LOCUS       NM_031252               1359 bp    mRNA    linear   ROD 11-MAR-2025
DEFINITION  Mus musculus interleukin 23, alpha subunit p19 (Il23a), mRNA.
ACCESSION   NM_031252
VERSION     NM_031252.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1359)
  AUTHORS   Frasconi,T.M., Kurts,C., Dhana,E., Kaiser,R., Reichelt,M.,
            Lukacs-Kornek,V., Boor,P., Hauser,A.E., Pascual-Reguant,A.,
            Bedoui,S., Turner,J.E., Becker-Gotot,J. and Ludwig-Portugall,I.
  TITLE     Renal IL-23-Dependent Type 3 Innate Lymphoid Cells Link
            Crystal-induced Intrarenal Inflammasome Activation with Kidney
            Fibrosis
  JOURNAL   J Immunol 213 (6), 865-875 (2024)
   PUBMED   39072698
  REMARK    GeneRIF: Renal IL-23-Dependent Type 3 Innate Lymphoid Cells Link
            Crystal-induced Intrarenal Inflammasome Activation with Kidney
            Fibrosis.
REFERENCE   2  (bases 1 to 1359)
  AUTHORS   Specht,C.A., Wang,R., Oliveira,L.V.N., Hester,M.M., Gomez,C.,
            Mou,Z., Carlson,D., Lee,C.K., Hole,C.R., Lam,W.C., Upadhya,R.,
            Lodge,J.K. and Levitz,S.M.
  TITLE     Immunological correlates of protection mediated by a whole
            organism, Cryptococcus neoformans, vaccine deficient in chitosan
  JOURNAL   mBio 15 (8), e0174624 (2024)
   PUBMED   38980038
REFERENCE   3  (bases 1 to 1359)
  AUTHORS   Lee,K.M., Lupancu,T., Chang,L., Manthey,C.L., Zeeman,M.,
            Fourie,A.M. and Hamilton,J.A.
  TITLE     The mode of action of IL-23 in experimental inflammatory arthritic
            pain and disease
  JOURNAL   Arthritis Res Ther 26 (1), 148 (2024)
   PUBMED   39107827
  REMARK    GeneRIF: The mode of action of IL-23 in experimental inflammatory
            arthritic pain and disease.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1359)
  AUTHORS   Fazazi,M.R., Doss,P.M.I.A., Pereira,R., Fudge,N., Regmi,A.,
            Joly-Beauparlant,C., Akbar,I., Yeola,A.P., Mailhot,B.,
            Baillargeon,J., Grenier,P., Bertrand,N., Lacroix,S., Droit,A.,
            Moore,C.S., Rojas,O.L. and Rangachari,M.
  TITLE     Myelin-reactive B cells exacerbate CD4+ T cell-driven CNS
            autoimmunity in an IL-23-dependent manner
  JOURNAL   Nat Commun 15 (1), 5404 (2024)
   PUBMED   38926356
  REMARK    GeneRIF: Myelin-reactive B cells exacerbate CD4[+] T cell-driven
            CNS autoimmunity in an IL-23-dependent manner.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1359)
  AUTHORS   Ahmed,A., Joseph,A.M., Zhou,J., Horn,V., Uddin,J., Lyu,M., Goc,J.,
            Sockolow,R.E., Wing,J.B., Vivier,E., Sakaguchi,S. and
            Sonnenberg,G.F.
  CONSRTM   JRI Live Cell Bank
  TITLE     CTLA-4-expressing ILC3s restrain interleukin-23-mediated
            inflammation
  JOURNAL   Nature 630 (8018), 976-983 (2024)
   PUBMED   38867048
  REMARK    GeneRIF: CTLA-4-expressing ILC3s restrain interleukin-23-mediated
            inflammation.
