LOCUS       NP_001020773             567 aa            linear   ROD 26-NOV-2024
DEFINITION  interleukin-1 receptor-like 1 isoform a precursor [Mus musculus].
ACCESSION   NP_001020773 XP_006495805
VERSION     NP_001020773.1
DBSOURCE    REFSEQ: accession NM_001025602.4
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 567)
  AUTHORS   Hu,Y., Feng,Z., An,G., Lv,Z., Wang,J., Cui,Y., Corrigan,C.J.,
            Wang,W., Li,Q. and Ying,S.
  TITLE     Edwardsiella tarda induces airways inflammation and production of
            autoantibodies against lung tissues through regulation of the
            IL-33-ST2 axis
  JOURNAL   Immunology 173 (3), 575-589 (2024)
   PUBMED   39126327
  REMARK    GeneRIF: Edwardsiella tarda induces airways inflammation and
            production of autoantibodies against lung tissues through
            regulation of the IL-33-ST2 axis.
REFERENCE   2  (residues 1 to 567)
  AUTHORS   Donahue,K.L., Watkoske,H.R., Kadiyala,P., Du,W., Brown,K.,
            Scales,M.K., Elhossiny,A.M., Espinoza,C.E., Lasse Opsahl,E.L.,
            Griffith,B.D., Wen,Y., Sun,L., Velez-Delgado,A., Renollet,N.M.,
            Morales,J., Nedzesky,N.M., Baliira,R.K., Menjivar,R.E.,
            Medina-Cabrera,P.I., Rao,A., Allen,B., Shi,J., Frankel,T.L.,
            Carpenter,E.S., Bednar,F., Zhang,Y. and Pasca di Magliano,M.
  TITLE     Oncogenic KRAS-Dependent Stromal Interleukin-33 Directs the
            Pancreatic Microenvironment to Promote Tumor Growth
  JOURNAL   Cancer Discov 14 (10), 1964-1989 (2024)
   PUBMED   38958646
REFERENCE   3  (residues 1 to 567)
  AUTHORS   Burton,O.T., Bricard,O., Tareen,S., Gergelits,V., Andrews,S.,
            Biggins,L., Roca,C.P., Whyte,C., Junius,S., Brajic,A., Pasciuto,E.,
            Ali,M., Lemaitre,P., Schlenner,S.M., Ishigame,H., Brown,B.D.,
            Dooley,J. and Liston,A.
  TITLE     The tissue-resident regulatory T cell pool is shaped by transient
            multi-tissue migration and a conserved residency program
  JOURNAL   Immunity 57 (7), 1586-1602 (2024)
   PUBMED   38897202
REFERENCE   4  (residues 1 to 567)
  AUTHORS   Liu,A., Hayashi,M., Ohsugi,Y., Katagiri,S., Akira,S., Iwata,T. and
            Nakashima,T.
  TITLE     The IL-33/ST2 axis is protective against acute inflammation during
            the course of periodontitis
  JOURNAL   Nat Commun 15 (1), 2707 (2024)
   PUBMED   38548743
  REMARK    GeneRIF: The IL-33/ST2 axis is protective against acute
            inflammation during the course of periodontitis.
            Publication Status: Online-Only
REFERENCE   5  (residues 1 to 567)
  AUTHORS   Wang,P., Yang,S., Li,C., Ma,B., Yi,M., Chen,X. and Yu,M.
  TITLE     Sulfotransferase homolog 2 receptors blockade on monocyte subsets
            along with their inflammatory cytokines for septic lung injury
  JOURNAL   Exp Lung Res 50 (1), 146-159 (2024)
   PUBMED   39243130
  REMARK    GeneRIF: Sulfotransferase homolog 2 receptors blockade on monocyte
            subsets along with their inflammatory cytokines for septic lung
            injury.
REFERENCE   6  (residues 1 to 567)
  AUTHORS   Lanahan,A., Williams,J.B., Sanders,L.K. and Nathans,D.
  TITLE     Growth factor-induced delayed early response genes
  JOURNAL   Mol Cell Biol 12 (9), 3919-3929 (1992)
   PUBMED   1508193
REFERENCE   7  (residues 1 to 567)
  AUTHORS   Yanagisawa,K., Tsukamoto,T., Takagi,T. and Tominaga,S.
  TITLE     Murine ST2 gene is a member of the primary response gene family
            induced by growth factors
  JOURNAL   FEBS Lett 302 (1), 51-53 (1992)
   PUBMED   1587353
REFERENCE   8  (residues 1 to 567)
  AUTHORS   McMahan,C.J., Slack,J.L., Mosley,B., Cosman,D., Lupton,S.D.,
            Brunton,L.L., Grubin,C.E., Wignall,J.M., Jenkins,N.A., Brannan,C.I.
            et al.
  TITLE     A novel IL-1 receptor, cloned from B cells by mammalian expression,
            is expressed in many cell types
  JOURNAL   EMBO J 10 (10), 2821-2832 (1991)
   PUBMED   1833184
REFERENCE   9  (residues 1 to 567)
  AUTHORS   Tominaga,S., Jenkins,N.A., Gilbert,D.J., Copeland,N.G. and
            Tetsuka,T.
