LOCUS       NM_001418946            1265 bp    mRNA    linear   ROD 12-NOV-2024
DEFINITION  Mus musculus interleukin 1 family, member 10 (Il1f10), transcript
            variant 1, mRNA.
ACCESSION   NM_001418946
VERSION     NM_001418946.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1265)
  AUTHORS   da Silva,P., Mora,J., You,X., Wiechmann,S., Putyrski,M.,
            Garcia-Pardo,J., Kannt,A., Ernst,A., Bruene,B. and Weigert,A.
  TITLE     Neutralizing IL-38 activates gammadelta T cell-dependent antitumor
            immunity and sensitizes for chemotherapy
  JOURNAL   J Immunother Cancer 12 (8), e008641 (2024)
   PUBMED   39209451
  REMARK    GeneRIF: Neutralizing IL-38 activates gammadelta T cell-dependent
            antitumor immunity and sensitizes for chemotherapy.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1265)
  AUTHORS   Yue,C., Hu,Y., Yu,J., Zhou,H., Zhou,P., Hu,J., Wang,X., Gu,L.,
            Li,Y., Feng,Y., Zeng,F., Zhao,F., Li,G., Zhao,Q., Zhang,C.,
            Zheng,H., Wu,W., Cui,X., Huang,N., Wang,Z., Cui,K. and Li,J.
  TITLE     IL-38 Aggravates Atopic Dermatitis via Facilitating Migration of
            Langerhans cells
  JOURNAL   Int J Biol Sci 20 (8), 3094-3112 (2024)
   PUBMED   38904012
  REMARK    GeneRIF: IL-38 Aggravates Atopic Dermatitis via Facilitating
            Migration of Langerhans cells.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1265)
  AUTHORS   Wei,Y., Xing,J., Su,X., Li,X., Yan,X., Zhao,J. and Tao,H.
  TITLE     IL-38 attenuates myocardial ischemia-reperfusion injury by
            inhibiting macrophage inflammation
  JOURNAL   Immun Inflamm Dis 11 (6), e898 (2023)
   PUBMED   37382260
  REMARK    GeneRIF: IL-38 attenuates myocardial ischemia-reperfusion injury by
            inhibiting macrophage inflammation.
REFERENCE   4  (bases 1 to 1265)
  AUTHORS   Huard,A., Wilmes,C., Kiprina,A., Netzer,C., Palmer,G., Brune,B. and
            Weigert,A.
  TITLE     Cell Intrinsic IL-38 Affects B Cell Differentiation and Antibody
            Production
  JOURNAL   Int J Mol Sci 24 (6), 5676 (2023)
   PUBMED   36982750
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1265)
  AUTHORS   Zhou,H., Zhao,Q., Yue,C., Yu,J., Zheng,H., Hu,J., Hu,Z., Zhang,H.,
            Teng,X., Liu,X., Wei,X., Zhou,Y., Zeng,F., Hao,Y., Hu,Y., Wang,X.,
            Zhang,C., Gu,L., Wu,W., Zhou,Y., Cui,K., Huang,N., Li,W., Wang,Z.
            and Li,J.
  TITLE     Interleukin-38 promotes skin tumorigenesis in an IL-1Rrp2-dependent
            manner
  JOURNAL   EMBO Rep 23 (6), e53791 (2022)
   PUBMED   35578812
  REMARK    GeneRIF: Interleukin-38 promotes skin tumorigenesis in an
            IL-1Rrp2-dependent manner.
REFERENCE   6  (bases 1 to 1265)
  AUTHORS   Boutet,M.A., Najm,A., Bart,G., Brion,R., Touchais,S., Trichet,V.,
            Layrolle,P., Gabay,C., Palmer,G., Blanchard,F. and Le Goff,B.
  TITLE     IL-38 overexpression induces anti-inflammatory effects in mice
            arthritis models and in human macrophages in vitro
  JOURNAL   Ann Rheum Dis 76 (7), 1304-1312 (2017)
   PUBMED   28288964
  REMARK    GeneRIF: IL-38 overexpression attenuates the severity of
            experimental arthritis. IL-38 may exert its anti-inflammatory
            effects by decreasing the production of proinflammatory cytokines
            by macrophages and synovial fibroblasts.
REFERENCE   7  (bases 1 to 1265)
  AUTHORS   Takenaka,S.I., Kaieda,S., Kawayama,T., Matsuoka,M., Kaku,Y.,
            Kinoshita,T., Sakazaki,Y., Okamoto,M., Tominaga,M., Kanesaki,K.,
            Chiba,A., Miyake,S., Ida,H. and Hoshino,T.