REFERENCE   6  (bases 1 to 1359)
  AUTHORS   Parham,C., Chirica,M., Timans,J., Vaisberg,E., Travis,M.,
            Cheung,J., Pflanz,S., Zhang,R., Singh,K.P., Vega,F., To,W.,
            Wagner,J., O'Farrell,A.M., McClanahan,T., Zurawski,S., Hannum,C.,
            Gorman,D., Rennick,D.M., Kastelein,R.A., de Waal Malefyt,R. and
            Moore,K.W.
  TITLE     A receptor for the heterodimeric cytokine IL-23 is composed of
            IL-12Rbeta1 and a novel cytokine receptor subunit, IL-23R
  JOURNAL   J Immunol 168 (11), 5699-5708 (2002)
   PUBMED   12023369
REFERENCE   7  (bases 1 to 1359)
  AUTHORS   Broberg,E.K., Setala,N., Eralinna,J.P., Salmi,A.A., Roytta,M. and
            Hukkanen,V.
  TITLE     Herpes simplex virus type 1 infection induces upregulation of
            interleukin-23 (p19) mRNA expression in trigeminal ganglia of
            BALB/c mice
  JOURNAL   J Interferon Cytokine Res 22 (6), 641-651 (2002)
   PUBMED   12162874
REFERENCE   8  (bases 1 to 1359)
  AUTHORS   Cooper,A.M., Kipnis,A., Turner,J., Magram,J., Ferrante,J. and
            Orme,I.M.
  TITLE     Mice lacking bioactive IL-12 can generate protective,
            antigen-specific cellular responses to mycobacterial infection only
            if the IL-12 p40 subunit is present
  JOURNAL   J Immunol 168 (3), 1322-1327 (2002)
   PUBMED   11801672
REFERENCE   9  (bases 1 to 1359)
  AUTHORS   Wiekowski,M.T., Leach,M.W., Evans,E.W., Sullivan,L., Chen,S.C.,
            Vassileva,G., Bazan,J.F., Gorman,D.M., Kastelein,R.A., Narula,S.
            and Lira,S.A.
  TITLE     Ubiquitous transgenic expression of the IL-23 subunit p19 induces
            multiorgan inflammation, runting, infertility, and premature death
  JOURNAL   J Immunol 166 (12), 7563-7570 (2001)
   PUBMED   11390512
REFERENCE   10 (bases 1 to 1359)
  AUTHORS   Oppmann,B., Lesley,R., Blom,B., Timans,J.C., Xu,Y., Hunte,B.,
            Vega,F., Yu,N., Wang,J., Singh,K., Zonin,F., Vaisberg,E.,
            Churakova,T., Liu,M., Gorman,D., Wagner,J., Zurawski,S., Liu,Y.,
            Abrams,J.S., Moore,K.W., Rennick,D., de Waal-Malefyt,R., Hannum,C.,
            Bazan,J.F. and Kastelein,R.A.
  TITLE     Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with
            biological activities similar as well as distinct from IL-12
  JOURNAL   Immunity 13 (5), 715-725 (2000)
   PUBMED   11114383
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC135859.4.
