LOCUS       NM_008361               1348 bp    mRNA    linear   ROD 14-JAN-2025
DEFINITION  Mus musculus interleukin 1 beta (Il1b), mRNA.
ACCESSION   NM_008361
VERSION     NM_008361.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1348)
  AUTHORS   McClure,J.J., McIlroy,G.D., Symons,R.A., Clark,S.M., Cunningham,I.,
            Han,W., Kania,K., Colella,F., Rochford,J.J., De Bari,C. and
            Roelofs,A.J.
  TITLE     Disentangling the detrimental effects of local from systemic
            adipose tissue dysfunction on articular cartilage in the knee
  JOURNAL   Osteoarthritis Cartilage 32 (12), 1552-1565 (2024)
   PUBMED   39103079
REFERENCE   2  (bases 1 to 1348)
  AUTHORS   Pryce,B.R., Oles,A., Talbert,E.E., Romeo,M.J., Vaena,S., Sharma,S.,
            Spadafora,V., Tolliver,L., Mahvi,D.A., Morgan,K.A., Lancaster,W.P.,
            Beal,E., Koren,N., Watts,B., Overstreet,M., Berto,S.,
            Subramanian,S., Calisir,K., Crawford,A., Neelon,B., Ostrowski,M.C.,
            Zimmers,T.A., Tidball,J.G., Wang,D.J. and Guttridge,D.C.
  TITLE     Muscle inflammation is regulated by NF-kappaB from multiple cells
            to control distinct states of wasting in cancer cachexia
  JOURNAL   Cell Rep 43 (11), 114925 (2024)
   PUBMED   39475511
REFERENCE   3  (bases 1 to 1348)
  AUTHORS   Gao,H., Li,W., Xu,S., Xu,Z., Hu,W., Pan,L., Luo,K., Xie,T., Yu,Y.,
            Sun,H., Huang,L., Chen,P., Wu,J., Yang,D., Li,L., Luan,S., Cao,M.
            and Chen,P.
  TITLE     Gasdermin D promotes development of intestinal tumors through
            regulating IL-1beta release and gut microbiota composition
  JOURNAL   Cell Commun Signal 22 (1), 511 (2024)
   PUBMED   39434144
  REMARK    GeneRIF: Gasdermin D promotes development of intestinal tumors
            through regulating IL-1beta release and gut microbiota composition.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1348)
  AUTHORS   Mao,Y., Meng,Y., Zou,K., Qin,N., Wang,Y., Yan,J., Chen,P.,
            Cheng,Y., Shi,W., Zhou,C., Chen,H., Sheng,J., Liu,X., Pan,J. and
            Huang,H.
  TITLE     Advanced paternal age exacerbates neuroinflammation in offspring
            via m6A modification-mediated intergenerational inheritance
  JOURNAL   J Neuroinflammation 21 (1), 249 (2024)
   PUBMED   39367406
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1348)
  AUTHORS   Hofwimmer,K., de Paula Souza,J., Subramanian,N., Vujicic,M.,
            Rachid,L., Mereau,H., Zhao,C., Dror,E., Barreby,E.,
            Bjorkstrom,N.K., Wernstedt Asterholm,I., Boni-Schnetzler,M.,
            Meier,D.T., Donath,M.Y. and Laurencikiene,J.
  TITLE     IL-1beta promotes adipogenesis by directly targeting adipocyte
            precursors
  JOURNAL   Nat Commun 15 (1), 7957 (2024)
   PUBMED   39261467
  REMARK    GeneRIF: IL-1beta promotes adipogenesis by directly targeting
            adipocyte precursors.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1348)
  AUTHORS   Dietrich,W., Katz,H., Lincoln,S.E., Shin,H.S., Friedman,J.,
            Dracopoli,N.C. and Lander,E.S.
  TITLE     A genetic map of the mouse suitable for typing intraspecific
            crosses
  JOURNAL   Genetics 131 (2), 423-447 (1992)
   PUBMED   1353738
REFERENCE   7  (bases 1 to 1348)
  AUTHORS   Moen,C.J., Snoek,M., Hart,A.A. and Demant,P.
  TITLE     Scc-1, a novel colon cancer susceptibility gene in the mouse:
            linkage to CD44 (Ly-24, Pgp-1) on chromosome 2
  JOURNAL   Oncogene 7 (3), 563-566 (1992)
   PUBMED   1347918
REFERENCE   8  (bases 1 to 1348)
  AUTHORS   Abbott,C., Pilz,A., Moseley,H. and Peter,J.
  TITLE     The gene for proliferating cell nuclear antigen (Pcna) maps to
            mouse chromosome 2
  JOURNAL   Mamm Genome 3 (5), 286-289 (1992)
   PUBMED   1353383
REFERENCE   9  (bases 1 to 1348)
  AUTHORS   Le Roy,H., Simon-Chazottes,D., Montagutelli,X. and Guenet,J.L.
  TITLE     A set of anonymous DNA clones as markers for mouse gene mapping
  JOURNAL   Mamm Genome 3 (4), 244-246 (1992)
   PUBMED   1351769
REFERENCE   10 (bases 1 to 1348)
  AUTHORS   Simon-Chazottes,D., Matsubara,S., Miyauchi,T., Muramatsu,T. and
            Guenet,J.L.
