LOCUS       NM_001039701            2480 bp    mRNA    linear   ROD 24-OCT-2024
DEFINITION  Mus musculus interleukin 1 receptor antagonist (Il1rn), transcript
            variant 2, mRNA.
ACCESSION   NM_001039701
VERSION     NM_001039701.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2480)
  AUTHORS   Wang,R., Zhu,Z., Peng,S., Xu,J., Chen,Y., Wei,S. and Liu,X.
  TITLE     Exosome microRNA-125a-5p derived from epithelium promotes M1
            macrophage polarization by targeting IL1RN in chronic obstructive
            pulmonary disease
  JOURNAL   Int Immunopharmacol 137, 112466 (2024)
   PUBMED   38875998
  REMARK    GeneRIF: Exosome microRNA-125a-5p derived from epithelium promotes
            M1 macrophage polarization by targeting IL1RN in chronic
            obstructive pulmonary disease.
REFERENCE   2  (bases 1 to 2480)
  AUTHORS   Belbezier,A., Engeroff,P., Fourcade,G., Vantomme,H., Vaineau,R.,
            Gouritin,B., Bellier,B., Brocheriou,I., Tchitchek,N.,
            Graff-Dubois,S. and Klatzmann,D.
  TITLE     Interleukin-1 regulates follicular T cells during the germinal
            center reaction
  JOURNAL   Front Immunol 15, 1393096 (2024)
   PUBMED   38855101
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2480)
  AUTHORS   Griffith,J.W., Faustino,L.D., Cottrell,V.I., Nepal,K., Hariri,L.P.,
            Chiu,R.S., Jones,M.C., Jule,A., Gabay,C. and Luster,A.D.
  TITLE     Regulatory T cell-derived IL-1Ra suppresses the innate response to
            respiratory viral infection
  JOURNAL   Nat Immunol 24 (12), 2091-2107 (2023)
   PUBMED   37945820
  REMARK    GeneRIF: Regulatory T cell-derived IL-1Ra suppresses the innate
            response to respiratory viral infection.
REFERENCE   4  (bases 1 to 2480)
  AUTHORS   Deshayes,S., Bauge,C., Dupont,P.A., Simard,C., Rida,H., de
            Boysson,H., Manrique,A. and Aouba,A.
  TITLE     [18F]FDG PET-MR characterization of aortitis in the IL1rn-/- mouse
            model of giant-cell arteritis
  JOURNAL   EJNMMI Res 13 (1), 103 (2023)
   PUBMED   38019303
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2480)
  AUTHORS   Cao,M., Chen,P., Peng,B., Cheng,Y., Xie,J., Hou,Z., Chen,H., Ye,L.,
            Li,H., Wang,H., Ren,L., Xiong,L., Geng,L. and Gong,S.
  TITLE     The transcription factor ELF4 alleviates inflammatory bowel disease
            by activating IL1RN transcription, suppressing inflammatory TH17
            cell activity, and inducing macrophage M2 polarization
  JOURNAL   Front Immunol 14, 1270411 (2023)
   PUBMED   38022496
  REMARK    GeneRIF: The transcription factor ELF4 alleviates inflammatory
            bowel disease by activating IL1RN transcription, suppressing
            inflammatory TH17 cell activity, and inducing macrophage M2
            polarization.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2480)
  AUTHORS   Hoopes,C.W., Taketo,M., Ozato,K., Liu,Q., Howard,T.A., Linney,E.
            and Seldin,M.F.
  TITLE     Mapping of the mouse Rxr loci encoding nuclear retinoid X receptors
            RXR alpha, RXR beta, and RXR gamma
  JOURNAL   Genomics 14 (3), 611-617 (1992)
   PUBMED   1358808
REFERENCE   7  (bases 1 to 2480)
  AUTHORS   Shuck,M.E., Eessalu,T.E., Tracey,D.E. and Bienkowski,M.J.
