LOCUS       NM_008362               4754 bp    mRNA    linear   ROD 28-JAN-2025
DEFINITION  Mus musculus interleukin 1 receptor, type I (Il1r1), transcript
            variant 1, mRNA.
ACCESSION   NM_008362 XM_979865
VERSION     NM_008362.3
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4754)
  AUTHORS   Nemeth,D.P., Liu,X., Monet,M.C., Niu,H., Maxey,G., Schrier,M.S.,
            Smirnova,M.I., McGovern,S.J., Herd,A., DiSabato,D.J., Floyd,T.,
            Atluri,R.R., Nusstein,A.C., Oliver,B., Witcher,K.G., Juste
            Ellis,J.S., Yip,J., Crider,A.D., McKim,D.B.,
            Gajewski-Kurdziel,P.A., Godbout,J.P., Zhang,Q., Blakely,R.D.,
            Sheridan,J.F. and Quan,N.
  TITLE     Localization of brain neuronal IL-1R1 reveals specific neural
            circuitries responsive to immune signaling
  JOURNAL   J Neuroinflammation 21 (1), 303 (2024)
   PUBMED   39563437
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4754)
  AUTHORS   Zhang,Y., Gao,Y., Wang,Y., Jiang,Y., Xiang,Y., Wang,X., Wang,Z.,
            Ding,Y., Chen,H., Rui,B., Huai,W., Cai,B., Ren,X., Ma,F., Xu,S.,
            Zhan,Z. and Liu,X.
  TITLE     RBM25 is required to restrain inflammation via ACLY RNA
            splicing-dependent metabolism rewiring
  JOURNAL   Cell Mol Immunol 21 (11), 1231-1250 (2024)
   PUBMED   39251781
REFERENCE   3  (bases 1 to 4754)
  AUTHORS   Park,M.D., Le Berichel,J., Hamon,P., Wilk,C.M., Belabed,M.,
            Yatim,N., Saffon,A., Boumelha,J., Falcomata,C., Tepper,A.,
            Hegde,S., Mattiuz,R., Soong,B.Y., LaMarche,N.M., Rentzeperis,F.,
            Troncoso,L., Halasz,L., Hennequin,C., Chin,T., Chen,E.P.,
            Reid,A.M., Su,M., Cahn,A.R., Koekkoek,L.L., Venturini,N.,
            Wood-Isenberg,S., D'souza,D., Chen,R., Dawson,T., Nie,K., Chen,Z.,
            Kim-Schulze,S., Casanova-Acebes,M., Swirski,F.K., Downward,J.,
            Vabret,N., Brown,B.D., Marron,T.U. and Merad,M.
  TITLE     Hematopoietic aging promotes cancer by fueling IL-1-driven
            emergency myelopoiesis
  JOURNAL   Science 386 (6720), eadn0327 (2024)
   PUBMED   39236155
REFERENCE   4  (bases 1 to 4754)
  AUTHORS   Li,N., Kumar,S.R.P., Cao,D., Munoz-Melero,M., Arisa,S., Brian,B.A.,
            Greenwood,C.M., Yamada,K., Duan,D. and Herzog,R.W.
  TITLE     Redundancy in Innate Immune Pathways That Promote CD8+ T-Cell
            Responses in AAV1 Muscle Gene Transfer
  JOURNAL   Viruses 16 (10), 1507 (2024)
   PUBMED   39459842
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4754)
  AUTHORS   van Baarle,L., De Simone,V., Schneider,L., Santhosh,S.,
            Abdurahiman,S., Biscu,F., Schneider,R., Zanoletti,L., Siqueira de
            Mello,R., Verbandt,S., Hu,Z., Stakenborg,M., Ke,B.J.,
            Stakenborg,N., Salvador Laureano,R., Garcia-Reyes,B., Henn,J.,
            Toma,M., Vanmechelen,M., Boeckxstaens,G., De Smet,F., Garg,A.D.,
            Ibiza,S., Tejpar,S., Wehner,S. and Matteoli,G.
  TITLE     IL-1R signaling drives enteric glia-macrophage interactions in
            colorectal cancer
  JOURNAL   Nat Commun 15 (1), 6079 (2024)
   PUBMED   39030280
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4754)
  AUTHORS   Deyerle,K.L., Sims,J.E., Dower,S.K. and Bothwell,M.A.
