LOCUS       NM_178257               5825 bp    mRNA    linear   ROD 18-MAR-2025
DEFINITION  Mus musculus interleukin 22 receptor, alpha 1 (Il22ra1), mRNA.
ACCESSION   NM_178257 XM_003086396
VERSION     NM_178257.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5825)
  AUTHORS   Xia,M., Lu,J., Lan,J., Teng,T., Shiao,R., Sun,H., Jin,Z., Liu,X.,
            Wang,J., Wu,H., Wang,C., Yi,H., Qi,Q., Li,J., Schneeberger,M.,
            Shen,W., Lu,B., Chen,L., Ilanges,A., Zhou,X. and Yu,X.
  TITLE     Elevated IL-22 as a result of stress-induced gut leakage suppresses
            septal neuron activation to ameliorate anxiety-like behavior
  JOURNAL   Immunity 58 (1), 218-231 (2025)
   PUBMED   39644894
REFERENCE   2  (bases 1 to 5825)
  AUTHORS   Cai,H., Chen,S., Sun,Y., Zheng,T., Liu,Y., Tao,J. and Zhang,Y.
  TITLE     Interleukin-22 receptor 1-mediated stimulation of T-type Ca2+
            channels enhances sensory neuronal excitability through the
            tyrosine-protein kinase Lyn-dependent PKA pathway
  JOURNAL   Cell Commun Signal 22 (1), 307 (2024)
   PUBMED   38831315
  REMARK    GeneRIF: Interleukin-22 receptor 1-mediated stimulation of T-type
            Ca[2+] channels enhances sensory neuronal excitability through the
            tyrosine-protein kinase Lyn-dependent PKA pathway.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5825)
  AUTHORS   Sajiir,H., Wong,K.Y., Muller,A., Keshvari,S., Burr,L., Aiello,E.,
            Mezza,T., Giaccari,A., Sebastiani,G., Dotta,F., Ramm,G.A.,
            Macdonald,G.A., McGuckin,M.A., Prins,J.B. and Hasnain,S.Z.
  TITLE     Pancreatic beta-cell IL-22 receptor deficiency induces
            age-dependent dysregulation of insulin biosynthesis and systemic
            glucose homeostasis
  JOURNAL   Nat Commun 15 (1), 4527 (2024)
   PUBMED   38811550
  REMARK    GeneRIF: Pancreatic beta-cell IL-22 receptor deficiency induces
            age-dependent dysregulation of insulin biosynthesis and systemic
            glucose homeostasis.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5825)
  AUTHORS   Sajiir,H., Keshvari,S., Wong,K.Y., Borg,D.J., Steyn,F.J.,
            Fercher,C., Taylor,K., Taylor,B., Barnard,R.T., Muller,A.,
            Moniruzzaman,M., Miller,G., Wang,R., Fotheringham,A., Schreiber,V.,
            Sheng,Y.H., Hancock,J.L., Loo,D., Burr,L., Huynh,T., Lockett,J.,
            Ramm,G.A., Macdonald,G.A., Prins,J.B., McGuckin,M.A. and
            Hasnain,S.Z.
  TITLE     Liver and pancreatic-targeted interleukin-22 as a therapeutic for
            metabolic dysfunction-associated steatohepatitis
  JOURNAL   Nat Commun 15 (1), 4528 (2024)
   PUBMED   38811532
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5825)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   6  (bases 1 to 5825)
  AUTHORS   Kirchhof,P., Kahr,P.C., Kaese,S., Piccini,I., Vokshi,I.,
            Scheld,H.H., Rotering,H., Fortmueller,L., Laakmann,S., Verheule,S.,
            Schotten,U., Fabritz,L. and Brown,N.A.
  TITLE     PITX2c is expressed in the adult left atrium, and reducing Pitx2c
            expression promotes atrial fibrillation inducibility and complex
            changes in gene expression
  JOURNAL   Circ Cardiovasc Genet 4 (2), 123-133 (2011)
   PUBMED   21282332
REFERENCE   7  (bases 1 to 5825)
  AUTHORS   Savan,R., McFarland,A.P., Reynolds,D.A., Feigenbaum,L.,
            Ramakrishnan,K., Karwan,M., Shirota,H., Klinman,D.M., Dunleavy,K.,
            Pittaluga,S., Anderson,S.K., Donnelly,R.P., Wilson,W.H. and
            Young,H.A.
