LOCUS       NM_001356478            4002 bp    mRNA    linear   ROD 10-DEC-2024
DEFINITION  Mus musculus interleukin 1 receptor-like 2 (Il1rl2), transcript
            variant 2, mRNA.
ACCESSION   NM_001356478 XM_006495608
VERSION     NM_001356478.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4002)
  AUTHORS   Hayashi,Y., Kamimura-Aoyagi,Y., Nishikawa,S., Noka,R., Iwata,R.,
            Iwabuchi,A., Watanabe,Y., Matsunuma,N., Yuki,K., Kobayashi,H.,
            Harada,Y. and Harada,H.
  TITLE     IL36G-producing neutrophil-like monocytes promote cachexia in
            cancer
  JOURNAL   Nat Commun 15 (1), 7662 (2024)
   PUBMED   39266531
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4002)
  AUTHORS   Tongmuang,N., Krishnan,M., Connor,V., Crump,C. and Jensen,L.E.
  TITLE     UL56 Is Essential for Herpes Simplex Virus-1 Virulence In Vivo but
            Is Dispensable for Induction of Host-Protective Immunity
  JOURNAL   Vaccines (Basel) 12 (8), 837 (2024)
   PUBMED   39203963
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4002)
  AUTHORS   Tongmuang,N., Cai,K.Q., An,J., Novy,M. and Jensen,L.E.
  TITLE     Floxed Il1rl2 Locus with mCherry Reporter Element Reveals Distinct
            Expression Patterns of the IL-36 Receptor in Barrier Tissues
  JOURNAL   Cells 13 (9), 787 (2024)
   PUBMED   38727323
  REMARK    GeneRIF: Floxed Il1rl2 Locus with mCherry Reporter Element Reveals
            Distinct Expression Patterns of the IL-36 Receptor in Barrier
            Tissues.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4002)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   5  (bases 1 to 4002)
  AUTHORS   Zhou,H., Zhao,Q., Yue,C., Yu,J., Zheng,H., Hu,J., Hu,Z., Zhang,H.,
            Teng,X., Liu,X., Wei,X., Zhou,Y., Zeng,F., Hao,Y., Hu,Y., Wang,X.,
            Zhang,C., Gu,L., Wu,W., Zhou,Y., Cui,K., Huang,N., Li,W., Wang,Z.
            and Li,J.
  TITLE     Interleukin-38 promotes skin tumorigenesis in an IL-1Rrp2-dependent
            manner
  JOURNAL   EMBO Rep 23 (6), e53791 (2022)
   PUBMED   35578812
  REMARK    GeneRIF: Interleukin-38 promotes skin tumorigenesis in an
            IL-1Rrp2-dependent manner.
REFERENCE   6  (bases 1 to 4002)
  AUTHORS   Vigne,S., Palmer,G., Lamacchia,C., Martin,P., Talabot-Ayer,D.,
            Rodriguez,E., Ronchi,F., Sallusto,F., Dinh,H., Sims,J.E. and
            Gabay,C.
  TITLE     IL-36R ligands are potent regulators of dendritic and T cells
  JOURNAL   Blood 118 (22), 5813-5823 (2011)
   PUBMED   21860022
REFERENCE   7  (bases 1 to 4002)
  AUTHORS   Blumberg,H., Dinh,H., Dean,C. Jr., Trueblood,E.S., Bailey,K.,
            Shows,D., Bhagavathula,N., Aslam,M.N., Varani,J., Towne,J.E. and
            Sims,J.E.
  TITLE     IL-1RL2 and its ligands contribute to the cytokine network in
            psoriasis
  JOURNAL   J Immunol 185 (7), 4354-4362 (2010)
   PUBMED   20833839
REFERENCE   8  (bases 1 to 4002)
  AUTHORS   Egawa,G., Osawa,M., Uemura,A., Miyachi,Y. and Nishikawa,S.
  TITLE     Transient expression of ephrin b2 in perinatal skin is required for
            maintenance of keratinocyte homeostasis
  JOURNAL   J Invest Dermatol 129 (10), 2386-2395 (2009)
   PUBMED   19571816
REFERENCE   9  (bases 1 to 4002)
  AUTHORS   Blumberg,H., Dinh,H., Trueblood,E.S., Pretorius,J., Kugler,D.,
            Weng,N., Kanaly,S.T., Towne,J.E., Willis,C.R., Kuechle,M.K.,
            Sims,J.E. and Peschon,J.J.
