LOCUS       NM_054079               1111 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus interleukin 22B (Il22b), mRNA.
ACCESSION   NM_054079 XM_001000613
VERSION     NM_054079.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1111)
  AUTHORS   Lumayag,S., Haldin,C.E., Corbett,N.J., Wahlin,K.J., Cowan,C.,
            Turturro,S., Larsen,P.E., Kovacs,B., Witmer,P.D., Valle,D.,
            Zack,D.J., Nicholson,D.A. and Xu,S.
  TITLE     Inactivation of the microRNA-183/96/182 cluster results in
            syndromic retinal degeneration
  JOURNAL   Proc Natl Acad Sci U S A 110 (6), E507-E516 (2013)
   PUBMED   23341629
REFERENCE   2  (bases 1 to 1111)
  AUTHORS   Dumoutier,L., Van Roost,E., Ameye,G., Michaux,L. and Renauld,J.C.
  TITLE     IL-TIF/IL-22: genomic organization and mapping of the human and
            mouse genes
  JOURNAL   Genes Immun 1 (8), 488-494 (2000)
   PUBMED   11197690
REFERENCE   3  (bases 1 to 1111)
  AUTHORS   Dumoutier,L., Louahed,J. and Renauld,J.C.
  TITLE     Cloning and characterization of IL-10-related T cell-derived
            inducible factor (IL-TIF), a novel cytokine structurally related to
            IL-10 and inducible by IL-9
  JOURNAL   J Immunol 164 (4), 1814-1819 (2000)
   PUBMED   10657629
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC158600.17.
            
            On Oct 31, 2009 this sequence version replaced NM_054079.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ249492.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849380 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-235               AC158600.17        91041-91275         c
            236-301             AC158600.17        90582-90647         c
            302-445             AC158600.17        90339-90482         c
            446-511             AC158600.17        89358-89423         c
            512-1111            AC158600.17        85866-86465         c
FEATURES             Location/Qualifiers
     source          1..1111
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 66.7 cM"
     gene            1..1111
                     /gene="Il22b"
                     /gene_synonym="If2b2; IL-22b; IL-TIFb; Iltifb"
                     /note="interleukin 22B"
                     /db_xref="GeneID:116849"
                     /db_xref="MGI:MGI:2151139"
     exon            1..235
                     /gene="Il22b"
                     /gene_synonym="If2b2; IL-22b; IL-TIFb; Iltifb"
                     /inference="alignment:Splign:2.1.0"
     CDS             50..589
                     /gene="Il22b"
                     /gene_synonym="If2b2; IL-22b; IL-TIFb; Iltifb"
                     /note="IL-TIF beta; IL-10-related T-cell-derived-inducible
                     factor beta; interleukin 10-related T cell-derived
                     inducible factor beta; interferon 2b2"
                     /codon_start=1
                     /product="interleukin-22b precursor"
                     /protein_id="NP_473420.2"
                     /db_xref="CCDS:CCDS48700.1"
                     /db_xref="GeneID:116849"
                     /db_xref="MGI:MGI:2151139"
                     /translation="MAVLQKSMSFSLMGTLAASCLLLIALWAQEANALPINTRCKLEV
                     SNFQQPYIVNRTFMLAKEVSLADNNTDVWLIGEKLFRGVSAKDQCYLMKQVLNFTLED
                     VLLPQSDRFQPYMQEVVPFLTKLSNQLSSCHISGDDQNIQKNVRRLKETVKKLGESGE
                     IKAIGELDLLFMSLRNACV"
     exon            236..301
                     /gene="Il22b"
                     /gene_synonym="If2b2; IL-22b; IL-TIFb; Iltifb"
                     /inference="alignment:Splign:2.1.0"
     exon            302..445
                     /gene="Il22b"
                     /gene_synonym="If2b2; IL-22b; IL-TIFb; Iltifb"
                     /inference="alignment:Splign:2.1.0"
     exon            446..511
                     /gene="Il22b"
                     /gene_synonym="If2b2; IL-22b; IL-TIFb; Iltifb"
                     /inference="alignment:Splign:2.1.0"
     exon            512..1111
                     /gene="Il22b"
                     /gene_synonym="If2b2; IL-22b; IL-TIFb; Iltifb"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1089..1094
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Il22b"
                     /gene_synonym="If2b2; IL-22b; IL-TIFb; Iltifb"
                     /note="hexamer: AATAAA"
     polyA_site      1111
                     /gene="Il22b"
                     /gene_synonym="If2b2; IL-22b; IL-TIFb; Iltifb"
                     /note="major polyA site"
ORIGIN      
        1 aacaggctct cctctcagtt atcaactttt gacacttgtg cgatcggtga tggctgtcct
       61 gcagaaatct atgagttttt cccttatggg gactttggcc gccagctgcc tgcttctcat
      121 tgccctgtgg gcccaggagg caaatgcgct gcccatcaac acccggtgca agcttgaggt
      181 gtccaacttc cagcagccgt acatcgtcaa ccgcaccttt atgctggcca aggaggtcag
      241 ccttgcagat aacaacacag acgtctggct catcggggag aaactgttcc gaggagtcag
      301 tgctaaagat cagtgctacc tgatgaagca ggtgctcaac ttcaccctgg aagacgttct
      361 gctcccccag tcagacaggt tccagcccta catgcaggag gtggtgcctt tcctgaccaa
      421 actcagcaat cagctcagct cctgtcacat cagcggtgac gaccagaaca tccagaagaa
      481 tgtcagaagg ctgaaggaga cagtgaaaaa gcttggagag agcggagaga tcaaagcgat
      541 cggggaactg gacctgctgt ttatgtctct gagaaatgct tgcgtctgag cgagaagaag
      601 ctagaaaacg aagaactgct ccttcctgcc ttctaaaaag aacaataaga tccctgaatg
      661 gactttttta ctaaaggaaa gtgagaagct aacgtccacc atcattagaa gatttcacat
      721 gaaacctggc tcagttgaaa aagaaaatag tgtcaagttg tccatgagac cagaggtaga
      781 cttgataacc acaaagattc attgacaata ttttattgtc actgataatg caacagaaaa
      841 agtatgtact ttaaaaaatt gtttgaaagg aggttacctc tcattcctct agaagaaaag
      901 cctatgtaac ttcatttcca taaccaatac tttatatatg taagtttatt tattataagt
      961 atacatttta tttatgtcag tttattaata tggatttatt tatagaaaaa ttatctgatg
     1021 ttgatatttg agtataaagc aaataatatt tatgataata actatagaaa caagatatct
     1081 taggctttaa taaacacatg aatatcataa a
//