  TITLE     A novel role for IL-22R1 as a driver of inflammation
  JOURNAL   Blood 117 (2), 575-584 (2011)
   PUBMED   20971950
  REMARK    GeneRIF: This study documents a previously unknown role of IL-22R1
            in inflammation and identifies the involvement of IL-22R1/IL-22 in
            anaplastic lymphoma kinase-positive anaplastic large cell lymphoma
REFERENCE   8  (bases 1 to 5825)
  AUTHORS   Tang,T., Li,L., Tang,J., Li,Y., Lin,W.Y., Martin,F., Grant,D.,
            Solloway,M., Parker,L., Ye,W., Forrest,W., Ghilardi,N., Oravecz,T.,
            Platt,K.A., Rice,D.S., Hansen,G.M., Abuin,A., Eberhart,D.E.,
            Godowski,P., Holt,K.H., Peterson,A., Zambrowicz,B.P. and de
            Sauvage,F.J.
  TITLE     A mouse knockout library for secreted and transmembrane proteins
  JOURNAL   Nat Biotechnol 28 (7), 749-755 (2010)
   PUBMED   20562862
REFERENCE   9  (bases 1 to 5825)
  AUTHORS   Tachiiri,A., Imamura,R., Wang,Y., Fukui,M., Umemura,M. and Suda,T.
  TITLE     Genomic structure and inducible expression of the IL-22 receptor
            alpha chain in mice
  JOURNAL   Genes Immun 4 (2), 153-159 (2003)
   PUBMED   12618864
  REMARK    GeneRIF: Genomic structure and inducible expression of the IL-22
            receptor alpha chain.
REFERENCE   10 (bases 1 to 5825)
  AUTHORS   Parrish-Novak,J., Xu,W., Brender,T., Yao,L., Jones,C., West,J.,
            Brandt,C., Jelinek,L., Madden,K., McKernan,P.A., Foster,D.C.,
            Jaspers,S. and Chandrasekher,Y.A.
  TITLE     Interleukins 19, 20, and 24 signal through two distinct receptor
            complexes. Differences in receptor-ligand interactions mediate
            unique biological functions
  JOURNAL   J Biol Chem 277 (49), 47517-47523 (2002)
   PUBMED   12351624
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK141289.1, AL662911.21 and AK162333.1.
            
            On or before Sep 25, 2011 this sequence version replaced
            XM_003086396.1, NM_178257.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK141289.1, BC140973.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849377
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1063              AK141289.1         2-1064
            1064-1064           AL662911.21        95242-95242
            1065-1664           AK141289.1         1066-1665
            1665-1665           AL662911.21        95843-95843
            1666-2619           AK141289.1         1667-2620
            2620-3492           AK162333.1         13-885
            3493-5229           AK162333.1         887-2623
            5230-5230           AL662911.21        99408-99408
            5231-5825           AK162333.1         2625-3219
FEATURES             Location/Qualifiers
     source          1..5825
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 67.99 cM"
     gene            1..5825
                     /gene="Il22ra1"
                     /gene_synonym="9130219A07Rik; IL-22R; Il22r"
                     /note="interleukin 22 receptor, alpha 1"
                     /db_xref="GeneID:230828"
                     /db_xref="MGI:MGI:2663588"
     exon            1..104
                     /gene="Il22ra1"
                     /gene_synonym="9130219A07Rik; IL-22R; Il22r"
                     /inference="alignment:Splign:2.1.0"
     CDS             62..1807
