LOCUS       NM_001159318            4320 bp    mRNA    linear   ROD 28-JAN-2025
DEFINITION  Mus musculus interleukin 1 receptor accessory protein (Il1rap),
            transcript variant 4, mRNA.
ACCESSION   NM_001159318
VERSION     NM_001159318.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4320)
  AUTHORS   Lee,Y., English,E.L., Schwartzmann,C.M., Liu,Y. and Krueger,J.M.
  TITLE     Sleep loss-induced oncogenic pathways are mediated via the
            neuron-specific interleukin-1 receptor accessory protein (AcPb)
  JOURNAL   Brain Behav Immun 123, 411-421 (2025)
   PUBMED   39343106
REFERENCE   2  (bases 1 to 4320)
  AUTHORS   Nemeth,D.P., Liu,X., Monet,M.C., Niu,H., Maxey,G., Schrier,M.S.,
            Smirnova,M.I., McGovern,S.J., Herd,A., DiSabato,D.J., Floyd,T.,
            Atluri,R.R., Nusstein,A.C., Oliver,B., Witcher,K.G., Juste
            Ellis,J.S., Yip,J., Crider,A.D., McKim,D.B.,
            Gajewski-Kurdziel,P.A., Godbout,J.P., Zhang,Q., Blakely,R.D.,
            Sheridan,J.F. and Quan,N.
  TITLE     Localization of brain neuronal IL-1R1 reveals specific neural
            circuitries responsive to immune signaling
  JOURNAL   J Neuroinflammation 21 (1), 303 (2024)
   PUBMED   39563437
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4320)
  AUTHORS   Tongmuang,N., Krishnan,M., Connor,V., Crump,C. and Jensen,L.E.
  TITLE     UL56 Is Essential for Herpes Simplex Virus-1 Virulence In Vivo but
            Is Dispensable for Induction of Host-Protective Immunity
  JOURNAL   Vaccines (Basel) 12 (8), 837 (2024)
   PUBMED   39203963
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4320)
  AUTHORS   He,Y.Q., Zhu,J.R., Sun,W.J., Luo,Y.Y., Wu,X.F., Yang,M. and
            Chen,D.F.
  TITLE     ZO-1 and IL-1RAP Phosphorylation: Potential Role in Mediated
            Brain-Gut Axis Dysregulation in Irritable Bowel Syndrome-like
            Stressed Mice
  JOURNAL   Int J Med Sci 21 (9), 1738-1755 (2024)
   PUBMED   39006851
  REMARK    GeneRIF: ZO-1 and IL-1RAP Phosphorylation: Potential Role in
            Mediated Brain-Gut Axis Dysregulation in Irritable Bowel
            Syndrome-like Stressed Mice.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4320)
  AUTHORS   Fields,J.K., Gyllenback,E.J., Bogacz,M., Obi,J., Birkedal,G.S.,
            Sjostrom,K., Maravillas,K., Gronberg,C., Rattik,S., Kihn,K.,
            Flowers,M., Smith,A.K., Hansen,N., Fioretos,T., Huyhn,C.,
            Liberg,D., Deredge,D. and Sundberg,E.J.
  TITLE     Antibodies targeting the shared cytokine receptor IL-1 receptor
            accessory protein invoke distinct mechanisms to block all cytokine
            signaling
  JOURNAL   Cell Rep 43 (5), 114099 (2024)
   PUBMED   38636519
REFERENCE   6  (bases 1 to 4320)
  AUTHORS   Cullinan,E.B., Kwee,L., Nunes,P., Shuster,D.J., Ju,G.,
            McIntyre,K.W., Chizzonite,R.A. and Labow,M.A.
  TITLE     IL-1 receptor accessory protein is an essential component of the
            IL-1 receptor
  JOURNAL   J Immunol 161 (10), 5614-5620 (1998)
   PUBMED   9820540
REFERENCE   7  (bases 1 to 4320)
  AUTHORS   Wesche,H., Neumann,D., Resch,K. and Martin,M.U.
  TITLE     Co-expression of mRNA for type I and type II interleukin-1
            receptors and the IL-1 receptor accessory protein correlates to
            IL-1 responsiveness
  JOURNAL   FEBS Lett 391 (1-2), 104-108 (1996)
   PUBMED   8706893
REFERENCE   8  (bases 1 to 4320)
  AUTHORS   Liu,C., Chalmers,D., Maki,R. and De Souza,E.B.
  TITLE     Rat homolog of mouse interleukin-1 receptor accessory protein:
            cloning, localization and modulation studies
  JOURNAL   J Neuroimmunol 66 (1-2), 41-48 (1996)
   PUBMED   8964912
REFERENCE   9  (bases 1 to 4320)
  AUTHORS   Parnet,P., Garka,K.E., Bonnert,T.P., Dower,S.K. and Sims,J.E.
