LOCUS       NM_080729               1064 bp    mRNA    linear   ROD 24-OCT-2024
DEFINITION  Mus musculus interleukin 25 (Il25), mRNA.
ACCESSION   NM_080729
VERSION     NM_080729.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1064)
  AUTHORS   Jin,J., Chen,X., Zhao,Y., Jia,J. and Zhang,J.
  TITLE     [The role and its regulatory significance of interleukin-25 in
            ovalbumin induced atopic dermatitis of mice]
  JOURNAL   Beijing Da Xue Xue Bao Yi Xue Ban 56 (5), 756-762 (2024)
   PUBMED   39397451
  REMARK    GeneRIF: [The role and its regulatory significance of
            interleukin-25 in ovalbumin induced atopic dermatitis of mice].
REFERENCE   2  (bases 1 to 1064)
  AUTHORS   Billipp,T.E., Fung,C., Webeck,L.M., Sargent,D.B., Gologorsky,M.B.,
            Chen,Z., McDaniel,M.M., Kasal,D.N., McGinty,J.W., Barrow,K.A.,
            Rich,L.M., Barilli,A., Sabat,M., Debley,J.S., Wu,C., Myers,R.,
            Howitt,M.R. and von Moltke,J.
  TITLE     Tuft cell-derived acetylcholine promotes epithelial chloride
            secretion and intestinal helminth clearance
  JOURNAL   Immunity 57 (6), 1243-1259 (2024)
   PUBMED   38744291
REFERENCE   3  (bases 1 to 1064)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 1064)
  AUTHORS   Kim,D.H., Wang,Y., Jung,H., Field,R.L., Zhang,X., Liu,T.C., Ma,C.,
            Fraser,J.S., Brestoff,J.R. and Van Dyken,S.J.
  TITLE     A type 2 immune circuit in the stomach controls mammalian
            adaptation to dietary chitin
  JOURNAL   Science 381 (6662), 1092-1098 (2023)
   PUBMED   37676935
REFERENCE   5  (bases 1 to 1064)
  AUTHORS   Jeerawattanawart,S., Hansakon,A., Roytrakul,S. and Angkasekwinai,P.
  TITLE     Regulation and function of adiponectin in the intestinal epithelial
            cells in response to Trichinella spiralis infection
  JOURNAL   Sci Rep 13 (1), 14004 (2023)
   PUBMED   37635188
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1064)
  AUTHORS   VanBuren,V., Piao,Y., Dudekula,D.B., Qian,Y., Carter,M.G.,
            Martin,P.R., Stagg,C.A., Bassey,U.C., Aiba,K., Hamatani,T.,
            Kargul,G.J., Luo,A.G., Kelso,J., Hide,W. and Ko,M.S.
  TITLE     Assembly, verification, and initial annotation of the NIA mouse
            7.4K cDNA clone set
  JOURNAL   Genome Res 12 (12), 1999-2003 (2002)
   PUBMED   12466305
REFERENCE   7  (bases 1 to 1064)
  AUTHORS   Kim,M.R., Manoukian,R., Yeh,R., Silbiger,S.M., Danilenko,D.M.,
            Scully,S., Sun,J., DeRose,M.L., Stolina,M., Chang,D., Van,G.Y.,
            Clarkin,K., Nguyen,H.Q., Yu,Y.B., Jing,S., Senaldi,G., Elliott,G.
            and Medlock,E.S.
  TITLE     Transgenic overexpression of human IL-17E results in eosinophilia,
            B-lymphocyte hyperplasia, and altered antibody production
  JOURNAL   Blood 100 (7), 2330-2340 (2002)
   PUBMED   12239140
REFERENCE   8  (bases 1 to 1064)
  AUTHORS   Hurst,S.D., Muchamuel,T., Gorman,D.M., Gilbert,J.M., Clifford,T.,
            Kwan,S., Menon,S., Seymour,B., Jackson,C., Kung,T.T.,
            Brieland,J.K., Zurawski,S.M., Chapman,R.W., Zurawski,G. and
            Coffman,R.L.
  TITLE     New IL-17 family members promote Th1 or Th2 responses in the lung:
            in vivo function of the novel cytokine IL-25
  JOURNAL   J Immunol 169 (1), 443-453 (2002)
   PUBMED   12077275
  REMARK    GeneRIF: Intranasal administration of IL-25 promotes Th2
            cell-mediated production of IL-4, IL-5, IL-13, and eotaxin mRNA in
            lung, eosinophilia in bronchoalveolar lavage and lung, epithelial
            cell hyperplasia, increased mucus secretion, and airway
            hyperreactivity.
REFERENCE   9  (bases 1 to 1064)
  AUTHORS   Pan,G., French,D., Mao,W., Maruoka,M., Risser,P., Lee,J.,
            Foster,J., Aggarwal,S., Nicholes,K., Guillet,S., Schow,P. and
            Gurney,A.L.
