LOCUS       NM_021380               1031 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus interleukin 20 (Il20), transcript variant 1, mRNA.
ACCESSION   NM_021380
VERSION     NM_021380.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1031)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1031)
  AUTHORS   Chiriac,M.T., Hracsko,Z., Gunther,C., Gonzalez-Acera,M., Atreya,R.,
            Stolzer,I., Wittner,L., Dressel,A., Schickedanz,L.,
            Gamez-Belmonte,R., Erkert,L., Hundorfean,G., Zundler,S., Rath,T.,
            Vetrano,S., Danese,S., Sturm,G., Trajanoski,Z., Kuhl,A.A.,
            Siegmund,B., Hartmann,A., Wirtz,S., Siebler,J., Finotto,S.,
            Becker,C. and Neurath,M.F.
  TITLE     IL-20 controls resolution of experimental colitis by regulating
            epithelial IFN/STAT2 signalling
  JOURNAL   Gut 73 (2), 282-297 (2024)
   PUBMED   37884352
  REMARK    GeneRIF: IL-20 controls resolution of experimental colitis by
            regulating epithelial IFN/STAT2 signalling.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1031)
  AUTHORS   Kaymak,T., Kaya,B., Wuggenig,P., Nuciforo,S., Goldi,A., Oswald,F.,
            Roux,J., Noti,M., Melhem,H., Hruz,P. and Niess,J.H.
  CONSRTM   Swiss EoE Cohort Study Group (SEECS)
  TITLE     IL-20 subfamily cytokines impair the oesophageal epithelial barrier
            by diminishing filaggrin in eosinophilic oesophagitis
  JOURNAL   Gut 72 (5), 821-833 (2023)
   PUBMED   35613844
  REMARK    GeneRIF: IL-20 subfamily cytokines impair the oesophageal
            epithelial barrier by diminishing filaggrin in eosinophilic
            oesophagitis.
REFERENCE   4  (bases 1 to 1031)
  AUTHORS   Lu,Z., Xiao,S., Chen,W., Zhu,R., Yang,H., Steinhoff,M., Li,Y.,
            Cheng,W., Yan,X., Li,L., Xue,S., Larkin,C., Zhang,W., Fan,Q.,
            Wang,R., Wang,J. and Meng,J.
  TITLE     IL-20 promotes cutaneous inflammation and peripheral itch sensation
            in atopic dermatitis
  JOURNAL   FASEB J 36 (6), e22334 (2022)
   PUBMED   35486004
  REMARK    GeneRIF: IL-20 promotes cutaneous inflammation and peripheral itch
            sensation in atopic dermatitis.
REFERENCE   5  (bases 1 to 1031)
  AUTHORS   Dayton,J.R., Yuan,Y., Pacumio,L.P., Dorflinger,B.G., Yoo,S.C.,
            Olson,M.J., Hernandez-Suarez,S.I., McMahon,M.M. and Cruz-Orengo,L.
  TITLE     Expression of IL-20 Receptor Subunit beta Is Linked to EAE
            Neuropathology and CNS Neuroinflammation
  JOURNAL   Front Cell Neurosci 15, 683687 (2021)
   PUBMED   34557075
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1031)
  AUTHORS   Tritsaris,K., Myren,M., Ditlev,S.B., Hubschmann,M.V., van der
            Blom,I., Hansen,A.J., Olsen,U.B., Cao,R., Zhang,J., Jia,T.,
            Wahlberg,E., Dissing,S. and Cao,Y.
  TITLE     IL-20 is an arteriogenic cytokine that remodels collateral networks
            and improves functions of ischemic hind limbs
  JOURNAL   Proc Natl Acad Sci U S A 104 (39), 15364-15369 (2007)
   PUBMED   17878297
  REMARK    GeneRIF: IL-20 is an arteriogenic cytokine that remodels collateral
            networks and improves functions of ischemic hind limbs
REFERENCE   7  (bases 1 to 1031)
  AUTHORS   Chen,W.Y., Cheng,B.C., Jiang,M.J., Hsieh,M.Y. and Chang,M.S.
  TITLE     IL-20 is expressed in atherosclerosis plaques and promotes
            atherosclerosis in apolipoprotein E-deficient mice
  JOURNAL   Arterioscler Thromb Vasc Biol 26 (9), 2090-2095 (2006)
   PUBMED   16778121
  REMARK    GeneRIF: IL-20 is a proatherogenic cytokine that contributes to the
            progression of atherosclerosis.
REFERENCE   8  (bases 1 to 1031)
  AUTHORS   Liu,L., Ding,C., Zeng,W., Heuer,J.G., Tetreault,J.W., Noblitt,T.W.,
            Hangoc,G., Cooper,S., Brune,K.A., Sharma,G., Fox,N.,
            Rowlinson,S.W., Rogers,D.P., Witcher,D.R., Lambooy,P.K.,
            Wroblewski,V.J., Miller,J.R. and Broxmeyer,H.E.
  TITLE     Selective enhancement of multipotential hematopoietic progenitors
            in vitro and in vivo by IL-20
  JOURNAL   Blood 102 (9), 3206-3209 (2003)
   PUBMED   12855566
REFERENCE   9  (bases 1 to 1031)
  AUTHORS   Rich,B.E. and Kupper,T.S.