                     /gene="Il22ra1"
                     /gene_synonym="9130219A07Rik; IL-22R; Il22r"
                     /note="interleukin-22 receptor alpha chain; interleukin-22
                     receptor subunit alpha-1; IL-22RA1; IL-22R-alpha-1; IL-22
                     receptor subunit alpha-1"
                     /codon_start=1
                     /product="interleukin-22 receptor subunit alpha-1
                     precursor"
                     /protein_id="NP_839988.1"
                     /db_xref="CCDS:CCDS18789.1"
                     /db_xref="GeneID:230828"
                     /db_xref="MGI:MGI:2663588"
                     /translation="MKTLLTILTVGSLAAHTTVDTSGLLQHVKFQSSNFENILTWDGG
                     PASTSDTVYSVEYKKYGERKWLAKAGCQRITQKFCNLTMETRNHTEFYYAKVTAVSAG
                     GPPVTKMTDRFSSLQHTTIKPPDVTCIPKVRSIQMLVHPTLTPVLSEDGHQLTLEEIF
                     HDLFYRLELHVNHTYQMHLEGKQREYEFLGLTPDTEFLGSITILTPILSKESAPYVCR
                     VKTLPDRTWAYSFSGAVLFSMGFLVGLLCYLGYKYITKPPVPPNSLNVQRVLTFQPLR
                     FIQEHVLIPVLDLSGPSSLPQPIQYSQVVVSGPREPPGAVWRQSLSDLTYVGQSDVSI
                     LQPTNVPAQQTLSPPSYAPKAVPEVQPPSYAPQVASDAKALFYSPQQGMKTRPATYDP
                     QDILDSCPASYAVCVEDSGKDSTPGILSTPKYLKTKGQLQEDTLVRSCLPGDLSLQKV
                     TSLGEGETQRPKSLPSPLGFCTDRGPDLHTLRSEEPETPRYLKGALSLLSSVQIEGHP
                     VSLPLHVHSVSCSPSDEGPSPWGLLDSLVCPKDEGPAVETEAMCPSAAASELEQSTEL
                     DSLFKGLALTVQWES"
     exon            105..237
                     /gene="Il22ra1"
                     /gene_synonym="9130219A07Rik; IL-22R; Il22r"
                     /inference="alignment:Splign:2.1.0"
     exon            238..416
                     /gene="Il22ra1"
                     /gene_synonym="9130219A07Rik; IL-22R; Il22r"
                     /inference="alignment:Splign:2.1.0"
     exon            417..592
                     /gene="Il22ra1"
                     /gene_synonym="9130219A07Rik; IL-22R; Il22r"
                     /inference="alignment:Splign:2.1.0"
     exon            593..731
                     /gene="Il22ra1"
                     /gene_synonym="9130219A07Rik; IL-22R; Il22r"
                     /inference="alignment:Splign:2.1.0"
     exon            732..853
                     /gene="Il22ra1"
                     /gene_synonym="9130219A07Rik; IL-22R; Il22r"
                     /inference="alignment:Splign:2.1.0"
     exon            854..5825
                     /gene="Il22ra1"
                     /gene_synonym="9130219A07Rik; IL-22R; Il22r"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acaccccagc ctctgtgcag gggtccagag ccgaggcccg aaggggccct ggagggaccc
       61 aatgaagaca ctactgacca tcctgacggt gggatccctg gccgctcaca ccactgtgga
      121 cacatccggt ctccttcaac acgtgaaatt ccagtccagc aactttgaga acatcttgac
      181 gtgggatggt gggcccgcta gcacctctga caccgtctac agtgtggaat ataagaaata
      241 cggagagaga aagtggctgg ccaaggcggg ctgccagcgg atcacccaga agttctgcaa
      301 cctgactatg gagacccgca accacactga gttttactac gccaaggtca cggcggtcag
      361 cgcgggaggc ccaccagtca caaagatgac tgatcgtttc agctcgctgc agcacactac
      421 catcaaaccg cctgatgtga cctgtatccc caaagtgagg tccattcaga tgctggtcca
      481 ccccacactc acaccggtcc tctcggaaga tggccaccag ctaaccctgg aggagatttt
      541 ccatgacctg ttctaccgct tagagctcca cgtcaaccac acctaccaga tgcaccttga
