LOCUS       NM_008366                955 bp    mRNA    linear   ROD 11-FEB-2025
DEFINITION  Mus musculus interleukin 2 (Il2), mRNA.
ACCESSION   NM_008366 XM_207774
VERSION     NM_008366.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 955)
  AUTHORS   Burrows,K., Ngai,L., Chiaranunt,P., Watt,J., Popple,S., Forde,B.,
            Denha,S., Olyntho,V.M., Tai,S.L., Cao,E.Y., Tejeda-Garibay,S.,
            Koenig,J.F.E., Mayer-Barber,K.D., Streutker,C.J., Hoyer,K.K.,
            Osborne,L.C., Liu,J., O'Mahony,L. and Mortha,A.
  TITLE     A gut commensal protozoan determines respiratory disease outcomes
            by shaping pulmonary immunity
  JOURNAL   Cell 188 (2), 316-330 (2025)
   PUBMED   39706191
REFERENCE   2  (bases 1 to 955)
  AUTHORS   He,K., Xiao,H., MacDonald,W.A., Mehta,I., Kishore,A., Vincent,A.,
            Xu,Z., Ray,A., Chen,W., Weaver,C.T., Lambrecht,B.N., Das,J. and
            Poholek,A.C.
  TITLE     Spatial microniches of IL-2 combine with IL-10 to drive lung
            migratory TH2 cells in response to inhaled allergen
  JOURNAL   Nat Immunol 25 (11), 2124-2139 (2024)
   PUBMED   39394532
  REMARK    GeneRIF: Spatial microniches of IL-2 combine with IL-10 to drive
            lung migratory TH2 cells in response to inhaled allergen.
REFERENCE   3  (bases 1 to 955)
  AUTHORS   Mitchell,J.S., Spanier,J.A., Dwyer,A.J., Knutson,T.P.,
            Alkhatib,M.H., Qian,G., Weno,M.E., Chen,Y., Shaheen,Z.R.,
            Tucker,C.G., Kangas,T.O., Morales,M.S., Silva,N., Kaisho,T.,
            Farrar,M.A. and Fife,B.T.
  TITLE     CD4+ T cells reactive to a hybrid peptide from insulin-chromogranin
            A adopt a distinct effector fate and are pathogenic in autoimmune
            diabetes
  JOURNAL   Immunity 57 (10), 2399-2415 (2024)
   PUBMED   39214091
REFERENCE   4  (bases 1 to 955)
  AUTHORS   Lin,J.X., Ge,M., Liu,C.Y., Holewinski,R., Andresson,T., Yu,Z.X.,
            Gebregiorgis,T., Spolski,R., Li,P. and Leonard,W.J.
  TITLE     Tyrosine phosphorylation of both STAT5A and STAT5B is necessary for
            maximal IL-2 signaling and T cell proliferation
  JOURNAL   Nat Commun 15 (1), 7372 (2024)
   PUBMED   39191751
  REMARK    GeneRIF: Tyrosine phosphorylation of both STAT5A and STAT5B is
            necessary for maximal IL-2 signaling and T cell proliferation.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 955)
  AUTHORS   Geels,S.N., Moshensky,A., Sousa,R.S., Murat,C., Bustos,M.A.,
            Walker,B.L., Singh,R., Harbour,S.N., Gutierrez,G., Hwang,M.,
            Mempel,T.R., Weaver,C.T., Nie,Q., Hoon,D.S.B., Ganesan,A.K.,
            Othy,S. and Marangoni,F.
  TITLE     Interruption of the intratumor CD8+ T cell:Treg crosstalk improves
            the efficacy of PD-1 immunotherapy
  JOURNAL   Cancer Cell 42 (6), 1051-1066 (2024)
   PUBMED   38861924
REFERENCE   6  (bases 1 to 955)
  AUTHORS   Yamashita,T. and Boros,D.L.
  TITLE     IL-4 influences IL-2 production and granulomatous inflammation in
            murine schistosomiasis mansoni
  JOURNAL   J Immunol 149 (11), 3659-3664 (1992)
   PUBMED   1431136
REFERENCE   7  (bases 1 to 955)
  AUTHORS   Cavallo,F., Giovarelli,M., Gulino,A., Vacca,A., Stoppacciaro,A.,
            Modesti,A. and Forni,G.
  TITLE     Role of neutrophils and CD4+ T lymphocytes in the primary and
            memory response to nonimmunogenic murine mammary adenocarcinoma
            made immunogenic by IL-2 gene
  JOURNAL   J Immunol 149 (11), 3627-3635 (1992)
   PUBMED   1358974
REFERENCE   8  (bases 1 to 955)
  AUTHORS   Matesanz,F., Alcina,A. and Pellicer,A.