  TITLE     Molecular cloning of the murine ST2 gene. Characterization and
            chromosomal mapping
  JOURNAL   Biochim Biophys Acta 1090 (1), 1-8 (1991)
   PUBMED   1832015
REFERENCE   10 (residues 1 to 567)
  AUTHORS   Klemenz,R., Hoffmann,S. and Werenskiold,A.K.
  TITLE     Serum- and oncoprotein-mediated induction of a gene with sequence
            similarity to the gene encoding carcinoembryonic antigen
  JOURNAL   Proc Natl Acad Sci U S A 86 (15), 5708-5712 (1989)
   PUBMED   2527364
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC167168.5 and AC167126.6.
            
            On Jun 26, 2014 this sequence version replaced XP_006495805.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK145118.1, SRR13948564.5087212.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN04095722, SAMN04095723
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..567
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 19.19 cM"
     Protein         1..567
                     /product="interleukin-1 receptor-like 1 isoform a
                     precursor"
                     /EC_number="3.2.2.6"
                     /note="lymphocyte antigen 84; interleukin-33 receptor
                     alpha chain"
                     /calculated_mol_wt=61826
     sig_peptide     1..26
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=2994
     mat_peptide     27..567
                     /product="Interleukin-1 receptor-like 1.
                     /id=PRO_0000015443"
                     /note="propagated from UniProtKB/Swiss-Prot (P14719.2)"
                     /calculated_mol_wt=61826
     Region          33..97
                     /region_name="Ig"
                     /note="Immunoglobulin domain; cl11960"
                     /db_xref="CDD:472250"
     Region          38..42
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          51..55
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Site            60
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P14719.2)"
     Region          76..80
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          90..95
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     Site            101
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P14719.2)"
     Site            107
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P14719.2)"
     Region          124..210
                     /region_name="Ig2_IL1R-like"
                     /note="Second immunoglobulin (Ig)-like domain of
                     interleukin-1 receptor (IL1R), and similar domains;
                     cd05757"
                     /db_xref="CDD:409415"
     Site            order(124..125,127..130,136,141,143,171,209)
                     /site_type="other"
                     /note="antagonist binding site [polypeptide binding]"
                     /db_xref="CDD:409415"
     Region          125..130
                     /region_name="Ig strand A"
                     /note="Ig strand A [structural motif]"
                     /db_xref="CDD:409415"
     Region          135..139
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409415"
     Site            146
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P14719.2)"
     Region          150..155
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409415"
     Region          158..160
                     /region_name="Ig strand C'"
                     /note="Ig strand C' [structural motif]"
                     /db_xref="CDD:409415"
     Region          164..168
                     /region_name="Ig strand D"
                     /note="Ig strand D [structural motif]"
                     /db_xref="CDD:409415"
     Region          170..175
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409415"
     Site            176
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P14719.2)"
     Region          184..193
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409415"
     Site            194
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P14719.2)"
     Region          196..209
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409415"
     Region          204..216
                     /region_name="Flexible linker. /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (P14719.2)"
     Site            225
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P14719.2)"
     Site            259
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P14719.2)"
     Site            278
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P14719.2)"
     Region          <291..324
                     /region_name="Ig"
                     /note="Immunoglobulin domain; cl11960"
                     /db_xref="CDD:472250"
     Region          291..294
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          305..310
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     Region          318..321
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409353"
     Site            333..355
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P14719.2)"
     Region          385..540
                     /region_name="TIR"
                     /note="TIR domain; pfam01582"
                     /db_xref="CDD:396246"
     Site            442
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by GSK3-beta.
                     /evidence=ECO:0000269|PubMed:22660580; propagated from
                     UniProtKB/Swiss-Prot (P14719.2)"
     CDS             1..567
                     /gene="Il1rl1"
                     /gene_synonym="DER4; Fit-1; Ly84; St2; St2-rs1; ST2L; T1;
                     T1/ST2"
                     /coded_by="NM_001025602.4:206..1909"
                     /note="isoform a precursor is encoded by transcript
                     variant 1"
                     /db_xref="CCDS:CCDS35548.1"
                     /db_xref="GeneID:17082"
                     /db_xref="MGI:MGI:98427"
ORIGIN      
        1 midrqrmglw alailtlpmy ltvtegskss wglenealiv rcpqrgrsty pvewyysdtn
       61 esiptqkrnr ifvsrdrlkf lparvedsgi yacvirspnl nktgylnvti hkkppscnip
      121 dylmystvrg sdknfkitcp tidlynwtap vqwfknckal qeprfrahrs ylfidnvthd
      181 degdytcqft haengtnyiv tatrsftvee kgfsmfpvit nppynhtmev eigkpasiac
      241 sacfgkgshf ladvlwqink tvvgnfgear iqeeegrnes ssndmdclts vlritgvtek
      301 dlsleydcla lnlhgmirht irlrrkqpid hrsiyyivag cslllmfinv lvivlkvfwi
      361 evalfwrdiv tpyktrndgk lydayiiypr vfrgsaagth sveyfvhhtl pdvlenkcgy
      421 klciygrdll pgqdaatvve ssiqnsrrqv fvlaphmmhs kefayeqeia lhsaliqnns
      481 kviliemepl geasrlqvgd lqdslqhlvk iqgtikwred hvadkqslss kfwkhvryqm
      541 pvperaskta svaaplsgka cldlkhf
//
