LOCUS       NM_016971               1088 bp    mRNA    linear   ROD 28-JAN-2025
DEFINITION  Mus musculus interleukin 22 (Il22), mRNA.
ACCESSION   NM_016971
VERSION     NM_016971.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1088)
  AUTHORS   Xia,M., Lu,J., Lan,J., Teng,T., Shiao,R., Sun,H., Jin,Z., Liu,X.,
            Wang,J., Wu,H., Wang,C., Yi,H., Qi,Q., Li,J., Schneeberger,M.,
            Shen,W., Lu,B., Chen,L., Ilanges,A., Zhou,X. and Yu,X.
  TITLE     Elevated IL-22 as a result of stress-induced gut leakage suppresses
            septal neuron activation to ameliorate anxiety-like behavior
  JOURNAL   Immunity 58 (1), 218-231 (2025)
   PUBMED   39644894
REFERENCE   2  (bases 1 to 1088)
  AUTHORS   Zhang,P., Liu,J., Lee,A., Tsaur,I., Ohira,M., Duong,V., Vo,N.,
            Watari,K., Su,H., Kim,J.Y., Gu,L., Zhu,M., Shalapour,S.,
            Hosseini,M., Bandyopadhyay,G., Zeng,S., Llorente,C., Zhao,H.N.,
            Lamichhane,S., Mohan,S., Dorrestein,P.C., Olefsky,J.M., Schnabl,B.,
            Soroosh,P. and Karin,M.
  TITLE     IL-22 resolves MASLD via enterocyte STAT3 restoration of
            diet-perturbed intestinal homeostasis
  JOURNAL   Cell Metab 36 (10), 2341-2354 (2024)
   PUBMED   39317186
  REMARK    GeneRIF: IL-22 resolves MASLD via enterocyte STAT3 restoration of
            diet-perturbed intestinal homeostasis.
REFERENCE   3  (bases 1 to 1088)
  AUTHORS   Felix,F.A., Zhou,J., Li,D., Onodera,S. and Yu,Q.
  TITLE     Endogenous IL-22 contributes to the pathogenesis of salivary gland
            dysfunction in the non-obese diabetic model of Sjogren's syndrome
  JOURNAL   Mol Immunol 173, 20-29 (2024)
   PUBMED   39018744
  REMARK    GeneRIF: Endogenous IL-22 contributes to the pathogenesis of
            salivary gland dysfunction in the non-obese diabetic model of
            Sjogren's syndrome.
REFERENCE   4  (bases 1 to 1088)
  AUTHORS   Su,X., Zhao,L., Zhang,H., Wang,D., Sun,J. and Shen,L.
  TITLE     Sirtuin 6 inhibits group 3 innate lymphoid cell function and gut
            immunity by suppressing IL-22 production
  JOURNAL   Front Immunol 15, 1402834 (2024)
   PUBMED   39253083
  REMARK    GeneRIF: Sirtuin 6 inhibits group 3 innate lymphoid cell function
            and gut immunity by suppressing IL-22 production.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1088)
  AUTHORS   Le Menn,G., Pikkarainen,K., Mennerich,D., Miroszewska,D.,
            Kietzmann,T. and Chen,Z.
  TITLE     USP28 protects development of inflammation in mouse intestine by
            regulating STAT5 phosphorylation and IL22 production in T
            lymphocytes
  JOURNAL   Front Immunol 15, 1401949 (2024)
   PUBMED   39076972
  REMARK    GeneRIF: USP28 protects development of inflammation in mouse
            intestine by regulating STAT5 phosphorylation and IL22 production
            in T lymphocytes.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1088)
  AUTHORS   Norkina,O. and De Lisle,R.C.
  TITLE     Potential genetic modifiers of the cystic fibrosis intestinal
            inflammatory phenotype on mouse chromosomes 1, 9, and 10
  JOURNAL   BMC Genet 6, 29 (2005)
   PUBMED   15921521
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 1088)
  AUTHORS   Lozier,J.N., Tayebi,N. and Zhang,P.
  TITLE     Mapping of genes that control the antibody response to human factor
            IX in mice
  JOURNAL   Blood 105 (3), 1029-1035 (2005)
   PUBMED   15383460
REFERENCE   8  (bases 1 to 1088)
  AUTHORS   Wei,C.C., Ho,T.W., Liang,W.G., Chen,G.Y. and Chang,M.S.
  TITLE     Cloning and characterization of mouse IL-22 binding protein
  JOURNAL   Genes Immun 4 (3), 204-211 (2003)
   PUBMED   12700595
REFERENCE   9  (bases 1 to 1088)
  AUTHORS   Dumoutier,L., Van Roost,E., Ameye,G., Michaux,L. and Renauld,J.C.
  TITLE     IL-TIF/IL-22: genomic organization and mapping of the human and
            mouse genes
  JOURNAL   Genes Immun 1 (8), 488-494 (2000)
   PUBMED   11197690
REFERENCE   10 (bases 1 to 1088)
  AUTHORS   Dumoutier,L., Louahed,J. and Renauld,J.C.
  TITLE     Cloning and characterization of IL-10-related T cell-derived
            inducible factor (IL-TIF), a novel cytokine structurally related to
            IL-10 and inducible by IL-9
  JOURNAL   J Immunol 164 (4), 1814-1819 (2000)
   PUBMED   10657629
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC153856.23.
