LOCUS       NM_144548               2497 bp    mRNA    linear   ROD 17-DEC-2024
DEFINITION  Mus musculus interleukin 23 receptor (Il23r), mRNA.
ACCESSION   NM_144548
VERSION     NM_144548.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2497)
  AUTHORS   Mangani,D., Subramanian,A., Huang,L., Cheng,H., Krovi,S.H., Wu,Y.,
            Yang,D., Moreira,T.G., Escobar,G., Schnell,A., Dixon,K.O.,
            Krishnan,R.K., Singh,V., Sobel,R.A., Weiner,H.L., Kuchroo,V.K. and
            Anderson,A.C.
  TITLE     Transcription factor TCF1 binds to RORgammat and orchestrates a
            regulatory network that determines homeostatic Th17 cell state
  JOURNAL   Immunity 57 (11), 2565-2582 (2024)
   PUBMED   39447575
REFERENCE   2  (bases 1 to 2497)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 2497)
  AUTHORS   Jacobse,J., Brown,R.E., Li,J., Pilat,J.M., Pham,L., Short,S.P.,
            Peek,C.T., Rolong,A., Washington,M.K., Martinez-Barricarte,R.,
            Byndloss,M.X., Shelton,C., Markle,J.G., Latour,Y.L., Allaman,M.M.,
            Cassat,J.E., Wilson,K.T., Choksi,Y.A., Williams,C.S., Lau,K.S.,
            Flynn,C.R., Casanova,J.L., Rings,E.H.H.M., Samsom,J.N. and
            Goettel,J.A.
  TITLE     Interleukin-23 receptor signaling impairs the stability and
            function of colonic regulatory T cells
  JOURNAL   Cell Rep 42 (2), 112128 (2023)
   PUBMED   36807140
  REMARK    GeneRIF: Interleukin-23 receptor signaling impairs the stability
            and function of colonic regulatory T cells.
REFERENCE   4  (bases 1 to 2497)
  AUTHORS   Hackstein,C.P., Costigan,D., Drexhage,L., Pearson,C., Bullers,S.,
            Ilott,N., Akther,H.D., Gu,Y., FitzPatrick,M.E.B., Harrison,O.J.,
            Garner,L.C., Mann,E.H., Pandey,S., Friedrich,M., Provine,N.M.,
            Uhlig,H.H., Marchi,E., Powrie,F., Klenerman,P. and Thornton,E.E.
  TITLE     A conserved population of MHC II-restricted, innate-like,
            commensal-reactive T cells in the gut of humans and mice
  JOURNAL   Nat Commun 13 (1), 7472 (2022)
   PUBMED   36463279
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2497)
  AUTHORS   Li,W., An,N., Wang,M., Liu,X. and Mei,Z.
  TITLE     Interleukin-23 receptor defines T helper 1-like regulatory T cells
            in oral squamous cell carcinoma
  JOURNAL   Immun Inflamm Dis 10 (12), e746 (2022)
   PUBMED   36444617
  REMARK    GeneRIF: Interleukin-23 receptor defines T helper 1-like regulatory
            T cells in oral squamous cell carcinoma.
REFERENCE   6  (bases 1 to 2497)
  AUTHORS   Chan,J.R., Blumenschein,W., Murphy,E., Diveu,C., Wiekowski,M.,
            Abbondanzo,S., Lucian,L., Geissler,R., Brodie,S., Kimball,A.B.,
            Gorman,D.M., Smith,K., de Waal Malefyt,R., Kastelein,R.A.,
            McClanahan,T.K. and Bowman,E.P.
  TITLE     IL-23 stimulates epidermal hyperplasia via TNF and
            IL-20R2-dependent mechanisms with implications for psoriasis
            pathogenesis
  JOURNAL   J Exp Med 203 (12), 2577-2587 (2006)
   PUBMED   17074928
REFERENCE   7  (bases 1 to 2497)
  AUTHORS   Langowski,J.L., Zhang,X., Wu,L., Mattson,J.D., Chen,T., Smith,K.,
            Basham,B., McClanahan,T., Kastelein,R.A. and Oft,M.
  TITLE     IL-23 promotes tumour incidence and growth
  JOURNAL   Nature 442 (7101), 461-465 (2006)
   PUBMED   16688182
REFERENCE   8  (bases 1 to 2497)
  AUTHORS   Hoeve,M.A., Savage,N.D., de Boer,T., Langenberg,D.M., de Waal
            Malefyt,R., Ottenhoff,T.H. and Verreck,F.A.