  TITLE     Pattern of IL-1 receptor gene expression suggests role in
            noninflammatory processes
  JOURNAL   J Immunol 149 (5), 1657-1665 (1992)
   PUBMED   1387148
REFERENCE   7  (bases 1 to 4754)
  AUTHORS   Cole,T.J., Copeland,N.G., Gilbert,D.J., Jenkins,N.A., Schutz,G. and
            Ruppert,S.
  TITLE     The mouse CREB (cAMP responsive element binding protein) gene:
            structure, promoter analysis, and chromosomal localization
  JOURNAL   Genomics 13 (4), 974-982 (1992)
   PUBMED   1387109
REFERENCE   8  (bases 1 to 4754)
  AUTHORS   Cunningham,E.T. Jr., Wada,E., Carter,D.B., Tracey,D.E., Battey,J.F.
            and De Souza,E.B.
  TITLE     Distribution of type I interleukin-1 receptor messenger RNA in
            testis: an in situ histochemical study in the mouse
  JOURNAL   Neuroendocrinology 56 (1), 94-99 (1992)
   PUBMED   1386414
REFERENCE   9  (bases 1 to 4754)
  AUTHORS   Ye,K., Koch,K.C., Clark,B.D. and Dinarello,C.A.
  TITLE     Interleukin-1 down-regulates gene and surface expression of
            interleukin-1 receptor type I by destabilizing its mRNA whereas
            interleukin-2 increases its expression
  JOURNAL   Immunology 75 (3), 427-434 (1992)
   PUBMED   1533388
REFERENCE   10 (bases 1 to 4754)
  AUTHORS   Cunningham,E.T. Jr., Wada,E., Carter,D.B., Tracey,D.E., Battey,J.F.
            and De Souza,E.B.
  TITLE     In situ histochemical localization of type I interleukin-1 receptor
            messenger RNA in the central nervous system, pituitary, and adrenal
            gland of the mouse
  JOURNAL   J Neurosci 12 (3), 1101-1114 (1992)
   PUBMED   1532025
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC135085.3 and AC167168.5.
            
            On Oct 11, 2022 this sequence version replaced NM_008362.2.
            
            Sequence Note:.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M20658.1, SRR17253014.3183290.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-249               AC135085.3         132186-132434
            250-313             AC135085.3         189361-189424
            314-551             AC135085.3         200248-200485
            552-741             AC135085.3         200586-200775
            742-910             AC135085.3         201886-202054
            911-976             AC135085.3         205037-205102
            977-1094            AC135085.3         207888-208005
            1095-1246           AC135085.3         209406-209557
            1247-1390           AC167168.5         130566-130709       c
            1391-1558           AC167168.5         128481-128648       c
            1559-4754           AC167168.5         124825-128020       c
FEATURES             Location/Qualifiers
     source          1..4754
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 18.81 cM"
     gene            1..4754
                     /gene="Il1r1"
                     /gene_synonym="CD121a; CD121b; IL-1R-1; IL-1R-alpha;
                     IL-1R1; IL-1RT-1; IL-1RT1; IL-iR; Il1r-1"
                     /note="interleukin 1 receptor, type I"
                     /db_xref="GeneID:16177"
                     /db_xref="MGI:MGI:96545"
     exon            1..249
                     /gene="Il1r1"
                     /gene_synonym="CD121a; CD121b; IL-1R-1; IL-1R-alpha;
                     IL-1R1; IL-1RT-1; IL-1RT1; IL-iR; Il1r-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             247..1977
                     /gene="Il1r1"
