LOCUS       NM_021887               2607 bp    mRNA    linear   ROD 28-JAN-2025
DEFINITION  Mus musculus interleukin 21 receptor (Il21r), mRNA.
ACCESSION   NM_021887 XM_915689 XM_923880 XM_923883
VERSION     NM_021887.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2607)
  AUTHORS   Kogl,T., Chang,H.F., Staniek,J., Chiang,S.C.C., Thoulass,G.,
            Lao,J., Weissert,K., Dettmer-Monaco,V., Geiger,K., Manna,P.T.,
            Beziat,V., Momenilandi,M., Tu,S.M., Keppler,S.J., Pattu,V.,
            Wolf,P., Kupferschmid,L., Tholen,S., Covill,L.E., Ebert,K.,
            Straub,T., Gross,M., Gather,R., Engel,H., Salzer,U., Schell,C.,
            Maier,S., Lehmberg,K., Cornu,T.I., Pircher,H., Shahrooei,M.,
            Parvaneh,N., Elling,R., Rizzi,M., Bryceson,Y.T., Ehl,S., Aichele,P.
            and Ammann,S.
  TITLE     Patients and mice with deficiency in the SNARE protein SYNTAXIN-11
            have a secondary B cell defect
  JOURNAL   J Exp Med 221 (7) (2024)
   PUBMED   38722309
  REMARK    Erratum:[J Exp Med. 2024 Jul 1;221(7):e2022112205142024c. doi:
            10.1084/jem.2022112205142024c. PMID: 38771261]
REFERENCE   2  (bases 1 to 2607)
  AUTHORS   Seyedsadr,M., Bang,M.F., McCarthy,E.C., Zhang,S., Chen,H.C.,
            Mohebbi,M., Hugo,W., Whitmire,J.K., Lechner,M.G. and Su,M.A.
  TITLE     A pathologically expanded, clonal lineage of IL-21-producing CD4+ T
            cells drives inflammatory neuropathy
  JOURNAL   J Clin Invest 134 (15), e178602 (2024)
   PUBMED   39087473
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2607)
  AUTHORS   Xie,Y., Huang,Y., Li,Z.Y., Jiang,W., Shi,N.X., Lu,Y., Cao,G.,
            Yin,Z. and Lin,X.J.
  TITLE     Interleukin-21 receptor signaling promotes metabolic
            dysfunction-associated steatohepatitis-driven hepatocellular
            carcinoma by inducing immunosuppressive IgA+ B cells
  JOURNAL   Mol Cancer 23 (1), 95 (2024)
   PUBMED   38720319
  REMARK    GeneRIF: Interleukin-21 receptor signaling promotes metabolic
            dysfunction-associated steatohepatitis-driven hepatocellular
            carcinoma by inducing immunosuppressive IgA[+] B cells.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2607)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   5  (bases 1 to 2607)
  AUTHORS   Han,M., Hu,L., Wu,D., Zhang,Y., Li,P., Zhao,X., Zeng,Y., Ren,G.,
            Hou,Z., Pang,Y., Zhao,T. and Zhong,C.
  TITLE     IL-21R-STAT3 signalling initiates a differentiation program in
            uterine tissue-resident NK cells to support pregnancy
  JOURNAL   Nat Commun 14 (1), 7109 (2023)
   PUBMED   37925507
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2607)
  AUTHORS   Habib,T., Senadheera,S., Weinberg,K. and Kaushansky,K.
  TITLE     The common gamma chain (gamma c) is a required signaling component
            of the IL-21 receptor and supports IL-21-induced cell proliferation
            via JAK3
  JOURNAL   Biochemistry 41 (27), 8725-8731 (2002)
   PUBMED   12093291
  REMARK    GeneRIF: The common gamma chain (gamma c) is a required signaling
            component and supports IL-21-induced cell proliferation via JAK3
REFERENCE   7  (bases 1 to 2607)
  AUTHORS   Lee,C.K., Raz,R., Gimeno,R., Gertner,R., Wistinghausen,B.,
            Takeshita,K., DePinho,R.A. and Levy,D.E.
  TITLE     STAT3 is a negative regulator of granulopoiesis but is not required
            for G-CSF-dependent differentiation
  JOURNAL   Immunity 17 (1), 63-72 (2002)
   PUBMED   12150892
REFERENCE   8  (bases 1 to 2607)
  AUTHORS   Kasaian,M.T., Whitters,M.J., Carter,L.L., Lowe,L.D., Jussif,J.M.,
            Deng,B., Johnson,K.A., Witek,J.S., Senices,M., Konz,R.F.,
            Wurster,A.L., Donaldson,D.D., Collins,M., Young,D.A. and
            Grusby,M.J.
