LOCUS       NM_010553               4889 bp    mRNA    linear   ROD 05-AUG-2023
DEFINITION  Mus musculus interleukin 18 receptor accessory protein (Il18rap),
            mRNA.
ACCESSION   NM_010553
VERSION     NM_010553.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4889)
  AUTHORS   Provine NM, Amini A, Garner LC, Spencer AJ, Dold C, Hutchings C,
            Silva Reyes L, FitzPatrick MEB, Chinnakannan S, Oguti B, Raymond M,
            Ulaszewska M, Troise F, Sharpe H, Morgan SB, Hinks TSC, Lambe T,
            Capone S, Folgori A, Barnes E, Rollier CS, Pollard AJ and Klenerman
            P.
  TITLE     MAIT cell activation augments adenovirus vector vaccine
            immunogenicity
  JOURNAL   Science 371 (6528), 521-526 (2021)
   PUBMED   33510029
REFERENCE   2  (bases 1 to 4889)
  AUTHORS   Castellanos-Rubio A, Fernandez-Jimenez N, Kratchmarov R, Luo X,
            Bhagat G, Green PH, Schneider R, Kiledjian M, Bilbao JR and Ghosh
            S.
  TITLE     A long noncoding RNA associated with susceptibility to celiac
            disease
  JOURNAL   Science 352 (6281), 91-95 (2016)
   PUBMED   27034373
REFERENCE   3  (bases 1 to 4889)
  AUTHORS   Alboni S, Montanari C, Benatti C, Blom JM, Simone ML, Brunello N,
            Caggia F, Guidotti G, Marcondes MC, Sanchez-Alavez M, Conti B and
            Tascedda F.
  TITLE     Constitutive and LPS-regulated expression of interleukin-18
            receptor beta variants in the mouse brain
  JOURNAL   Brain Behav Immun 25 (3), 483-493 (2011)
   PUBMED   21111041
  REMARK    GeneRIF: Our data highlight the considerable complexity of the
            IL-18 regulation activity in the mouse brain and further support an
            important central role for IL-18.
REFERENCE   4  (bases 1 to 4889)
  AUTHORS   Orelio C, Haak E, Peeters M and Dzierzak E.
  TITLE     Interleukin-1-mediated hematopoietic cell regulation in the
            aorta-gonad-mesonephros region of the mouse embryo
  JOURNAL   Blood 112 (13), 4895-4904 (2008)
   PUBMED   18805969
REFERENCE   5  (bases 1 to 4889)
  AUTHORS   Cheung H, Chen NJ, Cao Z, Ono N, Ohashi PS and Yeh WC.
  TITLE     Accessory protein-like is essential for IL-18-mediated signaling
  JOURNAL   J Immunol 174 (9), 5351-5357 (2005)
   PUBMED   15843532
  REMARK    GeneRIF: This study demonstrates that IL-18 signals are abolished
            in accessory protein-like (AcPL)-deficient mice and cells, and
            suggests that AcPL is a critical and specific cell surface receptor
            required for IL-18 signaling.
REFERENCE   6  (bases 1 to 4889)
  AUTHORS   Debets R, Timans JC, Churakowa T, Zurawski S, de Waal Malefyt R,
            Moore KW, Abrams JS, O'Garra A, Bazan JF and Kastelein RA.
  TITLE     IL-18 receptors, their role in ligand binding and function:
            anti-IL-1RAcPL antibody, a potent antagonist of IL-18
  JOURNAL   J Immunol 165 (9), 4950-4956 (2000)
   PUBMED   11046021
REFERENCE   7  (bases 1 to 4889)
  AUTHORS   Born TL, Thomassen E, Bird TA and Sims JE.
  TITLE     Cloning of a novel receptor subunit, AcPL, required for
            interleukin-18 signaling
  JOURNAL   J Biol Chem 273 (45), 29445-29450 (1998)
   PUBMED   9792649
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC120600.1, AK161196.1 and
            AC138210.10.
            
            [WARNING] On Jan 16, 2024 this sequence was replaced by
            NM_010553.5.
            
            On Jan 24, 2014 this sequence version replaced NM_010553.3.
            
            Summary: Interleukin-18 (or interferon-gamma inducing factor) is a
            proinflammatory cytokine that induces cell-mediated immunity
            following microbial infection. This gene encodes a member of the
            interleukin-1 receptor family. The encoded protein is an accessory
            subunit of the receptor for interleukin-18 and mediates signaling
            through this cytokine. Mice lacking this gene exhibit a defective
            cell-mediated immune response. [provided by RefSeq, Jan 2014].
