LOCUS       NM_178258               2468 bp    mRNA    linear   ROD 04-DEC-2024
DEFINITION  Mus musculus interleukin 22 receptor, alpha 2 (Il22ra2), mRNA.
ACCESSION   NM_178258
VERSION     NM_178258.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2468)
  AUTHORS   Fachi,J.L., Di Luccia,B., Gilfillan,S., Chang,H.W., Song,C.,
            Cheng,J., Cella,M., Vinolo,M.A., Gordon,J.I. and Colonna,M.
  TITLE     Deficiency of IL-22-binding protein enhances the ability of the gut
            microbiota to protect against enteric pathogens
  JOURNAL   Proc Natl Acad Sci U S A 121 (19), e2321836121 (2024)
   PUBMED   38687788
  REMARK    GeneRIF: Deficiency of IL-22-binding protein enhances the ability
            of the gut microbiota to protect against enteric pathogens.
REFERENCE   2  (bases 1 to 2468)
  AUTHORS   Zhang,Z., Chakawa,M.B., Galeas-Pena,M., Frydman,J.A., Allen,M.J.,
            Jones,M. and Pociask,D.
  TITLE     IL-22 Binding Protein Controls IL-22-Driven Bleomycin-Induced Lung
            Injury
  JOURNAL   Am J Pathol 194 (3), 338-352 (2024)
   PUBMED   38101567
  REMARK    GeneRIF: IL-22 Binding Protein Controls IL-22-Driven
            Bleomycin-Induced Lung Injury.
REFERENCE   3  (bases 1 to 2468)
  AUTHORS   Ke,Y., Li,B.Z., Nguyen,K., Wang,D., Wang,S., Young,C.D. and
            Wang,X.J.
  TITLE     IL-22RA2 Is a SMAD7 Target Mediating the Alleviation of Dermatitis
            and Psoriatic Phenotypes in Mice
  JOURNAL   J Invest Dermatol 143 (11), 2243-2254 (2023)
   PUBMED   37211203
  REMARK    GeneRIF: IL-22RA2 Is a SMAD7 Target Mediating the Alleviation of
            Dermatitis and Psoriatic Phenotypes in Mice.
REFERENCE   4  (bases 1 to 2468)
  AUTHORS   Gu,J., Zhou,P., Liu,Y., Xu,Q., Chen,X., Chen,M., Lu,C., Qu,C.,
            Tong,Y., Yu,Q., Lu,X., Yu,C. and Liu,Z.
  TITLE     Down-regulating Interleukin-22/Interleukin-22 binding protein axis
            promotes inflammation and aggravates diet-induced metabolic
            disorders
  JOURNAL   Mol Cell Endocrinol 557, 111776 (2022)
   PUBMED   36108991
  REMARK    GeneRIF: Down-regulating Interleukin-22/Interleukin-22 binding
            protein axis promotes inflammation and aggravates diet-induced
            metabolic disorders.
REFERENCE   5  (bases 1 to 2468)
  AUTHORS   Guendel,F., Kofoed-Branzk,M., Gronke,K., Tizian,C., Witkowski,M.,
            Cheng,H.W., Heinz,G.A., Heinrich,F., Durek,P., Norris,P.S.,
            Ware,C.F., Ruedl,C., Herold,S., Pfeffer,K., Hehlgans,T.,
            Waisman,A., Becher,B., Giannou,A.D., Brachs,S., Ebert,K.,
            Tanriver,Y., Ludewig,B., Mashreghi,M.F., Kruglov,A.A. and
            Diefenbach,A.
  TITLE     Group 3 Innate Lymphoid Cells Program a Distinct Subset of
            IL-22BP-Producing Dendritic Cells Demarcating Solitary Intestinal
            Lymphoid Tissues
  JOURNAL   Immunity 53 (5), 1015-1032 (2020)
   PUBMED   33207209
  REMARK    GeneRIF: Group 3 Innate Lymphoid Cells Program a Distinct Subset of
            IL-22BP-Producing Dendritic Cells Demarcating Solitary Intestinal
            Lymphoid Tissues.
REFERENCE   6  (bases 1 to 2468)
  AUTHORS   Huber,S., Gagliani,N., Zenewicz,L.A., Huber,F.J., Bosurgi,L.,
            Hu,B., Hedl,M., Zhang,W., O'Connor,W. Jr., Murphy,A.J.,
            Valenzuela,D.M., Yancopoulos,G.D., Booth,C.J., Cho,J.H., Ouyang,W.,
            Abraham,C. and Flavell,R.A.
