LOCUS       NM_010555               1402 bp    mRNA    linear   ROD 11-MAR-2025
DEFINITION  Mus musculus interleukin 1 receptor, type II (Il1r2), transcript
            variant 2, mRNA.
ACCESSION   NM_010555
VERSION     NM_010555.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1402)
  AUTHORS   Cros,A. and Segura,E.
  TITLE     IL1R2 Acts as a Negative Regulator of Monocyte Recruitment During
            Inflammation
  JOURNAL   Eur J Immunol 55 (1), e202451468 (2025)
   PUBMED   39610166
REFERENCE   2  (bases 1 to 1402)
  AUTHORS   Belbezier,A., Engeroff,P., Fourcade,G., Vantomme,H., Vaineau,R.,
            Gouritin,B., Bellier,B., Brocheriou,I., Tchitchek,N.,
            Graff-Dubois,S. and Klatzmann,D.
  TITLE     Interleukin-1 regulates follicular T cells during the germinal
            center reaction
  JOURNAL   Front Immunol 15, 1393096 (2024)
   PUBMED   38855101
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1402)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 1402)
  AUTHORS   Pyrillou,K., Humphry,M., Kitt,L.A., Rodgers,A., Nus,M.,
            Bennett,M.R., Smith,K.G., Lyons,P.A., Mallat,Z. and Clarke,M.C.
  TITLE     Loss of T follicular regulatory cell-derived IL-1R2 augments
            germinal center reactions via increased IL-1
  JOURNAL   JCI Insight 9 (5), e174005 (2024)
   PUBMED   38329807
  REMARK    GeneRIF: Loss of T follicular regulatory cell-derived IL-1R2
            augments germinal center reactions via increased IL-1.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1402)
  AUTHORS   Zhou,N., Liu,L. and Li,Q.
  TITLE     IL1R2 promotes retinal angiogenesis to participate in retinopathy
            of prematurity by activating the HIF1alpha/PFKFB3 pathway
  JOURNAL   Exp Eye Res 239, 109750 (2024)
   PUBMED   38097102
  REMARK    GeneRIF: IL1R2 promotes retinal angiogenesis to participate in
            retinopathy of prematurity by activating the HIF1alpha/PFKFB3
            pathway.
REFERENCE   6  (bases 1 to 1402)
  AUTHORS   Parnet,P., Brunke,D.L., Goujon,E., Mainard,J.D., Biragyn,A.,
            Arkins,S., Dantzer,R. and Kelley,K.W.
  TITLE     Molecular identification of two types of interleukin-1 receptors in
            the murine pituitary gland
  JOURNAL   J Neuroendocrinol 5 (2), 213-219 (1993)
   PUBMED   7683560
REFERENCE   7  (bases 1 to 1402)
  AUTHORS   Deyerle,K.L., Sims,J.E., Dower,S.K. and Bothwell,M.A.
  TITLE     Pattern of IL-1 receptor gene expression suggests role in
            noninflammatory processes
  JOURNAL   J Immunol 149 (5), 1657-1665 (1992)
   PUBMED   1387148
REFERENCE   8  (bases 1 to 1402)
  AUTHORS   Cunningham,E.T. Jr., Wada,E., Carter,D.B., Tracey,D.E., Battey,J.F.
            and De Souza,E.B.
  TITLE     Distribution of type I interleukin-1 receptor messenger RNA in
            testis: an in situ histochemical study in the mouse
  JOURNAL   Neuroendocrinology 56 (1), 94-99 (1992)
   PUBMED   1386414
REFERENCE   9  (bases 1 to 1402)
  AUTHORS   McMahan,C.J., Slack,J.L., Mosley,B., Cosman,D., Lupton,S.D.,
            Brunton,L.L., Grubin,C.E., Wignall,J.M., Jenkins,N.A., Brannan,C.I.
            et al.
  TITLE     A novel IL-1 receptor, cloned from B cells by mammalian expression,
            is expressed in many cell types
  JOURNAL   EMBO J 10 (10), 2821-2832 (1991)
   PUBMED   1833184
REFERENCE   10 (bases 1 to 1402)
  AUTHORS   Chizzonite,R., Truitt,T., Kilian,P.L., Stern,A.S., Nunes,P.,
            Parker,K.P., Kaffka,K.L., Chua,A.O., Lugg,D.K. and Gubler,U.
  TITLE     Two high-affinity interleukin 1 receptors represent separate gene
            products
  JOURNAL   Proc Natl Acad Sci U S A 86 (20), 8029-8033 (1989)
   PUBMED   2530579
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC161534.5 and AK132264.1.
            
            On Feb 14, 2018 this sequence version replaced NM_010555.4.
