LOCUS       NM_001009940            1124 bp    mRNA    linear   ROD 05-AUG-2024
DEFINITION  Mus musculus interleukin 19 (Il19), transcript variant 1, mRNA.
ACCESSION   NM_001009940 XM_006529706 XM_283649
VERSION     NM_001009940.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1124)
  AUTHORS   Nishiyama,K., Horikoshi,J., Maehara,T., Tanaka,M., Tanida,T.,
            Kawada,K., Takeshita,S., Ono,N., Izawa,T., Kuwamura,M. and
            Azuma,Y.T.
  TITLE     Deficiency of interleukin-19 exacerbates acute lung injury induced
            by intratracheal treatment of hydrochloric acid
  JOURNAL   J Pharmacol Sci 155 (3), 94-100 (2024)
   PUBMED   38797538
  REMARK    GeneRIF: Deficiency of interleukin-19 exacerbates acute lung injury
            induced by intratracheal treatment of hydrochloric acid.
REFERENCE   2  (bases 1 to 1124)
  AUTHORS   He,E., Sui,H., Wang,H., Zhao,X., Guo,W., Dai,Z., Wu,Z., Huang,K.
            and Zhao,Q.
  TITLE     Interleukin-19 in Bone Marrow Contributes to Bone Loss Via
            Suppressing Osteogenic Differentiation Potential of BMSCs in Old
            Mice
  JOURNAL   Stem Cell Rev Rep 20 (5), 1311-1324 (2024)
   PUBMED   38502291
  REMARK    GeneRIF: Interleukin-19 in Bone Marrow Contributes to Bone Loss Via
            Suppressing Osteogenic Differentiation Potential of BMSCs in Old
            Mice.
REFERENCE   3  (bases 1 to 1124)
  AUTHORS   Jiang,Y., Xu,L., Cao,Y., Meng,F., Jiang,S., Yang,M., Zheng,Z.,
            Zhang,Y., Yang,L., Wang,M., Sun,G., Liu,J., Li,C. and Cui,M.
  TITLE     Effects of Interleukin-19 overexpression in the medial prefrontal
            cortex on anxiety-related behaviors, BDNF expression and
            p38/JNK/ERK pathways
  JOURNAL   Brain Res Bull 212, 110952 (2024)
   PUBMED   38636611
  REMARK    GeneRIF: Effects of Interleukin-19 overexpression in the medial
            prefrontal cortex on anxiety-related behaviors, BDNF expression and
            p38/JNK/ERK pathways.
REFERENCE   4  (bases 1 to 1124)
  AUTHORS   Li,Q., Meng,F., Ma,X., Sun,Z., Dai,J., Liu,J., Li,D., Cong,P.,
            Xu,R., Zhao,D., Wang,W., Wang,D., Liu,C., Wang,F., Li,C. and
            Lian,H.
  TITLE     The colonic interleukin-19 aggravates the dextran sodium
            sulfate/stress-induced comorbidities due to colitis and anxiety
  JOURNAL   Front Immunol 14, 1153344 (2023)
   PUBMED   36936941
  REMARK    GeneRIF: The colonic interleukin-19 aggravates the dextran sodium
            sulfate/stress-induced comorbidities due to colitis and anxiety.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1124)
  AUTHORS   He,Y., Luo,W., Liu,Y., Wang,Y., Ma,C., Wu,Q., Tian,P., He,D.,
            Jia,Z., Lv,X., Ma,Y.S., Yang,H., Xu,K., Zhang,X., Xiao,Y.,
            Zhang,P., Liang,Y., Fu,D., Yao,F. and Hu,G.
  TITLE     IL-20RB mediates tumoral response to osteoclastic niches and
            promotes bone metastasis of lung cancer
  JOURNAL   J Clin Invest 132 (20), e157917 (2022)
   PUBMED   36006737
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1124)
  AUTHORS   Chan,J.R., Blumenschein,W., Murphy,E., Diveu,C., Wiekowski,M.,
            Abbondanzo,S., Lucian,L., Geissler,R., Brodie,S., Kimball,A.B.,
            Gorman,D.M., Smith,K., de Waal Malefyt,R., Kastelein,R.A.,
            McClanahan,T.K. and Bowman,E.P.
  TITLE     IL-23 stimulates epidermal hyperplasia via TNF and
            IL-20R2-dependent mechanisms with implications for psoriasis
            pathogenesis
  JOURNAL   J Exp Med 203 (12), 2577-2587 (2006)
   PUBMED   17074928
REFERENCE   7  (bases 1 to 1124)
  AUTHORS   Mesples,B., Fontaine,R.H., Lelievre,V., Launay,J.M. and Gressens,P.
  TITLE     Neuronal TGF-beta1 mediates IL-9/mast cell interaction and
            exacerbates excitotoxicity in newborn mice
  JOURNAL   Neurobiol Dis 18 (1), 193-205 (2005)
   PUBMED   15649710
REFERENCE   8  (bases 1 to 1124)
  AUTHORS   Liao,S.C., Cheng,Y.C., Wang,Y.C., Wang,C.W., Yang,S.M., Yu,C.K.,
            Shieh,C.C., Cheng,K.C., Lee,M.F., Chiang,S.R., Shieh,J.M. and
            Chang,M.S.