            
            Sequence Note: Removed 9 bases from the 5' end that did not align
            to the reference genome assembly.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF077347.1, BC120600.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849387, SAMN01164134
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2377              BC120600.1         8-2384
            2378-3594           AK161196.1         286-1502
            3595-3595           AC138210.10        119915-119915       c
            3596-4889           AK161196.1         1504-2797
FEATURES             Location/Qualifiers
     source          1..4889
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 19.37 cM"
     gene            1..4889
                     /gene="Il18rap"
                     /gene_synonym="AcPL; IL-18R-beta; IL-18RAcP; IL-18Rbeta;
                     IL-1RAcPL"
                     /note="interleukin 18 receptor accessory protein"
                     /db_xref="GeneID:16174"
                     /db_xref="MGI:MGI:1338888"
     exon            1..115
                     /gene="Il18rap"
                     /gene_synonym="AcPL; IL-18R-beta; IL-18RAcP; IL-18Rbeta;
                     IL-1RAcPL"
                     /inference="alignment:Splign:2.1.0"
     exon            116..191
                     /gene="Il18rap"
                     /gene_synonym="AcPL; IL-18R-beta; IL-18RAcP; IL-18Rbeta;
                     IL-1RAcPL"
                     /inference="alignment:Splign:2.1.0"
     exon            192..330
                     /gene="Il18rap"
                     /gene_synonym="AcPL; IL-18R-beta; IL-18RAcP; IL-18Rbeta;
                     IL-1RAcPL"
                     /inference="alignment:Splign:2.1.0"
     exon            331..497
                     /gene="Il18rap"
                     /gene_synonym="AcPL; IL-18R-beta; IL-18RAcP; IL-18Rbeta;
                     IL-1RAcPL"
                     /inference="alignment:Splign:2.1.0"
     CDS             428..2272
                     /gene="Il18rap"
                     /gene_synonym="AcPL; IL-18R-beta; IL-18RAcP; IL-18Rbeta;
                     IL-1RAcPL"
                     /EC_number="3.2.2.6"
                     /note="interleukin-18 receptor beta; IL-18 receptor
                     accessory protein; CD218 antigen-like family member B;
                     accessory protein-like; AcPL accessory protein-like)"
                     /codon_start=1
                     /product="interleukin-18 receptor accessory protein
                     precursor"
                     /protein_id="NP_034683.1"
                     /db_xref="CCDS:CCDS14912.1"
                     /db_xref="GeneID:16174"
                     /db_xref="MGI:MGI:1338888"
                     /translation="MLCLGWVFLWFVAGEKTTGFNHSACATKKLLWTYSARGAENFVL
                     FCDLQELQEQKFSHASQLSPTQSPAHKPCSGSQKDLSDVQWYMQPRSGSPLEEISRNS
                     PHMQSEGMLHILAPQTNSIWSYICRPRIRSPQDMACCIKTVLEVKPQRNVSCGNTAQD
                     EQVLLLGSTGSIHCPSLSCQSDVQSPEMTWYKDGRLLPEHKKNPIEMADIYVFNQGLY
                     VCDYTQSDNVSSWTVRAVVKVRTIGKDINVKPEILDPITDTLDVELGKPLTLPCRVQF
                     GFQRLSKPVIKWYVKESTQEWEMSVFEEKRIQSTFKNEVIERTIFLREVTQRDLSRKF
                     VCFAQNSIGNTTRTIRLRKKEEVVFVYILLGTALMLVGVLVAAAFLYWYWIEVVLLCR
                     TYKNKDETLGDKKEFDAFVSYSNWSSPETDAVGSLSEEHLALNLFPEVLEDTYGYRLC
                     LLDRDVTPGGVYADDIVSIIKKSRRGIFILSPSYLNGPRVFELQAAVNLALVDQTLKL
                     ILIKFCSFQEPESLPYLVKKALRVLPTVTWKGLKSVHASSRFWTQIRYHMPVKNSNRF
                     MFNGLRIFLKGFSPEKDLVTQKPLEGMPKSGNDHGAQNLLLYSDQKRC"
     exon            498..819
                     /gene="Il18rap"
