LOCUS       NM_001123382            4801 bp    mRNA    linear   ROD 28-JAN-2025
DEFINITION  Mus musculus interleukin 1 receptor, type I (Il1r1), transcript
            variant 2, mRNA.
ACCESSION   NM_001123382
VERSION     NM_001123382.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4801)
  AUTHORS   Nemeth,D.P., Liu,X., Monet,M.C., Niu,H., Maxey,G., Schrier,M.S.,
            Smirnova,M.I., McGovern,S.J., Herd,A., DiSabato,D.J., Floyd,T.,
            Atluri,R.R., Nusstein,A.C., Oliver,B., Witcher,K.G., Juste
            Ellis,J.S., Yip,J., Crider,A.D., McKim,D.B.,
            Gajewski-Kurdziel,P.A., Godbout,J.P., Zhang,Q., Blakely,R.D.,
            Sheridan,J.F. and Quan,N.
  TITLE     Localization of brain neuronal IL-1R1 reveals specific neural
            circuitries responsive to immune signaling
  JOURNAL   J Neuroinflammation 21 (1), 303 (2024)
   PUBMED   39563437
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4801)
  AUTHORS   Zhang,Y., Gao,Y., Wang,Y., Jiang,Y., Xiang,Y., Wang,X., Wang,Z.,
            Ding,Y., Chen,H., Rui,B., Huai,W., Cai,B., Ren,X., Ma,F., Xu,S.,
            Zhan,Z. and Liu,X.
  TITLE     RBM25 is required to restrain inflammation via ACLY RNA
            splicing-dependent metabolism rewiring
  JOURNAL   Cell Mol Immunol 21 (11), 1231-1250 (2024)
   PUBMED   39251781
REFERENCE   3  (bases 1 to 4801)
  AUTHORS   Park,M.D., Le Berichel,J., Hamon,P., Wilk,C.M., Belabed,M.,
            Yatim,N., Saffon,A., Boumelha,J., Falcomata,C., Tepper,A.,
            Hegde,S., Mattiuz,R., Soong,B.Y., LaMarche,N.M., Rentzeperis,F.,
            Troncoso,L., Halasz,L., Hennequin,C., Chin,T., Chen,E.P.,
            Reid,A.M., Su,M., Cahn,A.R., Koekkoek,L.L., Venturini,N.,
            Wood-Isenberg,S., D'souza,D., Chen,R., Dawson,T., Nie,K., Chen,Z.,
            Kim-Schulze,S., Casanova-Acebes,M., Swirski,F.K., Downward,J.,
            Vabret,N., Brown,B.D., Marron,T.U. and Merad,M.
  TITLE     Hematopoietic aging promotes cancer by fueling IL-1-driven
            emergency myelopoiesis
  JOURNAL   Science 386 (6720), eadn0327 (2024)
   PUBMED   39236155
REFERENCE   4  (bases 1 to 4801)
  AUTHORS   Li,N., Kumar,S.R.P., Cao,D., Munoz-Melero,M., Arisa,S., Brian,B.A.,
            Greenwood,C.M., Yamada,K., Duan,D. and Herzog,R.W.
  TITLE     Redundancy in Innate Immune Pathways That Promote CD8+ T-Cell
            Responses in AAV1 Muscle Gene Transfer
  JOURNAL   Viruses 16 (10), 1507 (2024)
   PUBMED   39459842
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4801)
  AUTHORS   van Baarle,L., De Simone,V., Schneider,L., Santhosh,S.,
            Abdurahiman,S., Biscu,F., Schneider,R., Zanoletti,L., Siqueira de
            Mello,R., Verbandt,S., Hu,Z., Stakenborg,M., Ke,B.J.,
            Stakenborg,N., Salvador Laureano,R., Garcia-Reyes,B., Henn,J.,
            Toma,M., Vanmechelen,M., Boeckxstaens,G., De Smet,F., Garg,A.D.,
            Ibiza,S., Tejpar,S., Wehner,S. and Matteoli,G.
  TITLE     IL-1R signaling drives enteric glia-macrophage interactions in
            colorectal cancer
  JOURNAL   Nat Commun 15 (1), 6079 (2024)
   PUBMED   39030280
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4801)
  AUTHORS   Deyerle,K.L., Sims,J.E., Dower,S.K. and Bothwell,M.A.
