaggg
      481 gacctggacc agctcagaga gggagcagct gtgggccatg aggctggatc tccgggacct
      541 gcacaggcac ctccgctttc aggtgctggc tgcaggattc aaatgttcaa aggaggagga
      601 ggacaaggag gaagaggaag aggaggaaga agaagaaaag aagctgcccc taggggctct
      661 gggtggcccc aatcaggtgt catcccaagt gtcctggccc cagctgctct atacctacca
      721 gctccttcac tccctggagc ttgtcctgtc tcgggctgtt cgggacctgc tgctgctgtc
      781 cctgcccagg cgcccaggct cagcctggga ttcctaacac ctagcttcaa gccctatgga
      841 gtgaccttcc agctccctcc ctcgcccgtt aagactctaa ggctggagtc tggccaatca
      901 caggacaggc tctagctcgt ttgccttaga ccaggcaggg cttcactagc tcccagccct
      961 gacccaataa tttaaaagcc ctccagtcct taccagatat ttatttcttg gatatttatt
     1021 tatttttaag aaatggttta tttattgttt cactcttgag ttaggccacc atgctgggtg
     1081 cctaataaag ccatccagcc cgg
//
