LOCUS       NM_001160403            9369 bp    mRNA    linear   ROD 08-JUN-2024
DEFINITION  Mus musculus interleukin 1 receptor accessory protein-like 1
            (Il1rapl1), mRNA.
ACCESSION   NM_001160403 NM_001368870 XM_486726 XM_982589
VERSION     NM_001160403.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 9369)
  AUTHORS   Meziane,H., Birling,M.C., Wendling,O., Leblanc,S., Dubos,A.,
            Selloum,M., Pavlovic,G., Sorg,T., Kalscheuer,V.M., Billuart,P.,
            Laumonnier,F., Chelly,J., van Bokhoven,H. and Herault,Y.
  TITLE     Large-Scale Functional Assessment of Genes Involved in Rare
            Diseases with Intellectual Disabilities Unravels Unique
            Developmental and Behaviour Profiles in Mouse Models
  JOURNAL   Biomedicines 10 (12), 3148 (2022)
   PUBMED   36551904
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 9369)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 9369)
  AUTHORS   Park,H., Choi,Y., Jung,H., Kim,S., Lee,S., Han,H., Kweon,H.,
            Kang,S., Sim,W.S., Koopmans,F., Yang,E., Kim,H., Smit,A.B.,
            Bae,Y.C. and Kim,E.
  TITLE     Splice-dependent trans-synaptic PTPdelta-IL1RAPL1 interaction
            regulates synapse formation and non-REM sleep
  JOURNAL   EMBO J 39 (11), e104150 (2020)
   PUBMED   32347567
  REMARK    GeneRIF: Splice-dependent trans-synaptic PTPdelta-IL1RAPL1
            interaction regulates synapse formation and non-REM sleep.
REFERENCE   4  (bases 1 to 9369)
  AUTHORS   Ponzoni,L., Sala,C., Verpelli,C., Sala,M. and Braida,D.
  TITLE     Different attentional dysfunctions in eEF2K-/-, IL1RAPL1-/- and
            SHANK3Delta11-/- mice
  JOURNAL   Genes Brain Behav 18 (5), e12563 (2019)
   PUBMED   30838762
  REMARK    GeneRIF: IL1RAPL1 -/- mice were impaired in novel object
            recognition and visual object recognition tasks.
REFERENCE   5  (bases 1 to 9369)
  AUTHORS   Han,Y., Mora,J., Huard,A., da Silva,P., Wiechmann,S., Putyrski,M.,
            Schuster,C., Elwakeel,E., Lang,G., Scholz,A., Scholz,T., Schmid,T.,
            de Bruin,N., Billuart,P., Sala,C., Burkhardt,H., Parnham,M.J.,
            Ernst,A., Brune,B. and Weigert,A.
  TITLE     IL-38 Ameliorates Skin Inflammation and Limits IL-17 Production
            from gammadelta T Cells
  JOURNAL   Cell Rep 27 (3), 835-846 (2019)
   PUBMED   30995480
REFERENCE   6  (bases 1 to 9369)
  AUTHORS   Houbaert,X., Zhang,C.L., Gambino,F., Lepleux,M., Deshors,M.,
            Normand,E., Levet,F., Ramos,M., Billuart,P., Chelly,J., Herzog,E.
            and Humeau,Y.
  TITLE     Target-specific vulnerability of excitatory synapses leads to
            deficits in associative memory in a model of intellectual disorder
  JOURNAL   J Neurosci 33 (34), 13805-13819 (2013)
   PUBMED   23966701
  REMARK    GeneRIF: the results of this study suggested that constitutive
            absence of Il1rapl1 disrupts this balance, possibly explaining the
            deficit in LTP induction in vivo and the behavioral deficits
            observed in KO mice.
REFERENCE   7  (bases 1 to 9369)
  AUTHORS   Hayashi,T., Yoshida,T., Ra,M., Taguchi,R. and Mishina,M.
