LOCUS       NM_001033543            2479 bp    mRNA    linear   ROD 01-AUG-2024
DEFINITION  Mus musculus interleukin 20 receptor beta (Il20rb), mRNA.
ACCESSION   NM_001033543 XM_358706 XM_897601 XM_897607 XM_897614 XM_897623
            XM_906440 XM_919838 XM_919854
VERSION     NM_001033543.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2479)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2479)
  AUTHORS   Cai,Y., He,C., Dai,Y., Zhang,D., Lv,G., Lu,H. and Chen,G.
  TITLE     Spinal interleukin-24 contributes to neuropathic pain after
            peripheral nerve injury through interleukin-20 receptor2 in mice
  JOURNAL   Exp Neurol 372, 114643 (2024)
   PUBMED   38056582
  REMARK    GeneRIF: Spinal interleukin-24 contributes to neuropathic pain
            after peripheral nerve injury through interleukin-20 receptor2 in
            mice.
REFERENCE   3  (bases 1 to 2479)
  AUTHORS   Chiriac,M.T., Hracsko,Z., Gunther,C., Gonzalez-Acera,M., Atreya,R.,
            Stolzer,I., Wittner,L., Dressel,A., Schickedanz,L.,
            Gamez-Belmonte,R., Erkert,L., Hundorfean,G., Zundler,S., Rath,T.,
            Vetrano,S., Danese,S., Sturm,G., Trajanoski,Z., Kuhl,A.A.,
            Siegmund,B., Hartmann,A., Wirtz,S., Siebler,J., Finotto,S.,
            Becker,C. and Neurath,M.F.
  TITLE     IL-20 controls resolution of experimental colitis by regulating
            epithelial IFN/STAT2 signalling
  JOURNAL   Gut 73 (2), 282-297 (2024)
   PUBMED   37884352
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2479)
  AUTHORS   Liu,S., Hur,Y.H., Cai,X., Cong,Q., Yang,Y., Xu,C., Bilate,A.M.,
            Gonzales,K.A.U., Parigi,S.M., Cowley,C.J., Hurwitz,B., Luo,J.D.,
            Tseng,T., Gur-Cohen,S., Sribour,M., Omelchenko,T., Levorse,J.,
            Pasolli,H.A., Thompson,C.B., Mucida,D. and Fuchs,E.
  TITLE     A tissue injury sensing and repair pathway distinct from host
            pathogen defense
  JOURNAL   Cell 186 (10), 2127-2143 (2023)
   PUBMED   37098344
REFERENCE   5  (bases 1 to 2479)
  AUTHORS   Beute,J.E., Kim,A.Y., Park,J.J., Yang,A., Torres-Shafer,K.,
            Mullins,D.W. and Sundstrom,P.
  TITLE     The IL-20RB receptor and the IL-20 signaling pathway in regulating
            host defense in oral mucosal candidiasis
  JOURNAL   Front Cell Infect Microbiol 12, 979701 (2022)
   PUBMED   36225230
  REMARK    GeneRIF: The IL-20RB receptor and the IL-20 signaling pathway in
            regulating host defense in oral mucosal candidiasis.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2479)
  AUTHORS   Zheng,Y., Valdez,P.A., Danilenko,D.M., Hu,Y., Sa,S.M., Gong,Q.,
            Abbas,A.R., Modrusan,Z., Ghilardi,N., de Sauvage,F.J. and Ouyang,W.
  TITLE     Interleukin-22 mediates early host defense against attaching and
            effacing bacterial pathogens
  JOURNAL   Nat Med 14 (3), 282-289 (2008)
   PUBMED   18264109
REFERENCE   7  (bases 1 to 2479)
  AUTHORS   Wegenka,U.M., Dikopoulos,N., Reimann,J., Adler,G. and Wahl,C.