  TITLE     IL-19 induced Th2 cytokines and was up-regulated in asthma patients
  JOURNAL   J Immunol 173 (11), 6712-6718 (2004)
   PUBMED   15557163
  REMARK    GeneRIF: In a dust mite-induced murine model of asthma, the IL-19
            level in asthmatic BALB/cJ mice is twice that of healthy control
            mice.
REFERENCE   9  (bases 1 to 1124)
  AUTHORS   Sugimoto,T., Ishikawa,Y., Yoshimoto,T., Hayashi,N., Fujimoto,J. and
            Nakanishi,K.
  TITLE     Interleukin 18 acts on memory T helper cells type 1 to induce
            airway inflammation and hyperresponsiveness in a naive host mouse
  JOURNAL   J Exp Med 199 (4), 535-545 (2004)
   PUBMED   14970180
REFERENCE   10 (bases 1 to 1124)
  AUTHORS   Liao,Y.C., Liang,W.G., Chen,F.W., Hsu,J.H., Yang,J.J. and
            Chang,M.S.
  TITLE     IL-19 induces production of IL-6 and TNF-alpha and results in cell
            apoptosis through TNF-alpha
  JOURNAL   J Immunol 169 (8), 4288-4297 (2002)
   PUBMED   12370360
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC165322.12.
            
            On or before Sep 8, 2017 this sequence version replaced
            XM_006529706.1, NM_001009940.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC115793.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849382,
                                           SAMN00849383 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-64                AC165322.12        56102-56165
            65-245              AC165322.12        56939-57119
            246-308             AC165322.12        57238-57300
            309-461             AC165322.12        60172-60324
            462-536             AC165322.12        61168-61242
            537-1124            AC165322.12        62974-63561
FEATURES             Location/Qualifiers
     source          1..1124
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 56.89 cM"
     gene            1..1124
                     /gene="Il19"
                     /note="interleukin 19"
                     /db_xref="GeneID:329244"
                     /db_xref="MGI:MGI:1890472"
     exon            1..64
                     /gene="Il19"
                     /inference="alignment:Splign:2.1.0"
     exon            65..245
                     /gene="Il19"
                     /inference="alignment:Splign:2.1.0"
     exon            246..308
                     /gene="Il19"
                     /inference="alignment:Splign:2.1.0"
     exon            309..461
                     /gene="Il19"
                     /inference="alignment:Splign:2.1.0"
     exon            462..536
                     /gene="Il19"
                     /inference="alignment:Splign:2.1.0"
     exon            537..1124
                     /gene="Il19"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1095..1100
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Il19"
                     /note="hexamer: AATAAA"
     polyA_site      1117
                     /gene="Il19"
                     /note="major polyA site"
ORIGIN      
        1 agtttctaag tggcaaagag cacagggaga gaggactctg ctggagcagg agacaccagg
       61 agagtctagg tggacagctg actttcacct ttgcagaaga catgaagaca cagtgcgcgt
      121 ctacctggct cctgggcatg acgttgattc tctgctcagt tcatatctac agtcttagga
      181 gatgtctgat ttctgtggac atgcgcctca tagaaaagag tttccacgag atcaagagag
      241 ccatgcaaac taaggacacc tttaaaaatg tcaccatcct gtccctggag aacctcagga
      301 gcattaagcc tggagatgtg tgctgcatga ccaacaacct gctgacattc tacagagaca
      361 gggtgttcca ggaccatcag gagagaagcc ttgaggtctt aaggagaatc agcagcattg
      421 ccaactcttt cctctgcgtg cagaaatctc tggagcgatg tcaggtgcac agacaatgta
      481 actgcagtca ggaagccacc aatgcaacta ggatcatcca tgacaactac aatcagctgg
      541 aggtctcatc tgctgccctt aagtctctag gagaactgaa catactttta gcctggattg
      601 acaggaatca tctggaaact cctgcagcct gacacgaaac gcctcgtctg attatctaaa
      661 taacggactg tgagggtttt ttttttaatt gttgctgttt tattttgttt ttgtttgttt
      721 gttttgtggt caacagctac ttctgaagaa gagagagaca tggaaagttc acataattat
      781 ctagaatgag ggtcttttct ggtaacttgc tgatgtggaa ggaatcctct cttctgggct
      841 tggagccttt cagaaaaaca attgggattt gaatggatct cagctcctgg ctgaggtctc
      901 tgctctctga tcccacctgc aatagctaag ttggctgctg tggtatttat agcaatatgt
      961 ggctgttgag agatctcaga tatcatagga gcaatagaca gcccctctaa cttattgtaa
     1021 agcggcttct tccaggccta tgctgtgcac cttgtggtgt gctgtagtgc atattgtact
     1081 gactgacgtt tacgaataaa ctgtggttta cctatgagga tgaa
//