  TITLE     Forced expression of murine IL-17E induces growth retardation,
            jaundice, a Th2-biased response, and multiorgan inflammation in
            mice
  JOURNAL   J Immunol 167 (11), 6559-6567 (2001)
   PUBMED   11714825
REFERENCE   10 (bases 1 to 1064)
  AUTHORS   Fort,M.M., Cheung,J., Yen,D., Li,J., Zurawski,S.M., Lo,S.,
            Menon,S., Clifford,T., Hunte,B., Lesley,R., Muchamuel,T.,
            Hurst,S.D., Zurawski,G., Leach,M.W., Gorman,D.M. and Rennick,D.M.
  TITLE     IL-25 induces IL-4, IL-5, and IL-13 and Th2-associated pathologies
            in vivo
  JOURNAL   Immunity 15 (6), 985-995 (2001)
   PUBMED   11754819
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BQ554452.1, AF458060.1, BX517868.1 and AI429629.1.
            
            On Jun 19, 2010 this sequence version replaced NM_080729.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC120568.1, AF458060.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849376
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-76                BQ554452.1         108-183
            77-492              AF458060.1         1-416
            493-717             BX517868.1         302-526
            718-1038            AF458060.1         642-962
            1039-1064           AI429629.1         6-31                c
FEATURES             Location/Qualifiers
     source          1..1064
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 28.0 cM"
     gene            1..1064
                     /gene="Il25"
                     /gene_synonym="IL-17e; IL-25; Il17e"
                     /note="interleukin 25"
                     /db_xref="GeneID:140806"
                     /db_xref="MGI:MGI:2155888"
     exon            1..85
                     /gene="Il25"
                     /gene_synonym="IL-17e; IL-25; Il17e"
                     /inference="alignment:Splign:2.1.0"
     CDS             77..586
                     /gene="Il25"
                     /gene_synonym="IL-17e; IL-25; Il17e"
                     /note="interleukin 17E"
                     /codon_start=1
                     /product="interleukin-25 precursor"
                     /protein_id="NP_542767.1"
                     /db_xref="CCDS:CCDS36926.1"
                     /db_xref="GeneID:140806"
                     /db_xref="MGI:MGI:2155888"
                     /translation="MYQAVAFLAMIVGTHTVSLRIQEGCSHLPSCCPSKEQEPPEEWL
                     KWSSASVSPPEPLSHTHHAESCRASKDGPLNSRAISPWSYELDRDLNRVPQDLYHARC
                     LCPHCVSLQTGSHMDPLGNSVPLYHNQTVFYRRPCHGEEGTHRRYCLERRLYRVSLAC
                     VCVRPRVMA"
     exon            86..330
                     /gene="Il25"
                     /gene_synonym="IL-17e; IL-25; Il17e"
                     /inference="alignment:Splign:2.1.0"
     exon            331..1064
                     /gene="Il25"
                     /gene_synonym="IL-17e; IL-25; Il17e"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cagctgctcc agtcagcctc tctcagaagg cctgtcaggc aggggtagta cctgtgactg
       61 gtgagcagtg tccggcatgt accaggctgt tgcattcttg gcaatgatcg tgggaaccca
      121 caccgtcagc ttgcggatcc aggagggctg cagtcacttg cccagctgct gccccagcaa
      181 agagcaagaa cccccggagg agtggctgaa gtggagctct gcatctgtgt cccccccaga
      241 gcctctgagc cacacccacc acgcagaatc ctgcagggcc agcaaggatg gccccctcaa
      301 cagcagggcc atctctcctt ggagctatga gttggacagg gacttgaatc gggtccccca
      361 ggacctgtac cacgctcgat gcctgtgccc acactgcgtc agcctacaga caggctccca
      421 catggacccg ctgggcaact ccgtcccact ttaccacaac cagacggtct tctaccggcg
      481 gccatgccat ggcgaggaag gtacccatcg ccgctactgc ttggagcgca ggctctaccg
      541 agtctccttg gcttgtgtgt gtgtgcggcc ccgggtcatg gcttagtcat gctcaccacc
      601 tgcctgaggc tgatgcccgg ttgggagaga gggccaggtg tacaatcacc ttgccaatgc
      661 gggccgggtt caagccctcc aaagccctac ctgaagcagc aggctcccgg gacaagatgg
      721 aggacttggg gagaaactct gacttttgca ctttttggaa gcacttttgg gaaggagcag
      781 gttccgcttg tgctgctaga ggatgctgtt gtggcatttc tactcaggaa cggactccaa
      841 aggcctgctg accctggaag ccatactcct ggctcctttc ccctgaatcc cccaactcct
      901 ggcacaggca ctttctccac ctctccccct ttgccttttg ttgtgtttgt ttgtgcatgc
      961 caactctgcg tgcagccagg tgtaattgcc ttgaaggatg gttctgaggt gaaagctgtt
     1021 atcgaaagtg aagagattta tccaaataaa catctgtgtt taaa
//