  TITLE     IL1RAPL1 associated with mental retardation and autism regulates
            the formation and stabilization of glutamatergic synapses of
            cortical neurons through RhoA signaling pathway
  JOURNAL   PLoS One 8 (6), e66254 (2013)
   PUBMED   23785489
  REMARK    GeneRIF: IL1RAPL1 associated with mental retardation and autism
            regulates the formation and stabilization of glutamatergic synapses
            of cortical neurons through RhoA signaling pathway.
            Publication Status: Online-Only
REFERENCE   8  (bases 1 to 9369)
  AUTHORS   Yoshida,T., Yasumura,M., Uemura,T., Lee,S.J., Ra,M., Taguchi,R.,
            Iwakura,Y. and Mishina,M.
  TITLE     IL-1 receptor accessory protein-like 1 associated with mental
            retardation and autism mediates synapse formation by trans-synaptic
            interaction with protein tyrosine phosphatase delta
  JOURNAL   J Neurosci 31 (38), 13485-13499 (2011)
   PUBMED   21940441
  REMARK    GeneRIF: results suggest that IL1RAPL1 mediates synapse formation
            through trans-synaptic interaction with PTPdelta.
REFERENCE   9  (bases 1 to 9369)
  AUTHORS   Pavlowsky,A., Gianfelice,A., Pallotto,M., Zanchi,A., Vara,H.,
            Khelfaoui,M., Valnegri,P., Rezai,X., Bassani,S., Brambilla,D.,
            Kumpost,J., Blahos,J., Roux,M.J., Humeau,Y., Chelly,J.,
            Passafaro,M., Giustetto,M., Billuart,P. and Sala,C.
  TITLE     A postsynaptic signaling pathway that may account for the cognitive
            defect due to IL1RAPL1 mutation
  JOURNAL   Curr Biol 20 (2), 103-115 (2010)
   PUBMED   20096586
REFERENCE   10 (bases 1 to 9369)
  AUTHORS   Gambino,F., Kneib,M., Pavlowsky,A., Skala,H., Heitz,S., Vitale,N.,
            Poulain,B., Khelfaoui,M., Chelly,J., Billuart,P. and Humeau,Y.
  TITLE     IL1RAPL1 controls inhibitory networks during cerebellar development
            in mice
  JOURNAL   Eur J Neurosci 30 (8), 1476-1486 (2009)
   PUBMED   19811529
  REMARK    GeneRIF: Absence of IL1RAPL1 causes a transient disinhibition of
            deep cerebellar nuclei neurons between postnatal days 10 and 14.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL954362.9, AL844869.5, BX005231.8, AL672059.7, AL627409.9 and
            AL844900.3.
            
            On or before Mar 11, 2019 this sequence version replaced
            NM_001368870.1, NM_001160403.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: ERR3363660.888938.1,
                                           SRR7345562.2824755.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN01164131,
                                           SAMN01164132 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-950               AL954362.9         59783-60732         c
            951-1055            AL844869.5         83020-83124         c
            1056-1335           BX005231.8         115419-115698       c
            1336-1522           AL672059.7         141621-141807       c