  TITLE     Cytokines: IL-20 - a new effector in skin inflammation
  JOURNAL   Curr Biol 11 (13), R531-R534 (2001)
   PUBMED   11470428
REFERENCE   10 (bases 1 to 1031)
  AUTHORS   Blumberg,H., Conklin,D., Xu,W.F., Grossmann,A., Brender,T.,
            Carollo,S., Eagan,M., Foster,D., Haldeman,B.A., Hammond,A.,
            Haugen,H., Jelinek,L., Kelly,J.D., Madden,K., Maurer,M.F.,
            Parrish-Novak,J., Prunkard,D., Sexson,S., Sprecher,C., Waggie,K.,
            West,J., Whitmore,T.E., Yao,L., Kuechle,M.K., Dale,B.A. and
            Chandrasekher,Y.A.
  TITLE     Interleukin 20: discovery, receptor identification, and role in
            epidermal function
  JOURNAL   Cell 104 (1), 9-19 (2001)
   PUBMED   11163236
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AF224267.1 and BB064801.2.
            
            On Jul 24, 2015 this sequence version replaced NM_021380.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK078698.1, BC111821.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-824               AF224267.1         1-824
            825-1031            BB064801.2         489-695
FEATURES             Location/Qualifiers
     source          1..1031
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 56.89 cM"
     gene            1..1031
                     /gene="Il20"
                     /gene_synonym="If2d; Zcyto10"
                     /note="interleukin 20"
                     /db_xref="GeneID:58181"
                     /db_xref="MGI:MGI:1890473"
     exon            1..229
                     /gene="Il20"
                     /gene_synonym="If2d; Zcyto10"
                     /inference="alignment:Splign:2.1.0"
     CDS             71..601
                     /gene="Il20"
                     /gene_synonym="If2d; Zcyto10"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; four helix bundle cytokine 10; IL-20; four
                     alpha helix cytokine ZCYTO10; cytokine Zcyto10; interferon
                     2d"
                     /codon_start=1
                     /product="interleukin-20 isoform 1 precursor"
                     /protein_id="NP_067355.1"
                     /db_xref="CCDS:CCDS15263.1"
                     /db_xref="GeneID:58181"
                     /db_xref="MGI:MGI:1890473"
                     /translation="MKGFGLAFGLFSAVGFLLWTPLTGLKTLHLGSCVITANLQAIQK
                     EFSEIRDSVQAEDTNIDIRILRTTESLKDIKSLDRCCFLRHLVRFYLDRVFKVYQTPD
                     HHTLRKISSLANSFLIIKKDLSVCHSHMACHCGEEAMEKYNQILSHFIELELQAAVVK
                     ALGELGILLRWMEEML"
     exon            230..295
                     /gene="Il20"
                     /gene_synonym="If2d; Zcyto10"
                     /inference="alignment:Splign:2.1.0"
     exon            296..448
                     /gene="Il20"
                     /gene_synonym="If2d; Zcyto10"
                     /inference="alignment:Splign:2.1.0"
     exon            449..523
                     /gene="Il20"
                     /gene_synonym="If2d; Zcyto10"
                     /inference="alignment:Splign:2.1.0"
     exon            524..1031
                     /gene="Il20"
                     /gene_synonym="If2d; Zcyto10"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tgggagacat cgatagccct gattgatctc tttgaatttt cgcttctggt ctccaggatc
       61 taggtgtaag atgaaaggct ttggtcttgc ctttggactg ttctccgctg tgggttttct
      121 tctctggact cctttaactg ggctcaagac cctccatttg ggaagctgtg tgattactgc
      181 aaacctacag gcaatacaaa aggaattttc tgagattcgg gatagtgtgc aagctgaaga
      241 tacaaatatt gacatcagaa ttttaaggac gactgagtct ttgaaagaca taaagtcttt
      301 ggataggtgc tgcttccttc gtcatctagt gagattctat ctggacaggg tattcaaagt
      361 ctaccagacc cctgaccacc ataccctgag aaagatcagc agcctcgcca actcctttct
      421 tatcatcaag aaggacctct cagtctgtca ttctcacatg gcatgtcatt gtggggaaga
      481 agcaatggag aaatacaacc aaattctgag tcacttcata gagttggaac ttcaggcagc
      541 ggtggtaaag gctttgggag aactaggcat tcttctgaga tggatggagg agatgctata
      601 gatgaaagtg gagaggctgc tgagaacact cctgtccaag aatctcagac ctcagcacca
      661 tgaagacatg gccccaggtg ctggcatttc tactcaagag ttccagtcct cagcaccacg
      721 aagatggcct caaaccacca cccctttgtg atataactta gtgctagcta tgtgtatatt
      781 atttctacat tattggctcc cttatgtgaa tgccttcatg tgtctctgta ttcccttaca
      841 ctgcaatttt gtaaaatatt ctgtaatgta ctttctaatg ctatctatat ttattcattg
      901 atatgtgtat ttattttcta tttaacttct atttattttt ttacttgaac acaagactta
      961 gaagattata tttataacct gtcaagagca ggtgatgtat tttcatataa taaacaagcc
     1021 tgttaaattc c
//
