LOCUS       NM_172786               2088 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus interleukin 20 receptor, alpha (Il20ra), mRNA.
ACCESSION   NM_172786
VERSION     NM_172786.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2088)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2088)
  AUTHORS   Chiriac,M.T., Hracsko,Z., Gunther,C., Gonzalez-Acera,M., Atreya,R.,
            Stolzer,I., Wittner,L., Dressel,A., Schickedanz,L.,
            Gamez-Belmonte,R., Erkert,L., Hundorfean,G., Zundler,S., Rath,T.,
            Vetrano,S., Danese,S., Sturm,G., Trajanoski,Z., Kuhl,A.A.,
            Siegmund,B., Hartmann,A., Wirtz,S., Siebler,J., Finotto,S.,
            Becker,C. and Neurath,M.F.
  TITLE     IL-20 controls resolution of experimental colitis by regulating
            epithelial IFN/STAT2 signalling
  JOURNAL   Gut 73 (2), 282-297 (2024)
   PUBMED   37884352
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2088)
  AUTHORS   Lu,S.W., Pan,H.C., Hsu,Y.H., Chang,K.C., Wu,L.W., Chen,W.Y. and
            Chang,M.S.
  TITLE     IL-20 antagonist suppresses PD-L1 expression and prolongs survival
            in pancreatic cancer models
  JOURNAL   Nat Commun 11 (1), 4611 (2020)
   PUBMED   32929072
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2088)
  AUTHORS   Weng,Y.H., Chen,W.Y., Lin,Y.L., Wang,J.Y. and Chang,M.S.
  TITLE     Blocking IL-19 Signaling Ameliorates Allergen-Induced Airway
            Inflammation
  JOURNAL   Front Immunol 10, 968 (2019)
   PUBMED   31114590
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2088)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   6  (bases 1 to 2088)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   7  (bases 1 to 2088)
  AUTHORS   Abd Nikfarjam,B., Ebtekar,M., Sabouni,F., Pourpak,Z. and
            Kheirandish,M.
  TITLE     Detection of IL-20R1 and IL-20R2 mRNA in C57BL/6 mice astroglial
            cells and brain cortex following LPS stimulation
  JOURNAL   Iran J Immunol 10 (2), 62-69 (2013)
   PUBMED   23811545
  REMARK    GeneRIF: IL-20R1 and IL-20R2 are constitutively express in the
            brain.
REFERENCE   8  (bases 1 to 2088)
  AUTHORS   Hsu,Y.H., Li,H.H., Sung,J.M., Chen,W.T., Hou,Y.C. and Chang,M.S.
  TITLE     Interleukin-19 mediates tissue damage in murine ischemic acute
            kidney injury
  JOURNAL   PLoS One 8 (2), e56028 (2013)
   PUBMED   23468852
REFERENCE   9  (bases 1 to 2088)
  AUTHORS   Hsu,Y.H., Chen,W.Y., Chan,C.H., Wu,C.H., Sun,Z.J. and Chang,M.S.
  TITLE     Anti-IL-20 monoclonal antibody inhibits the differentiation of
            osteoclasts and protects against osteoporotic bone loss
  JOURNAL   J Exp Med 208 (9), 1849-1861 (2011)
   PUBMED   21844205
REFERENCE   10 (bases 1 to 2088)
  AUTHORS   Wei,C.C. and Chang,M.S.
  TITLE     Mouse interleukin-20 receptor 1a targets renal epithelial cells and
            is associated with renal calcium deposition
  JOURNAL   Genes Immun 10 (3), 237-247 (2009)
   PUBMED   19078987
  REMARK    GeneRIF: mIL-20R1a functioned as an aggravating factor in promoting
            calcium deposition in kidney of mice.
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AK054215.1.
            
            On Apr 5, 2007 this sequence version replaced NM_172786.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK054215.1, BC056628.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2088              AK054215.1         2-2089
FEATURES             Location/Qualifiers
     source          1..2088
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 8.76 cM"
     gene            1..2088
                     /gene="Il20ra"
                     /gene_synonym="E230031K19"
                     /note="interleukin 20 receptor, alpha"
                     /db_xref="GeneID:237313"
                     /db_xref="MGI:MGI:3605069"
     exon            1..144
                     /gene="Il20ra"
                     /gene_synonym="E230031K19"
                     /inference="alignment:Splign:2.1.0"
     CDS             48..1688
                     /gene="Il20ra"
                     /gene_synonym="E230031K19"
                     /note="interleukin-20 receptor subunit alpha; IL-20R1;
                     IL-20RA; IL-20R-alpha; IL-20 receptor subunit alpha"
                     /codon_start=1
                     /product="interleukin-20 receptor subunit alpha precursor"
                     /protein_id="NP_766374.1"
                     /db_xref="CCDS:CCDS23718.1"
                     /db_xref="GeneID:237313"