  TITLE     Cloning, heterologous expression and characterization of murine
            interleukin 1 receptor antagonist protein
  JOURNAL   Eur J Immunol 21 (11), 2775-2780 (1991)
   PUBMED   1834470
REFERENCE   8  (bases 1 to 2480)
  AUTHORS   Matsushime,H., Roussel,M.F., Matsushima,K., Hishinuma,A. and
            Sherr,C.J.
  TITLE     Cloning and expression of murine interleukin-1 receptor antagonist
            in macrophages stimulated by colony-stimulating factor 1
  JOURNAL   Blood 78 (3), 616-623 (1991)
   PUBMED   1830498
REFERENCE   9  (bases 1 to 2480)
  AUTHORS   Eisenberg,S.P., Brewer,M.T., Verderber,E., Heimdal,P.,
            Brandhuber,B.J. and Thompson,R.C.
  TITLE     Interleukin 1 receptor antagonist is a member of the interleukin 1
            gene family: evolution of a cytokine control mechanism
  JOURNAL   Proc Natl Acad Sci U S A 88 (12), 5232-5236 (1991)
   PUBMED   1828896
REFERENCE   10 (bases 1 to 2480)
  AUTHORS   Zahedi,K., Seldin,M.F., Rits,M., Ezekowitz,R.A. and Whitehead,A.S.
  TITLE     Mouse IL-1 receptor antagonist protein. Molecular characterization,
            gene mapping, and expression of mRNA in vitro and in vivo
  JOURNAL   J Immunol 146 (12), 4228-4233 (1991)
   PUBMED   1828262
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK155641.1 and AL732528.12.
            
            On Apr 21, 2009 this sequence version replaced NM_001039701.2.
            
            Transcript Variant: This variant (2) lacks an alternate segment
            compared to variant 3, that removes the translation initiation
            site. The resulting isoform (2) starts at a downstream AUG and has
            a shorter and distinct N-terminus compared to isoform 3.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK155641.1, AK154601.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1415              AK155641.1         2-1416
            1416-2480           AL732528.12        30817-31881
FEATURES             Location/Qualifiers
     source          1..2480
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 16.36 cM"
     gene            1..2480
                     /gene="Il1rn"
                     /gene_synonym="F630041P17Rik; IL-1ra"
                     /note="interleukin 1 receptor antagonist"
                     /db_xref="GeneID:16181"
                     /db_xref="MGI:MGI:96547"
     exon            1..201
                     /gene="Il1rn"
                     /gene_synonym="F630041P17Rik; IL-1ra"
                     /inference="alignment:Splign:2.1.0"
     exon            202..290
                     /gene="Il1rn"
                     /gene_synonym="F630041P17Rik; IL-1ra"
                     /inference="alignment:Splign:2.1.0"
     exon            291..403
                     /gene="Il1rn"
                     /gene_synonym="F630041P17Rik; IL-1ra"
                     /inference="alignment:Splign:2.1.0"
     exon            404..2480
                     /gene="Il1rn"
                     /gene_synonym="F630041P17Rik; IL-1ra"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1906..1911
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Il1rn"
                     /gene_synonym="F630041P17Rik; IL-1ra"
                     /note="hexamer: AATAAA"
     polyA_site      1925
                     /gene="Il1rn"
                     /gene_synonym="F630041P17Rik; IL-1ra"
                     /note="major polyA site"
     regulatory      2455..2460