  TITLE     A new cDNA sequence for the murine interleukin-2 gene
  JOURNAL   Biochim Biophys Acta 1132 (3), 335-336 (1992)
   PUBMED   1420317
REFERENCE   9  (bases 1 to 955)
  AUTHORS   Wang,F., Millet,I., Bottomly,K. and Vignery,A.
  TITLE     Calcitonin gene-related peptide inhibits interleukin 2 production
            by murine T lymphocytes
  JOURNAL   J Biol Chem 267 (29), 21052-21057 (1992)
   PUBMED   1383217
REFERENCE   10 (bases 1 to 955)
  AUTHORS   Kim,T.S., Russell,S.J., Collins,M.K. and Cohen,E.P.
  TITLE     Immunity to B16 melanoma in mice immunized with IL-2-secreting
            allogeneic mouse fibroblasts expressing melanoma-associated
            antigens
  JOURNAL   Int J Cancer 51 (2), 283-289 (1992)
   PUBMED   1533203
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            K02292.1 and BX519775.1.
            
            On Mar 26, 2010 this sequence version replaced NM_008366.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: K02292.1, X01772.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164133 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-824               K02292.1           1-824
            825-955             BX519775.1         304-434
FEATURES             Location/Qualifiers
     source          1..955
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 18.3 cM"
     gene            1..955
                     /gene="Il2"
                     /gene_synonym="Il-2"
                     /note="interleukin 2"
                     /db_xref="GeneID:16183"
                     /db_xref="MGI:MGI:96548"
     exon            1..237
                     /gene="Il2"
                     /gene_synonym="Il-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             49..558
                     /gene="Il2"
                     /gene_synonym="Il-2"
                     /note="TCGF; T-cell growth factor"
                     /codon_start=1
                     /product="interleukin-2 precursor"
                     /protein_id="NP_032392.1"
                     /db_xref="CCDS:CCDS17316.1"
                     /db_xref="GeneID:16183"
                     /db_xref="MGI:MGI:96548"
                     /translation="MYSMQLASCVTLTLVLLVNSAPTSSSTSSSTAEAQQQQQQQQQQ
                     QQHLEQLLMDLQELLSRMENYRNLKLPRMLTFKFYLPKQATELKDLQCLEDELGPLRH
                     VLDLTQSKSFQLEDAENFISNIRVTVVKLKGSDNTFECQFDDESATVVDFLRRWIAFC
                     QSIISTSPQ"
     exon            238..297
                     /gene="Il2"
                     /gene_synonym="Il-2"
                     /inference="alignment:Splign:2.1.0"
     exon            298..444
                     /gene="Il2"
                     /gene_synonym="Il-2"
                     /inference="alignment:Splign:2.1.0"
     exon            445..949
                     /gene="Il2"
                     /gene_synonym="Il-2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      794..799
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Il2"
                     /gene_synonym="Il-2"
                     /note="hexamer: AATAAA"
     polyA_site      824
                     /gene="Il2"
                     /gene_synonym="Il-2"
                     /note="major polyA site"
ORIGIN      
        1 tatcaccctt gctaatcact cctcacagtg acctcaagtc ctgcaggcat gtacagcatg
       61 cagctcgcat cctgtgtcac attgacactt gtgctccttg tcaacagcgc acccacttca
      121 agctccactt caagctctac agcggaagca cagcagcagc agcagcagca gcagcagcag
      181 cagcagcacc tggagcagct gttgatggac ctacaggagc tcctgagcag gatggagaat
      241 tacaggaacc tgaaactccc caggatgctc accttcaaat tttacttgcc caagcaggcc
      301 acagaattga aagatcttca gtgcctagaa gatgaacttg gacctctgcg gcatgttctg
      361 gatttgactc aaagcaaaag ctttcaattg gaagatgctg agaatttcat cagcaatatc
      421 agagtaactg ttgtaaaact aaagggctct gacaacacat ttgagtgcca attcgatgat
      481 gagtcagcaa ctgtggtgga ctttctgagg agatggatag ccttctgtca aagcatcatc
      541 tcaacaagcc ctcaataact atgtacctcc tgcttacaac acataaggct ctctatttat
      601 ttaaatattt aactttaatt tatttttgga tgtattgttt actatctttt gtaactacta
      661 gtcttcagat gataaatatg gatctttaaa gattcttttt gtaagcccca agggctcaaa
      721 aatgttttaa actatttatc tgaaattatt tattatattg aattgttaaa tatcatgtgt
      781 aggtagactc attaataaaa gtatttagat gattcaaata taaataagct cagatgtctg
      841 tcatttttag gacagcacaa agtaagcgct aaaataactt ctcagttatt cctgtgaact
      901 ctatgttaat cagtgttttc aagaaataaa gctctcctct aaaaaaaaaa aaaaa
//