  TITLE     Chromosomal localization of two cell surface-associated molecules
            of potential importance in development: midkine (Mdk) and basigin
            (Bsg)
  JOURNAL   Mamm Genome 2 (4), 269-271 (1992)
   PUBMED   1347477
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK225002.1.
            
            On Aug 22, 2015 this sequence version replaced NM_008361.3.
            
            Summary: The protein encoded by this gene is a member of the
            interleukin 1 cytokine family. This cytokine is produced by
            activated macrophages as a proprotein, which is proteolytically
            processed to its active form by caspase 1. The encoded protein
            plays a role in thymocyte proliferation and is involved in the
            inflammatory response. [provided by RefSeq, Aug 2015].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK225002.1, M15131.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849377, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1348
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 62.97 cM"
     gene            1..1348
                     /gene="Il1b"
                     /gene_synonym="Il-1b; IL-1beta"
                     /note="interleukin 1 beta"
                     /db_xref="GeneID:16176"
                     /db_xref="MGI:MGI:96543"
     exon            1..72
                     /gene="Il1b"
                     /gene_synonym="Il-1b; IL-1beta"
                     /inference="alignment:Splign:2.1.0"
     exon            73..134
                     /gene="Il1b"
                     /gene_synonym="Il-1b; IL-1beta"
                     /inference="alignment:Splign:2.1.0"
     exon            135..183
                     /gene="Il1b"
                     /gene_synonym="Il-1b; IL-1beta"
                     /inference="alignment:Splign:2.1.0"
     exon            184..385
                     /gene="Il1b"
                     /gene_synonym="Il-1b; IL-1beta"
                     /inference="alignment:Splign:2.1.0"
     exon            386..556
                     /gene="Il1b"
                     /gene_synonym="Il-1b; IL-1beta"
                     /inference="alignment:Splign:2.1.0"
     exon            557..687
                     /gene="Il1b"
                     /gene_synonym="Il-1b; IL-1beta"
                     /inference="alignment:Splign:2.1.0"
     exon            688..1348
                     /gene="Il1b"
                     /gene_synonym="Il-1b; IL-1beta"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1249..1254
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Il1b"
                     /gene_synonym="Il-1b; IL-1beta"
                     /note="hexamer: AATAAA"
     polyA_site      1267
                     /gene="Il1b"
                     /gene_synonym="Il-1b; IL-1beta"
                     /note="major polyA site"
ORIGIN      
        1 aacaaaccct gcagtggttc gaggcctaat aggctcatct gggatcctct ccagccaagc
       61 ttccttgtgc aagtgtctga agcagctatg gcaactgttc ctgaactcaa ctgtgaaatg
      121 ccaccttttg acagtgatga gaatgacctg ttctttgaag ttgacggacc ccaaaagatg
      181 aagggctgct tccaaacctt tgacctgggc tgtcctgatg agagcatcca gcttcaaatc
      241 tcgcagcagc acatcaacaa gagcttcagg caggcagtat cactcattgt ggctgtggag
      301 aagctgtggc agctacctgt gtctttcccg tggaccttcc aggatgagga catgagcacc
      361 ttcttttcct tcatctttga agaagagccc atcctctgtg actcatggga tgatgatgat
      421 aacctgctgg tgtgtgacgt tcccattaga caactgcact acaggctccg agatgaacaa
      481 caaaaaagcc tcgtgctgtc ggacccatat gagctgaaag ctctccacct caatggacag
      541 aatatcaacc aacaagtgat attctccatg agctttgtac aaggagaacc aagcaacgac
      601 aaaatacctg tggccttggg cctcaaagga aagaatctat acctgtcctg tgtaatgaaa
      661 gacggcacac ccaccctgca gctggagagt gtggatccca agcaataccc aaagaagaag
      721 atggaaaaac ggtttgtctt caacaagata gaagtcaaga gcaaagtgga gtttgagtct
      781 gcagagttcc ccaactggta catcagcacc tcacaagcag agcacaagcc tgtcttcctg
      841 ggaaacaaca gtggtcagga cataattgac ttcaccatgg aatccgtgtc ttcctaaagt
      901 atgggctgga ctgtttctaa tgccttcccc agggcatgtt aaggagctcc cttttcgtga
      961 atgagcagac agctcaatct ccaggggact ccttagtcct cggccaagac aggtcgctca
     1021 gggtcacaag aaaccatggc acattctgtt caaagagagc ctgtgttttc ctccttgcct
     1081 ctgatgggca accacttacc tatttattta tgtatttatt gattggttga tctatttaag
     1141 ttgattcaag gggacattag gcagcactct ctagaacaga acctagctgt caacgtgtgg
     1201 gggatgaatt ggtcatagcc cgcactgagg tctttcattg aagctgagaa taaataggtt
     1261 cctataatat ggatgagact ttttatgaat gaagcaccag cacattgctt tgatgagtat
     1321 gaaataaatt tcattaaaac aaacaaac
//
