LOCUS       NM_053095               1131 bp    mRNA    linear   ROD 28-JAN-2025
DEFINITION  Mus musculus interleukin 24 (Il24), mRNA.
ACCESSION   NM_053095
VERSION     NM_053095.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1131)
  AUTHORS   Oka,T., Smith,S.S., Son,H.G., Lee,T., Oliver-Garcia,V.S.,
            Mortaja,M., Trerice,K.E., Isakoff,L.S., Conrad,D.N., Azin,M.,
            Raval,N.S., Tabacchi,M., Emdad,L., Das,S.K., Fisher,P.B.,
            Cornelius,L.A. and Demehri,S.
  TITLE     T helper 2 cell-directed immunotherapy eliminates precancerous skin
            lesions
  JOURNAL   J Clin Invest 135 (1), e183274 (2025)
   PUBMED   39744942
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1131)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 1131)
  AUTHORS   Cai,Y., He,C., Dai,Y., Zhang,D., Lv,G., Lu,H. and Chen,G.
  TITLE     Spinal interleukin-24 contributes to neuropathic pain after
            peripheral nerve injury through interleukin-20 receptor2 in mice
  JOURNAL   Exp Neurol 372, 114643 (2024)
   PUBMED   38056582
  REMARK    GeneRIF: Spinal interleukin-24 contributes to neuropathic pain
            after peripheral nerve injury through interleukin-20 receptor2 in
            mice.
REFERENCE   4  (bases 1 to 1131)
  AUTHORS   Chen,J., Zhang,Y., Zhang,H., Zhang,M., Dong,H., Qin,T., Gao,S. and
            Wang,S.
  TITLE     IL-24 is the key effector of Th9 cell-mediated tumor immunotherapy
  JOURNAL   iScience 26 (9), 107531 (2023)
   PUBMED   37680459
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1131)
  AUTHORS   Liu,S., Hur,Y.H., Cai,X., Cong,Q., Yang,Y., Xu,C., Bilate,A.M.,
            Gonzales,K.A.U., Parigi,S.M., Cowley,C.J., Hurwitz,B., Luo,J.D.,
            Tseng,T., Gur-Cohen,S., Sribour,M., Omelchenko,T., Levorse,J.,
            Pasolli,H.A., Thompson,C.B., Mucida,D. and Fuchs,E.
  TITLE     A tissue injury sensing and repair pathway distinct from host
            pathogen defense
  JOURNAL   Cell 186 (10), 2127-2143 (2023)
   PUBMED   37098344
  REMARK    GeneRIF: A tissue injury sensing and repair pathway distinct from
            host pathogen defense.
REFERENCE   6  (bases 1 to 1131)
  AUTHORS   Gao,P., Sun,X., Chen,X., Wang,Y., Foster,B.A., Subjeck,J.,
            Fisher,P.B. and Wang,X.Y.
  TITLE     Secretable chaperone Grp170 enhances therapeutic activity of a
            novel tumor suppressor, mda-7/IL-24
  JOURNAL   Cancer Res 68 (10), 3890-3898 (2008)
   PUBMED   18483274
  REMARK    GeneRIF: Grp170 enhances therapeutic activity of a novel tumor
            suppressor, mda-7/IL-24
REFERENCE   7  (bases 1 to 1131)
  AUTHORS   Chan,J.R., Blumenschein,W., Murphy,E., Diveu,C., Wiekowski,M.,
            Abbondanzo,S., Lucian,L., Geissler,R., Brodie,S., Kimball,A.B.,
            Gorman,D.M., Smith,K., de Waal Malefyt,R., Kastelein,R.A.,
            McClanahan,T.K. and Bowman,E.P.
  TITLE     IL-23 stimulates epidermal hyperplasia via TNF and
            IL-20R2-dependent mechanisms with implications for psoriasis
            pathogenesis
  JOURNAL   J Exp Med 203 (12), 2577-2587 (2006)
   PUBMED   17074928
REFERENCE   8  (bases 1 to 1131)
  AUTHORS   Shinohara,S. and Rothstein,J.L.
  TITLE     Interleukin 24 is induced by the RET/PTC3 oncoprotein and is an
            autocrine growth factor for epithelial cells
  JOURNAL   Oncogene 23 (45), 7571-7579 (2004)
   PUBMED   15326486
  REMARK    GeneRIF: induction of Il24 by oncogenes may support tumor growth at
            the early stages of cancer
REFERENCE   9  (bases 1 to 1131)
  AUTHORS   Schaefer,G., Venkataraman,C. and Schindler,U.
  TITLE     Cutting edge: FISP (IL-4-induced secreted protein), a novel
            cytokine-like molecule secreted by Th2 cells
  JOURNAL   J Immunol 166 (10), 5859-5863 (2001)
   PUBMED   11342597
REFERENCE   10 (bases 1 to 1131)
  AUTHORS   Soo,C., Shaw,W.W., Freymiller,E., Longaker,M.T., Bertolami,C.N.,
            Chiu,R., Tieu,A. and Ting,K.
  TITLE     Cutaneous rat wounds express c49a, a novel gene with homology to
            the human melanoma differentiation associated gene, mda-7
  JOURNAL   J Cell Biochem 74 (1), 1-10 (1999)
   PUBMED   10381256
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC165322.12.
            
            On Jul 29, 2021 this sequence version replaced NM_053095.2.
