LOCUS       NP_001152790             685 aa            linear   ROD 13-MAY-2025
DEFINITION  interleukin-1 receptor accessory protein isoform d precursor [Mus
            musculus].
ACCESSION   NP_001152790
VERSION     NP_001152790.1
DBSOURCE    REFSEQ: accession NM_001159318.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 685)
  AUTHORS   Lee,Y., English,E.L., Schwartzmann,C.M., Liu,Y. and Krueger,J.M.
  TITLE     Sleep loss-induced oncogenic pathways are mediated via the
            neuron-specific interleukin-1 receptor accessory protein (AcPb)
  JOURNAL   Brain Behav Immun 123, 411-421 (2025)
   PUBMED   39343106
REFERENCE   2  (residues 1 to 685)
  AUTHORS   Nemeth,D.P., Liu,X., Monet,M.C., Niu,H., Maxey,G., Schrier,M.S.,
            Smirnova,M.I., McGovern,S.J., Herd,A., DiSabato,D.J., Floyd,T.,
            Atluri,R.R., Nusstein,A.C., Oliver,B., Witcher,K.G., Juste
            Ellis,J.S., Yip,J., Crider,A.D., McKim,D.B.,
            Gajewski-Kurdziel,P.A., Godbout,J.P., Zhang,Q., Blakely,R.D.,
            Sheridan,J.F. and Quan,N.
  TITLE     Localization of brain neuronal IL-1R1 reveals specific neural
            circuitries responsive to immune signaling
  JOURNAL   J Neuroinflammation 21 (1), 303 (2024)
   PUBMED   39563437
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 685)
  AUTHORS   Babcock,I.W., Sibley,L.A., Labuzan,S.A., Cowan,M.N., Sethi,I.,
            Alemu,S., Kelly,A.G., Kovacs,M.A., Lukens,J.R. and Harris,T.H.
  TITLE     Caspase-1 in Cx3cr1-expressing cells drives an IL-18-dependent T
            cell response that promotes parasite control during acute
            Toxoplasma gondii infection
  JOURNAL   PLoS Pathog 20 (10), e1012006 (2024)
   PUBMED   39446964
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 685)
  AUTHORS   Tongmuang,N., Krishnan,M., Connor,V., Crump,C. and Jensen,L.E.
  TITLE     UL56 Is Essential for Herpes Simplex Virus-1 Virulence In Vivo but
            Is Dispensable for Induction of Host-Protective Immunity
  JOURNAL   Vaccines (Basel) 12 (8), 837 (2024)
   PUBMED   39203963
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 685)
  AUTHORS   He,Y.Q., Zhu,J.R., Sun,W.J., Luo,Y.Y., Wu,X.F., Yang,M. and
            Chen,D.F.
  TITLE     ZO-1 and IL-1RAP Phosphorylation: Potential Role in Mediated
            Brain-Gut Axis Dysregulation in Irritable Bowel Syndrome-like
            Stressed Mice
  JOURNAL   Int J Med Sci 21 (9), 1738-1755 (2024)
   PUBMED   39006851
  REMARK    GeneRIF: ZO-1 and IL-1RAP Phosphorylation: Potential Role in
            Mediated Brain-Gut Axis Dysregulation in Irritable Bowel
            Syndrome-like Stressed Mice.
            Publication Status: Online-Only
REFERENCE   6  (residues 1 to 685)
  AUTHORS   Cullinan,E.B., Kwee,L., Nunes,P., Shuster,D.J., Ju,G.,
            McIntyre,K.W., Chizzonite,R.A. and Labow,M.A.
  TITLE     IL-1 receptor accessory protein is an essential component of the
            IL-1 receptor
  JOURNAL   J Immunol 161 (10), 5614-5620 (1998)
   PUBMED   9820540
REFERENCE   7  (residues 1 to 685)
  AUTHORS   Wesche,H., Neumann,D., Resch,K. and Martin,M.U.
  TITLE     Co-expression of mRNA for type I and type II interleukin-1
            receptors and the IL-1 receptor accessory protein correlates to
            IL-1 responsiveness
  JOURNAL   FEBS Lett 391 (1-2), 104-108 (1996)
   PUBMED   8706893
REFERENCE   8  (residues 1 to 685)
  AUTHORS   Liu,C., Chalmers,D., Maki,R. and De Souza,E.B.
  TITLE     Rat homolog of mouse interleukin-1 receptor accessory protein:
            cloning, localization and modulation studies
  JOURNAL   J Neuroimmunol 66 (1-2), 41-48 (1996)
   PUBMED   8964912
REFERENCE   9  (residues 1 to 685)
  AUTHORS   Parnet,P., Garka,K.E., Bonnert,T.P., Dower,S.K. and Sims,J.E.
  TITLE     IL-1Rrp is a novel receptor-like molecule similar to the type I
            interleukin-1 receptor and its homologues T1/ST2 and IL-1R AcP
  JOURNAL   J Biol Chem 271 (8), 3967-3970 (1996)
   PUBMED   8626725
REFERENCE   10 (residues 1 to 685)
  AUTHORS   Greenfeder,S.A., Nunes,P., Kwee,L., Labow,M., Chizzonite,R.A. and
            Ju,G.