      601 aggcaaacag agagaatacg agttccttgg cctgactccc gacacagagt tcctcggctc
      661 catcacaatt ttgactccga tattgtccaa ggaaagtgcc ccctacgtgt gccgagtgaa
      721 gacgctgccc gatcggacgt gggcctactc cttctcgggc gccgtgctct tttccatggg
      781 tttcctcgtc ggcttgctct gttatctggg ctacaaatac atcaccaagc cacctgtacc
      841 tcctaactcc ctgaacgtcc aacgtgtcct gacctttcaa cccctacgct tcatccaaga
      901 acacgtactg atccctgtct tggacctcag tggccccagc agtctgcctc agcccatcca
      961 gtactcccaa gtggtggtgt ctgggcccag ggagcctcct ggagctgtgt ggcggcagag
     1021 cctgtctgac ctcacctacg tagggcagtc agatgtctcc atcctgcaac ctaccaacgt
     1081 gccagctcag cagacactgt ccccaccatc ctacgctccg aaggctgtcc ctgaggtcca
     1141 gcccccttcc tatgcgcctc aggtagcctc ggatgccaaa gctctgttct actcaccaca
     1201 acaggggatg aagaccaggc ctgccaccta tgacccgcag gacattctgg acagctgccc
     1261 tgcttcttat gctgtgtgtg tggaagactc tggcaaagac tctaccccag gcatcctctc
     1321 cactcccaaa tacctcaaga caaaaggtca gctccaggaa gacacacttg ttagaagctg
     1381 tctcccaggg gacctttctc tacagaaagt cacctcctta ggtgaagggg agacacagag
     1441 accaaaatca ctcccctcac ctctgggatt ttgcacagac agaggacctg accttcacac
     1501 actgcgcagt gaggaaccag agacaccacg gtacctgaag ggggcgctgt ctctcctgtc
     1561 ctctgtgcag atcgagggcc accctgtctc cctccctttg cacgtccatt ctgtctcatg
     1621 ttccccctca gacgagggac caagtccctg gggcctgctg gactcccttg tgtgtccaaa
     1681 ggatgagggt cccgcggttg agactgaggc catgtgcccc agtgctgcag cctctgagct
     1741 ggagcagtcc acagaactgg actctctttt caaaggcttg gccctgactg tgcagtggga
     1801 atcctgaagg gagatcggag caagcaggcc taagtttcct tctgccccac ccagctaaca
     1861 cacccacacc cactaagtca caggttctag ggcccagccc cgggtgggtg ccctcgagag
     1921 aatgagagga agatttgggc cccatgtggg aacacaaatg tacggtgaag actctagtgg
     1981 agaagctaca ggcaggcggc gtgtgcgaat agcctgtggc acagggccca gcaggcaggt
     2041 cacacagagt ggggtaatgc agggaaatct ggagagccac ccagctccct caaccaagag
     2101 tgaggcattc accatctctg aaggttcttg gactggaagc tggggaccaa gtgtaacagg
     2161 cacttcagcc aaggccagag gccacacagc agcaagactt gagagcagag tgcagtggag
     2221 gctcactccc agtcagggaa cctttctttg ctctactgtg agaggcttca cccaggagtg
     2281 actccttaat ccatcaggag gtgaggggtg ttgcataaag gttttctgca gtcaggcgtc
     2341 cagagaaaag catttgaaag gagcatggcg ccttggaagc caaaggcttt tgaatctcgg
     2401 cttgtctggg gtcacattcc agcctctcta ccatctacag gacttcaagc aagtgaagtg
     2461 agtgagctca gacctcagct tctccatcaa tgaaatgggc gtcatcacac ttaccttctg
     2521 gggtggtgcc aaggatggca ttaatgtctg ggaattgctt tgtagcaccc agcacagggc
     2581 aggctcttgg ctgctgtctc ctgctgggat tttttttttt aatctggaaa cacgaggaat
     2641 gcctccttct gttctcaaat ggctcatggg tgttttctca tggattagag actgttgcag
     2701 gcaagaactg gaatatctag ggcagacatg aacagtctct acagagcctt ctggaaacag
     2761 gcccagagaa acaacgaatg gcacagagcc ttctctttga ggttgcaggt agaagctgtt
     2821 tgggcagagg ccatctcacc gggctttctc tgcatggagg gagccccagg cctctgctgt
     2881 ctgccccacc tggagataca tcatcagcat tccaccaccc tggccctctg gcccctgcct
     2941 gcacacagca agaagaagcc tttactctct gctgtcagga agctgtgtct gtcatatcac
     3001 tctcagatgg gcctcaccag gaggaagcca aggcccgggc caatgcaggg ctctgctgtg
     3061 gagtctacaa ctcaaacaca gggcccttgt gccaagggcg gatgctctcc gccctgtttg
     3121 aattcttggg ggctgagttt ggcaggacac aaagtaaggg ggccccagtg gagttcctga