  TITLE     Divergent effects of IL-12 and IL-23 on the production of IL-17 by
            human T cells
  JOURNAL   Eur J Immunol 36 (3), 661-670 (2006)
   PUBMED   16482511
REFERENCE   9  (bases 1 to 2497)
  AUTHORS   Parham,C., Chirica,M., Timans,J., Vaisberg,E., Travis,M.,
            Cheung,J., Pflanz,S., Zhang,R., Singh,K.P., Vega,F., To,W.,
            Wagner,J., O'Farrell,A.M., McClanahan,T., Zurawski,S., Hannum,C.,
            Gorman,D., Rennick,D.M., Kastelein,R.A., de Waal Malefyt,R. and
            Moore,K.W.
  TITLE     A receptor for the heterodimeric cytokine IL-23 is composed of
            IL-12Rbeta1 and a novel cytokine receptor subunit, IL-23R
  JOURNAL   J Immunol 168 (11), 5699-5708 (2002)
   PUBMED   12023369
REFERENCE   10 (bases 1 to 2497)
  AUTHORS   Oppmann,B., Lesley,R., Blom,B., Timans,J.C., Xu,Y., Hunte,B.,
            Vega,F., Yu,N., Wang,J., Singh,K., Zonin,F., Vaisberg,E.,
            Churakova,T., Liu,M., Gorman,D., Wagner,J., Zurawski,S., Liu,Y.,
            Abrams,J.S., Moore,K.W., Rennick,D., de Waal-Malefyt,R., Hannum,C.,
            Bazan,J.F. and Kastelein,R.A.
  TITLE     Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with
            biological activities similar as well as distinct from IL-12
  JOURNAL   Immunity 13 (5), 715-725 (2000)
   PUBMED   11114383
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC124758.6 and AC159129.4.
            
            On Jul 29, 2021 this sequence version replaced NM_144548.1.
            
            CCDS Note: The coding region has been updated to extend the
            N-terminus. The use of an alternative upstream start codon would
            result in a protein that is 15 aa longer at the N-terminal.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF461423.1, BC112425.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            RefSeq Select criteria           :: based on single protein-coding
                                                transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-86                AC124758.6         79316-79401         c
            87-189              AC124758.6         78214-78316         c
            190-486             AC124758.6         73643-73939         c
            487-610             AC159129.4         606-729
            611-771             AC159129.4         5719-5879
            772-917             AC159129.4         13256-13401
            918-1134            AC159129.4         27163-27379
            1135-1221           AC159129.4         44985-45071
            1222-1324           AC159129.4         47968-48070
            1325-1415           AC159129.4         53011-53101
            1416-2497           AC159129.4         55673-56754
FEATURES             Location/Qualifiers
     source          1..2497
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 30.85 cM"
     gene            1..2497
                     /gene="Il23r"
                     /gene_synonym="IL-23R"
                     /note="interleukin 23 receptor"
                     /db_xref="GeneID:209590"
                     /db_xref="MGI:MGI:2181693"
     exon            1..86
                     /gene="Il23r"
                     /gene_synonym="IL-23R"
                     /inference="alignment:Splign:2.1.0"
     exon            87..189
                     /gene="Il23r"
                     /gene_synonym="IL-23R"
                     /inference="alignment:Splign:2.1.0"
     exon            190..486
                     /gene="Il23r"
                     /gene_synonym="IL-23R"
                     /inference="alignment:Splign:2.1.0"
     exon            487..610
                     /gene="Il23r"
                     /gene_synonym="IL-23R"
                     /inference="alignment:Splign:2.1.0"
     exon            611..771
                     /gene="Il23r"
                     /gene_synonym="IL-23R"
                     /inference="alignment:Splign:2.1.0"
     exon            772..917
                     /gene="Il23r"
                     /gene_synonym="IL-23R"
                     /inference="alignment:Splign:2.1.0"
     exon            918..1134
                     /gene="Il23r"
                     /gene_synonym="IL-23R"