            
            Transcript Variant: This variant (2) differs in the 5' UTR and
            coding sequence compared to variant 1. The resulting isoform (2) is
            shorter at the N-terminus compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X59769.1, AK132264.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-28                AC161534.5         65109-65136
            29-1391             AK132264.1         2-1364
            1392-1402           AC161534.5         105615-105625
FEATURES             Location/Qualifiers
     source          1..1402
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 18.65 cM"
     gene            1..1402
                     /gene="Il1r2"
                     /gene_synonym="CD121b; Il1r-2"
                     /note="interleukin 1 receptor, type II"
                     /db_xref="GeneID:16178"
                     /db_xref="MGI:MGI:96546"
     exon            1..106
                     /gene="Il1r2"
                     /gene_synonym="CD121b; Il1r-2"
                     /inference="alignment:Splign:2.1.0"
     exon            107..255
                     /gene="Il1r2"
                     /gene_synonym="CD121b; Il1r-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             147..1379
                     /gene="Il1r2"
                     /gene_synonym="CD121b; Il1r-2"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 2; interleukin-1 receptor type 2; IL-1R-2;
                     IL-1RT2; IL-1RT-2; IL-1R-beta; interleukin-1 receptor
                     beta; CD121 antigen-like family member B; IL-1 receptor
                     beta chain; IL-1 type II receptor"
                     /codon_start=1
                     /product="interleukin-1 receptor type 2 isoform 2
                     precursor"
                     /protein_id="NP_034685.1"
                     /db_xref="CCDS:CCDS14909.1"
                     /db_xref="GeneID:16178"
                     /db_xref="MGI:MGI:96546"
                     /translation="MFILLVLVTGVSAFTTPTVVHTGKVSESPITSEKPTVHGDNCQF
                     RGREFKSELRLEGEPVVLRCPLAPHSDISSSSHSFLTWSKLDSSQLIPRDEPRMWVKG
                     NILWILPAVQQDSGTYICTFRNASHCEQMSVELKVFKNTEASLPHVSYLQISALSTTG
                     LLVCPDLKEFISSNADGKIQWYKGAILLDKGNKEFLSAGDPTRLLISNTSMDDAGYYR
                     CVMTFTYNGQEYNITRNIELRVKGTTTEPIPVIISPLETIPASLGSRLIVPCKVFLGT
                     GTSSNTIVWWLANSTFISAAYPRGRVTEGLHHQYSENDENYVEVSLIFDPVTREDLHT
                     DFKCVASNPRSSQSLHTTVKEVSSTFSWSIALAPLSLIILVVGAIWMRRRCKRRAGKT
                     YGLTKLRTDNQDFPSSPN"
     exon            256..514
                     /gene="Il1r2"
                     /gene_synonym="CD121b; Il1r-2"
                     /inference="alignment:Splign:2.1.0"
     exon            515..695
                     /gene="Il1r2"
                     /gene_synonym="CD121b; Il1r-2"
                     /inference="alignment:Splign:2.1.0"
     exon            696..870
                     /gene="Il1r2"
                     /gene_synonym="CD121b; Il1r-2"
                     /inference="alignment:Splign:2.1.0"
     exon            871..933
                     /gene="Il1r2"
                     /gene_synonym="CD121b; Il1r-2"
                     /inference="alignment:Splign:2.1.0"
     exon            934..1069
                     /gene="Il1r2"
                     /gene_synonym="CD121b; Il1r-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1070..1212
                     /gene="Il1r2"
                     /gene_synonym="CD121b; Il1r-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1213..1402
                     /gene="Il1r2"
                     /gene_synonym="CD121b; Il1r-2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1375..1380
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Il1r2"
                     /gene_synonym="CD121b; Il1r-2"
                     /note="hexamer: ACTAAA"
     regulatory      1379..1384
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Il1r2"
                     /gene_synonym="CD121b; Il1r-2"
                     /note="hexamer: AATAAA"
     polyA_site      1394
                     /gene="Il1r2"
                     /gene_synonym="CD121b; Il1r-2"
     polyA_site      1399
                     /gene="Il1r2"
                     /gene_synonym="CD121b; Il1r-2"
                     /note="major polyA site"
ORIGIN      
        1 aaatccctga gggggctgct gggacatcac agaaggtgaa agtctggccc agcagccttc
       61 cccagtcagg caagaagcag caaggtacaa gaatacacag ctccaggctc caagggtcct
      121 gtgcgctcag gaagttggtg cggacaatgt tcatcttgct tgtgttagta actggagttt
      181 ctgctttcac cactccaaca gtggtgcaca caggaaaggt ttctgaatcc cccattacat
      241 cggagaagcc cacagtccat ggagacaact gtcagtttcg tggcagagag ttcaaatctg
      301 aattgaggct ggaaggtgaa cctgtggttc tgaggtgccc cttggcacct cactccgaca
      361 tctccagcag ttcccatagt tttctgacct ggagtaaatt ggactcttct cagctgatcc
      421 caagagatga gccaaggatg tgggtgaagg gtaacatact ctggattctg ccagcagtgc
      481 agcaagactc tggtacctac atttgcacat tcagaaacgc atcccactgt gagcaaatgt
      541 ctgtggaact caaggtcttt aagaatactg aagcatctct gcctcatgtc tcctacttgc
      601 aaatctcagc tctctccacc accgggttac tagtgtgccc tgacctgaaa gaattcatct
      661 ccagcaacgc tgatggaaag atacagtggt ataagggcgc catactcttg gataaaggca
      721 ataaggaatt tctgagtgca ggagacccca cacgcctatt gatatccaac acgtccatgg
      781 acgatgcagg ctattacaga tgtgttatga catttaccta caatggccag gaatacaaca
      841 tcactaggaa tattgaactc cgggtcaaag gaacaaccac ggaacccatc cctgtgatca
      901 tttctcccct ggagacaata ccagcatcat tggggtcaag actgatagtc ccgtgcaaag
      961 tgtttctggg aactggtaca tcttccaaca ccattgtgtg gtggttggct aacagcacgt
     1021 ttatctcggc tgcttaccca agaggccgtg tgaccgaggg gctacaccac cagtactcag
     1081 agaatgatga aaactatgtg gaagtgtcgc tgatttttga tccagtcaca agggaggatc
     1141 tgcatacaga ttttaaatgt gttgcctcga atccacggag ttctcagtca ctccatacca
     1201 cagtcaaaga agtctcttcc acgttctcct ggagcattgc gctggcacct ctgtctctga
     1261 tcatcttggt tgtgggggca atatggatgc gcagacggtg taaacgcagg gctggaaaga
     1321 catatggact gaccaagcta cggactgaca accaggactt cccttccagc ccaaactaaa
     1381 taaaggaaat gaaataatac ga
//