  TITLE     Pattern of IL-1 receptor gene expression suggests role in
            noninflammatory processes
  JOURNAL   J Immunol 149 (5), 1657-1665 (1992)
   PUBMED   1387148
REFERENCE   7  (bases 1 to 4801)
  AUTHORS   Cole,T.J., Copeland,N.G., Gilbert,D.J., Jenkins,N.A., Schutz,G. and
            Ruppert,S.
  TITLE     The mouse CREB (cAMP responsive element binding protein) gene:
            structure, promoter analysis, and chromosomal localization
  JOURNAL   Genomics 13 (4), 974-982 (1992)
   PUBMED   1387109
REFERENCE   8  (bases 1 to 4801)
  AUTHORS   Cunningham,E.T. Jr., Wada,E., Carter,D.B., Tracey,D.E., Battey,J.F.
            and De Souza,E.B.
  TITLE     Distribution of type I interleukin-1 receptor messenger RNA in
            testis: an in situ histochemical study in the mouse
  JOURNAL   Neuroendocrinology 56 (1), 94-99 (1992)
   PUBMED   1386414
REFERENCE   9  (bases 1 to 4801)
  AUTHORS   Ye,K., Koch,K.C., Clark,B.D. and Dinarello,C.A.
  TITLE     Interleukin-1 down-regulates gene and surface expression of
            interleukin-1 receptor type I by destabilizing its mRNA whereas
            interleukin-2 increases its expression
  JOURNAL   Immunology 75 (3), 427-434 (1992)
   PUBMED   1533388
REFERENCE   10 (bases 1 to 4801)
  AUTHORS   Cunningham,E.T. Jr., Wada,E., Carter,D.B., Tracey,D.E., Battey,J.F.
            and De Souza,E.B.
  TITLE     In situ histochemical localization of type I interleukin-1 receptor
            messenger RNA in the central nervous system, pituitary, and adrenal
            gland of the mouse
  JOURNAL   J Neurosci 12 (3), 1101-1114 (1992)
   PUBMED   1532025
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC135085.3 and AC167168.5.
            
            On Oct 11, 2022 this sequence version replaced NM_001123382.1.
            
            Sequence Note:.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK054137.1, AK048550.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-296               AC135085.3         173714-174009
            297-360             AC135085.3         189361-189424
            361-598             AC135085.3         200248-200485
            599-788             AC135085.3         200586-200775
            789-957             AC135085.3         201886-202054
            958-1023            AC135085.3         205037-205102
            1024-1141           AC135085.3         207888-208005
            1142-1293           AC135085.3         209406-209557
            1294-1437           AC167168.5         130566-130709       c
            1438-1605           AC167168.5         128481-128648       c
            1606-4801           AC167168.5         124825-128020       c
FEATURES             Location/Qualifiers
     source          1..4801
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 18.81 cM"
     gene            1..4801
                     /gene="Il1r1"
                     /gene_synonym="CD121a; CD121b; IL-1R-1; IL-1R-alpha;
                     IL-1R1; IL-1RT-1; IL-1RT1; IL-iR; Il1r-1"
                     /note="interleukin 1 receptor, type I"
                     /db_xref="GeneID:16177"
                     /db_xref="MGI:MGI:96545"
     exon            1..296
                     /gene="Il1r1"
                     /gene_synonym="CD121a; CD121b; IL-1R-1; IL-1R-alpha;
                     IL-1R1; IL-1RT-1; IL-1RT1; IL-iR; Il1r-1"
                     /inference="alignment:Splign:2.1.0"
     exon            297..360
                     /gene="Il1r1"