                     /gene_synonym="CD121a; CD121b; IL-1R-1; IL-1R-alpha;
                     IL-1R1; IL-1RT-1; IL-1RT1; IL-iR; Il1r-1"
                     /EC_number="3.2.2.6"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; interleukin-1 receptor type 1; interleukin-1
                     receptor alpha; CD121 antigen-like family member A; IL-1
                     receptor alpha chain"
                     /codon_start=1
                     /product="interleukin-1 receptor type 1 isoform 1
                     precursor"
                     /protein_id="NP_032388.1"
                     /db_xref="CCDS:CCDS35547.1"
                     /db_xref="GeneID:16177"
                     /db_xref="MGI:MGI:96545"
                     /translation="MENMKVLLGLICLMVPLLSLEIDVCTEYPNQIVLFLSVNEIDIR
                     KCPLTPNKMHGDTIIWYKNDSKTPISADRDSRIHQQNEHLWFVPAKVEDSGYYYCIVR
                     NSTYCLKTKVTVTVLENDPGLCYSTQATFPQRLHIAGDGSLVCPYVSYFKDENNELPE
                     VQWYKNCKPLLLDNVSFFGVKDKLLVRNVAEEHRGDYICRMSYTFRGKQYPVTRVIQF
                     ITIDENKRDRPVILSPRNETIEADPGSMIQLICNVTGQFSDLVYWKWNGSEIEWNDPF
                     LAEDYQFVEHPSTKRKYTLITTLNISEVKSQFYRYPFICVVKNTNIFESAHVQLIYPV
                     PDFKNYLIGGFIILTATIVCCVCIYKVFKVDIVLWYRDSCSGFLPSKASDGKTYDAYI
                     LYPKTLGEGSFSDLDTFVFKLLPEVLEGQFGYKLFIYGRDDYVGEDTIEVTNENVKKS
                     RRLIIILVRDMGGFSWLGQSSEEQIAIYNALIQEGIKIVLLELEKIQDYEKMPDSIQF
                     IKQKHGVICWSGDFQERPQSAKTRFWKNLRYQMPAQRRSPLSKHRLLTLDPVRDTKEK
                     LPAATHLPLG"
     exon            250..313
                     /gene="Il1r1"
                     /gene_synonym="CD121a; CD121b; IL-1R-1; IL-1R-alpha;
                     IL-1R1; IL-1RT-1; IL-1RT1; IL-iR; Il1r-1"
                     /inference="alignment:Splign:2.1.0"
     exon            314..551
                     /gene="Il1r1"
                     /gene_synonym="CD121a; CD121b; IL-1R-1; IL-1R-alpha;
                     IL-1R1; IL-1RT-1; IL-1RT1; IL-iR; Il1r-1"
                     /inference="alignment:Splign:2.1.0"
     exon            552..741
                     /gene="Il1r1"
                     /gene_synonym="CD121a; CD121b; IL-1R-1; IL-1R-alpha;
                     IL-1R1; IL-1RT-1; IL-1RT1; IL-iR; Il1r-1"
                     /inference="alignment:Splign:2.1.0"
     exon            742..910
                     /gene="Il1r1"
                     /gene_synonym="CD121a; CD121b; IL-1R-1; IL-1R-alpha;
                     IL-1R1; IL-1RT-1; IL-1RT1; IL-iR; Il1r-1"
                     /inference="alignment:Splign:2.1.0"
     exon            911..976
                     /gene="Il1r1"
                     /gene_synonym="CD121a; CD121b; IL-1R-1; IL-1R-alpha;
                     IL-1R1; IL-1RT-1; IL-1RT1; IL-iR; Il1r-1"
                     /inference="alignment:Splign:2.1.0"
     exon            977..1094
                     /gene="Il1r1"
                     /gene_synonym="CD121a; CD121b; IL-1R-1; IL-1R-alpha;
                     IL-1R1; IL-1RT-1; IL-1RT1; IL-iR; Il1r-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1095..1246
                     /gene="Il1r1"
                     /gene_synonym="CD121a; CD121b; IL-1R-1; IL-1R-alpha;
                     IL-1R1; IL-1RT-1; IL-1RT1; IL-iR; Il1r-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1247..1390
                     /gene="Il1r1"
                     /gene_synonym="CD121a; CD121b; IL-1R-1; IL-1R-alpha;
                     IL-1R1; IL-1RT-1; IL-1RT1; IL-iR; Il1r-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1391..1558