            
            CCDS Note: The coding region was updated to begin from a downstream
            start codon based on currently available conservation data.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF333251.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            RefSeq Select criteria           :: based on single protein-coding
                                                transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-165               AC165322.12        108801-108965
            166-359             AC165322.12        110447-110640
            360-422             AC165322.12        111367-111429
            423-581             AC165322.12        112225-112383
            582-656             AC165322.12        112809-112883
            657-1131            AC165322.12        113679-114153
FEATURES             Location/Qualifiers
     source          1..1131
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 56.89 cM"
     gene            1..1131
                     /gene="Il24"
                     /gene_synonym="FISP; If2e; Mda-7; Mda7; St16"
                     /note="interleukin 24"
                     /db_xref="GeneID:93672"
                     /db_xref="MGI:MGI:2135548"
     exon            1..165
                     /gene="Il24"
                     /gene_synonym="FISP; If2e; Mda-7; Mda7; St16"
                     /inference="alignment:Splign:2.1.0"
     exon            166..359
                     /gene="Il24"
                     /gene_synonym="FISP; If2e; Mda-7; Mda7; St16"
                     /inference="alignment:Splign:2.1.0"
     CDS             195..740
                     /gene="Il24"
                     /gene_synonym="FISP; If2e; Mda-7; Mda7; St16"
                     /note="IL-24; th2-specific cytokine FISP; IL-4-induced
                     secreted protein; melanoma differentiation-associated gene
                     7 protein; interferon 2e"
                     /codon_start=1
                     /product="interleukin-24 precursor"
                     /protein_id="NP_444325.3"
                     /db_xref="CCDS:CCDS15262.2"
                     /db_xref="GeneID:93672"
                     /db_xref="MGI:MGI:2135548"
                     /translation="MSWGLQILPCLSLILLLWNQVPGLEGQEFRFGSCQVTGVVLPEL
                     WEAFWTVKNTVQTQDDITSIRLLKPQVLRNVSGAESCYLAHSLLKFYLNTVFKNYHSK
                     IAKFKVLRSFSTLANNFIVIMSQLQPSKDNSMLPISESAHQRFLLFRRAFKQLDTEVA
                     LVKAFGEVDILLTWMQKFYHL"
     exon            360..422
                     /gene="Il24"
                     /gene_synonym="FISP; If2e; Mda-7; Mda7; St16"
                     /inference="alignment:Splign:2.1.0"
     exon            423..581
                     /gene="Il24"
                     /gene_synonym="FISP; If2e; Mda-7; Mda7; St16"
                     /inference="alignment:Splign:2.1.0"
     exon            582..656
                     /gene="Il24"
                     /gene_synonym="FISP; If2e; Mda-7; Mda7; St16"
                     /inference="alignment:Splign:2.1.0"
     exon            657..1131
                     /gene="Il24"
                     /gene_synonym="FISP; If2e; Mda-7; Mda7; St16"
                     /inference="alignment:Splign:2.1.0"
     regulatory      962..967
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Il24"
                     /gene_synonym="FISP; If2e; Mda-7; Mda7; St16"
                     /note="hexamer: ATTAAA"
     polyA_site      989
                     /gene="Il24"
                     /gene_synonym="FISP; If2e; Mda-7; Mda7; St16"
     regulatory      1103..1108
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Il24"
                     /gene_synonym="FISP; If2e; Mda-7; Mda7; St16"
                     /note="hexamer: AGTAAA"
     polyA_site      1131
                     /gene="Il24"
                     /gene_synonym="FISP; If2e; Mda-7; Mda7; St16"
                     /note="major polyA site"
ORIGIN      
        1 ctcagtcttt cacttttgaa atcatttcca cagctgagaa ggagcttccc acccagcaga
       61 agatcctcta ccaatgaatg ctgactgagc ctgcccaact ttttgtgcac aagaagaacc
      121 agccaccttc acacagcagc ctccggcttc actttaggac cctagcagga gcactggccc
      181 tttcttcaac acagatgagt tggggactac agattctccc ctgcctgagc ctaatccttc
      241 ttctttggaa ccaagtgcca gggcttgagg gtcaagagtt ccgatttggg tcttgccaag
      301 tgacaggggt ggttctccca gaactgtggg aggccttctg gactgtgaag aacactgtgc
      361 aaactcagga tgacatcaca agcatccggc tgttgaagcc gcaggttctg cggaatgtct
      421 cgggtgctga gagctgttac cttgcccaca gcctgctgaa gttctacttg aacactgttt
      481 tcaagaacta ccacagcaaa atagccaaat tcaaggtctt gaggtcattc tccactctgg
      541 ccaacaactt catagtcatc atgtcacaac tacagcccag taaggacaat tccatgcttc
      601 ccattagtga gagtgcacac cagcggtttt tgctgttccg cagagcattc aaacagttgg
      661 atacagaagt cgctttggtg aaagcctttg gggaagtgga cattctcctg acctggatgc
      721 agaaattcta ccatctctga ctgctgattg gataacttcc tcctttgctc tccatgccat
      781 ttcaaggcat tgtgtacatc cctgctgtcc tcaaggcact tcagaccctt ggccatggac
      841 cccgttgttg gctcaggctt ttcctcagac ctcactcttc agtccaaatg acagccatag
      901 atggcacctt tggatgctcc gactgaccca caaagtagat ttgcatattt attacagccc
      961 tattaaatta ttgtcacctt ccctggaaac cgtatttatt tgtgagacca gaagttccat
     1021 gaaagcatca gaatttagtg ccccatgcct cctcctcact tcctgtgatc tggctcagca
     1081 tgggggcagt ggatggttgc tcagtaaata tttaaaatgg attggttttt a
//