            1523-1676           AL672059.7         137442-137595       c
            1677-1751           AL627409.9         70848-70922         c
            1752-1884           AL844900.3         111587-111719       c
            1885-2030           AL844900.3         109164-109309       c
            2031-2174           AL844900.3         85901-86044         c
            2175-2345           AL844900.3         72212-72382         c
            2346-9369           AL844900.3         64808-71831         c
FEATURES             Location/Qualifiers
     source          1..9369
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 39.89 cM"
     gene            1..9369
                     /gene="Il1rapl1"
                     /gene_synonym="6330532G10Rik; C030039N24; IL1R8; IL1RAPL;
                     IL1RAPL-1; MRX34; OPHN4; TIGIRR-2"
                     /note="interleukin 1 receptor accessory protein-like 1"
                     /db_xref="GeneID:331461"
                     /db_xref="MGI:MGI:2687319"
     exon            1..950
                     /gene="Il1rapl1"
                     /gene_synonym="6330532G10Rik; C030039N24; IL1R8; IL1RAPL;
                     IL1RAPL-1; MRX34; OPHN4; TIGIRR-2"
                     /inference="alignment:Splign:2.1.0"
     exon            951..1055
                     /gene="Il1rapl1"
                     /gene_synonym="6330532G10Rik; C030039N24; IL1R8; IL1RAPL;
                     IL1RAPL-1; MRX34; OPHN4; TIGIRR-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             974..3064
                     /gene="Il1rapl1"
                     /gene_synonym="6330532G10Rik; C030039N24; IL1R8; IL1RAPL;
                     IL1RAPL-1; MRX34; OPHN4; TIGIRR-2"
                     /EC_number="3.2.2.6"
                     /note="X-linked interleukin-1 receptor accessory
                     protein-like 1"
                     /codon_start=1
                     /product="interleukin-1 receptor accessory protein-like 1
                     precursor"
                     /protein_id="NP_001153875.1"
                     /db_xref="CCDS:CCDS53128.1"
                     /db_xref="GeneID:331461"
                     /db_xref="MGI:MGI:2687319"
                     /translation="MKAPIPHLILLYATFTQSLKVVTKRGSADGCTDWSVDIKKYQVL
                     VGEPVRIKCALFYGYIRTNYSLAQSAGLSLMWYKSSGPGDFEEPIAFDGSRMSKEEDS
                     IWFRPTLLQDSGLYACVIRNSTYCMKVSISLTVGENDTGLCYNSKMKYFEKAELSKSK
                     EISCRDIEDFLLPTREPEILWYKECRTKAWRPSIVFKRDTLLIKEVKEDDIGNYTCEL
                     KYGGFVVRRTTELTVTAPLTDKPPKLLYPMESKLTVQETQLGGSANLTCRAFFGYSGD
                     VSPLIYWMKGEKFIEDLDENRVWESDIRILKEHLGEQEVSISLIVDSVEEGDLGNYSC
                     YVENGNGRRHASVLLHKRELMYTVELAGGLGAILLLLICSVTIYKCYKIEIMLFYRNH
                     FGAEELDGDNKDYDAYLSYTKVDPDQWNQETGEEERFALEILPDMLEKHYGYKLFIPD
                     RDLIPTGTYIEDVARCVDQSKRLIIVMTPNYVVRRGWSIFELETRLRNMLVTGEIKVI