     3181 gagataggtg ccctccgtaa caccttcttg ccccagattt ctgagacaca acaccagact
     3241 ccatttgcgt catcgcggcc ctccagaggt acactgtgtc cttctgccgt gctcacctgt
     3301 gtttcccctt cttttcccca ccggatcccc ttgatgacac acggtgacag gtgggtctct
     3361 tatctacatg tcattaatat ttaacctccc tctaaggtca ttgactccat atctcaggcc
     3421 aaaggttaac tgtctttact tcctttacaa tcgaatggct ggtcttttct tgcctggtca
     3481 gtacaaccag ggttacagag cgcttttata gaaggccata aactggctgt cagctcccag
     3541 ggctataagt gtggcaacca tggtaacaat gagggagaag ctggagtgtc tgaggaggag
     3601 ccctgcagcc tccttctgag agcctctctc agagagatca ccacacacct ccctggcatc
     3661 ccaggcccat agctgggctg gatcctccct gctacaagac aatctgtcaa agtcccacca
     3721 gggatggatg gtaagcttgg cttttctgag agcctgacac tctgacccag tagcctgaaa
     3781 agtctccagc cctgcctgct gtgctctgtc ccacccagga gtctccaagt ctcctgtcta
     3841 acaaggaagg ccagagccag gggtaaaaga atagtgacct tagcatcccc ccaactttat
     3901 cctccaggga acgttccaag tccctggacc cctgtccagc cagaactcac aagccctgca
     3961 cagacaagga gagctgtgac tgcagcccaa caaatagtag actcacctaa aacggcagag
     4021 tttggggttt gggtttgttt tgttttggtg atgcagttgt ctggttttcc aagtgtgaag
     4081 atgacagttt tgcatccaga tgatgcttca agccacagat gccactgagc ctgcagatgc
     4141 tctgctctgt gataaagctt aatctataaa ccaggcagga agggacaaac agacgcataa
     4201 cggaacggca actgtagcaa gtgcagtaaa ggttacttga acacaaatac ttaggtacca
     4261 aaaaccagtc tgactgaatg atgtggtgtg tagcatatag agtggaccac aggacgaggc
     4321 ttgtggctgg ataaaacagg atagcagctg ggatggtcat ggggagaggt ggccatggta
     4381 tgcgcgcaca cacacacaca cacacacaca cacacacaca cgcacgtgtg tgtgtgtgtg
     4441 tgtgtgtgtg tgtgcgcgcg cgagcgctca cgtctgtatg tgatgagaat ctggtttttt
     4501 ttagaaaccc agttatgtta tgtgaatgcg gttttgcttt aatcctaggc gtgggataag
     4561 agactgcttc gcagcaggtg actatgattt gcctcatgct ctagcaaggg tgtgcttttg
     4621 ccagcagcag ctagttacta taagtgtgta atgtttggaa ttctggaaac ttttcaaggg
     4681 ggtataaatg gcagagccct gagcggggct gagctcactc tgaggaggct gttgctcccc
     4741 actgctgctg gctcctgttg tggtggtttg tcaagtggtt gggagcaaag tgaaaagaag
     4801 aaattgtaga tatccttaca atgacaaaga ctgaacttac cccaaggaac tcgacacctt
     4861 aaatcagcag gaagtagtcg aaaaaggtca aggtcccctt tcaccttctt tctcttctac
     4921 ctactggggg gttggaaggg agtaaggagg aataagggtg gtagatataa ggactcaata
     4981 aagtagcaca aaaagtacac caatgtgtgc tcacattcgt gtgtgtgtgt gtgtgtgtgt
     5041 gtgtgtgtgt atttgtgtgt gtatatgcac atgcaactgt gagaacgcca gaagtcaaca
     5101 tcagtgttct tcaatcacac cctaccttac tttctgagag tctctcattg aatgtggagc
     5161 tctctgattg gctaaactgg ctgaccatca agatcccaga atcatcctgt gtctgcctcc
     5221 cagtgctgga atcacagcca catgcccggc tcaggtcctc aagattgctc tacaagcagt
     5281 ttacccactg gaccgtctct ggagccctca gatgctgaaa cttaaccgct aacatgcctg
     5341 ggtcaagggc tggggtcttt actgcctaat tagatcatga tgaggggttg gtgggtgtgt
     5401 cctaacctct ttggctcttc tgtcacacaa aaacacaacc agaactatct gagatatggt
     5461 gtgctggtta gttgtatgtc aacttgacac aaactaaagt catctgagag gagggagcct
     5521 caactgagga gatgcctctg taaaatcaga ctgtaggcaa agctataggg cattttctta
     5581 attagtggtt gataggggag gacccagccc actgtgggtg gggccatcct aagctagtgg
     5641 tcttgggtta tataaaaaag caggctgggc aaaccatgag aagcaagcca gtaagcagca
     5701 ctcctccatg gcctctgcat cagctcgtgc ctcctgattc atgccctgtt tgagttcctg
     5761 tcctggtttc tttccatgat ggaccatgat gtggaagtgt aaactgaata aaccctttcc
     5821 tctcc
//