  TITLE     The murine liver is a potential target organ for IL-19, IL-20 and
            IL-24: Type I Interferons and LPS regulate the expression of
            IL-20R2
  JOURNAL   J Hepatol 46 (2), 257-265 (2007)
   PUBMED   17069926
  REMARK    GeneRIF: IL-20R2 receptor subunit is up-regulated by LPS in the
            liver of normal mice.
REFERENCE   8  (bases 1 to 2479)
  AUTHORS   Chan,J.R., Blumenschein,W., Murphy,E., Diveu,C., Wiekowski,M.,
            Abbondanzo,S., Lucian,L., Geissler,R., Brodie,S., Kimball,A.B.,
            Gorman,D.M., Smith,K., de Waal Malefyt,R., Kastelein,R.A.,
            McClanahan,T.K. and Bowman,E.P.
  TITLE     IL-23 stimulates epidermal hyperplasia via TNF and
            IL-20R2-dependent mechanisms with implications for psoriasis
            pathogenesis
  JOURNAL   J Exp Med 203 (12), 2577-2587 (2006)
   PUBMED   17074928
REFERENCE   9  (bases 1 to 2479)
  AUTHORS   Carninci,P., Waki,K., Shiraki,T., Konno,H., Shibata,K., Itoh,M.,
            Aizawa,K., Arakawa,T., Ishii,Y., Sasaki,D., Bono,H., Kondo,S.,
            Sugahara,Y., Saito,R., Osato,N., Fukuda,S., Sato,K., Watahiki,A.,
            Hirozane-Kishikawa,T., Nakamura,M., Shibata,Y., Yasunishi,A.,
            Kikuchi,N., Yoshiki,A., Kusakabe,M., Gustincich,S., Beisel,K.,
            Pavan,W., Aidinis,V., Nakagawara,A., Held,W.A., Iwata,H., Kono,T.,
            Nakauchi,H., Lyons,P., Wells,C., Hume,D.A., Fagiolini,M.,
            Hensch,T.K., Brinkmeier,M., Camper,S., Hirota,J., Mombaerts,P.,
            Muramatsu,M., Okazaki,Y., Kawai,J. and Hayashizaki,Y.
  TITLE     Targeting a complex transcriptome: the construction of the mouse
            full-length cDNA encyclopedia
  JOURNAL   Genome Res 13 (6B), 1273-1289 (2003)
   PUBMED   12819125
REFERENCE   10 (bases 1 to 2479)
  AUTHORS   VanBuren,V., Piao,Y., Dudekula,D.B., Qian,Y., Carter,M.G.,
            Martin,P.R., Stagg,C.A., Bassey,U.C., Aiba,K., Hamatani,T.,
            Kargul,G.J., Luo,A.G., Kelso,J., Hide,W. and Ko,M.S.
  TITLE     Assembly, verification, and initial annotation of the NIA mouse
            7.4K cDNA clone set
  JOURNAL   Genome Res 12 (12), 1999-2003 (2002)
   PUBMED   12466305
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY772000.1, CK331954.1, AC134590.5 and BE852308.1.