  TITLE     Opposing activities of two novel members of the IL-1 ligand family
            regulate skin inflammation
  JOURNAL   J Exp Med 204 (11), 2603-2614 (2007)
   PUBMED   17908936
REFERENCE   10 (bases 1 to 4002)
  AUTHORS   Born,T.L., Smith,D.E., Garka,K.E., Renshaw,B.R., Bertles,J.S. and
            Sims,J.E.
  TITLE     Identification and characterization of two members of a novel class
            of the interleukin-1 receptor (IL-1R) family. Delineation of a new
            class of IL-1R-related proteins based on signaling
  JOURNAL   J Biol Chem 275 (39), 29946-29954 (2000)
   PUBMED   10882729
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC167168.5.
            
            On Oct 5, 2017 this sequence version replaced XM_006495608.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK085780.1, SRR9219382.35126.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-161               AC167168.5         116246-116406       c
            162-231             AC167168.5         114437-114506       c
            232-466             AC167168.5         113389-113623       c
            467-665             AC167168.5         111826-112024       c
            666-828             AC167168.5         97805-97967         c
            829-900             AC167168.5         95118-95189         c
            901-1030            AC167168.5         89930-90059         c
            1031-1167           AC167168.5         89097-89233         c
            1168-1311           AC167168.5         84033-84176         c
            1312-1473           AC167168.5         77642-77803         c
            1474-4002           AC167168.5         73440-75968         c
FEATURES             Location/Qualifiers
     source          1..4002
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 18.96 cM"
     gene            1..4002
                     /gene="Il1rl2"
                     /gene_synonym="IL-1Rrp2"
                     /note="interleukin 1 receptor-like 2"
                     /db_xref="GeneID:107527"
                     /db_xref="MGI:MGI:1913107"
     exon            1..161
                     /gene="Il1rl2"
                     /gene_synonym="IL-1Rrp2"
                     /inference="alignment:Splign:2.1.0"
     exon            162..231
                     /gene="Il1rl2"
                     /gene_synonym="IL-1Rrp2"
                     /inference="alignment:Splign:2.1.0"
     CDS             168..1892
                     /gene="Il1rl2"
                     /gene_synonym="IL-1Rrp2"
                     /EC_number="3.2.2.6"
                     /note="interleukin-1 receptor related protein 2; IL1R-rp2;
                     IL-36 receptor"
                     /codon_start=1
                     /product="interleukin-1 receptor-like 2 precursor"
                     /protein_id="NP_001343407.1"
                     /db_xref="CCDS:CCDS14910.1"
                     /db_xref="GeneID:107527"
                     /db_xref="MGI:MGI:1913107"
                     /translation="MGVTSLLFCGVFFLLLLFVAADTCEDIFMHNVIISEGQPFPFNC
                     TYPPETNGAVNLTWYKTPSKSPVSNNRHLRVHQDQTWILFLPLTLEDSGIYQCVIRNA
                     HNCYQIAVNLTVLKNHWCDSSMEGSPVNSPDVYQQILPIGKSGSLNCHLYFPESCALD
                     SIKWYKGCEEIKAGKKYSPSGAKLLVNNVAVEDGGSYACSARLTHLGRHFTIRNYIAV
                     NTKEVEYGRRIPNITYPKNNSIEVPLGSTLIVNCNITDTKENTNLRCWRVNNTLVDDY
                     YKDSKRIQEGIETNVSLRDQIRYTVNITFLKVKMEDYGRPFTCHAGVSAAYIILIYPV
                     PDFRAYLLGGLMAFLLLVVSVLFIYNSFKIDIMLWYRSAFHTAQAPDDEKLYDAYVLY
