LOCUS       NP_068687                529 aa            linear   ROD 10-FEB-2025
DEFINITION  interleukin-21 receptor precursor [Mus musculus].
ACCESSION   NP_068687 XP_920782 XP_928973 XP_928976
VERSION     NP_068687.1
DBSOURCE    REFSEQ: accession NM_021887.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 529)
  AUTHORS   Kogl,T., Chang,H.F., Staniek,J., Chiang,S.C.C., Thoulass,G.,
            Lao,J., Weissert,K., Dettmer-Monaco,V., Geiger,K., Manna,P.T.,
            Beziat,V., Momenilandi,M., Tu,S.M., Keppler,S.J., Pattu,V.,
            Wolf,P., Kupferschmid,L., Tholen,S., Covill,L.E., Ebert,K.,
            Straub,T., Gross,M., Gather,R., Engel,H., Salzer,U., Schell,C.,
            Maier,S., Lehmberg,K., Cornu,T.I., Pircher,H., Shahrooei,M.,
            Parvaneh,N., Elling,R., Rizzi,M., Bryceson,Y.T., Ehl,S., Aichele,P.
            and Ammann,S.
  TITLE     Patients and mice with deficiency in the SNARE protein SYNTAXIN-11
            have a secondary B cell defect
  JOURNAL   J Exp Med 221 (7) (2024)
   PUBMED   38722309
  REMARK    Erratum:[J Exp Med. 2024 Jul 1;221(7):e2022112205142024c. doi:
            10.1084/jem.2022112205142024c.. PMID: 38771261]
REFERENCE   2  (residues 1 to 529)
  AUTHORS   Seyedsadr,M., Bang,M.F., McCarthy,E.C., Zhang,S., Chen,H.C.,
            Mohebbi,M., Hugo,W., Whitmire,J.K., Lechner,M.G. and Su,M.A.
  TITLE     A pathologically expanded, clonal lineage of IL-21-producing CD4+ T
            cells drives inflammatory neuropathy
  JOURNAL   J Clin Invest 134 (15), e178602 (2024)
   PUBMED   39087473
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 529)
  AUTHORS   Xie,Y., Huang,Y., Li,Z.Y., Jiang,W., Shi,N.X., Lu,Y., Cao,G.,
            Yin,Z. and Lin,X.J.
  TITLE     Interleukin-21 receptor signaling promotes metabolic
            dysfunction-associated steatohepatitis-driven hepatocellular
            carcinoma by inducing immunosuppressive IgA+ B cells
  JOURNAL   Mol Cancer 23 (1), 95 (2024)
   PUBMED   38720319
  REMARK    GeneRIF: Interleukin-21 receptor signaling promotes metabolic
            dysfunction-associated steatohepatitis-driven hepatocellular
            carcinoma by inducing immunosuppressive IgA[+] B cells.
            Publication Status: Online-Only
REFERENCE   4  (residues 1 to 529)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   5  (residues 1 to 529)
  AUTHORS   Han,M., Hu,L., Wu,D., Zhang,Y., Li,P., Zhao,X., Zeng,Y., Ren,G.,
            Hou,Z., Pang,Y., Zhao,T. and Zhong,C.
  TITLE     IL-21R-STAT3 signalling initiates a differentiation program in
            uterine tissue-resident NK cells to support pregnancy
  JOURNAL   Nat Commun 14 (1), 7109 (2023)
   PUBMED   37925507
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 529)
  AUTHORS   Habib,T., Senadheera,S., Weinberg,K. and Kaushansky,K.
  TITLE     The common gamma chain (gamma c) is a required signaling component
            of the IL-21 receptor and supports IL-21-induced cell proliferation
            via JAK3
  JOURNAL   Biochemistry 41 (27), 8725-8731 (2002)
   PUBMED   12093291
  REMARK    GeneRIF: The common gamma chain (gamma c) is a required signaling
            component and supports IL-21-induced cell proliferation via JAK3
REFERENCE   7  (residues 1 to 529)
  AUTHORS   Lee,C.K., Raz,R., Gimeno,R., Gertner,R., Wistinghausen,B.,
            Takeshita,K., DePinho,R.A. and Levy,D.E.
  TITLE     STAT3 is a negative regulator of granulopoiesis but is not required
            for G-CSF-dependent differentiation
  JOURNAL   Immunity 17 (1), 63-72 (2002)
   PUBMED   12150892
REFERENCE   8  (residues 1 to 529)
  AUTHORS   Kasaian,M.T., Whitters,M.J., Carter,L.L., Lowe,L.D., Jussif,J.M.,
            Deng,B., Johnson,K.A., Witek,J.S., Senices,M., Konz,R.F.,
            Wurster,A.L., Donaldson,D.D., Collins,M., Young,D.A. and
            Grusby,M.J.