                     /gene_synonym="CD121a; CD121b; IL-1R-1; IL-1R-alpha;
                     IL-1R1; IL-1RT-1; IL-1RT1; IL-iR; Il1r-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             303..2024
                     /gene="Il1r1"
                     /gene_synonym="CD121a; CD121b; IL-1R-1; IL-1R-alpha;
                     IL-1R1; IL-1RT-1; IL-1RT1; IL-iR; Il1r-1"
                     /EC_number="3.2.2.6"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 2; interleukin-1 receptor type 1; interleukin-1
                     receptor alpha; CD121 antigen-like family member A; IL-1
                     receptor alpha chain"
                     /codon_start=1
                     /product="interleukin-1 receptor type 1 isoform 2
                     precursor"
                     /protein_id="NP_001116854.1"
                     /db_xref="CCDS:CCDS48246.1"
                     /db_xref="GeneID:16177"
                     /db_xref="MGI:MGI:96545"
                     /translation="MKVLLGLICLMVPLLSLEIDVCTEYPNQIVLFLSVNEIDIRKCP
                     LTPNKMHGDTIIWYKNDSKTPISADRDSRIHQQNEHLWFVPAKVEDSGYYYCIVRNST
                     YCLKTKVTVTVLENDPGLCYSTQATFPQRLHIAGDGSLVCPYVSYFKDENNELPEVQW
                     YKNCKPLLLDNVSFFGVKDKLLVRNVAEEHRGDYICRMSYTFRGKQYPVTRVIQFITI
                     DENKRDRPVILSPRNETIEADPGSMIQLICNVTGQFSDLVYWKWNGSEIEWNDPFLAE
                     DYQFVEHPSTKRKYTLITTLNISEVKSQFYRYPFICVVKNTNIFESAHVQLIYPVPDF
                     KNYLIGGFIILTATIVCCVCIYKVFKVDIVLWYRDSCSGFLPSKASDGKTYDAYILYP
                     KTLGEGSFSDLDTFVFKLLPEVLEGQFGYKLFIYGRDDYVGEDTIEVTNENVKKSRRL
                     IIILVRDMGGFSWLGQSSEEQIAIYNALIQEGIKIVLLELEKIQDYEKMPDSIQFIKQ
                     KHGVICWSGDFQERPQSAKTRFWKNLRYQMPAQRRSPLSKHRLLTLDPVRDTKEKLPA
                     ATHLPLG"
     exon            361..598
                     /gene="Il1r1"
                     /gene_synonym="CD121a; CD121b; IL-1R-1; IL-1R-alpha;
                     IL-1R1; IL-1RT-1; IL-1RT1; IL-iR; Il1r-1"
                     /inference="alignment:Splign:2.1.0"
     exon            599..788
                     /gene="Il1r1"
                     /gene_synonym="CD121a; CD121b; IL-1R-1; IL-1R-alpha;
                     IL-1R1; IL-1RT-1; IL-1RT1; IL-iR; Il1r-1"
                     /inference="alignment:Splign:2.1.0"
     exon            789..957
                     /gene="Il1r1"
                     /gene_synonym="CD121a; CD121b; IL-1R-1; IL-1R-alpha;
                     IL-1R1; IL-1RT-1; IL-1RT1; IL-iR; Il1r-1"
                     /inference="alignment:Splign:2.1.0"
     exon            958..1023
                     /gene="Il1r1"
                     /gene_synonym="CD121a; CD121b; IL-1R-1; IL-1R-alpha;
                     IL-1R1; IL-1RT-1; IL-1RT1; IL-iR; Il1r-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1024..1141
                     /gene="Il1r1"
                     /gene_synonym="CD121a; CD121b; IL-1R-1; IL-1R-alpha;
                     IL-1R1; IL-1RT-1; IL-1RT1; IL-iR; Il1r-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1142..1293
                     /gene="Il1r1"
                     /gene_synonym="CD121a; CD121b; IL-1R-1; IL-1R-alpha;
                     IL-1R1; IL-1RT-1; IL-1RT1; IL-iR; Il1r-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1294..1437
                     /gene="Il1r1"
                     /gene_synonym="CD121a; CD121b; IL-1R-1; IL-1R-alpha;
                     IL-1R1; IL-1RT-1; IL-1RT1; IL-iR; Il1r-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1438..1605