                     PKYPRGSQGHDVDTLVLKILPEVLEKQCGYKLFIFGRDEFPGQAVASVIDENIKLCRR
                     LMVFVAPESSSFGFLKNLSEEQIAVYNALIQHGMKVILIELEKVKDYSTMPESIQYIR
                     QKHGAIQWDGDFTEQSQCAKTKFWKKVRYHMPPRRYPASSPVQLLGHIPCNCKAGKCN
                     AATGLITP"
     exon            232..466
                     /gene="Il1rl2"
                     /gene_synonym="IL-1Rrp2"
                     /inference="alignment:Splign:2.1.0"
     exon            467..665
                     /gene="Il1rl2"
                     /gene_synonym="IL-1Rrp2"
                     /inference="alignment:Splign:2.1.0"
     exon            666..828
                     /gene="Il1rl2"
                     /gene_synonym="IL-1Rrp2"
                     /inference="alignment:Splign:2.1.0"
     exon            829..900
                     /gene="Il1rl2"
                     /gene_synonym="IL-1Rrp2"
                     /inference="alignment:Splign:2.1.0"
     exon            901..1030
                     /gene="Il1rl2"
                     /gene_synonym="IL-1Rrp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1031..1167
                     /gene="Il1rl2"
                     /gene_synonym="IL-1Rrp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1168..1311
                     /gene="Il1rl2"
                     /gene_synonym="IL-1Rrp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1312..1473
                     /gene="Il1rl2"
                     /gene_synonym="IL-1Rrp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1474..4002
                     /gene="Il1rl2"
                     /gene_synonym="IL-1Rrp2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3981..3986
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Il1rl2"
                     /gene_synonym="IL-1Rrp2"
                     /note="hexamer: AATAAA"
     polyA_site      4002
                     /gene="Il1rl2"
                     /gene_synonym="IL-1Rrp2"
                     /note="major polyA site"
ORIGIN      
        1 ggcggacaga gaccggaagc tgggagatga tggcttctga tgtttgttgc ttacgcgaca
       61 cagcttgttt ggaattatgt ggcccttgac aactgcgtgg cacacacttc aagatacaaa
      121 agtgagaaga agaggggggt caccagagga gactgaagtc acctgagatg ggggttacat
      181 ctttgctctt ctgtggggtg tttttcctgc ttctgctttt cgtggcagca gatacgtgtg
      241 aggacatttt tatgcacaat gtgataattt cagagggcca gccttttcct ttcaactgca
      301 catacccgcc agaaacaaac ggggcagtaa atctgacatg gtacaaaaca cctagcaaaa
      361 gcccagtatc taacaacaga caccttagag ttcaccagga ccagacctgg atcttgtttc
      421 ttccattgac actggaggac tccggtatct atcagtgtgt tataaggaat gcccacaact
      481 gctaccaaat agctgtgaac ctaaccgttt taaaaaacca ctggtgtgac tcttccatgg
      541 aggggagtcc cgtaaattca ccagatgtgt accagcaaat attacccata ggaaaatcgg
      601 gcagtctgaa ttgtcatctc tacttcccag aaagttgtgc tttggattca ataaaatggt
      661 ataagggttg tgaagagatt aaagcgggga aaaagtacag cccttcagga gcaaagcttc
      721 ttgtgaacaa cgttgctgtg gaggacggcg ggagctatgc gtgctcagcc agactgactc
      781 acttggggag acacttcacc attagaaact acattgctgt gaacaccaag gaagttgagt
      841 atggaagaag gatccctaac atcacgtatc caaagaacaa ctccattgaa gttccacttg
      901 gctccaccct catcgtgaac tgcaatataa cagacacgaa ggagaataca aacctgaggt
      961 gctggagagt caacaacacc ctggtggatg actactacaa agactccaaa cgcatccagg
     1021 aaggaatcga aaccaatgtg tccttgaggg atcaaattcg gtacacagtg aacataacat
     1081 tcttaaaagt gaaaatggag gactacggcc gtcctttcac gtgtcatgct ggagtgtccg
     1141 cagcctacat cattctgata tacccagttc cagacttcag ggcttacctc ttaggagggc