            
            On Oct 18, 2007 this sequence version replaced NM_001033543.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript from the same
            strain was available for the full length of the gene. The extent of
            this transcript is supported by transcript alignments and
            orthologous data.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14995048.20963.1,
                                           SRR15390195.232285.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-127               BY772000.1         3-129
            128-495             CK331954.1         1-368
            496-536             AC134590.5         164834-164874       c
            537-661             AC134590.5         160159-160283       c
            662-812             AC134590.5         158049-158199       c
            813-955             AC134590.5         153226-153368       c
            956-2049            AC134590.5         149984-151077       c
            2050-2479           BE852308.1         1-430               c
FEATURES             Location/Qualifiers
     source          1..2479
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 52.66 cM"
     gene            1..2479
                     /gene="Il20rb"
                     /gene_synonym="Fndc6; Gm186; Il20R2"
                     /note="interleukin 20 receptor beta"
                     /db_xref="GeneID:213208"
                     /db_xref="MGI:MGI:2143266"
     exon            1..218
                     /gene="Il20rb"
                     /gene_synonym="Fndc6; Gm186; Il20R2"
                     /inference="alignment:Splign:2.1.0"
     CDS             146..1072
                     /gene="Il20rb"
                     /gene_synonym="Fndc6; Gm186; Il20R2"
                     /note="fibronectin type III domain containing 6;
                     interleukin-20 receptor subunit beta"
                     /codon_start=1
                     /product="interleukin-20 receptor subunit beta precursor"
                     /protein_id="NP_001028715.2"
                     /db_xref="CCDS:CCDS23438.2"
                     /db_xref="GeneID:213208"
                     /db_xref="MGI:MGI:2143266"
                     /translation="MISQGVWTSPFMWFFYSMTSGFLTDAVSVLPAPQNLSVQSTNMK
                     HLLMWNPVTQPGETVLYCVEYQGEYESLYMSHIWIPSSQCSPTKSLECDVTDDITATV
                     PYNFRVKAMLGSQTSAWSNLEHPFNRNATVLTPPRMEVTEHGLHLVIELEDLGPQFEF
                     LVVYWRREPGAAEHVKMVRSGDIPVHLETMEPGAMYCVKAQALVKAIGRHSAFSQPTC
                     VEMQGESLPLALALFAFVGFMLILVVVLLSVWKMGQLLRYSCCPAVVLPDTLKITSSS
                     QKLISCRKEEVDACAVAVLSSEHLFGVWISQT"
     exon            219..345
                     /gene="Il20rb"
                     /gene_synonym="Fndc6; Gm186; Il20R2"
                     /inference="alignment:Splign:2.1.0"
     exon            346..536
                     /gene="Il20rb"
                     /gene_synonym="Fndc6; Gm186; Il20R2"
                     /inference="alignment:Splign:2.1.0"
     exon            537..661
                     /gene="Il20rb"
                     /gene_synonym="Fndc6; Gm186; Il20R2"
                     /inference="alignment:Splign:2.1.0"
     exon            662..812
                     /gene="Il20rb"
                     /gene_synonym="Fndc6; Gm186; Il20R2"
                     /inference="alignment:Splign:2.1.0"
     exon            813..955
                     /gene="Il20rb"
                     /gene_synonym="Fndc6; Gm186; Il20R2"
                     /inference="alignment:Splign:2.1.0"
     exon            956..2478
                     /gene="Il20rb"
                     /gene_synonym="Fndc6; Gm186; Il20R2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2363..2368