  TITLE     IL-21 limits NK cell responses and promotes antigen-specific T cell
            activation: a mediator of the transition from innate to adaptive
            immunity
  JOURNAL   Immunity 16 (4), 559-569 (2002)
   PUBMED   11970879
REFERENCE   9  (bases 1 to 2607)
  AUTHORS   Parrish-Novak,J., Dillon,S.R., Nelson,A., Hammond,A., Sprecher,C.,
            Gross,J.A., Johnston,J., Madden,K., Xu,W., West,J., Schrader,S.,
            Burkhead,S., Heipel,M., Brandt,C., Kuijper,J.L., Kramer,J.,
            Conklin,D., Presnell,S.R., Berry,J., Shiota,F., Bort,S., Hambly,K.,
            Mudri,S., Clegg,C., Moore,M., Grant,F.J., Lofton-Day,C.,
            Gilbert,T., Rayond,F., Ching,A., Yao,L., Smith,D., Webster,P.,
            Whitmore,T., Maurer,M., Kaushansky,K., Holly,R.D. and Foster,D.
  TITLE     Interleukin 21 and its receptor are involved in NK cell expansion
            and regulation of lymphocyte function
  JOURNAL   Nature 408 (6808), 57-63 (2000)
   PUBMED   11081504
REFERENCE   10 (bases 1 to 2607)
  AUTHORS   Ozaki,K., Kikly,K., Michalovich,D., Young,P.R. and Leonard,W.J.
  TITLE     Cloning of a type I cytokine receptor most related to the IL-2
            receptor beta chain
  JOURNAL   Proc Natl Acad Sci U S A 97 (21), 11439-11444 (2000)
   PUBMED   11016959
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB634399.1, AF254068.1 and AC125213.3.
            
            On Jul 29, 2009 this sequence version replaced NM_021887.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF279436.1, AB049137.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-580               BB634399.1         1-580
            581-2031            AF254068.1         285-1735
            2032-2607           AC125213.3         41179-41754         c
FEATURES             Location/Qualifiers
     source          1..2607
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 68.98 cM"
     gene            1..2607
                     /gene="Il21r"
                     /gene_synonym="NILR"
                     /note="interleukin 21 receptor"
                     /db_xref="GeneID:60504"
                     /db_xref="MGI:MGI:1890475"
     exon            1..424
                     /gene="Il21r"
                     /gene_synonym="NILR"
                     /inference="alignment:Splign:2.1.0"
     exon            425..487
                     /gene="Il21r"
                     /gene_synonym="NILR"
                     /inference="alignment:Splign:2.1.0"
     exon            488..590
                     /gene="Il21r"
                     /gene_synonym="NILR"
                     /inference="alignment:Splign:2.1.0"
     exon            591..790
                     /gene="Il21r"
                     /gene_synonym="NILR"
                     /inference="alignment:Splign:2.1.0"
     exon            791..945
                     /gene="Il21r"
                     /gene_synonym="NILR"
                     /inference="alignment:Splign:2.1.0"
     exon            946..1123
                     /gene="Il21r"
                     /gene_synonym="NILR"
                     /inference="alignment:Splign:2.1.0"
     exon            1124..1220
                     /gene="Il21r"
                     /gene_synonym="NILR"
                     /inference="alignment:Splign:2.1.0"
     exon            1221..1305
                     /gene="Il21r"
                     /gene_synonym="NILR"
                     /inference="alignment:Splign:2.1.0"
     exon            1306..2607
                     /gene="Il21r"
                     /gene_synonym="NILR"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2289..2294
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Il21r"
