LOCUS       NM_010554               1974 bp    mRNA    linear   ROD 17-DEC-2024
DEFINITION  Mus musculus interleukin 1 alpha (Il1a), mRNA.
ACCESSION   NM_010554
VERSION     NM_010554.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1974)
  AUTHORS   Park,M.D., Le Berichel,J., Hamon,P., Wilk,C.M., Belabed,M.,
            Yatim,N., Saffon,A., Boumelha,J., Falcomata,C., Tepper,A.,
            Hegde,S., Mattiuz,R., Soong,B.Y., LaMarche,N.M., Rentzeperis,F.,
            Troncoso,L., Halasz,L., Hennequin,C., Chin,T., Chen,E.P.,
            Reid,A.M., Su,M., Cahn,A.R., Koekkoek,L.L., Venturini,N.,
            Wood-Isenberg,S., D'souza,D., Chen,R., Dawson,T., Nie,K., Chen,Z.,
            Kim-Schulze,S., Casanova-Acebes,M., Swirski,F.K., Downward,J.,
            Vabret,N., Brown,B.D., Marron,T.U. and Merad,M.
  TITLE     Hematopoietic aging promotes cancer by fueling IL-1-driven
            emergency myelopoiesis
  JOURNAL   Science 386 (6720), eadn0327 (2024)
   PUBMED   39236155
REFERENCE   2  (bases 1 to 1974)
  AUTHORS   Renz,P., Steinfort,M., Haesler,V., Tscherrig,V., Huang,E.J.,
            Chavali,M., Liddelow,S., Rowitch,D.H., Surbek,D., Schoeberlein,A.
            and Brosius Lutz,A.
  TITLE     Neuroinflammatory reactive astrocyte formation correlates with
            adverse outcomes in perinatal white matter injury
  JOURNAL   Glia 72 (9), 1663-1673 (2024)
   PUBMED   38924630
REFERENCE   3  (bases 1 to 1974)
  AUTHORS   Zhang,C., Ma,J., Zhang,X., Zhou,D., Cao,Z., Qiao,L., Chen,G.,
            Yang,L. and Ding,B.S.
  TITLE     Processing of angiocrine alarmin IL-1alpha in endothelial cells
            promotes lung and liver fibrosis
  JOURNAL   Int Immunopharmacol 134, 112176 (2024)
   PUBMED   38723369
  REMARK    GeneRIF: Processing of angiocrine alarmin IL-1alpha in endothelial
            cells promotes lung and liver fibrosis.
REFERENCE   4  (bases 1 to 1974)
  AUTHORS   Salib,A.N., Crane,M.J., Lee,S.H., Wainger,B.J., Jamieson,A.M. and
            Lipscombe,D.
  TITLE     Interleukin-1alpha links peripheral CaV2.2 channel activation to
            rapid adaptive increases in heat sensitivity in skin
  JOURNAL   Sci Rep 14 (1), 9051 (2024)
   PUBMED   38643253
  REMARK    GeneRIF: Interleukin-1alpha links peripheral CaV2.2 channel
            activation to rapid adaptive increases in heat sensitivity in skin.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1974)
  AUTHORS   Hoffmann,J.P., Srivastava,A., Yang,H., Iwanaga,N., Remcho,T.P.,
            Hewes,J.L., Sharoff,R., Song,K., Norton,E.B., Kolls,J.K. and
            McCombs,J.E.
  TITLE     Vaccine-elicited IL-1R signaling results in Th17 TRM-mediated
            immunity
  JOURNAL   Commun Biol 7 (1), 433 (2024)
   PUBMED   38594380
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1974)
  AUTHORS   White,R.A., Peters,L.L., Adkison,L.R., Korsgren,C., Cohen,C.M. and
            Lux,S.E.
  TITLE     The murine pallid mutation is a platelet storage pool disease
            associated with the protein 4.2 (pallidin) gene
  JOURNAL   Nat Genet 2 (1), 80-83 (1992)
   PUBMED   1284644
REFERENCE   7  (bases 1 to 1974)
  AUTHORS   Dush,M.K. and Martin,G.R.
  TITLE     Analysis of mouse Evx genes: Evx-1 displays graded expression in
            the primitive streak
  JOURNAL   Dev Biol 151 (1), 273-287 (1992)
   PUBMED   1349539
REFERENCE   8  (bases 1 to 1974)
  AUTHORS   Laherty,C.D., O'Rourke,K., Wolf,F.W., Katz,R., Seldin,M.F. and
            Dixit,V.M.
  TITLE     Characterization of mouse thrombospondin 2 sequence and expression
            during cell growth and development
  JOURNAL   J Biol Chem 267 (5), 3274-3281 (1992)
   PUBMED   1371115
REFERENCE   9  (bases 1 to 1974)
  AUTHORS   Gaskins,H.R., Prochazka,M. and Leiter,E.H.
  TITLE     Chromosomal localization of the murine stress protein gene encoding
            glucose-regulated protein 78 (BiP)
  JOURNAL   Mamm Genome 3 (12), 709-711 (1992)
   PUBMED   1362103
REFERENCE   10 (bases 1 to 1974)
  AUTHORS   Abbott,C., Pilz,A., Moseley,H. and Peter,J.
  TITLE     The gene for proliferating cell nuclear antigen (Pcna) maps to
            mouse chromosome 2
  JOURNAL   Mamm Genome 3 (5), 286-289 (1992)
   PUBMED   1353383
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL772347.6.