                     LIECSELRGIMNYQEVEALKHTIKLLTVIKWHGPKCNKLNSKFWKRLQYEMPFKRIEP
                     ITHEQALDVSEQGPFGELQTVSAISMAAATSTALATAHPDLRSTFHNTYHSQMRQKHY
                     YRSYEYDVPPTGTLPLTSIGNQHTYCNIPMTLINGQRPQTKSNREPNPDEAHTNSAIL
                     PLLPRETSISSVIW"
     exon            1056..1335
                     /gene="Il1rapl1"
                     /gene_synonym="6330532G10Rik; C030039N24; IL1R8; IL1RAPL;
                     IL1RAPL-1; MRX34; OPHN4; TIGIRR-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1336..1522
                     /gene="Il1rapl1"
                     /gene_synonym="6330532G10Rik; C030039N24; IL1R8; IL1RAPL;
                     IL1RAPL-1; MRX34; OPHN4; TIGIRR-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1523..1676
                     /gene="Il1rapl1"
                     /gene_synonym="6330532G10Rik; C030039N24; IL1R8; IL1RAPL;
                     IL1RAPL-1; MRX34; OPHN4; TIGIRR-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1677..1751
                     /gene="Il1rapl1"
                     /gene_synonym="6330532G10Rik; C030039N24; IL1R8; IL1RAPL;
                     IL1RAPL-1; MRX34; OPHN4; TIGIRR-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1752..1884
                     /gene="Il1rapl1"
                     /gene_synonym="6330532G10Rik; C030039N24; IL1R8; IL1RAPL;
                     IL1RAPL-1; MRX34; OPHN4; TIGIRR-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1885..2030
                     /gene="Il1rapl1"
                     /gene_synonym="6330532G10Rik; C030039N24; IL1R8; IL1RAPL;
                     IL1RAPL-1; MRX34; OPHN4; TIGIRR-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2031..2174
                     /gene="Il1rapl1"
                     /gene_synonym="6330532G10Rik; C030039N24; IL1R8; IL1RAPL;
                     IL1RAPL-1; MRX34; OPHN4; TIGIRR-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2175..2345
                     /gene="Il1rapl1"
                     /gene_synonym="6330532G10Rik; C030039N24; IL1R8; IL1RAPL;
                     IL1RAPL-1; MRX34; OPHN4; TIGIRR-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2346..9369
                     /gene="Il1rapl1"
                     /gene_synonym="6330532G10Rik; C030039N24; IL1R8; IL1RAPL;
                     IL1RAPL-1; MRX34; OPHN4; TIGIRR-2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5682..5687
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Il1rapl1"
                     /gene_synonym="6330532G10Rik; C030039N24; IL1R8; IL1RAPL;
                     IL1RAPL-1; MRX34; OPHN4; TIGIRR-2"
                     /note="hexamer: AATAAA"
     polyA_site      5719
                     /gene="Il1rapl1"
                     /gene_synonym="6330532G10Rik; C030039N24; IL1R8; IL1RAPL;
                     IL1RAPL-1; MRX34; OPHN4; TIGIRR-2"
                     /note="major polyA site"
ORIGIN      
        1 attcaatcaa atgaaccgat cttgtagaaa cactggaatc atttatgcat tgcagtttct