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Il1rn"
                     /gene_synonym="F630041P17Rik; IL-1ra"
                     /note="hexamer: AATAAA"
     polyA_site      2474
                     /gene="Il1rn"
                     /gene_synonym="F630041P17Rik; IL-1ra"
                     /note="major polyA site"
ORIGIN      
        1 gaatgactac tttctttata agcaaccacc ttgagcctga aatggcagtc gctagtctct
       61 attgccttgc tgtggcctcg ggatggaaat ctgctgggga ccctacagtc acctaatctc
      121 tctccttctc atccttctgt ttcattcaga ggcagcctgc cgcccttctg ggaaaagacc
      181 ctgcaagatg caagccttca gaatctggga tactaaccag aagacctttt acctgagaaa
      241 caaccagctc attgctgggt acttacaagg accaaatatc aaactagaag aaaagataga
      301 catggtgcct attgaccttc atagtgtgtt cttgggcatc cacgggggca agctgtgcct
      361 gtcttgtgcc aagtctggag atgatatcaa gctccagctg gaggaagtta acatcactga
      421 tctgagcaag aacaaagaag aagacaagcg ctttaccttc atccgctctg agaaaggccc
      481 caccaccagc tttgagtcag ctgcctgtcc aggatggttc ctctgcacaa cactagaggc
      541 tgaccgtcct gtgagcctca ccaacacacc ggaagagccc cttatagtca cgaagttcta
      601 cttccaggaa gaccaatagt actgccgagg cctgtaataa tcaccaactg cctgatcact
      661 ctggccatca ttggggcctg aggaacaact tttgcagggt gtatgtacag tagaaggaga
      721 cagaagagtt ctgatgatag atctctgcct cagtctgttg gctggcctaa tccccatgat
      781 gattccagaa taatcttgca aattggatca tggcaggtgc ttgttcaaag ccctttcttg
      841 ttgcctctgc catctgggtg aagtctagac cacttgcttg gcctaggtgt cttctgctct
      901 accacccacc ctacccctgc cacaaacaca cacttttttt gtttttgttt tttccattgt
      961 tctgcacttc cacagtccag accaatcaag tcacttgaca atatgcccca agtgactccc
     1021 ttaccctgtt ttataaacct gtgcctgtct atggagaagg ttttaattct ccttgttatt
     1081 cattttgggc tttttgatga aaccaccagg gcatcacata tactaagcat gtgctctacc
     1141 atcatgctat gcttccagct caggggggca cttttaagga tctagaaaac agaaattaag
     1201 gatctcatag ttattttatt aggccagcct tattccatgt cggcaagagg tttcttgtgg
     1261 aaattatgtc ctttctgaga ggagctgggg attagatgct cctgcatttg tgaaatggtt
     1321 ataagcatag aaaaataggt ggtaagcttt ccttctttcc ttattttgtg tgatgcctta
     1381 aactgaaaag ttaaaaattg atggattgta gcattcccat aatctccccc ttcttttttt
     1441 ttcctttgga aatgtccaat agtctatatt cctctgtccc gcccaaacac catcttcact
     1501 ccaagcctac cacagatgcc tgaagaagtt cctcactatc tgcaaatgtg gctctcaggc
     1561 ccttcctgat gtgatgaatg aatctactaa tcatttcttg accattcatt ttatcacttc
     1621 taaccttgaa acatgtggaa gtagctatgt tcctgactgt ttcctctgcc agacaatgaa
     1681 ctctggagat cagggagctt cgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg
     1741 tgtgcgtgcg cgcgcgcgtg cgcacgcacg tgcatgcaca tgctatgtat tgggtccctc
     1801 caaggatgaa ccctctcttt ggcttagaag gcactcagag aatatgtgtt attcgtgctc
     1861 acggaaagtt tcttactcat ccctgtgact ttggctttat tttacaataa aacactgaaa
     1921 atgtccactt tgttagttgt gaacatgagc ccaggcctaa ggtgctggga aacagaaagg
     1981 gcgggagatt tttctttatt ctatggctag aaaatagtta cctcctctct gaaagtcttc
     2041 ttcctcattt ctgggtaaca gaatatcaaa caccttgctt ataagttata aagtagtgtt
     2101 gtccaccatg aacccaccaa gtaaaaacaa cccaaatacc tatcatggat gaataatcat
     2161 gcaagtatca gatctgcact caatgccaca caatgacaaa gatagcaaat gagccacaga
     2221 cggctccacc caacccaata gatgaacact tggttcaaaa tcactaaagc tcaaatactc
     2281 ccaggtcaaa caccaggtaa caagttaata ctcaacaaag ggggaaaaca aatgttccac
     2341 tgaatcctgt gaccctgtgg gcgtggttca cctcctgtgt tgtttgccat gtgtgctcag
     2401 gatgagctga ttaaagctct tctcaggggt tcagttttcc catctctgct tgtaaataaa
     2461 aagcttatgc agaatactga
//