            
            On Nov 17, 2006 this sequence version replaced NM_010554.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X01450.1, AK156449.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-52                AL772347.6         140818-140869       c
            53-107              AL772347.6         139952-140006       c
            108-156             AL772347.6         138780-138828       c
            157-385             AL772347.6         137361-137589       c
            386-559             AL772347.6         135570-135743       c
            560-684             AL772347.6         133770-133894       c
            685-1974            AL772347.6         130507-131796       c
FEATURES             Location/Qualifiers
     source          1..1974
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 62.9 cM"
     gene            1..1974
                     /gene="Il1a"
                     /gene_synonym="Il-1a"
                     /note="interleukin 1 alpha"
                     /db_xref="GeneID:16175"
                     /db_xref="MGI:MGI:96542"
     exon            1..52
                     /gene="Il1a"
                     /gene_synonym="Il-1a"
                     /inference="alignment:Splign:2.1.0"
     exon            53..107
                     /gene="Il1a"
                     /gene_synonym="Il-1a"
                     /inference="alignment:Splign:2.1.0"
     exon            108..156
                     /gene="Il1a"
                     /gene_synonym="Il-1a"
                     /inference="alignment:Splign:2.1.0"
     exon            157..385
                     /gene="Il1a"
                     /gene_synonym="Il-1a"
                     /inference="alignment:Splign:2.1.0"
     exon            386..559
                     /gene="Il1a"
                     /gene_synonym="Il-1a"
                     /inference="alignment:Splign:2.1.0"
     exon            560..684
                     /gene="Il1a"
                     /gene_synonym="Il-1a"
                     /inference="alignment:Splign:2.1.0"
     exon            685..1974
                     /gene="Il1a"
                     /gene_synonym="Il-1a"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aagtctccag ggcagagagg gagtcaactc attggcgctt gagtcggcaa agaaatcaag
       61 atggccaaag ttcctgactt gtttgaagac ctaaagaact gttacagtga aaacgaagac
      121 tacagttctg ccattgacca tctctctctg aatcagaaat ccttctatga tgcaagctat
      181 ggctcacttc atgagacttg cacagatcag tttgtatctc tgagaacctc tgaaacgtca
      241 aagatgtcca acttcacctt caaggagagc cgggtgacag tatcagcaac gtcaagcaac
      301 gggaagattc tgaagaagag acggctgagt ttcagtgaga ccttcactga agatgacctg
      361 cagtccataa cccatgatct ggaagagacc atccaaccca gatcagcacc ttacacctac
      421 cagagtgatt tgagatacaa actgatgaag ctcgtcaggc agaagtttgt catgaatgat
      481 tccctcaacc aaactatata tcaggatgtg gacaaacact atctcagcac cacttggtta
      541 aatgacctgc aacaggaagt aaaatttgac atgtatgcct actcgtcggg aggagacgac
      601 tctaaatatc ctgttactct aaaaatctca gattcacaac tgttcgtgag cgctcaagga
      661 gaagaccagc ccgtgttgct gaaggagttg ccagaaacac caaaactcat cacaggtagt
      721 gagaccgacc tcattttctt ctggaaaagt atcaactcta agaactactt cacatcagct
      781 gcttatccag agctgtttat tgccaccaaa gaacaaagtc gggtgcacct ggcacgggga
      841 ctgccctcta tgacagactt ccagatatca taaaagcagc cttatttcgg gagtctattc
      901 acttgggaag tgctgacagt ctgtatgtac catgtacagg aaccttcctc accctgagtc
      961 acttgcacag catgtgctga gtctctgtaa ttctaaatga atgtttaccc tctttgtaag
     1021 agaagagcaa accctagtgg agccaccccg acatatgata ctatctgtta ttttaaagag
     1081 taccctatag tttgctcagt actaatcatt ttaattacta ttctgcatgg cattcttagg
     1141 aggatcaaaa agactctaca catattacag atgggttaac aaagggataa aacaactgaa
     1201 aagcacactc aatgcatttg gaatataaat tcacagacca atctcactgt gcaccttcgg
     1261 cttcaaaatg ccagttgagt aggataaagg tataagaact taatgctgtc attttcaaaa
     1321 ggaaggggac aatagctaca tctttcctac ctcagtgggt tttactccag tgagatcatt
     1381 tggatgaaat cctcctgtaa cagacctcaa gaaggagaca gactgttgaa tgttattttt
     1441 aagttatttt atctatgtat ttataaatat atttatgata attatattat ttatggaaca
     1501 tccttaaatc ctctgagctt gacggcaccc tcgcagcagg gttttctagg tggtcagtta
     1561 gatgtagtct cctctagagc tccatgctac agacttttac actttttcca cagccacgaa
     1621 gctctccgta cattcctgca cttgggagcc ctttcatcat gatcttaatc tgtgctgttt
     1681 actttgtgca tctaaaatga taattgagtc agtctttctc cctcccgtcc ttaaagctgt
     1741 ctgggtattc ttacatcatt cagtctcacc tgtaactaac accaaccatc taaagatgga
     1801 aagagcttaa ctgtgacaac cacatcactg atacctgaag tttcttttct agaatgtaat
     1861 cagtgtttcc cctggattcc aatttttttt tcaaaccaca gtgtcatgta actatcaaca
     1921 ataacaatca actcattatt attaatcata attaaataaa acaggtttga gctg
//