                     /gene="Il1r1"
                     /gene_synonym="CD121a; CD121b; IL-1R-1; IL-1R-alpha;
                     IL-1R1; IL-1RT-1; IL-1RT1; IL-iR; Il1r-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1559..4754
                     /gene="Il1r1"
                     /gene_synonym="CD121a; CD121b; IL-1R-1; IL-1R-alpha;
                     IL-1R1; IL-1RT-1; IL-1RT1; IL-iR; Il1r-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4749..4754
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Il1r1"
                     /gene_synonym="CD121a; CD121b; IL-1R-1; IL-1R-alpha;
                     IL-1R1; IL-1RT-1; IL-1RT1; IL-iR; Il1r-1"
                     /note="hexamer: AATAAA"
     polyA_site      4754
                     /gene="Il1r1"
                     /gene_synonym="CD121a; CD121b; IL-1R-1; IL-1R-alpha;
                     IL-1R1; IL-1RT-1; IL-1RT1; IL-iR; Il1r-1"
                     /note="major polyA site"
ORIGIN      
        1 gtcatcagga gcccactttc tctgggtcgt ctgactagaa gtgagctgtc tgtcattctt
       61 gtgcacgcca gcccagtaat catttggagg caaagcaaac tgtaagtaat gctgtcctgg
      121 gctgacttga ggaggcagtt ttcgttttaa cagccagtgt ttatttgctc agcaaacgtt
      181 gtctcgggga gaaatgtcgc tggatgtcat cagagttccc agtgccccga accgtgaaca
      241 acacaaatgg agaatatgaa agtgctactg gggctcattt gtctcatggt gcctctgctg
      301 tcgctggaga ttgacgtatg tacagaatat ccaaatcaga tcgttttgtt tttatctgta
      361 aatgaaattg atattcgcaa gtgtcctctt actccaaata aaatgcacgg cgacaccata
      421 atttggtaca agaatgacag caagaccccc atatcagcgg accgggactc caggattcat
      481 cagcagaatg aacatctttg gtttgtacct gccaaggtgg aggactcagg atattactat
      541 tgtatagtaa gaaactcaac ttactgcctc aaaactaaag taaccgtaac tgtgttagag
      601 aatgaccctg gcttgtgtta cagcacacag gccaccttcc cacagcggct ccacattgcc
      661 ggggatggaa gtcttgtgtg cccttatgtg agttatttta aagatgaaaa taatgagtta
      721 cccgaggtcc agtggtataa gaactgtaaa cctctgcttc ttgacaacgt gagcttcttc
      781 ggagtaaaag ataaactgtt ggtgaggaat gtggctgaag agcacagagg ggactatata
      841 tgccgtatgt cctatacgtt ccgggggaag caatatccgg tcacacgagt aatacaattt
      901 atcacaatag atgaaaacaa gagggacaga cctgttatcc tgagccctcg gaatgagacg
      961 atcgaagctg acccaggatc aatgatacaa ctgatctgca acgtcacggg ccagttctca
     1021 gaccttgtct actggaagtg gaatggatca gaaattgaat ggaatgatcc atttctagct
     1081 gaagactatc aatttgtgga acatccttca accaaaagaa aatacacact cattacaaca
     1141 cttaacattt cagaagttaa aagccagttt tatcgctatc cgtttatctg tgttgttaag
     1201 aacacaaata tttttgagtc ggcgcatgtg cagttaatat acccagtccc tgacttcaag
     1261 aattacctca tcgggggctt tatcatcctc acggctacaa ttgtatgctg tgtgtgcatc
     1321 tataaagtct tcaaggttga catagtgctt tggtacaggg actcctgctc tggttttctt
     1381 ccttcaaaag cttcagatgg aaagacatac gatgcctata ttctttatcc caagaccctg
     1441 ggagaggggt ccttctcaga cttagatact tttgttttta aactgttgcc tgaggtcttg
     1501 gagggacagt ttggatacaa gctgttcatt tatggaaggg atgactatgt tggagaagat
     1561 accatcgagg ttactaatga aaatgtaaag aaaagcagga ggctgattat cattctagtg
     1621 agagatatgg gaggcttcag ctggctgggc cagtcatctg aagagcaaat agccatatac
     1681 aatgctctca tccaggaagg aattaaaatc gtcctgcttg agttggagaa aatccaagac
     1741 tatgagaaaa tgccagattc tattcagttc attaagcaga aacacggagt catttgctgg
     1801 tcaggagact ttcaagaaag accacagtct gcaaagacca ggttctggaa aaacttaaga
     1861 taccagatgc cagcccaacg gagatcacca ttgtctaaac accgcttact aaccctggat
     1921 cctgtgcggg acactaagga gaaactgccg gcagcaacac acttaccact cggctagcat