       61 ctttcttgtt ttcgctcctt cttccttggg atattttgag tggattctgg ctattaatca
      121 agatctcgtg ctgttcgtgg cttgcttgtc gttttcgctc aggattagca tcattcaaga
      181 taaacgcaaa gctgcttccc cccacccact ctcttttgaa aaatcatttt tggggtctgc
      241 tgaagagagc taggacccag gagacacctt cccaaacagc aggggttgtg tgctttcaca
      301 tagcagtact gtacaaggaa aaccccgtcg gatctgttat tgcgggatac ttgtgaaata
      361 cacataggat tctttcttat ggctgcatcc cggatctgga aattttactt ggggaccagg
      421 aagatttgaa aggctacatg tatccagaag atttgcaagc aagactccga ttcttgtcgt
      481 agagctcaca gacttattca cttatcgtcc gatttccttc cttctttaaa aaataaccaa
      541 aacaaaacaa aacacattta aaaaatttct ccctcttttt ctgatctctc cttcttcagt
      601 ctctccctct ctctctctct ttttattctg cctcttcttt tttttttctt cctagtcctt
      661 ttttttcccc tttcctgctc tgcacctgga ttgtatcgtc actaaacaat cgggcacttt
      721 gagaactaac tggcgacagt cttgtaggga agatctgtat ggaattatct gcttttatgg
      781 tgaacttggc atttgtgaat gggtaccttg ttcacaatat taattgctag caaaaacaag
      841 aaaaagaaca caggagtaaa acgtggattt ttctgaatac gcattgtgat gaccagcaat
      901 taccttaccg gctgatatcc agaggagaat aatttggaag acagttgtgg gaacagcctg
      961 taagaactgg aagatgaaag ctccgatccc acatttgatt ctcttatatg ctactttcac
     1021 tcagagtctg aaggttgtga ctaaaagagg ttctgctgat ggatgcacag attggtctgt
     1081 tgatatcaag aagtaccaag ttttggtggg agaacctgtt agaatcaagt gtgcactctt
     1141 ttatggttat ataagaacaa actactcgct cgcccaaagt gctggactca gcttaatgtg
     1201 gtataaaagc tctggtccag gagattttga agagcctatc gcctttgatg gaagtagaat
     1261 gagcaaagag gaagattcca tttggttcag accaacatta ctacaggaca gtgggcttta
     1321 tgcctgtgtc atcaggaatt ccacatactg tatgaaagtc tccatctcac tgacagtggg
     1381 agaaaatgac actggacttt gctacaattc caagatgaag tactttgaaa aagctgaact
     1441 tagcaaaagc aaggaaattt catgccgaga catagaggac tttttattac caaccaggga
     1501 acctgaaatc ctttggtaca aggaatgtag aacaaaagca tggagaccaa gtattgtctt
     1561 caaaagagat accttgctta taaaagaagt caaagaagat gacattggaa actatacctg
     1621 tgaattaaaa tacggaggct ttgttgtgag aagaacgact gagttaactg ttacagctcc
     1681 tctaactgat aagccaccta agcttttgta tcccatggaa agtaaactga cagttcagga
     1741 gactcaacta ggtggctcag ccaacctcac ctgcagagct ttctttgggt acagtggaga
     1801 tgtcagtcct ttaatttact ggatgaaagg agagaaattt attgaagatc tggatgaaaa
     1861 tagagtttgg gaaagtgaca ttagaatcct taaggaacat cttggagaac aggaagtttc
     1921 tatttcatta attgttgact ccgtggaaga aggtgacctg gggaactatt cctgttatgt
     1981 tgaaaatgga aacggacgtc ggcatgccag tgttctcctt cataaacgag agttaatgta
     2041 caccgttgaa cttgctggag ggcttggcgc tattctcttg ctgctcatct gttcggtgac
     2101 catatataaa tgttacaaga tagaaatcat gctcttctac aggaatcatt ttggagctga
     2161 ggaactggat ggagataaca aagattatga tgcctatctg tcatatacca aagtggatcc
     2221 tgaccagtgg aatcaagaga ctggggaaga agaacgtttt gcccttgaaa tcctccctga
     2281 tatgcttgaa aagcattatg gatataagtt gtttatacca gatagagatc tgatcccaac