                     /inference="alignment:Splign:2.1.0"
     exon            1135..1221
                     /gene="Il23r"
                     /gene_synonym="IL-23R"
                     /inference="alignment:Splign:2.1.0"
     exon            1222..1324
                     /gene="Il23r"
                     /gene_synonym="IL-23R"
                     /inference="alignment:Splign:2.1.0"
     exon            1325..1415
                     /gene="Il23r"
                     /gene_synonym="IL-23R"
                     /inference="alignment:Splign:2.1.0"
     exon            1416..2497
                     /gene="Il23r"
                     /gene_synonym="IL-23R"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2464..2469
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Il23r"
                     /gene_synonym="IL-23R"
                     /note="hexamer: AATAAA"
     polyA_site      2497
                     /gene="Il23r"
                     /gene_synonym="IL-23R"
                     /note="major polyA site"
ORIGIN      
        1 aggcagtggg aaagaagaca gcacagccag gagggcagcg gcttgattct gaagagagaa
       61 agtaatgcaa acaaatgaaa agagagagag aaatgagagg cttctactac atttgggaca
      121 tgagtcacct cacacttcag ctgcatgtgg tgatagccct ttatgtgctc ttcagatggt
      181 gtcacggagg aatcacaagt ataaactgct ctggtgacat gtgggttgag cctggtgaaa
      241 tttttcagat gggcatgaat gtttctatat attgccaaga agcccttaag cactgccgac
      301 caaggaatct ttacttttat aaaaatggct tcaaagaaga atttgatatc acaaggatta
      361 atagaacaac agctcggatt tggtataaag gcttttcgga acctcatgcc tatatgcatt
      421 gcactgctga atgtcctggt cattttcaag agacactgat ttgtgggaaa gacatttcct
      481 ctggacatcc accggatgcc cccagcaatc tgacatgtgt catttatgaa tactcaggca
      541 acatgacatg cacctggaac actgggaagc ctacctacat agataccaag tatattgtgc
      601 atgtgaagag tttggagaca gaagaagaac aacaatatct tgcctcaagc tatgttaaga
      661 tctccactga ctcactgcaa ggcagcagga agtatttggt atgggtccaa gctgtcaatt
      721 ccctaggcat ggagaactca caacaactac acgtccatct ggatgatata gtgatacctt
      781 ctgcgtccat catttccagg gctgagacta caaacgatac tgtacccaag accatagttt
      841 actggaaaag caaaactatg attgagaaag tattctgtga gatgagatac aaaacaacaa
      901 caaaccaaac gtggagtgtt aaagaatttg acgccaattt cacatatgta cagcagtcag
      961 aattctacct ggagccagac agcaagtatg tatttcaagt gcgatgtcaa gaaactggta
     1021 aaagaaactg gcagccttgg agttccccct ttgtccacca aacttcccaa gaaactggta
     1081 aaagaaactg gcagccttgg agttccccct ttgtccacca aacttcccag acagtttccc
     1141 aggttacagc aaaatcatcc cacgaacctc agaagatgga gatgctcagt gctacaatct
     1201 tcagaggaca tcctgcttca ggtaatcatc aagacattgg acttttgtcg ggaatggtct
     1261 tcttggccat catgttgccg attttttctc tgattgggat atttaacaga tcacttcgaa
     1321 taggaattaa aagaaaagtt ttactgatga tcccaaagtg gctttatgaa gatattccta
     1381 atatggaaaa tagcaatgtt gcaaaattat tacaggaaaa aagtgtattt gagaatgata
     1441 atgccagtga gcaggccctg tatgtggatc ctgtccttac agagataagt gaaatctctc
     1501 ccctggaaca caaacccaca gattacaaag aagaaaggct cacaggactc cttgagacaa
     1561 gagactgtcc tctaggaatg ttgtctacca gttcttctgt tgtgtatatt cctgacctca
     1621 acactggata caaaccccag gtttcaaatg ttcctcctgg aggaaacctt ttcattaaca
     1681 gagatgaaag agaccctaca tcccttgaga ccacagatga ccactttgcc agattgaaaa
     1741 catatcccaa cttccaattt tctgcttcaa gtatggcttt actaaacaaa acactaattc
     1801 ttgatgaatt gtgcctcgtt ttaaatcaag gagaattcaa ttctcttgac ataaaaaact
     1861 caagacagga ggaaaccagc atcgttttgc aaagtgactc acccagtgaa actatcccag
     1921 cgcagactct gttgtctgat gaatttgtct cctgtttggc aattgggaat gaagacttgc
     1981 catctattaa ttcttacttt ccacagaacg ttttggaaag ccatttcagt agaatttcac
     2041 tcttccaaaa gtagactatg ccatcaaagt caaggtgaga agctgccttt ccactgcaag
     2101 ccaaaacttc cctcaaaaga agtataagta cactgccatg actccaggat ggaacttacc
     2161 tcactggcaa aacaaagcaa aacaaaaaca atgaggctgt gcttgtttgc ttgtttgctc
     2221 atttgtcagt tttcatctca ttttaatatc tccacttgag acaggaggtc acaaagccca
     2281 aaaggactaa ctcactatat atttgaggat ggctgaactc ttggttttcc tgcctcttct
     2341 tcccaagtgc taggattaaa ggtgtgtgcc accagggcta tttctttcct acttctgtca
     2401 ttaaattgta cagtacagct cagtttgtac aaaggataaa tcgtgcagaa tgcatagtag
     2461 tgaaataaat gtagaaaatg ggtctttaaa atcaaaa
//