  TITLE     IL-22BP is regulated by the inflammasome and modulates
            tumorigenesis in the intestine
  JOURNAL   Nature 491 (7423), 259-263 (2012)
   PUBMED   23075849
  REMARK    GeneRIF: the IL-22-IL-22BP axis critically regulates intestinal
            tissue repair and tumorigenesis in the colon
REFERENCE   7  (bases 1 to 2468)
  AUTHORS   Tang,T., Li,L., Tang,J., Li,Y., Lin,W.Y., Martin,F., Grant,D.,
            Solloway,M., Parker,L., Ye,W., Forrest,W., Ghilardi,N., Oravecz,T.,
            Platt,K.A., Rice,D.S., Hansen,G.M., Abuin,A., Eberhart,D.E.,
            Godowski,P., Holt,K.H., Peterson,A., Zambrowicz,B.P. and de
            Sauvage,F.J.
  TITLE     A mouse knockout library for secreted and transmembrane proteins
  JOURNAL   Nat Biotechnol 28 (7), 749-755 (2010)
   PUBMED   20562862
REFERENCE   8  (bases 1 to 2468)
  AUTHORS   Wolk,K., Witte,E., Hoffmann,U., Doecke,W.D., Endesfelder,S.,
            Asadullah,K., Sterry,W., Volk,H.D., Wittig,B.M. and Sabat,R.
  TITLE     IL-22 induces lipopolysaccharide-binding protein in hepatocytes: a
            potential systemic role of IL-22 in Crohn's disease
  JOURNAL   J Immunol 178 (9), 5973-5981 (2007)
   PUBMED   17442982
REFERENCE   9  (bases 1 to 2468)
  AUTHORS   Weiss,B., Wolk,K., Grunberg,B.H., Volk,H.D., Sterry,W.,
            Asadullah,K. and Sabat,R.
  TITLE     Cloning of murine IL-22 receptor alpha 2 and comparison with its
            human counterpart
  JOURNAL   Genes Immun 5 (5), 330-336 (2004)
   PUBMED   15201862
REFERENCE   10 (bases 1 to 2468)
  AUTHORS   Wei,C.C., Ho,T.W., Liang,W.G., Chen,G.Y. and Chang,M.S.
  TITLE     Cloning and characterization of mouse IL-22 binding protein
  JOURNAL   Genes Immun 4 (3), 204-211 (2003)
   PUBMED   12700595
  REMARK    GeneRIF: cloning and characterization; gene encodes a protein of
            230 amino acids that share 67.1% amino-acid sequence identity with
            human IL-22 binding protein; upregulated by LPS stimulation in
            monocytes
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AK138913.1.
            
            On Apr 6, 2007 this sequence version replaced NM_178258.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK138913.1, AJ555484.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2468              AK138913.1         2-2469
FEATURES             Location/Qualifiers
     source          1..2468
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 8.52 cM"
     gene            1..2468
                     /gene="Il22ra2"
                     /gene_synonym="CRF2-10; CRF2-s1; CRF2X; Il-22bp"
                     /note="interleukin 22 receptor, alpha 2"
                     /db_xref="GeneID:237310"
                     /db_xref="MGI:MGI:2665114"
     exon            1..70
                     /gene="Il22ra2"
                     /gene_synonym="CRF2-10; CRF2-s1; CRF2X; Il-22bp"
                     /inference="alignment:Splign:2.1.0"
     CDS             13..705
                     /gene="Il22ra2"
                     /gene_synonym="CRF2-10; CRF2-s1; CRF2X; Il-22bp"
                     /note="cytokine receptor family II soluble 1;
                     interleukin-22 receptor subunit alpha-2; IL22BP; IL-22RA2;
                     zcytoR16; IL-22R-alpha-2; IL-22 receptor subunit alpha-2;
                     interleukin-22-binding protein; cytokine receptor family
                     type 2, soluble 1"
                     /codon_start=1
                     /product="interleukin-22 receptor subunit alpha-2
                     precursor"
                     /protein_id="NP_839989.2"
                     /db_xref="CCDS:CCDS23717.1"
                     /db_xref="GeneID:237310"
                     /db_xref="MGI:MGI:2665114"
                     /translation="MMPKHCLLGLLIILLSSATEIQPARVSLTPQKVRFQSRNFHNIL
                     HWQAGSSLPSNNSIYFVQYKMYGQSQWEDKVDCWGTTALFCDLTNETLDPYELYYGRV
                     MTACAGRHSAWTRTPRFTPWWETKLDPPVVTITRVNASLRVLLRPPELPNRNQSGKNA
                     SMETYYGLVYRVFTINNSLEKEQKAYEGTQRAVEIEGLIPHSSYCVVAEMYQPMFDRR
                     SPRSKERCVHIP"