     2341 tggaacatac attgaagatg tggctagatg cgtagatcaa agtaagcggc tgattattgt
     2401 catgacccca aattatgtag ttcgaagggg ctggagcatc tttgagctgg aaacgagact
     2461 tcgaaacatg cttgtgactg gagaaattaa agtgatactg attgaatgca gcgaactccg
     2521 aggaattatg aactaccagg aggtggaggc cctcaagcat accatcaagc ttctgacggt
     2581 tattaaatgg catggaccaa aatgcaacaa gttgaactcg aagttctgga aacgtttaca
     2641 gtacgaaatg ccttttaaga ggatagaacc cattacacat gagcaggctt tagatgtcag
     2701 tgagcagggg ccttttgggg agctgcagac tgtctcggcc atttcaatgg ctgcagccac
     2761 ctccacagct ctagccactg cccatccaga tctccgttct acctttcata acacctacca
     2821 ttcacaaatg cgtcagaaac actactatcg aagctatgag tacgacgtac ctcctacggg
     2881 caccctgcca cttacctcca taggaaatca gcatacctac tgtaacatcc ctatgacact
     2941 catcaatggg cagcggccac agacaaagtc gaacagggag ccgaatccag acgaagccca
     3001 cacaaacagt gccatcctgc cgttgttgcc aagggagacc agtatatcca gtgtgatctg
     3061 gtgacagaaa agcaaaggac atcccgttcc tgggagtttg aaaggaatct gcagtccagt
     3121 gcctggaact caatcctcga ctgctgctgt taaaaacatg cattacaatc tctagaacac
     3181 gaggaaaaac agggtcttgt acatatattt tttggaattt ctttgtagca tcagtgtctt
     3241 catgttttac catgtctctt accattacat tttttgactt tgttttatat gtcattggat
     3301 ttgtaaattt acattttttt taaagaagag actgatgtat agatagaaac tccccctccc
     3361 ttttttgctt cactaattta gttttagaat gggttttgaa tcttcttttt aaattttatt
     3421 ttgcttttaa catttccttg gggtgcttgg acaaatctat ctgatgggac aaggagcacc
     3481 ggatcctctc tcgggttctt cctaggacca gcttggccat atgggccttc agaaagcagt
     3541 gcgactgaac gccaggcttg cattgccatt tgggaacaaa agagagagag aaagagagaa
     3601 gaagatctgt tcataggagg gccctgactt cagagccctg aaatctcttc cttgtcccca
     3661 cctcattccc cacctctacc ctctaatggc agcatgatgt gtaaactctg cagggggtag
     3721 ggggaggtct aactgtctta acattgaatt cactgctctt cagaatacac tctagaccca
     3781 aagttgtgct agtcattcaa cagtgaccac tacagagtgc tcactacaga gtgaagatca
     3841 tgggcatgaa aatggggaga gtgttgtttc cgttttttaa aaaatgagtt gatgtatcct
     3901 tatatatata aatataaata tatatatata tatatatata taacagcaaa acaaaacaaa
     3961 acaaagaaaa aaacacacaa aaatacaaaa ccaaaaaaaa aaagccctat atttgatcac
     4021 ttcctggaaa ggcatgaatg tgtttgtggc tgtttttgtt tgataatcta cttcctcttt
     4081 tccctctata attaattttt ctgcaaatga gattatgtgc aaataccagg caagttaact
     4141 cagataagtg aatcaaggca agtaaaaatg aaatttacac tgaaagcttc caaaccaaag
     4201 ggaagaacag gatgtgtcat caaataggtt ttgttacctt gtattataca aaatgttatc
     4261 ttctaaaaaa gagtcagaaa aaacaatctg tgaaacttat tgtggggtcc ccttgtcctt
     4321 aaatgttaac tgacttgtat ttacttctca atgctacatg cagaacttaa gtggtttcag
     4381 tttaagaaca taaacagcat ttattaatat caaggttgtt taaataatat ctcaggaggt
     4441 caaacttatg aataacaaca caaactacta ctttcaaaat aaacattatt tacacaaaat
     4501 agttttaaat tagatcagaa aatacttaaa atacttaatt tttgtataga aattaattta
     4561 attttaacta tatgattcta tctttcagaa acagaaagtt gatgctccca ggaaatttgt
     4621 cacttactat ctagctttat gttggaaatc aatcacataa gcagcgaatt ccctctcatg