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Il20rb"
                     /gene_synonym="Fndc6; Gm186; Il20R2"
                     /note="hexamer: ATTAAA"
     polyA_site      2393
                     /gene="Il20rb"
                     /gene_synonym="Fndc6; Gm186; Il20R2"
     regulatory      2461..2466
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Il20rb"
                     /gene_synonym="Fndc6; Gm186; Il20R2"
                     /note="hexamer: AATAAA"
     polyA_site      2478
                     /gene="Il20rb"
                     /gene_synonym="Fndc6; Gm186; Il20R2"
                     /note="major polyA site"
ORIGIN      
        1 ttcattgcaa ctctgacctc agcaccagca tctgcttcct gaagggagat ggctaggatg
       61 gacacacagc ctccttctgg aagaaaacag tgtctccggg caagctgagt ttgctagaga
      121 ccctcacacc aaacagacca gcacaatgat ttcccaggga gtctggacaa gtccgttcat
      181 gtggtttttc tacagcatga cctcaggttt tctcacggat gcagtgtccg ttttacctgc
      241 ccctcagaac ctctctgtac agtcaaccaa catgaagcat ctcttgatgt ggaacccagt
      301 gacccagccg ggggagacgg tgctctattg tgtggagtat cagggggagt acgagagcct
      361 gtacatgagc cacatctgga tccccagcag tcaatgctca ccgaccaaaa gtctggagtg
      421 tgatgtcacc gatgacataa ccgccacagt gccatataac ttcagggtca aggccatgct
      481 gggctcacag acttcagcct ggagcaacct ggagcacccc tttaaccgaa atgcaactgt
      541 cctcacccca cccaggatgg aggtcactga acatgggctg catctggtta ttgagctgga
      601 agacctgggg ccccagtttg agttccttgt ggtctactgg aggagggagc ctggcgccgc
      661 ggaacatgtt aagatggtga ggagtgggga cattccggtg cacctagaaa ccatggaacc
      721 gggggccatg tactgtgtga aggcgcaggc actggtgaaa gccatcggga ggcacagtgc
      781 cttcagccag cctacgtgtg tggagatgca aggagagtct cttccgctgg cactagctct
      841 gtttgcgttt gttggcttca tgctgattct cgtggttgta ctactctccg tctggaagat
      901 gggccagctg ctccggtatt cttgctgccc cgccgttgtc ctcccagaca ccttgaaaat
      961 aaccagttcg tctcagaagc tgatcagctg caggaaggag gaggtggacg cctgtgctgt
     1021 ggctgtgctg tcctcggagc atctctttgg ggtctggatc tcacagactt gagaaggacc
     1081 tgatggatta acagcctggt ctgcaggacc cagaaccctg gatggggtgg gttgtgtttc
     1141 tgttttcctc tgtggacaaa agacaaagag aagtaacagg agcctactgt gtgcacgtct
     1201 agcagtgacc gtcagaggca gagtggcgtg accatccaag agtgacagaa atagtctaga
     1261 gaggtgatcc ccagacacac agttaccata cgctcactga aaaacagtgg agaaaatggc
     1321 ttcatacctc ggacccccgc tttgtcacct gtagtgggga ttaaatggtt tctcccctca
     1381 tctctgtgtg tatacaaact cgcacttgca ggttggcaag gagactggtg gcactgtgca
     1441 caacggtgag ttcagatcat gcggactgtg gggcatacgc gtgtgctaag aatgatcaga
     1501 gtactcagcc gggtgcaaaa tctcagcact ttggaggagc gggagagaaa atcacagcct
     1561 agacgacacg gtgaaacccc atctgaagta aacaaccgaa caaccaagag taataaacct
     1621 ccttttgtca aatcaaactc agaccactgt tggtttggac ttccctcttt acaagaggaa
     1681 acccgaggag ggacggaaga atgggagggc tgtttcactt caagccaaat cctgtcagca
     1741 cgctctgctg agggtgacat cgagagaggc cgtagcccgt ccatgatggg acatgcgcgg
     1801 atgctgctgt gggttcatga aatgtcatca gatcctagga ccttgtccac agtaaatcac
     1861 accagctctc ttcctaagga caattcactc agggtttctc agtcgctctc aggtactcat
     1921 caggaacccc tgactagagg cataaccatc actacctcca ggcagcgagg gaggggtgga
     1981 ggacagcttc agtcagagga ggatgaaagg aggtggcttc atctctctct gcagagtcag
     2041 gctcaccacc acctccccct ctggaacctg gagctggctt gtctctgccc caacttcctg
     2101 ggcttcacca gccagacaag ggtagagaca gtgtaacggt ttcaaccagg tgcttccagt
     2161 ccgtcttcag cacagatgcc aacggcctca tctctacttt ggggactcca ggagagatat
     2221 gtaggggtgt gggcagatat gtaggggtgt gggctgaggc tccctgcctt tgtcctgttc
     2281 tgtatatttc tgccttgact cttttgtgaa gcgtgtgtta aatgttatat ttcaactggt
     2341 ctggaaatgt gctgtttaca gaattaaaaa ttgcatactt acattaacct tcatcttttc
     2401 tcccctctct tctctgctcc ctcaccccag ggacttcatt cctctgttac ctaagctcag
     2461 aataaagaat taccccgaa
//