                     /gene_synonym="NILR"
                     /note="hexamer: AATAAA"
     polyA_site      2306
                     /gene="Il21r"
                     /gene_synonym="NILR"
                     /note="major polyA site"
     polyA_site      2607
                     /gene="Il21r"
                     /gene_synonym="NILR"
ORIGIN      
        1 agatagacac cgaagcctcc gctggtggcc ctgtgtttca gtcgcacaca gctgtctgcc
       61 cacttctcct gtggtgtgcc tcacggtcac ttgcttgtct gaccgcaagt ctgcccatcc
      121 ctggggcagc caactggcct cagcccgtgc cccaggcgtg ccctgtctct gtctggctgc
      181 cccagcccta ctgtcttcct ctgtgtaggc tctgcccaga tgcccggctg gtcctcagcc
      241 tcaggactat ctcagcagtg actcccctga ttctggactt gcacctgact gaactcctgc
      301 ccacctcaaa ccttcacctc ccaccaccac cactccgagt cccgctgtga ctcccacgcc
      361 caggagacca cccaagtgcc ccagcctaaa gaatggcttt ctgagaaaga ccctgaagga
      421 gtaggtctgg gacacagcat gccccggggc ccagtggctg ccttactcct gctgattctc
      481 catggagctt ggagctgcct ggacctcact tgctacactg actacctctg gaccatcacc
      541 tgtgtcctgg agacacggag ccccaacccc agcatactca gtctcacctg gcaagatgaa
      601 tatgaggaac ttcaggacca agagaccttc tgcagcctac acaggtctgg ccacaacacc
      661 acacatatat ggtacacgtg ccatatgcgc ttgtctcaat tcctgtccga tgaagttttc
      721 attgtcaatg tgacggacca gtctggcaac aactcccaag agtgtggcag ctttgtcctg
      781 gctgagagca tcaaaccagc tccccccttg aacgtgactg tggccttctc aggacgctat
      841 gatatctcct gggactcagc ttatgacgaa ccctccaact acgtgctgag gggcaagcta
      901 caatatgagc tgcagtatcg gaacctcaga gacccctatg ctgtgaggcc ggtgaccaag
      961 ctgatctcag tggactcaag aaacgtctct cttctccctg aagagttcca caaagattct
     1021 agctaccagc tgcaggtgcg ggcagcgcct cagccaggca cttcattcag ggggacctgg
     1081 agtgagtgga gtgaccccgt catctttcag acccaggctg gggagcccga ggcaggctgg
     1141 gaccctcaca tgctgctgct cctggctgtc ttgatcattg tcctggtttt catgggtctg
     1201 aagatccacc tgccttggag gctatggaaa aagatatggg caccagtgcc cacccctgag
     1261 agtttcttcc agcccctgta cagggagcac agcgggaact tcaagaaatg ggttaatacc
     1321 cctttcacgg cctccagcat agagttggtg ccacagagtt ccacaacaac atcagcctta
     1381 catctgtcat tgtatccagc caaggagaag aagttcccgg ggctgccggg tctggaagag
     1441 caactggagt gtgatggaat gtctgagcct ggtcactggt gcataatccc cttggcagct
     1501 ggccaagcgg tctcagccta cagtgaggag agagaccggc catatggtct ggtgtccatt
     1561 gacacagtga ctgtgggaga tgcagagggc ctgtgtgtct ggccctgtag ctgtgaggat
     1621 gatggctatc cagccatgaa cctggatgct ggccgagagt ctggccctaa ttcagaggat
     1681 ctgctcttgg tcacagaccc tgcttttctg tcttgcggct gtgtctcagg tagtggtctc
     1741 aggcttggag gctccccagg cagcctactg gacaggttga ggctgtcatt tgcaaaggaa
     1801 ggggactgga cagcagaccc aacctggaga actgggtccc caggaggggg ctctgagagt
     1861 gaagcaggtt ccccccctgg tctggacatg gacacatttg acagtggctt tgcaggttca
     1921 gactgtggca gccccgtgga gactgatgaa ggaccccctc gaagctatct ccgccagtgg
     1981 gtggtcagga cccctccacc tgtggacagt ggagcccaga gcagctagca tataataacc
     2041 agctatagtg agaagaggcc tctgagcctg gcatttacag tgtgaacatg taggggtgtg
     2101 tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tcttgggttg tgtgttagca catccatgtt
     2161 gggatttggt ctgttgctat gtattgtaat gctaaattct ctacccaaag ttctaggcct
     2221 acgagtgaat tctcatgttt acaaacttgc tgtgtaaacc ttgttcctta atttaatacc
     2281 attggttaaa taaaattggc tgcaaccaat tactggaggg attagaggta gggggctttt
     2341 gagttacctg tttggagatg gagaaggaga gaggagagac caagaggaga aggaggaagg
     2401 agaggagagg agaggagagg agaggagagg agaggagagg agaggagagg agaggagagg
     2461 ctgccgtgag gggagaggga ccatgagcct gtggccagga gaaacagcaa gtatctgggg
     2521 tacactggtg aggaggtggc caggccagca gttagaagag tagattaggg gtgacctcca
     2581 gtatttgtca aagccaatta aaataac
//