     4681 ttaactatga tgctaaatca atcacgaaag atcctgcaga agacagaatt cttaaaagga
     4741 caatgttacc tatgtagact ttagttttct ttaaaagaaa tcaacgtgac aaaaccactg
     4801 ataataaacc ttaggcttta tagaacttac tttagtaagt catcatggga aattcctact
     4861 cagtcatcac ctgtgggttc atgtagtgac tactctgtgt ttgcttaatt cctgccactc
     4921 cctataagga gaaaacaatt ctagagtttg ggtcaaaggc taagatgtaa gtaggccata
     4981 gacataaaag taggaactgc actagagttc actggagagg acaagctaga accataagca
     5041 taggagagac aagtacaaac atttgtaaca atgcaaaggt ctcagtgtct gtgtgacaag
     5101 gcaaaggagc cttgggacgt gcattgattt ttatttgctt aaaaatattg acttccctga
     5161 caacttgcct gggtcttctc tacagtatgt ctctattctt gtgctcccct tggttctgtg
     5221 tcacattttc aaaaaccaga actgaagctt caaggacagc taaacatttc aggtcagctt
     5281 tgcacacttg ggttattttc agaaacggag aaggccactg tttccttcgt actatggaca
     5341 cttggcattg gactggattc caaactcccc caatactcac aagagtggaa atgtggcaat
     5401 ggcctgattt agttcttgtt tgtttgtttg tttgttttta attttttaag tgcacgatgg
     5461 gtgtgtggaa taaatgtaaa ggaagtaatc agaccacagt catattttag gcattcatag
     5521 gtgttaattt agctgcattg ggagtacatt ttttgttcta tttttagtgt agatttaagc
     5581 actttgaata gcatgattca gggattgatg ggtaatattt gatactctca caatgtaaga
     5641 aacgtttttt tcctccaatg ctttgttata tttacaaatg aaataaatgc aaaggaagct
     5701 atctatagct ttagaaacat tcctcccaag tttctattcc tctatcagct ccacatgaga
     5761 accagagaag ggaactcatg ggttcacgtg ttctgtgtat aacagaagtt ctgtgagaac
     5821 tcaataaaat gaagagaaaa aaaaacatgt attttcccta gtgcttaggt ttcatccttc
     5881 tctttctgtt tgtttggggt tctggggtat aagattattc tagctataaa aacacatttg
     5941 aaaatgtgaa tgtgttagcc aagctggggg aaagaatgga cttccagact tggacacgtg
     6001 tgatatttgg tattgcctgt ttttcatcaa tcaccgcctg agctctgaat ggtacattat
     6061 ggattcaaag tccatttggt tctttagtgt aacctcaact tgctgcttct gagcatctta
     6121 gtctttattc tggtgctcaa atctttgatt atttaatttg tatcccatcc ctttggtctt
     6181 caacaggcag agaagacctt tgtatgttgt gttaccagct gatctaagct tagatgaagt
     6241 ctatgaaatc caagacgtga tgagatctga acttactata tttctatagc taagcatatg
     6301 attgttcagt caaccatttt gtgattatta ttttttcata ctgtatgtat ttggactcta
     6361 tcaacttaat cttaaatatg tagatgctgg tttctttcat atttcattgt taatacatat
     6421 tttgtaacaa gaggaaatat taactaagag ccaattccta aactctaagt atgctttgtt
     6481 catcctagaa tagtcattaa cttttcagag actatttatg tgaattgaga ttactatttc
     6541 taggaaaaca ttaatttgta cattataagc tattttctga ttctgtaatg gtacccttgc
     6601 tctcatttta aagaagtttt taatcttgtg tttatttttt ctcttttatt tgttgttttg
     6661 tttattttgt ttttgagaca ggattcgggc tgggctggct tcaacctctc aattctcctg
     6721 cctcagcctc ttgactgctg aaattttagg catatacacc caaaccacca atttcttctt
     6781 tattagttta ggtgtataca ttagtcccac aagaaatctt attgacattc taaggagaac
     6841 atcaacatca cacaagtgaa ataattgaat ggaactaaga gaatatacat atacaaaaga
     6901 ggaaaatgtc tttttgtctc tgatctgaat ttgtttgacc attcattcca tcactgctgt
     6961 agttgatgaa aaatagaggc aaaatattaa atagcttaga catcacatta cagattccta