  TITLE     IL-1Rrp is a novel receptor-like molecule similar to the type I
            interleukin-1 receptor and its homologues T1/ST2 and IL-1R AcP
  JOURNAL   J Biol Chem 271 (8), 3967-3970 (1996)
   PUBMED   8626725
REFERENCE   10 (bases 1 to 4320)
  AUTHORS   Greenfeder,S.A., Nunes,P., Kwee,L., Labow,M., Chizzonite,R.A. and
            Ju,G.
  TITLE     Molecular cloning and characterization of a second subunit of the
            interleukin 1 receptor complex
  JOURNAL   J Biol Chem 270 (23), 13757-13765 (1995)
   PUBMED   7775431
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BU526001.1, AK136782.1, AK034269.1 and AK083209.1.
            
            Transcript Variant: This variant (4) encodes the longest isoform
            (d).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK033972.1, AK083209.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164132
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-148               BU526001.1         1-148
            149-2823            AK136782.1         100-2774
            2824-3287           AK034269.1         2499-2962
            3288-3541           AK083209.1         3285-3538
            3542-4320           AK083209.1         3540-4318
FEATURES             Location/Qualifiers
     source          1..4320
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 18.21 cM"
     gene            1..4320
                     /gene="Il1rap"
                     /gene_synonym="6430709H04Rik; IL-1RAcP"
                     /note="interleukin 1 receptor accessory protein"
                     /db_xref="GeneID:16180"
                     /db_xref="MGI:MGI:104975"
     exon            1..182
                     /gene="Il1rap"
                     /gene_synonym="6430709H04Rik; IL-1RAcP"
                     /inference="alignment:Splign:2.1.0"
     exon            183..247
                     /gene="Il1rap"
                     /gene_synonym="6430709H04Rik; IL-1RAcP"
                     /inference="alignment:Splign:2.1.0"
     CDS             184..2241
                     /gene="Il1rap"
                     /gene_synonym="6430709H04Rik; IL-1RAcP"
                     /EC_number="3.2.2.6"
                     /note="isoform d precursor is encoded by transcript
                     variant 4; IL-1 receptor accessory protein; interleukin-33
                     receptot beta chain"
                     /codon_start=1
                     /product="interleukin-1 receptor accessory protein isoform
                     d precursor"
                     /protein_id="NP_001152790.1"
                     /db_xref="CCDS:CCDS49815.1"
                     /db_xref="GeneID:16180"
                     /db_xref="MGI:MGI:104975"
                     /translation="MGLLWYLMSLSFYGILQSHASERCDDWGLDTMRQIQVFEDEPAR
                     IKCPLFEHFLKYNYSTAHSSGLTLIWYWTRQDRDLEEPINFRLPENRISKEKDVLWFR
                     PTLLNDTGNYTCMLRNTTYCSKVAFPLEVVQKDSCFNSAMRFPVHKMYIEHGIHKITC
                     PNVDGYFPSSVKPSVTWYKGCTEIVDFHNVLPEGMNLSFFIPLVSNNGNYTCVVTYPE
                     NGRLFHLTRTVTVKVVGSPKDALPPQIYSPNDRVVYEKEPGEELVIPCKVYFSFIMDS
                     HNEVWWTIDGKKPDDVTVDITINESVSYSSTEDETRTQILSIKKVTPEDLRRNYVCHA
                     RNTKGEAEQAAKVKQKVIPPRYTVELACGFGATVFLVVVLIVVYHVYWLEMVLFYRAH
                     FGTDETILDGKEYDIYVSYARNVEEEEFVLLTLRGVLENEFGYKLCIFDRDSLPGGNT
                     VEAVFDFIQRSRRMIVVLSPDYVTEKSISMLEFKLGVMCQNSIATKLIVVEYRPLEQP
                     HPGIMQLKESVSFVSWKGEKSKHSGSKFWKALRLALPLRSLSASSGWNESCSSQSDIS
                     LDHVQRRSRLKEPPELRSSERVSGAEPAPGTMSKHRGKPSAACRCCVTYCEGESHLRS
                     KSRAEMHTHPQWETHLCKPPLQESESQWIQNGTRPEPAPQISALALRHFTDLSNNNDF
                     YIL"
     exon            248..533