  TITLE     Molecular cloning and characterization of a second subunit of the
            interleukin 1 receptor complex
  JOURNAL   J Biol Chem 270 (23), 13757-13765 (1995)
   PUBMED   7775431
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BU526001.1, AK136782.1, AK034269.1 and AK083209.1.
            
            Transcript Variant: This variant (4) encodes the longest isoform
            (d).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK033972.1, AK083209.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164132
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..685
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 18.21 cM"
     Protein         1..685
                     /product="interleukin-1 receptor accessory protein isoform
                     d precursor"
                     /EC_number="3.2.2.6"
                     /note="IL-1 receptor accessory protein; interleukin-33
                     receptot beta chain"
                     /calculated_mol_wt=76327
     sig_peptide     1..20
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=2331
     Region          25..132
                     /region_name="Ig1_IL1R_like"
                     /note="First immunoglobulin (Ig)-like domain of
                     interleukin-1 receptor (IL1R), and similar domains;
                     cd20992"
                     /db_xref="CDD:409584"
     Region          26..29
                     /region_name="Ig strand A"
                     /note="Ig strand A [structural motif]"
                     /db_xref="CDD:409584"
     Site            order(27,29..36)
                     /site_type="other"
                     /note="antagonist binding site [polypeptide binding]"
                     /db_xref="CDD:409584"
     Region          34..38
                     /region_name="Ig strand A'"
                     /note="Ig strand A' [structural motif]"
                     /db_xref="CDD:409584"
     Region          42..47
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409584"
     Region          67..71
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409584"
     Region          80..82
                     /region_name="Ig strand C'"
                     /note="Ig strand C' [structural motif]"
                     /db_xref="CDD:409584"
     Region          91..95
                     /region_name="Ig strand D"
                     /note="Ig strand D [structural motif]"
                     /db_xref="CDD:409584"
     Region          97..101
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409584"
     Region          110..118
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409584"
     Region          121..132
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409584"
     Region          145..235
                     /region_name="Ig"
                     /note="Immunoglobulin domain; cl11960"
                     /db_xref="CDD:472250"
     Region          156..160
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409585"
     Region          174..178
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409585"
     Region          195..199
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409585"
     Region          209..214
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409585"
     Region          226..229
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409585"
     Region          243..349
                     /region_name="Ig3_IL1RAP"
                     /note="Third immunoglobulin domain of interleukin-1
                     receptor accessory protein (IL1RAP); cd20931"
                     /db_xref="CDD:409525"
     Region          243..246
                     /region_name="Ig strand A"
                     /note="Ig strand A [structural motif]"
                     /db_xref="CDD:409525"
     Region          254..258
                     /region_name="Ig strand A'"
                     /note="Ig strand A' [structural motif]"
                     /db_xref="CDD:409525"
     Region          260..269
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409525"
     Region          278..283
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409525"
     Region          286..288
                     /region_name="Ig strand C'"
                     /note="Ig strand C' [structural motif]"
                     /db_xref="CDD:409525"
     Region          296..304
                     /region_name="Ig strand D"
                     /note="Ig strand D [structural motif]"
                     /db_xref="CDD:409525"
     Region          310..318
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409525"
     Region          329..335
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409525"
     Region          339..345
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409525"
     Region          404..547
                     /region_name="TIR"
                     /note="Toll - interleukin 1 - resistance; smart00255"
                     /db_xref="CDD:214587"
     CDS             1..685
                     /gene="Il1rap"
                     /gene_synonym="6430709H04Rik; IL-1RAcP"
                     /coded_by="NM_001159318.1:184..2241"
                     /note="isoform d precursor is encoded by transcript
                     variant 4"
                     /db_xref="CCDS:CCDS49815.1"
                     /db_xref="GeneID:16180"
                     /db_xref="MGI:MGI:104975"
ORIGIN      
        1 mgllwylmsl sfygilqsha sercddwgld tmrqiqvfed eparikcplf ehflkynyst
       61 ahssgltliw ywtrqdrdle epinfrlpen riskekdvlw frptllndtg nytcmlrntt
      121 ycskvafple vvqkdscfns amrfpvhkmy iehgihkitc pnvdgyfpss vkpsvtwykg
      181 cteivdfhnv lpegmnlsff iplvsnngny tcvvtypeng rlfhltrtvt vkvvgspkda
      241 lppqiyspnd rvvyekepge elvipckvyf sfimdshnev wwtidgkkpd dvtvditine
      301 svsysstede trtqilsikk vtpedlrrny vcharntkge aeqaakvkqk vipprytvel
      361 acgfgatvfl vvvlivvyhv ywlemvlfyr ahfgtdetil dgkeydiyvs yarnveeeef
      421 vlltlrgvle nefgyklcif drdslpggnt veavfdfiqr srrmivvlsp dyvteksism
      481 lefklgvmcq nsiatklivv eyrpleqphp gimqlkesvs fvswkgeksk hsgskfwkal
      541 rlalplrsls assgwnescs sqsdisldhv qrrsrlkepp elrsservsg aepapgtmsk
      601 hrgkpsaacr ccvtyceges hlrsksraem hthpqwethl ckpplqeses qwiqngtrpe
      661 papqisalal rhftdlsnnn dfyil
//