                     /gene="Il1r1"
                     /gene_synonym="CD121a; CD121b; IL-1R-1; IL-1R-alpha;
                     IL-1R1; IL-1RT-1; IL-1RT1; IL-iR; Il1r-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1606..4801
                     /gene="Il1r1"
                     /gene_synonym="CD121a; CD121b; IL-1R-1; IL-1R-alpha;
                     IL-1R1; IL-1RT-1; IL-1RT1; IL-iR; Il1r-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4796..4801
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Il1r1"
                     /gene_synonym="CD121a; CD121b; IL-1R-1; IL-1R-alpha;
                     IL-1R1; IL-1RT-1; IL-1RT1; IL-iR; Il1r-1"
                     /note="hexamer: AATAAA"
     polyA_site      4801
                     /gene="Il1r1"
                     /gene_synonym="CD121a; CD121b; IL-1R-1; IL-1R-alpha;
                     IL-1R1; IL-1RT-1; IL-1RT1; IL-iR; Il1r-1"
                     /note="major polyA site"
ORIGIN      
        1 agtctccgcc cgctgcacgc ccccgcgggc ggctcagagt gggagcagcg tgctgctcag
       61 aaggtcttag ctggtgcggg gttccaggag ccgcctggga gcgcggcgcc cacctagaag
      121 ggcgggagcc cagctggtgc ccgcctgccc cagagcggaa ggaatgtgac ccccgagcga
      181 gcgcggagca gcccttgagc ggctcccagg gctccggttg ctcccggcct gaacgggttt
      241 agttcggagc tgctggattg ttgaacatcg ccactggggc acccgggcac gcccaggaga
      301 atatgaaagt gctactgggg ctcatttgtc tcatggtgcc tctgctgtcg ctggagattg
      361 acgtatgtac agaatatcca aatcagatcg ttttgttttt atctgtaaat gaaattgata
      421 ttcgcaagtg tcctcttact ccaaataaaa tgcacggcga caccataatt tggtacaaga
      481 atgacagcaa gacccccata tcagcggacc gggactccag gattcatcag cagaatgaac
      541 atctttggtt tgtacctgcc aaggtggagg actcaggata ttactattgt atagtaagaa
      601 actcaactta ctgcctcaaa actaaagtaa ccgtaactgt gttagagaat gaccctggct
      661 tgtgttacag cacacaggcc accttcccac agcggctcca cattgccggg gatggaagtc
      721 ttgtgtgccc ttatgtgagt tattttaaag atgaaaataa tgagttaccc gaggtccagt
      781 ggtataagaa ctgtaaacct ctgcttcttg acaacgtgag cttcttcgga gtaaaagata
      841 aactgttggt gaggaatgtg gctgaagagc acagagggga ctatatatgc cgtatgtcct
      901 atacgttccg ggggaagcaa tatccggtca cacgagtaat acaatttatc acaatagatg
      961 aaaacaagag ggacagacct gttatcctga gccctcggaa tgagacgatc gaagctgacc
     1021 caggatcaat gatacaactg atctgcaacg tcacgggcca gttctcagac cttgtctact
     1081 ggaagtggaa tggatcagaa attgaatgga atgatccatt tctagctgaa gactatcaat
     1141 ttgtggaaca tccttcaacc aaaagaaaat acacactcat tacaacactt aacatttcag
     1201 aagttaaaag ccagttttat cgctatccgt ttatctgtgt tgttaagaac acaaatattt
     1261 ttgagtcggc gcatgtgcag ttaatatacc cagtccctga cttcaagaat tacctcatcg
     1321 ggggctttat catcctcacg gctacaattg tatgctgtgt gtgcatctat aaagtcttca
     1381 aggttgacat agtgctttgg tacagggact cctgctctgg ttttcttcct tcaaaagctt
     1441 cagatggaaa gacatacgat gcctatattc tttatcccaa gaccctggga gaggggtcct
     1501 tctcagactt agatactttt gtttttaaac tgttgcctga ggtcttggag ggacagtttg
     1561 gatacaagct gttcatttat ggaagggatg actatgttgg agaagatacc atcgaggtta
     1621 ctaatgaaaa tgtaaagaaa agcaggaggc tgattatcat tctagtgaga gatatgggag
     1681 gcttcagctg gctgggccag tcatctgaag agcaaatagc catatacaat gctctcatcc
     1741 aggaaggaat taaaatcgtc ctgcttgagt tggagaaaat ccaagactat gagaaaatgc
     1801 cagattctat tcagttcatt aagcagaaac acggagtcat ttgctggtca ggagactttc
     1861 aagaaagacc acagtctgca aagaccaggt tctggaaaaa cttaagatac cagatgccag
     1921 cccaacggag atcaccattg tctaaacacc gcttactaac cctggatcct gtgcgggaca
     1981 ctaaggagaa actgccggca gcaacacact taccactcgg ctagcatggc aaaagtgggc
