LOCUS       NM_001360801            1143 bp    mRNA    linear   ROD 11-MAR-2025
DEFINITION  Mus musculus interleukin 1 receptor, type II (Il1r2), transcript
            variant 3, mRNA.
ACCESSION   NM_001360801
VERSION     NM_001360801.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1143)
  AUTHORS   Cros,A. and Segura,E.
  TITLE     IL1R2 Acts as a Negative Regulator of Monocyte Recruitment During
            Inflammation
  JOURNAL   Eur J Immunol 55 (1), e202451468 (2025)
   PUBMED   39610166
REFERENCE   2  (bases 1 to 1143)
  AUTHORS   Belbezier,A., Engeroff,P., Fourcade,G., Vantomme,H., Vaineau,R.,
            Gouritin,B., Bellier,B., Brocheriou,I., Tchitchek,N.,
            Graff-Dubois,S. and Klatzmann,D.
  TITLE     Interleukin-1 regulates follicular T cells during the germinal
            center reaction
  JOURNAL   Front Immunol 15, 1393096 (2024)
   PUBMED   38855101
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1143)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 1143)
  AUTHORS   Pyrillou,K., Humphry,M., Kitt,L.A., Rodgers,A., Nus,M.,
            Bennett,M.R., Smith,K.G., Lyons,P.A., Mallat,Z. and Clarke,M.C.
  TITLE     Loss of T follicular regulatory cell-derived IL-1R2 augments
            germinal center reactions via increased IL-1
  JOURNAL   JCI Insight 9 (5), e174005 (2024)
   PUBMED   38329807
  REMARK    GeneRIF: Loss of T follicular regulatory cell-derived IL-1R2
            augments germinal center reactions via increased IL-1.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1143)
  AUTHORS   Zhou,N., Liu,L. and Li,Q.
  TITLE     IL1R2 promotes retinal angiogenesis to participate in retinopathy
            of prematurity by activating the HIF1alpha/PFKFB3 pathway
  JOURNAL   Exp Eye Res 239, 109750 (2024)
   PUBMED   38097102
  REMARK    GeneRIF: IL1R2 promotes retinal angiogenesis to participate in
            retinopathy of prematurity by activating the HIF1alpha/PFKFB3
            pathway.
REFERENCE   6  (bases 1 to 1143)
  AUTHORS   Parnet,P., Brunke,D.L., Goujon,E., Mainard,J.D., Biragyn,A.,
            Arkins,S., Dantzer,R. and Kelley,K.W.
  TITLE     Molecular identification of two types of interleukin-1 receptors in
            the murine pituitary gland
  JOURNAL   J Neuroendocrinol 5 (2), 213-219 (1993)
   PUBMED   7683560
REFERENCE   7  (bases 1 to 1143)
  AUTHORS   Deyerle,K.L., Sims,J.E., Dower,S.K. and Bothwell,M.A.
  TITLE     Pattern of IL-1 receptor gene expression suggests role in
            noninflammatory processes
  JOURNAL   J Immunol 149 (5), 1657-1665 (1992)
   PUBMED   1387148
REFERENCE   8  (bases 1 to 1143)
  AUTHORS   Cunningham,E.T. Jr., Wada,E., Carter,D.B., Tracey,D.E., Battey,J.F.
            and De Souza,E.B.
  TITLE     Distribution of type I interleukin-1 receptor messenger RNA in
            testis: an in situ histochemical study in the mouse
  JOURNAL   Neuroendocrinology 56 (1), 94-99 (1992)
   PUBMED   1386414
REFERENCE   9  (bases 1 to 1143)
  AUTHORS   McMahan,C.J., Slack,J.L., Mosley,B., Cosman,D., Lupton,S.D.,
            Brunton,L.L., Grubin,C.E., Wignall,J.M., Jenkins,N.A., Brannan,C.I.
            et al.
  TITLE     A novel IL-1 receptor, cloned from B cells by mammalian expression,
            is expressed in many cell types
  JOURNAL   EMBO J 10 (10), 2821-2832 (1991)
   PUBMED   1833184
REFERENCE   10 (bases 1 to 1143)
  AUTHORS   Chizzonite,R., Truitt,T., Kilian,P.L., Stern,A.S., Nunes,P.,
            Parker,K.P., Kaffka,K.L., Chua,A.O., Lugg,D.K. and Gubler,U.
  TITLE     Two high-affinity interleukin 1 receptors represent separate gene
            products
  JOURNAL   Proc Natl Acad Sci U S A 86 (20), 8029-8033 (1989)
   PUBMED   2530579
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC161534.5 and BC032962.1.