                     /db_xref="MGI:MGI:3605069"
                     /translation="MHTPGTPAPGHPDPPPLLLLTLLLLLAASGRAVPCVFCGLPKPT
                     NITFLSINMKNVLHWNPPESLHGVEVTYTVQYFIYGQKKWLNASKCGSINRTYCDLSV
                     ETSDYEHQFYAKVKAIWEARCSEWAETERFYPFLETQVSPPEVALTTGEKSISIALTA
                     PEKWKRNPQDHTVSMQQIYPNLKYNVSVYNTKSRRTWSQCVTNSTLVLSWLEPNTLYC
                     VHVESLVPGPPRLPMPSQKQCISTLEVQTSAWKAKVIFWYVFLTSVIVFLFSAIGYLV
                     YRYIHVGKEKHPANLVLIYRNEIGTRVFEPTETITLNFITFSMLDDTKISPKDMNLLD
                     KSSDDISVNDPEHNEAWEPHWEEVEGQHLGCSSHLMDAVCGAEQRDGDTSLTQHGWLN
                     STIPTGETDTEPQYKVLSDFYGEGEIQLSCEPEEAARTEKISEPLVTSANLDPQLEDL
                     HHLGQEHTVSEDGPEEETSITVVDWDPQTGRLCIPSLPIFGRDPENYGHYERDQLLEG
                     GLLSRLYENQAPDKPEKENENCLTRFMEEWGLHVQMES"
     exon            145..280
                     /gene="Il20ra"
                     /gene_synonym="E230031K19"
                     /inference="alignment:Splign:2.1.0"
     exon            281..459
                     /gene="Il20ra"
                     /gene_synonym="E230031K19"
                     /inference="alignment:Splign:2.1.0"
     exon            460..635
                     /gene="Il20ra"
                     /gene_synonym="E230031K19"
                     /inference="alignment:Splign:2.1.0"
     exon            636..780
                     /gene="Il20ra"
                     /gene_synonym="E230031K19"
                     /inference="alignment:Splign:2.1.0"
     exon            781..920
                     /gene="Il20ra"
                     /gene_synonym="E230031K19"
                     /inference="alignment:Splign:2.1.0"
     exon            921..2088
                     /gene="Il20ra"
                     /gene_synonym="E230031K19"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggggaggcca cgccgcgttc ccgagatgtg acccgaactg acagcccatg cacactcccg
       61 ggaccccggc gccgggccac ccggacccgc cgccactgtt gctgctcacg ctgcttctgc
      121 tgctggccgc ttcgggacgc gcagttcctt gtgtcttctg tggtttgcct aaacctacaa
      181 atatcacctt cttatccatc aacatgaaga atgtcctgca ttggaatcca ccagagagtc
      241 tacacggagt tgaagtcaca tacactgtgc aatatttcat atatgggcag aagaaatggc
      301 tgaatgcctc taaatgcggg agtatcaaca ggacctactg tgacctttct gttgagacct
      361 cagactatga acaccagttc tatgccaaag tgaaggccat ttgggaagcc aggtgctccg
      421 aatgggccga gacggaacgc ttctatcctt tcttggaaac tcaagtcagc ccaccagagg
      481 ttgccctgac aactggcgag aagtccatct ctattgccct gacagcacca gagaagtgga
      541 aaagaaatcc acaagaccac actgtttcta tgcaacagat ataccccaat ttgaagtaca
      601 atgtgtctgt gtataacact aagtcgagaa gaacgtggtc ccagtgtgtc accaacagca
      661 cactggtcct cagctggctg gagcccaaca ctctgtattg tgtccacgtg gagtcccttg
      721 tcccagggcc ccctcgcctc ccgatgcctt ctcagaagca gtgcatcagt actttggaag
      781 ttcaaacatc agcatggaag gctaaagtca tcttctggta tgtcttcctc acatctgtta
      841 tcgtgtttct tttctccgca attggctact tggtttaccg ttacatccat gttggcaagg
      901 aaaaacaccc agcaaatttg gtactgattt atagaaatga aattggcaca agagtctttg
      961 aacctactga aacaatcaca cttaatttta tcaccttcag tatgttggat gatactaaaa
     1021 tttctccaaa ggatatgaat ttactggaca aaagcagtga tgacatcagt gttaatgacc
     1081 ctgagcacaa tgaggcctgg gagccgcact gggaggaggt ggaggggcaa catttaggat
     1141 gctcttcgca tttgatggac gctgtctgtg gtgctgagca aagagacgga gacacctccc
     1201 taacccagca tgggtggctt aacagcacca tccccacagg agagacagac actgagcctc
     1261 aatacaaagt cctaagtgac ttctacgggg agggtgaaat ccaactgtcc tgtgagccgg
     1321 aagaggcggc cagaacagag aaaatatctg agccactggt gacttcagca aacttggacc
     1381 cacagcttga agacctacat cacctgggtc aggagcatac tgtctccgag gatgggccag
     1441 aggaagagac atctataaca gtagtggatt gggaccctca aactggcagg ctgtgtatcc
     1501 cttccttacc tatctttggc cgtgatcctg agaactatgg tcattatgag agagaccagc
     1561 tcttagaggg tggccttttg tctagactct atgagaacca ggcacctgac aagccagaga
     1621 aagaaaatga aaactgtctc acacggttta tggaggaatg ggggttacat gtacaaatgg
     1681 aaagctagtg ccaggctttc tgttgactgc caacaaatga aggaaccatc ccagggggtg
     1741 aacagtgttc aggttatcag tgtcagcaat gagactgttc tctctgttca tgaactttgt
     1801 cagccctgcc tcatccatgt gattggcttc catccaacct tcttcccaat ccacagagag
     1861 tcctagagga actttctgaa atgcagagcc ctgagctttg ttgtagacag agtaagattt
     1921 gcaggttggg tggggacttt atacagaaga gctcaccatg atcccagttt attattttct
     1981 aacagttatt ttctgaattt ttactgtata tatgtaaaaa tatttcaaat catatttcaa
     2041 aatatttcat aaaaatcatt tattttataa aacccttttc tagaattt
//