            
            On Mar 21, 2007 this sequence version replaced NM_031252.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF301619.1, BC019953.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-274               AC135859.4         9392-9665
            275-376             AC135859.4         9885-9986
            377-523             AC135859.4         10252-10398
            524-1359            AC135859.4         10501-11336
FEATURES             Location/Qualifiers
     source          1..1359
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 76.51 cM"
     gene            1..1359
                     /gene="Il23a"
                     /gene_synonym="IL-23; p19"
                     /note="interleukin 23, alpha subunit p19"
                     /db_xref="GeneID:83430"
                     /db_xref="MGI:MGI:1932410"
     exon            1..274
                     /gene="Il23a"
                     /gene_synonym="IL-23; p19"
                     /inference="alignment:Splign:2.1.0"
     CDS             113..703
                     /gene="Il23a"
                     /gene_synonym="IL-23; p19"
                     /note="interleukin-23 subunit alpha; IL-23-A; IL-23p19;
                     IL-23 subunit alpha; interleukin-23 subunit p19"
                     /codon_start=1
                     /product="interleukin-23 subunit alpha precursor"
                     /protein_id="NP_112542.1"
                     /db_xref="CCDS:CCDS24270.1"
                     /db_xref="GeneID:83430"
                     /db_xref="MGI:MGI:1932410"
                     /translation="MLDCRAVIMLWLLPWVTQGLAVPRSSSPDWAQCQQLSRNLCMLA
                     WNAHAPAGHMNLLREEEDEETKNNVPRIQCEDGCDPQGLKDNSQFCLQRIRQGLAFYK
                     HLLDSDIFKGEPALLPDSPMEQLHTSLLGLSQLLQPEDHPRETQQMPSLSSSQQWQRP
                     LLRSKILRSLQAFLAIAARVFAHGAATLTEPLVPTA"
     exon            275..376
                     /gene="Il23a"
                     /gene_synonym="IL-23; p19"
                     /inference="alignment:Splign:2.1.0"
     exon            377..523
                     /gene="Il23a"
                     /gene_synonym="IL-23; p19"
                     /inference="alignment:Splign:2.1.0"
     exon            524..1359
                     /gene="Il23a"
                     /gene_synonym="IL-23; p19"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1338..1343
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Il23a"
                     /gene_synonym="IL-23; p19"
                     /note="hexamer: AATAAA"
     polyA_site      1359
                     /gene="Il23a"
                     /gene_synonym="IL-23; p19"
                     /note="major polyA site"
ORIGIN      
        1 cgcttagaag tcggactaca gagttagact cagaaccaaa ggaggtggat agggggtcca
       61 caggcctggt gcagatcaca gagccagcca gatctgagaa gcagggaaca agatgctgga
      121 ttgcagagca gtaataatgc tatggctgtt gccctgggtc actcagggcc tggctgtgcc
      181 taggagtagc agtcctgact gggctcagtg ccagcagctc tctcggaatc tctgcatgct
      241 agcctggaac gcacatgcac cagcgggaca tatgaatcta ctaagagaag aagaggatga
      301 agagactaaa aataatgtgc cccgtatcca gtgtgaagat ggttgtgacc cacaaggact
      361 caaggacaac agccagttct gcttgcaaag gatccgccaa ggtctggctt tttataagca
      421 cctgcttgac tctgacatct tcaaagggga gcctgctcta ctccctgata gccccatgga
      481 gcaacttcac acctccctac taggactcag ccaactcctc cagccagagg atcacccccg
      541 ggagacccaa cagatgccca gcctgagttc tagtcagcag tggcagcgcc cccttctccg
      601 ttccaagatc cttcgaagcc tccaggcctt tttggccata gctgcccggg tctttgccca
      661 cggagcagca actctgactg agcccttagt gccaacagct taaggatgcc caggttccca
      721 tggctaccat gataagacta atctatcagc ccagacatct accagttaat taacccatta
      781 ggacttgtgc tgttcttgtt ttgtttgttt tgcgtgaagg gcaaggacac cattattaaa
      841 gagaaaagaa acaaacccca gagcaggcag ctggctagag aaaggagctg gagaagaaga
      901 ataaagtctc gagcccttgg ccttggaagc gggcaagcag ctgcgtggcc tgaggggaag
      961 ggggcggtgg catcgagaaa ctgtgagaaa acccagagca tcagaaaaag tgagcccagg
     1021 ctttggccat tatctgtaag aaaaacaaga aaaggggaac attatacttt cctgggtggc
     1081 tcagggaaat gtgcagatgc acagtactcc agacagcagc tctgtacctg cctgctctgt
     1141 ccctcagttc taacagaatc tagtcactaa gaactaacag gactaccaat acgaactgac
     1201 aaatactacc actatgacct gtgacaaagc tgcatattta ttaagtggga agggaacttt
     1261 tgatattatt tatccttgta acagtataga tgatggttat ttattctatt tataaggaat
     1321 tatgtatttt ttttttcaat aaagatttat ttatgtggc
//