                     /gene="Il1rap"
                     /gene_synonym="6430709H04Rik; IL-1RAcP"
                     /inference="alignment:Splign:2.1.0"
     exon            534..720
                     /gene="Il1rap"
                     /gene_synonym="6430709H04Rik; IL-1RAcP"
                     /inference="alignment:Splign:2.1.0"
     exon            721..886
                     /gene="Il1rap"
                     /gene_synonym="6430709H04Rik; IL-1RAcP"
                     /inference="alignment:Splign:2.1.0"
     exon            887..958
                     /gene="Il1rap"
                     /gene_synonym="6430709H04Rik; IL-1RAcP"
                     /inference="alignment:Splign:2.1.0"
     exon            959..1085
                     /gene="Il1rap"
                     /gene_synonym="6430709H04Rik; IL-1RAcP"
                     /inference="alignment:Splign:2.1.0"
     exon            1086..1234
                     /gene="Il1rap"
                     /gene_synonym="6430709H04Rik; IL-1RAcP"
                     /inference="alignment:Splign:2.1.0"
     exon            1235..1384
                     /gene="Il1rap"
                     /gene_synonym="6430709H04Rik; IL-1RAcP"
                     /inference="alignment:Splign:2.1.0"
     exon            1385..1528
                     /gene="Il1rap"
                     /gene_synonym="6430709H04Rik; IL-1RAcP"
                     /inference="alignment:Splign:2.1.0"
     exon            1529..4320
                     /gene="Il1rap"
                     /gene_synonym="6430709H04Rik; IL-1RAcP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2802..2807
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Il1rap"
                     /gene_synonym="6430709H04Rik; IL-1RAcP"
                     /note="hexamer: AATAAA"
     polyA_site      2824
                     /gene="Il1rap"
                     /gene_synonym="6430709H04Rik; IL-1RAcP"
                     /note="major polyA site"
ORIGIN      
        1 ggggaggagc tccggagggg gaaaaagaaa gtgcggcgga aagtaagagg ctagtcgggg
       61 aaggctgcca gcatctggct ttcctaggtt cggcttggac cagggcgctg aaagaggcag
      121 tggtcggcca ccctgcatcc atctggtcgc tgtcgccgag cctgctgggc tggcccgata
      181 aggatgggac ttctgtggta tttgatgagt ctgtccttct atgggatcct gcagagtcat
      241 gcttcggagc gctgtgatga ctggggacta gataccatgc gacaaatcca agtgtttgaa
      301 gatgagccgg ctcgaatcaa gtgccccctc tttgaacact tcctgaagta caactacagc
      361 actgcccatt cctctggcct taccctgatc tggtactgga ccaggcaaga ccgggacctg
      421 gaggagccca ttaacttccg cctcccagag aatcgcatca gtaaggagaa agatgtgctc
      481 tggttccggc ccaccctcct caatgacacg ggcaattaca cctgcatgtt gaggaacaca
      541 acttactgca gcaaagttgc atttcccctg gaagttgttc agaaggacag ctgtttcaat
      601 tctgccatga gattcccagt gcacaagatg tatattgaac atggcattca taagatcaca
      661 tgtccaaatg tagacggata ctttccttcc agtgtcaaac catcggtcac ttggtataag
      721 ggttgtactg aaatagtgga ctttcataat gtactacccg agggcatgaa cttgagcttt
      781 ttcatcccct tggtttcaaa taacggaaat tacacatgtg tggttacata tcctgaaaac
      841 ggacgtctct ttcacctcac caggactgtg actgtaaagg tggtgggctc accaaaggat
      901 gcattgccac cccagatcta ttctccaaat gaccgtgttg tctatgagaa agaaccagga
      961 gaggaactgg ttattccctg caaagtctat ttcagtttca ttatggactc ccacaatgag
     1021 gtctggtgga ccattgatgg aaagaagcct gatgacgtca cagtcgacat cactattaat
     1081 gaaagtgtaa gttattcttc aacggaagat gaaacaagga ctcagatttt gagcatcaag
     1141 aaagtcaccc cggaggatct caggcgcaac tatgtctgtc atgctcgaaa taccaaaggg
     1201 gaagctgagc aggctgccaa ggtgaaacag aaagtcatac caccaaggta cacagtagaa
     1261 ctcgcctgtg gttttggagc cacggtcttt ctggtagtgg ttctcattgt ggtttaccat
     1321 gtttactggc tggagatggt cctcttttac cgagctcact ttggaacaga tgaaacaatt