     1981 ggcaaaagtg ggcaggccaa gaacttcgga atatctccca tcataagagg ctgcagctgg
     2041 gctgtgcctc ccagtaaaac agtcacgaac caaacctgtg cagtcccttg ttccagatca
     2101 cctggaactg gattgggaag agaacaggac ttggtggcca ggaccgctca gagagccatg
     2161 gttgctcagg gatgctgctc cgggatgctt gactaacagt cgaggcagtg aactgggtgt
     2221 agaaagcgtc aggaaatggc cacatgtgtg gatggtttaa ttagattctg tggagtctca
     2281 cagtgggatt gtggttgtct gaggacactt tggggggtcg ctgtccaaga agtggctccc
     2341 caaagtataa gtgcgggtga ggtttactga taccccacag tggaaggcat ttcttccaga
     2401 tattttccag ataccttggc cgccaaactt cgttttcaaa cactgtgttt tattgtgtag
     2461 accttgaaaa ccacggtttc agtgaagaag gattctgtag ggttcactct tctgcagtca
     2521 ctttagcttt ctgcagaagt ctagatttta aattaactgt agaaggaagt cagacaccca
     2581 caggtttctt ctaatcaagc ttccaccctg caatggctgt cgtgccatct tccttctgtg
     2641 ttttactcgg ctcattgctt ctctggagac aaatgcaatg cttcctaccc ccgtcctgtc
     2701 acaggcagtc tgaggactca ccttcacacg tgagacttcg ctcttacccc agcccccacc
     2761 gctggagggg tttcaatccc ccaccctggg gctcttctgc gcagaagctg aagtctacgc
     2821 tcctcccaat ctttggtccc agtgccgctg ttcgccttcc tgctggttga ttgcagaacc
     2881 acctctgaga cctctgtacc tgctcttgga atgtctctgt ctttgccctg ccgcccactt
     2941 cccgtgccta tgatttgctc tagcatttct gccacctgac aaggagagga gcttgctaaa
     3001 gtttaaagtt tatttcaacg ctaagatccc aaccttccga tctctgccta ctctcagact
     3061 tggccagccc tcttgcctgt catcccaacc ctgctgcttc tctgtaaaag gttgtttctt
     3121 tactagcaga aatcagtctg cagggagggg tagtgcgtgt atctcactgt tttccgtatt
     3181 gggaacagat ggtatagatt tgccaaggcc tttattttaa agtgttcttg gaaaatcgta
     3241 tttaaatttg caattattct aatttgatat agagagaaac tgacctattt aacaaatgga
     3301 ctctcttaat tctactggac ccaggccttg aactttctgg tttctgtctc tgtgctctga
     3361 ctttttgatt tcaggtctag ccctgtgcac ttacctcagt actcagtact tactcagtac
     3421 taactcagta ctcgtgggag gacacccgac ccgggtgttc tttgagaagc agctgagtga
     3481 ggcatgtttt gacaggagga acccagttct tttcactgtt ggtatttata gcacctacct
     3541 tcagattttt cagtatgatg tttctatttt ccaatactgg ttccctaacg gtcaacattt
     3601 cttctcccaa ctaaaaatgt aagaagaaaa aaaaattttt ttctttttct cttttttttt
     3661 ttttttgtgg tacagaagtt ttttgtttgg ttatttgttt gtttgatttt aactagatga
     3721 ctgtcttcag aataatcctc acagttctgg aagattgaaa aaccaagttc acatgacaag
     3781 aacaaacccg gttttaaggg ttgaatgtag ggggatacca ttctgtcttt tagactttca
     3841 acatctgcta tggtggagca caaatgttat ttaaaagcat cttctcacct acatagaagt
     3901 aaacaaaaca cacaatttgg gattttgact cttcagtttt gacctcactt ctcctggatc
     3961 caacctgaca ggagatgact ggattgctgg ggtagagaag gaaaggctgt ccccgacagc
     4021 agccagaagt ctgtgggagt gaggtcattc ctgacccgtg atgctttcaa ggcttggttt
     4081 ttctgataat tatttttgcc tgtcatccca aaaacgtatt gacatgcgtg tatattacct
     4141 gtgagtgaga gttcttagaa acttggccag agaggataaa ggggagagca gtgacagaga
     4201 accgccgatc ttgtgacacc ggagtctgag gtggaacaga gccagtgtca ggaaagcccc
     4261 tcagcaagaa agaagagtca ttgctggttc ccaggggcag tcacagagga tgaaatacca
     4321 catcaaggca gtgggaactt cctgcgactt ctcctggtcc tccccagaag tatctggtgt
     4381 cagctgaaga ccatgtgtcc cccaatactt agatttcacc gtactttctg atggtgtttt
     4441 taaaaggcca agtgttgcaa aagtttgcac gtgcaaccgt atattaatcg ccagtgttta
     4501 aaactggttt atcagaattt atatttttgt ctctcctgcc ttttgaattt tacttatgac
     4561 agagaaagta ttgagccatg actttttaaa aataatttat atttatactg gtcaataatg
     4621 aaggtttttt tttattatta aagaacttga ttttataatt ctgcagcaga tgccaaatgt
     4681 tatctatcac aaaccacaaa atttatgtac agtgcatatt attgatcaat aaactaaact
     4741 tgttttccaa taaa
//