     1201 ttatggcgtt cctacttctg gttgtatctg ttctgttcat ctacaacagc tttaagatcg
     1261 acatcatgct ttggtacaga agcgccttcc acactgccca ggctccagat gatgagaagc
     1321 tgtatgatgc ctatgtctta taccccaagt acccgagagg aagccagggc catgatgtag
     1381 acacactggt actgaagatc ttgcccgagg tgctggagaa acagtgtgga tataagttat
     1441 ttatatttgg cagggatgaa ttccctggac aagctgtggc cagcgtcatt gatgaaaaca
     1501 ttaagctgtg taggaggctg atggtctttg tggcaccaga gtcgtctagc ttcggctttc
     1561 taaagaactt gtcagaagaa caaattgccg tctacaatgc cctcatccag catggcatga
     1621 aggtcattct gatcgaactg gagaaagtca aagactacag caccatgccc gagtccattc
     1681 agtatatccg acagaagcac ggggccatcc aatgggatgg ggacttcaca gagcagtcac
     1741 agtgtgccaa gaccaagttc tggaagaaag tgagatacca tatgccaccc aggaggtatc
     1801 cagcatcttc cccagtccag ctgctgggac acataccctg caattgcaag gcaggcaaat
     1861 gcaatgctgc cacagggctc ataactccct gagagtggtt agtgtgtgtt ggctcacact
     1921 acatcctctc tgaattgtct actcatgtag ctggctcttt tgtgcttgtg agcgaccttg
     1981 tccttgccct tgtagctttt tgtttatttg tattgtttgc tggatgcttt cagtcatagc
     2041 tgatccttat tactcctgtt tgcttcatgg ctcctgaaaa cccatatact ccccaagcat
     2101 ggggtggctc taacgttggg cctccgtgtc agtgggatac tgaggatgac agatcaggtg
     2161 tccaggatgc ttgatcctgg tttgagatgg gaggctgggc agtctgagga taccaagtag
     2221 atagccttag ggaagatcag caaggacagt agtgcaatgt ctgtgtttgt ccagggtcca
     2281 caagattcta gtcctcaggc agtgtagact gcatttgaat ctccttcatt ttcctattgc
     2341 atttagttaa ctaaccattg tgagaacagg acagaggact gggagttggg ggtgggggga
     2401 ggtgacagag gatgggagtg tgtgtgtaag aggtgacagt tacatgatca atcctgggaa
     2461 atcagactca ggaaaccagc attagggtgc agatctgagt tttttgtgca gcccttaagc
     2521 ttatatacag cgttcgagcc aatcccaagc ccctaaaccc tcggccaatc atatcttgcc
     2581 acatcatcac tatgcctcaa tgaaagccct gcctgatgag gtaactcaaa aggaattggg
     2641 gtgggaagca tcatcccctg tcagaacttc cgtgaagatg gaggacgtag ccactacccc
     2701 acctcagttt ctttttgttg tctcaggttt gcaccagagc catcttaaat ctagtgacat
     2761 gtgcagcaaa tcatgactct tcaaggagct gcgggagcct gtggtgcctc gctctccatc
     2821 ccactttttc cttcacaggg ttgacttcca cgtcccccaa accatggtat tagcacgatg
     2881 cccctagaag ccgcttagat gtcgccagga ccaatggtct tcatttccct ctttcccagc
     2941 ccctgtgaat cttactattc taggaaattc aaatgagaga cacggtgcat tcacggtttc
     3001 tcattttatg actggcttct ttcatacacc acggatttct caagtgctct cgagattcat
     3061 ccattgatta gccttttgtt ttattattat cactactgtc tttctcttct ttttcttcct
     3121 ctttaaattt ctccccctcc tcacgagcat ccggagagga gcatagactc tctgcatgcc
     3181 tacagcgtga tgagctcacc gagggtccct tcaatcacaa gcttgtatgt tttgcttttc
     3241 ggtttctctt tgcaccatgg gaattgtaac tccttacaga ggatttgaag gttcgggtac
     3301 aaaggcgtca ctgactggtt ccttcttctg tcttcctcac cctgaatggg ctttgcttct
     3361 gggtgattcc tggaaattgt cagcagtgat ggagaaacct agggacaggg ctgactaatg
     3421 gggcctggcc tttcttcttt gaagcccagg acacagtgcc tgcctagtgg gtcctggaca
     3481 caccaggtgg ttccactctg ctcagtggta acatttttta gctgagtcat caacatcggg
     3541 tcctttagtg aggaggtgcg ggcatctctc cccagttaga tttggactct tacttccctg
     3601 ctcatttccc tttgaaagat tcaggagact atgtcagaag cagggagcca gcaccctgtg
     3661 tcttctccac gtggctcctt gtcacacctg tgaccaccaa ttttagaaaa tgtgtttcct
     3721 tgttctgacc acacttatgc ggacattagt tgaggctgtt gtcagaaagg aaaattaact
     3781 catttgaagt aaacattttc tggaaatctc tgacttctgt caggccaatg gtgctgaaaa
     3841 atttaaaact gaattcactt ttttggccag aaagctttcc tcttgccaac atgtcttaat
     3901 tttccttttg cttaaactta ttggagatgt attatgaatg ctaagatgtg agtgtgttat
     3961 atcagtacat tgacatttta aataaagtat attttaataa aa
//