     7021 ttccctactg tggaaaattt ttccaaccat acataaacgg ttattaaaaa caaatcacaa
     7081 tgtgactctg taataagcga agaagatttt gtcaatggaa gcagaggtta tttcttgcct
     7141 tattgtggat ctttcccgcc tgattattct gaacaaagaa agtagccaac agtttcaatt
     7201 atccttatta ataggcctta cacttgagtt tcagggatat cgtggttcta taaaataaat
     7261 gaaaggaaat aacgaaacac gtaaatctgt tttcctgggt gtgactctca agacatccag
     7321 catccaagaa agccatagac gtttagattc agagaacagt cttttatgct aatattaata
     7381 taaactcaca ttttgtgaag gcattgttgt gtccttgatt tttttatctt catttatgaa
     7441 aattcagggt cacttttttt tttaactaag attgctctcc atccaaaatg agctaacttt
     7501 ttgagagaaa ttgtgtgaag aaaaatttaa caataataat taataaaatc cataattttc
     7561 aaccaaatat atgaggaacc tatccattat tattagttta gtttattcat ttttatactc
     7621 atttaaaaca ggaggatatg caaaaatcct aattttacaa ttatgactta cttcattaat
     7681 tttttgtttg taaaaacaca ttatctgcca aaaaattcaa acagtagaga aagagaagaa
     7741 atacccattt gatgtgtttt tctataagaa accagtttta ttatgaaaat gtttagagtt
     7801 tgttattgac ttctcttttg gtgattacaa ttttgctact ttcatgaatt caaatatgac
     7861 cttggaacaa tatatagaac tttgaaaagt gaggtggtga taatttaaag ttgcaggttt
     7921 tttgtttgtt tttgtttttg cttttgtttt tattttgttc attgcagagt gaaaacctat
     7981 gctctatggt aaagactgtc agaaggagct gtaaaaatcc tagttaaata aaacaaaagg
     8041 aggaagaaga gaaggagtag aagagttaat tctactctta atttgatgtg cccttatcat
     8101 agtcagcttt tggttacatc catagaaaat gttttaagga aaaataaaag gagatcaact
     8161 ttaattttcc attcagcatt atatcttttt tactgactca gaacacaaga tgtttctcga
     8221 ttacagataa gataggcata tatatttata agatatatat ggctttataa atatatatgt
     8281 gtgtgaaatt ccttctgttc attagtaaat tttcctctaa tagcctctgc gttcactgac
     8341 aaactcattc ttctgaattc ttcattaaag taagttactt ttattttttt tctatttact
     8401 gctttcattg atatatcccc caatgttcat aaatctgaat tttttctcat ttttaacaca
     8461 aggaagcact ctaaaataaa atcactacac tgtgttccct ctactaccaa aatcaacctc
     8521 aaaaaaaaaa aaaaaactgc ccatgaactt cagagtacta agtgtaatat ttatgttgta
     8581 aatttcaatc ttcataatct aaatgttacc tttcaaaagg catgctgtgt catttaaaaa
     8641 aaaaagagtt aatgtgaaat gaccttatta catagtgcat gaatacgtgg caaagtatta
     8701 cggatctatc tttactagtc aatgagaggt taaatttggg gagatcagat atgttttagg
     8761 ctaatgtcaa ttggaaggat ggaatcttaa tgttagcata atgggcagtt ttccatactg
     8821 cttgcagtat atgctcctgt taacaacaat ccttagtgta ctctttccac caaagtagtg
     8881 gagatgtgtt catataatct gctatttaat tacaactttt acaacttcag aaattgaggg
     8941 aacccaaata ggaaagtgta tgtaatcatt ttcctctgct ggcgttcaag ttgtatttta
     9001 aactcagaca ctctcagatc tgttcacagt cagtacaagt gcattttaca tagtacttct
     9061 cttgagtttt gctcaccctc ttttgacttt gtacaatcta ggatgtaggt gactcatgag
     9121 taggtgatgg gggcgctcct ttttttctta gaatacttac aattatatat ttggttttgc
     9181 tttgactagc aataggaaaa tagacaaata caagtgtaca aatgagaaat tttaacctcg
     9241 acttataatt tgtgttttat agtcgtttca taagtctgtt gctctctatg agtatgctct
     9301 ctatatatcc tgtaaaaata aatttatatg ttacatagaa attcaagaaa ttaaattatt
     9361 tattaagct
//