            
            Transcript Variant: This variant (3) differs in the 5' UTR and
            coding sequence compared to variant 1. The resulting isoform (3) is
            shorter at the N-terminus compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC032962.1, SRR5189676.27711.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849383
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-78                AC161534.5         65109-65186
            79-809              BC032962.1         1-731
            810-810             AC161534.5         101439-101439
            811-1140            BC032962.1         733-1062
            1141-1143           AC161534.5         105623-105625
FEATURES             Location/Qualifiers
     source          1..1143
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 18.65 cM"
     gene            1..1143
                     /gene="Il1r2"
                     /gene_synonym="CD121b; Il1r-2"
                     /note="interleukin 1 receptor, type II"
                     /db_xref="GeneID:16178"
                     /db_xref="MGI:MGI:96546"
     exon            1..106
                     /gene="Il1r2"
                     /gene_synonym="CD121b; Il1r-2"
                     /inference="alignment:Splign:2.1.0"
     exon            107..255
                     /gene="Il1r2"
                     /gene_synonym="CD121b; Il1r-2"
                     /inference="alignment:Splign:2.1.0"
     exon            256..436
                     /gene="Il1r2"
                     /gene_synonym="CD121b; Il1r-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             278..1120
                     /gene="Il1r2"
                     /gene_synonym="CD121b; Il1r-2"
                     /note="isoform 3 is encoded by transcript variant 3;
                     interleukin-1 receptor type 2; IL-1R-2; IL-1RT2; IL-1RT-2;
                     IL-1R-beta; interleukin-1 receptor beta; CD121
                     antigen-like family member B; IL-1 receptor beta chain;
                     IL-1 type II receptor"
                     /codon_start=1
                     /product="interleukin-1 receptor type 2 isoform 3"
                     /protein_id="NP_001347730.1"
                     /db_xref="GeneID:16178"
                     /db_xref="MGI:MGI:96546"
                     /translation="MSVELKVFKNTEASLPHVSYLQISALSTTGLLVCPDLKEFISSN
                     ADGKIQWYKGAILLDKGNKEFLSAGDPTRLLISNTSMDDAGYYRCVMTFTYNGQEYNI
                     TRNIELRVKGTTTEPIPVIISPLETIPASLGSRLIVPCKVFLGTGTSSNTIVWWLANS
                     TFISAAYPRGRVTEGLHHQYSENDENYVEVSLIFDPVTREDLHTDFKCVASNPRSSQS
                     LHTTVKEVSSTFSWSIALAPLSLIILVVGAIWMRRRCKRRAGKTYGLTKLRTDNQDFP
                     SSPN"
     exon            437..611
                     /gene="Il1r2"
                     /gene_synonym="CD121b; Il1r-2"
                     /inference="alignment:Splign:2.1.0"
     exon            612..674
                     /gene="Il1r2"
                     /gene_synonym="CD121b; Il1r-2"
                     /inference="alignment:Splign:2.1.0"
     exon            675..810
                     /gene="Il1r2"
                     /gene_synonym="CD121b; Il1r-2"
                     /inference="alignment:Splign:2.1.0"
     exon            811..953
                     /gene="Il1r2"
                     /gene_synonym="CD121b; Il1r-2"
                     /inference="alignment:Splign:2.1.0"
     exon            954..1143
                     /gene="Il1r2"
                     /gene_synonym="CD121b; Il1r-2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1116..1121
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Il1r2"
                     /gene_synonym="CD121b; Il1r-2"
                     /note="hexamer: ACTAAA"
     regulatory      1120..1125
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Il1r2"
                     /gene_synonym="CD121b; Il1r-2"
                     /note="hexamer: AATAAA"
     polyA_site      1135
                     /gene="Il1r2"
                     /gene_synonym="CD121b; Il1r-2"
     polyA_site      1140
                     /gene="Il1r2"
                     /gene_synonym="CD121b; Il1r-2"
                     /note="major polyA site"
ORIGIN      
        1 aaatccctga gggggctgct gggacatcac agaaggtgaa agtctggccc agcagccttc
       61 cccagtcagg caagaagcag caaggtacaa gaatacacag ctccaggctc caagggtcct
      121 gtgcgctcag gaagttggtg cggacaatgt tcatcttgct tgtgttagta actggagttt
      181 ctgctttcac cactccaaca gtggtgcaca caggaaaggt ttctgaatcc cccattacat
      241 cggagaagcc cacagaaacg catcccactg tgagcaaatg tctgtggaac tcaaggtctt
      301 taagaatact gaagcatctc tgcctcatgt ctcctacttg caaatctcag ctctctccac
      361 caccgggtta ctagtgtgcc ctgacctgaa agaattcatc tccagcaacg ctgatggaaa
      421 gatacagtgg tataagggcg ccatactctt ggataaaggc aataaggaat ttctgagtgc
      481 aggagacccc acacgcctat tgatatccaa cacgtccatg gacgatgcag gctattacag
      541 atgtgttatg acatttacct acaatggcca ggaatacaac atcactagga atattgaact
      601 ccgggtcaaa ggaacaacca cggaacccat ccctgtgatc atttctcccc tggagacaat
      661 accagcatca ttggggtcaa gactgatagt cccgtgcaaa gtgtttctgg gaactggtac
      721 atcttccaac accattgtgt ggtggttggc taacagcacg tttatctcgg ctgcttaccc
      781 aagaggccgt gtgaccgagg ggctacacca ccagtactca gagaatgatg aaaactatgt
      841 ggaagtgtcg ctgatttttg atccagtcac aagggaggat ctgcatacag attttaaatg
      901 tgttgcctcg aatccacgga gttctcagtc actccatacc acagtcaaag aagtctcttc
      961 cacgttctcc tggagcattg cgctggcacc tctgtctctg atcatcttgg ttgtgggggc
     1021 aatatggatg cgcagacggt gtaaacgcag ggctggaaag acatatggac tgaccaagct
     1081 acggactgac aaccaggact tcccttccag cccaaactaa ataaaggaaa tgaaataata
     1141 cga
//