     exon            71..206
                     /gene="Il22ra2"
                     /gene_synonym="CRF2-10; CRF2-s1; CRF2X; Il-22bp"
                     /inference="alignment:Splign:2.1.0"
     exon            207..385
                     /gene="Il22ra2"
                     /gene_synonym="CRF2-10; CRF2-s1; CRF2X; Il-22bp"
                     /inference="alignment:Splign:2.1.0"
     exon            386..555
                     /gene="Il22ra2"
                     /gene_synonym="CRF2-10; CRF2-s1; CRF2X; Il-22bp"
                     /inference="alignment:Splign:2.1.0"
     exon            556..2468
                     /gene="Il22ra2"
                     /gene_synonym="CRF2-10; CRF2-s1; CRF2X; Il-22bp"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      2468
                     /gene="Il22ra2"
                     /gene_synonym="CRF2-10; CRF2-s1; CRF2X; Il-22bp"
                     /note="putative"
ORIGIN      
        1 acacttgcaa ccatgatgcc taagcattgc cttctaggtc tcctcatcat actcttgagc
       61 agtgcaacag aaatacaacc agctcgtgta tctctgacgc cccagaaggt ccgatttcag
      121 tccagaaatt tccacaatat tttgcactgg caagcaggga gctctctccc cagcaacaac
      181 agcatctact ttgtgcagta caagatgtat ggacagagcc aatgggaaga taaagttgac
      241 tgctggggga ccacggcgct cttctgtgac ctgaccaatg aaaccttaga cccatacgag
      301 ctgtattacg ggagggtgat gacggcctgt gctggacgcc actctgcctg gaccaggaca
      361 ccccgcttca ctccatggtg ggaaacaaaa ctagatcctc cggtcgtgac tataacccga
      421 gttaacgcat ctttgcgggt gcttctccgt cctccagagt tgccaaatag aaaccaaagt
      481 ggaaaaaatg catccatgga aacttactac ggcttagtat acagagtttt cacaatcaac
      541 aattcactag agaaggagca aaaagcctat gaaggaactc agagagctgt tgaaattgaa
      601 ggtctgatac ctcattccag ctactgcgta gtggctgaaa tgtaccagcc catgtttgac
      661 agaagaagcc caagaagcaa ggagagatgt gtgcacattc catgaactgg tctgaggcgc
      721 taaaaccgga agcatattga gaacgggatg tcttctgcct agaacagctt actaaacttc
      781 tgttttgatt ttcttagagc aatgtctacc cacacttttc aaggatttct ttgtcagtac
      841 tttcttttct gtttatttca gttataaagt aaatttgaac agattcaaaa atagaattta
      901 aagagaaggt aaagaataaa gatcttgtgg taaggcacat ctttaatccc agcattgaaa
      961 ggcagaatca gtcagatctc tgacttttgg gccaacctgg tctgcataga gagttccagg
     1021 ctagccaggg ccacacaatg agaccatgca tcaacatgat aagatgttaa gatagaaatg
     1081 ttctataaaa aatggaagct tatctgaata tatcaaccct aacaataatc ttttttctgg
     1141 tttaaccctc aaataagaat caattaatag taggcattta ataaatgttg taataagttt
     1201 taaagtatta tatatagaaa atcctgcaac aataatttta tactctatta agccttttac
     1261 tttgccagag atacactgat ttaatatttt gtgtgaatga gtatacttct gtgcatttct
     1321 attttatatt aatgtctttt ttatttctta taaggtattt ctacttagtg aactatctct
     1381 ctaaaaataa acttgtggct ctgaattgat ctctagaata agattttcaa taatagcatg
     1441 taaatatcga agaaaatctt cataatgcaa tttcccatca cttaacacat aatcttagta
     1501 agaataccct ttctggtttt gcttttaata gtgccttaga atttaaccta tgttgtctaa
     1561 atgcagcata tatttttcag cagcaaagac agaagaaaca tataagccac agtgataact
     1621 cagccattca ggcaaagtgg cctctctgtc cacagaatga gagttgggct ggagacactg
     1681 gagtccatac aggaaccttg acttgaagcc aaaggcacac agtggatgct taaattattt
     1741 ctgagattat aaggaaactc acagccctgt ggactacact gcatctcctg agcaatgatc
     1801 aggtggccta aggctcaaaa agtgaccagc ttttctaagc ctttctctag ctcttgagct
     1861 tagactatca gctactgaaa atacatgtag gagagaacat ttgtgatctt catgaaagat
     1921 gctccaaaat ataactctga aaagtatagt cggtacgtct gtcttcttac gttttttaat
     1981 ggtaaatggt cacagaccat taagaacata agagacatgt gaaaagcaag agcattgtcc
     2041 tggctgtcct gtgtgttcag aaaacactgg ccttcattct tatttttgaa ttattcaatt
     2101 tttatttctt ttgtggctta gtacctgctt gggaattctt tgggtttttt gttcgttgtt
     2161 tgtttatttt ctattttgta ctttgggaag ggtgagactt gagaaggata actcctcttt
     2221 gggaatcagg accatgtgtg gtcccagcat ttaggttgta agactcagta gtctaattcc
     2281 tcataataca aaaggcaatt gttggtttat gagtgttgtc agcaatcaga gttttgcttt
     2341 gactttgttt gcttgggttt tccctcacac aagtataaga tgctttgaaa tatattatga
     2401 ttttcacatt ctggatcatg ttaagaatat attgtctaag tacttcaata aatcttactt
     2461 tgtacttt
//