            
            On Aug 14, 2009 this sequence version replaced NM_016971.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ249491.1, BC104349.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849383
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-213               AC153856.23        121621-121833
            214-279             AC153856.23        122227-122292
            280-423             AC153856.23        122392-122535
            424-489             AC153856.23        123503-123568
            490-1088            AC153856.23        126106-126704
FEATURES             Location/Qualifiers
     source          1..1088
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 66.67 cM"
     gene            1..1088
                     /gene="Il22"
                     /gene_synonym="If2b1; IL-22; IL-22a; Iltif; ILTIFa"
                     /note="interleukin 22"
                     /db_xref="GeneID:50929"
                     /db_xref="MGI:MGI:1355307"
     exon            1..213
                     /gene="Il22"
                     /gene_synonym="If2b1; IL-22; IL-22a; Iltif; ILTIFa"
                     /inference="alignment:Splign:2.1.0"
     CDS             28..567
                     /gene="Il22"
                     /gene_synonym="If2b1; IL-22; IL-22a; Iltif; ILTIFa"
                     /note="ILTIF alpha; IL-TIF alpha; interleukin-22a;
                     IL-10-related T-cell-derived-inducible factor; interleukin
                     10-related T cell-derived inducible factor; interferon
                     2b1"
                     /codon_start=1
                     /product="interleukin-22 precursor"
                     /protein_id="NP_058667.1"
                     /db_xref="CCDS:CCDS36070.1"
                     /db_xref="GeneID:50929"
                     /db_xref="MGI:MGI:1355307"
                     /translation="MAVLQKSMSFSLMGTLAASCLLLIALWAQEANALPVNTRCKLEV
                     SNFQQPYIVNRTFMLAKEASLADNNTDVRLIGEKLFRGVSAKDQCYLMKQVLNFTLED
                     VLLPQSDRFQPYMQEVVPFLTKLSNQLSSCHISGDDQNIQKNVRRLKETVKKLGESGE
                     IKAIGELDLLFMSLRNACV"
     exon            214..279
                     /gene="Il22"
                     /gene_synonym="If2b1; IL-22; IL-22a; Iltif; ILTIFa"
                     /inference="alignment:Splign:2.1.0"
     exon            280..423
                     /gene="Il22"
                     /gene_synonym="If2b1; IL-22; IL-22a; Iltif; ILTIFa"
                     /inference="alignment:Splign:2.1.0"
     exon            424..489
                     /gene="Il22"
                     /gene_synonym="If2b1; IL-22; IL-22a; Iltif; ILTIFa"
                     /inference="alignment:Splign:2.1.0"
     exon            490..1088
                     /gene="Il22"
                     /gene_synonym="If2b1; IL-22; IL-22a; Iltif; ILTIFa"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1066..1071
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Il22"
                     /gene_synonym="If2b1; IL-22; IL-22a; Iltif; ILTIFa"
                     /note="hexamer: AATAAA"
     polyA_site      1088
                     /gene="Il22"
                     /gene_synonym="If2b1; IL-22; IL-22a; Iltif; ILTIFa"
                     /note="major polyA site"
ORIGIN      
        1 caactgttga cacttgtgcg atctctgatg gctgtcctgc agaaatctat gagtttttcc
       61 cttatgggga ctttggccgc cagctgcctg cttctcattg ccctgtgggc ccaggaggca
      121 aatgcgctgc ccgtcaacac ccggtgcaag cttgaggtgt ccaacttcca gcagccatac
      181 atcgtcaacc gcacctttat gctggccaag gaggccagcc ttgcagataa caacacagat
      241 gtccggctca tcggggagaa actgttccga ggagtcagtg ctaaggatca gtgctacctg
      301 atgaagcagg tgctcaactt caccctggaa gacgttctgc tcccccagtc agacaggttc
      361 cagccctaca tgcaggaggt ggtgcctttc ctgaccaaac tcagcaatca gctcagctcc
      421 tgtcacatca gcggtgacga ccagaacatc cagaagaatg tcagaaggct gaaggagaca
      481 gtgaaaaagc ttggagagag tggagagatc aaggcgattg gggaactgga cctgctgttt
      541 atgtctctga gaaatgcttg cgtctgagcg agaagaagct agaaaacgaa gaactgctcc
      601 ttcctgcctt ctaaaaagaa caataagatc cctgaatgga cttttttact aaaggaaagt
      661 gagaagctaa cgtccatcat tattagaaga tttcacatga aacctggctc agttgaaaaa
      721 gaaaatagtg tcaagttgtc catgagacca gaggtagact tgataaccac aaagattcat
      781 tgacaatatt ttattgtcac tgatgataca acagaaaaat aatgtacttt aaaaaattgt
      841 ttgaaaggag gttacctctc attcctttag aaaaaaagct tatgtaactt catttccata
      901 accaatattt tatatatgta agtttattta ttataagtat acattttatt tatgtcagtt
      961 tattaatatg gatttattta tagaaacatt atctgctatt gatatttagt ataaggcaaa
     1021 taatatttat gacaataact atggaaacaa gatatcttag gctttaataa acacatggat
     1081 atcataaa
//