  TITLE     IL-38: A new factor in rheumatoid arthritis
  JOURNAL   Biochem Biophys Rep 4, 386-391 (2015)
   PUBMED   29124228
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 1265)
  AUTHORS   Tang,T., Li,L., Tang,J., Li,Y., Lin,W.Y., Martin,F., Grant,D.,
            Solloway,M., Parker,L., Ye,W., Forrest,W., Ghilardi,N., Oravecz,T.,
            Platt,K.A., Rice,D.S., Hansen,G.M., Abuin,A., Eberhart,D.E.,
            Godowski,P., Holt,K.H., Peterson,A., Zambrowicz,B.P. and de
            Sauvage,F.J.
  TITLE     A mouse knockout library for secreted and transmembrane proteins
  JOURNAL   Nat Biotechnol 28 (7), 749-755 (2010)
   PUBMED   20562862
REFERENCE   9  (bases 1 to 1265)
  AUTHORS   Rogers,M.S., Rohan,R.M., Birsner,A.E. and D'Amato,R.J.
  TITLE     Genetic loci that control vascular endothelial growth
            factor-induced angiogenesis
  JOURNAL   FASEB J 17 (14), 2112-2114 (2003)
   PUBMED   12958152
REFERENCE   10 (bases 1 to 1265)
  AUTHORS   Taylor,S.L., Renshaw,B.R., Garka,K.E., Smith,D.E. and Sims,J.E.
  TITLE     Genomic organization of the interleukin-1 locus
  JOURNAL   Genomics 79 (5), 726-733 (2002)
   PUBMED   11991723
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL732430.5.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189676.44175.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMN00849383,
                                           SAMN01164133 [ECO:0000350]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-45                AL732430.5         167083-167127
            46-105              AL732430.5         171196-171255
            106-469             AL732430.5         172468-172831
            470-597             AL732430.5         173164-173291
            598-1265            AL732430.5         173557-174224
FEATURES             Location/Qualifiers
     source          1..1265
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 16.32 cM"
     gene            1..1265
                     /gene="Il1f10"
                     /note="interleukin 1 family, member 10"
                     /db_xref="GeneID:215274"
                     /db_xref="MGI:MGI:2652548"
     exon            1..45
                     /gene="Il1f10"
                     /inference="alignment:Splign:2.1.0"
     exon            46..105
                     /gene="Il1f10"
                     /inference="alignment:Splign:2.1.0"
     exon            106..469
                     /gene="Il1f10"
                     /inference="alignment:Splign:2.1.0"
     exon            470..597
                     /gene="Il1f10"
                     /inference="alignment:Splign:2.1.0"
     exon            598..1265
                     /gene="Il1f10"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1241..1246
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Il1f10"
                     /note="hexamer: AATAAA"
     polyA_site      1265
                     /gene="Il1f10"
                     /note="major polyA site"
ORIGIN      
        1 agttggagac tccaggcatt agaatccagg caccaggaac tacagtgaag accagacact
       61 cccaactgca ggaatgtgct cccttcccat ggcaagatac tacatggtac ctgagcttca
      121 aagcaactcc tcagacagcc atgaaaacat cctcaattac ctcatgagaa gacactattg
      181 tcatttctgg agcctctgat aatcctgagc ctaggcagct ttgggatgaa acaatttcta
      241 cccttattgg aacagtgtcc ctctcctgtc tggaaacaat tcaccaaagg ctccatgtgg
      301 ttgtccagta aggtggtatg gggacagaaa tggacaatga tccctgaggg cagtgatcca
      361 ttaaccttgc cctcctattt cagaatcaag gatgcacatc aaaaggcttt gtacacacgg
      421 aatggccagc tcctgctggg agaccctgat tcagacaatt atagtccaga gaaggtctgt
      481 atccttccta accgaggcct agaccgctcc aaggtcccca tcttcctggg gatgcaggga
      541 ggaagttgct gcctggcgtg tgtaaagaca agagagggac ctctcctgca gctggaggat
      601 gtgaacatcg aggacctata caagggaggt gaacaaacca cccgtttcac ctttttccag
      661 agaagcttgg gatctgcctt caggcttgag gctgctgcct gccctggctg gtttctctgt
      721 ggcccagctg agccccagca gccagtgcag ctcaccaaag agagtgaacc ctccacccat
      781 actgaattct actttgagat gagtcggtaa agagacataa ggctggggcc tcgtctagtg
      841 cccccagtct gagatcttct tgctcagcat ctctggaaag cagaataagg aagataccaa
      901 agatgtttgg gtcttaatcc ccagaatctg tgaccgtgtt acattaaatg gcaaagggat
      961 tttttttttc cttcatggtc catttgggcc cattggaatc atctgaggcc tcatgaggag
     1021 aaggaagagg tcagagggag actggggcaa actttggtac taaaagtaac aatggagaca
     1081 gggaccataa gctgatgggt aacagtggtt tctagaaacc ggaaatgatg agagctctcc
     1141 tgacacaggt tctggatttt tctggactga agaatggtga aataatacag ctccattatt
     1201 ttaagccact gagtttgaga tcattcaatg aagctgtcat aataaaacct gtgcttcaca
     1261 tacaa
//