  TITLE     IL-21 limits NK cell responses and promotes antigen-specific T cell
            activation: a mediator of the transition from innate to adaptive
            immunity
  JOURNAL   Immunity 16 (4), 559-569 (2002)
   PUBMED   11970879
REFERENCE   9  (residues 1 to 529)
  AUTHORS   Parrish-Novak,J., Dillon,S.R., Nelson,A., Hammond,A., Sprecher,C.,
            Gross,J.A., Johnston,J., Madden,K., Xu,W., West,J., Schrader,S.,
            Burkhead,S., Heipel,M., Brandt,C., Kuijper,J.L., Kramer,J.,
            Conklin,D., Presnell,S.R., Berry,J., Shiota,F., Bort,S., Hambly,K.,
            Mudri,S., Clegg,C., Moore,M., Grant,F.J., Lofton-Day,C.,
            Gilbert,T., Rayond,F., Ching,A., Yao,L., Smith,D., Webster,P.,
            Whitmore,T., Maurer,M., Kaushansky,K., Holly,R.D. and Foster,D.
  TITLE     Interleukin 21 and its receptor are involved in NK cell expansion
            and regulation of lymphocyte function
  JOURNAL   Nature 408 (6808), 57-63 (2000)
   PUBMED   11081504
REFERENCE   10 (residues 1 to 529)
  AUTHORS   Ozaki,K., Kikly,K., Michalovich,D., Young,P.R. and Leonard,W.J.
  TITLE     Cloning of a type I cytokine receptor most related to the IL-2
            receptor beta chain
  JOURNAL   Proc Natl Acad Sci U S A 97 (21), 11439-11444 (2000)
   PUBMED   11016959
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB634399.1, AF254068.1 and AC125213.3.
            
            On or before Dec 7, 2005 this sequence version replaced
            XP_928973.1, XP_928976.1, XP_920782.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF279436.1, AB049137.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..529
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 68.98 cM"
     Protein         1..529
                     /product="interleukin-21 receptor precursor"
                     /note="NR8; IL-21R; LR-beta; IL-21 receptor; lymphocyte
                     receptor beta; novel cytokine receptor 8; novel
                     interleukin receptor"
                     /calculated_mol_wt=56357
     sig_peptide     1..19
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=2016
     mat_peptide     20..529
                     /product="Interleukin-21 receptor. /id=PRO_0000010882"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JHX3.1)"
                     /calculated_mol_wt=56357
     Site            73
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9JHX3.1)"
     Site            97
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9JHX3.1)"
     Site            104
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9JHX3.1)"
     Region          120..225
                     /region_name="FN3"
                     /note="Fibronectin type 3 domain; One of three types of
                     internal repeats found in the plasma protein fibronectin.
                     Its tenth fibronectin type III repeat contains an RGD cell
                     recognition sequence in a flexible loop between 2 strands.
                     Approximately 2% of all...; cd00063"
                     /db_xref="CDD:238020"
     Site            order(120,187,207)
                     /site_type="active"
                     /note="Interdomain contacts [active]"
                     /db_xref="CDD:238020"
     Site            125
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9JHX3.1)"
     Site            182
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9JHX3.1)"
     Region          214..218
                     /region_name="WSXWS motif"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JHX3.1)"
     Site            order(214..215,217..218)
                     /site_type="active"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     Site            214
                     /site_type="glycosylation"
                     /note="C-linked (Man) tryptophan.
                     /evidence=ECO:0000250|UniProtKB:Q9HBE5; propagated from
                     UniProtKB/Swiss-Prot (Q9JHX3.1)"
     Site            238..258
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JHX3.1)"
     Region          266..274
                     /region_name="Box 1 motif"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JHX3.1)"
     Region          458..529
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JHX3.1)"
     CDS             1..529
                     /gene="Il21r"
                     /gene_synonym="NILR"
                     /coded_by="NM_021887.2:439..2028"
                     /db_xref="CCDS:CCDS21823.1"
                     /db_xref="GeneID:60504"
                     /db_xref="MGI:MGI:1890475"
ORIGIN      
        1 mprgpvaall llilhgawsc ldltcytdyl wtitcvletr spnpsilslt wqdeyeelqd
       61 qetfcslhrs ghntthiwyt chmrlsqfls devfivnvtd qsgnnsqecg sfvlaesikp
      121 applnvtvaf sgrydiswds aydepsnyvl rgklqyelqy rnlrdpyavr pvtklisvds
      181 rnvsllpeef hkdssyqlqv raapqpgtsf rgtwsewsdp vifqtqagep eagwdphmll
      241 llavliivlv fmglkihlpw rlwkkiwapv ptpesffqpl yrehsgnfkk wvntpftass
      301 ielvpqsstt tsalhlslyp akekkfpglp gleeqlecdg msepghwcii plaagqavsa
      361 yseerdrpyg lvsidtvtvg daeglcvwpc sceddgypam nldagresgp nsedlllvtd
      421 paflscgcvs gsglrlggsp gslldrlrls fakegdwtad ptwrtgspgg gseseagspp
      481 gldmdtfdsg fagsdcgspv etdegpprsy lrqwvvrtpp pvdsgaqss
//