     2041 aggccaagaa cttcggaata tctcccatca taagaggctg cagctgggct gtgcctccca
     2101 gtaaaacagt cacgaaccaa acctgtgcag tcccttgttc cagatcacct ggaactggat
     2161 tgggaagaga acaggacttg gtggccagga ccgctcagag agccatggtt gctcagggat
     2221 gctgctccgg gatgcttgac taacagtcga ggcagtgaac tgggtgtaga aagcgtcagg
     2281 aaatggccac atgtgtggat ggtttaatta gattctgtgg agtctcacag tgggattgtg
     2341 gttgtctgag gacactttgg ggggtcgctg tccaagaagt ggctccccaa agtataagtg
     2401 cgggtgaggt ttactgatac cccacagtgg aaggcatttc ttccagatat tttccagata
     2461 ccttggccgc caaacttcgt tttcaaacac tgtgttttat tgtgtagacc ttgaaaacca
     2521 cggtttcagt gaagaaggat tctgtagggt tcactcttct gcagtcactt tagctttctg
     2581 cagaagtcta gattttaaat taactgtaga aggaagtcag acacccacag gtttcttcta
     2641 atcaagcttc caccctgcaa tggctgtcgt gccatcttcc ttctgtgttt tactcggctc
     2701 attgcttctc tggagacaaa tgcaatgctt cctacccccg tcctgtcaca ggcagtctga
     2761 ggactcacct tcacacgtga gacttcgctc ttaccccagc ccccaccgct ggaggggttt
     2821 caatccccca ccctggggct cttctgcgca gaagctgaag tctacgctcc tcccaatctt
     2881 tggtcccagt gccgctgttc gccttcctgc tggttgattg cagaaccacc tctgagacct
     2941 ctgtacctgc tcttggaatg tctctgtctt tgccctgccg cccacttccc gtgcctatga
     3001 tttgctctag catttctgcc acctgacaag gagaggagct tgctaaagtt taaagtttat
     3061 ttcaacgcta agatcccaac cttccgatct ctgcctactc tcagacttgg ccagccctct
     3121 tgcctgtcat cccaaccctg ctgcttctct gtaaaaggtt gtttctttac tagcagaaat
     3181 cagtctgcag ggaggggtag tgcgtgtatc tcactgtttt ccgtattggg aacagatggt
     3241 atagatttgc caaggccttt attttaaagt gttcttggaa aatcgtattt aaatttgcaa
     3301 ttattctaat ttgatataga gagaaactga cctatttaac aaatggactc tcttaattct
     3361 actggaccca ggccttgaac tttctggttt ctgtctctgt gctctgactt tttgatttca
     3421 ggtctagccc tgtgcactta cctcagtact cagtacttac tcagtactaa ctcagtactc
     3481 gtgggaggac acccgacccg ggtgttcttt gagaagcagc tgagtgaggc atgttttgac
     3541 aggaggaacc cagttctttt cactgttggt atttatagca cctaccttca gatttttcag
     3601 tatgatgttt ctattttcca atactggttc cctaacggtc aacatttctt ctcccaacta
     3661 aaaatgtaag aagaaaaaaa aatttttttc tttttctctt tttttttttt tttgtggtac
     3721 agaagttttt tgtttggtta tttgtttgtt tgattttaac tagatgactg tcttcagaat
     3781 aatcctcaca gttctggaag attgaaaaac caagttcaca tgacaagaac aaacccggtt
     3841 ttaagggttg aatgtagggg gataccattc tgtcttttag actttcaaca tctgctatgg
     3901 tggagcacaa atgttattta aaagcatctt ctcacctaca tagaagtaaa caaaacacac
     3961 aatttgggat tttgactctt cagttttgac ctcacttctc ctggatccaa cctgacagga
     4021 gatgactgga ttgctggggt agagaaggaa aggctgtccc cgacagcagc cagaagtctg
     4081 tgggagtgag gtcattcctg acccgtgatg ctttcaaggc ttggtttttc tgataattat
     4141 ttttgcctgt catcccaaaa acgtattgac atgcgtgtat attacctgtg agtgagagtt
     4201 cttagaaact tggccagaga ggataaaggg gagagcagtg acagagaacc gccgatcttg
     4261 tgacaccgga gtctgaggtg gaacagagcc agtgtcagga aagcccctca gcaagaaaga
     4321 agagtcattg ctggttccca ggggcagtca cagaggatga aataccacat caaggcagtg
     4381 ggaacttcct gcgacttctc ctggtcctcc ccagaagtat ctggtgtcag ctgaagacca
     4441 tgtgtccccc aatacttaga tttcaccgta ctttctgatg gtgtttttaa aaggccaagt
     4501 gttgcaaaag tttgcacgtg caaccgtata ttaatcgcca gtgtttaaaa ctggtttatc
     4561 agaatttata tttttgtctc tcctgccttt tgaattttac ttatgacaga gaaagtattg
     4621 agccatgact ttttaaaaat aatttatatt tatactggtc aataatgaag gttttttttt
     4681 attattaaag aacttgattt tataattctg cagcagatgc caaatgttat ctatcacaaa
     4741 ccacaaaatt tatgtacagt gcatattatt gatcaataaa ctaaacttgt tttccaataa
     4801 a
//