     1381 cttgatggaa aggagtatga tatttatgtt tcctatgcaa gaaatgtgga agaagaggaa
     1441 tttgtgctgc tgacgctgcg tggagttttg gagaatgagt ttggatacaa gctgtgcatc
     1501 ttcgacagag acagcctgcc tgggggaaat accgtggaag cagtttttga tttcattcag
     1561 aggagccgaa ggatgattgt tgtcctgagc cctgactatg tgacagaaaa gagcatcagc
     1621 atgctggagt ttaagctggg tgtcatgtgc cagaactcca ttgccactaa gctcattgtg
     1681 gtggagtacc gtccgcttga gcaaccccat ccaggcatca tgcagctgaa ggagtctgtg
     1741 tcttttgtaa gctggaaggg agaaaagtcc aaacattctg gctccaagtt ctggaaggcc
     1801 ttgcgtttgg ctcttcccct gagaagtctg agcgccagct ccggctggaa tgagagctgt
     1861 tcttctcagt ctgacatcag tctggatcat gttcagagga gaagtcgttt gaaagagccc
     1921 ccagaactcc gaagctcaga gagggtgtct ggagcagagc cagccccggg cacgatgtcc
     1981 aagcaccgag ggaaaccctc agcagcctgt cgctgctgtg tcacctactg tgaaggagaa
     2041 agtcacctca ggagcaagag ccgggcagag atgcacacgc atccccagtg ggaaacacac
     2101 ctctgtaagc ctcctctcca agagtctgaa agtcagtgga tacaaaatgg cacccgaccc
     2161 gaacccgctc cccagatctc agctcttgca ctccgccact ttacagattt atccaataac
     2221 aatgactttt atatcctata atcactttat gtggagggtg gtggctgctg tttctaccaa
     2281 ctctctttgg gtcaaaaact tttggaaata atcgacattt taaatcattt aatagactat
     2341 cagatttgtg tccccctttt attgattttt ttaaaaaaac tatttatttc taggagacaa
     2401 aagacctgaa gcacctgtat ccagttattg cctctaacgg ccttggaaga gcaagcacac
     2461 tcttctcggg ccctagaagg tcagtatgta aaagttgctt agagtctgat cttgccaagg
     2521 gattcaaagg tagctaggaa ctggtgtctc cttgtgatgt gggccagtaa agagtacttc
     2581 ggctttgaca ctcattgagt ttttgcaccc aaaagaccag ggctttgaca ctcacaggat
     2641 gtgtctatcc caaggagtga cttgaaaggg agcaggttct ggtagacaga gctcaacagc
     2701 aaaccgccag cacatttgtg tccccaggga ccaaatcttt ccataggaat ccctgcttcc
     2761 cattgccccc tgtaaatagt atgctttttg tcattggtct caataaaggt atatttttat
     2821 gccatgcctt ttgtactaac atatttttaa tgtcctctcc tcaatttgca ttttctggca
     2881 tttatattca aatccagaga acattacatt tcagaaaatt gagatttaat aggaatggtg
     2941 agggatattt gttgtggtgg ttgttttttg tttgtttgtt ttgttttctg atgtgaattg
     3001 gacctctata agaagttgag tttaagtaag aatcatgttt tgttcaaatg atagaaaatt
     3061 tcattggcaa ggaactgtag gtagattttg gtgcctgcag ccgttcttca caattctgaa
     3121 attagatgtt gagttcaaat tcctccaagg gccagaaggt gagagaaagg gggaacaaag
     3181 gagcagatgc aagtctaaca cccataggct tgattgaaca ccaaggacaa agagcagctt
     3241 cagacaagta gggtctttct gcagtcagtc acatgccaac caaaggtcca tggcacatgg
     3301 ccttcaagcc aggacctatc aggcaccctt gagcatgcag atgactaaag aacacatgag
     3361 tgtttcccca cctctgtttg gttgttgcca ctgaatcagc ttctgcgtgg caacttgtgc
     3421 aatttctttc acaagtttca aaacataaat atgtgaatat atgttttcaa ttaaatcctg
     3481 gcttaaattt gtaaaataaa gtcaaagaat caaaacaaac aaacattaaa aaaaaaaaaa
     3541 actctcagct aaagaatata tgctgaaata ggggtccaag tgcctcaggc aactgtgacc
     3601 tgaggacaac gcaagtaaga acatatggga aatgtatatt ccttctccaa gctgaaaaca
     3661 tctggccttc ataatagtgt tggtctgatg aatcctccag cccaggaaac agctgagaat
     3721 cctgtctcct ctttcagttc catatgttgc ctgcttactc taggaaagtt acaagcacaa
     3781 aaaccaatgt ttctaaagag aagcagatct aaaaccgtag taggtgacat tagatgggag
     3841 gtgtcactac gttacagcag cctctactgc tagtgagttt ggccccgagc cagcctctca
     3901 atcaaaggca aaggaagtga tacagagtta agacatgcat ggaaagcctt catttcatct
     3961 gtttgactag aactcccact gtcgaaaaca ttccttatga tggaatatgt acctagctgt
     4021 gatacacagc agaaatgact cagctcaatg cagagttctc atttcacatt gcatcacctt
     4081 tagaagagat gttcaaaggc ttcatgttag ccatcagaaa gtggataata gacatgactt
     4141 caaattctat gagagagaag gctgtggctc acaactgtct gcaactcaca ttctggagaa
     4201 tccaattaca ttttacttct agggattcca atacataagt ggtgcacata catacacttg
     4261 gtacacatat acacaaaaat aaaagtaaat aattaattgc taattaaagt attagtagat
//