                     /gene_synonym="AcPL; IL-18R-beta; IL-18RAcP; IL-18Rbeta;
                     IL-1RAcPL"
                     /inference="alignment:Splign:2.1.0"
     exon            820..1003
                     /gene="Il18rap"
                     /gene_synonym="AcPL; IL-18R-beta; IL-18RAcP; IL-18Rbeta;
                     IL-1RAcPL"
                     /inference="alignment:Splign:2.1.0"
     exon            1004..1154
                     /gene="Il18rap"
                     /gene_synonym="AcPL; IL-18R-beta; IL-18RAcP; IL-18Rbeta;
                     IL-1RAcPL"
                     /inference="alignment:Splign:2.1.0"
     exon            1155..1220
                     /gene="Il18rap"
                     /gene_synonym="AcPL; IL-18R-beta; IL-18RAcP; IL-18Rbeta;
                     IL-1RAcPL"
                     /inference="alignment:Splign:2.1.0"
     exon            1221..1344
                     /gene="Il18rap"
                     /gene_synonym="AcPL; IL-18R-beta; IL-18RAcP; IL-18Rbeta;
                     IL-1RAcPL"
                     /inference="alignment:Splign:2.1.0"
     exon            1345..1496
                     /gene="Il18rap"
                     /gene_synonym="AcPL; IL-18R-beta; IL-18RAcP; IL-18Rbeta;
                     IL-1RAcPL"
                     /inference="alignment:Splign:2.1.0"
     exon            1497..1634
                     /gene="Il18rap"
                     /gene_synonym="AcPL; IL-18R-beta; IL-18RAcP; IL-18Rbeta;
                     IL-1RAcPL"
                     /inference="alignment:Splign:2.1.0"
     exon            1635..1808
                     /gene="Il18rap"
                     /gene_synonym="AcPL; IL-18R-beta; IL-18RAcP; IL-18Rbeta;
                     IL-1RAcPL"
                     /inference="alignment:Splign:2.1.0"
     exon            1809..4889
                     /gene="Il18rap"
                     /gene_synonym="AcPL; IL-18R-beta; IL-18RAcP; IL-18Rbeta;
                     IL-1RAcPL"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcaggcttac tcaccatttc aactaaacct aaccacaacc cctttcttgt caaggaggct
       61 ggccagagga cagctttgaa tgctttattt caggagtttt cttccgtgga taaagatgca
      121 caagctggca ttcactgaca taaagacttg aatttcttta tttgttgtgt atgtaagagc
      181 aggaaacaaa ggaaagagac cttgcagatc ttcagatcat ctcaccggcc tccgacctcc
      241 ttctgtagag aaggcgaata gtggtggcaa gatgagaaac tttgaaaccc tcttcctcca
      301 gatatgattc tcccttctac tactgaacag aagtgaagag gatgccagag aaagaggttt
      361 gcctctctgc actctccaca ctggcgatca gaagtagctg aagccatgac aggagcaaag
      421 gggaaccatg ctctgtttgg gctgggtgtt tctttggttt gttgcaggag agaagaccac
      481 aggatttaat cattcagctt gtgccaccaa aaaacttctg tggacatatt ctgcaagggg
      541 tgcagagaat tttgtcctat tttgtgactt acaagagctt caggagcaaa aattctccca
      601 tgcaagtcaa ctgtcaccaa cacaaagtcc tgctcacaaa ccttgcagtg gcagtcagaa
      661 ggacctatct gatgtccagt ggtacatgca acctcggagt ggaagtccac tagaggagat
      721 cagtagaaac tctccccata tgcagagtga aggcatgctg catatattgg ccccacagac
      781 gaacagcatt tggtcatata tttgtagacc cagaattagg agcccccagg atatggcctg
      841 ttgtatcaag acagtcttag aagttaagcc tcagagaaac gtgtcctgtg ggaacacagc
      901 acaagatgaa caagtcctac ttcttggcag tactggctcc attcattgtc ccagtctcag
      961 ctgccaaagt gatgtacaga gtccagagat gacctggtac aaggatggaa gactacttcc
     1021 tgagcacaag aaaaatccaa ttgagatggc agatatttat gtttttaatc aaggcttgta
     1081 tgtatgtgat tacacacagt cagataatgt gagttcctgg acagtccgag ctgtggttaa
     1141 agtgagaacc attggtaagg acatcaatgt gaagccggaa attctggatc ccattacaga
     1201 tacactggac gtagagcttg gaaagccttt aactctcccc tgcagagtac agtttggctt
     1261 ccaaagactt tcaaagcctg tgataaagtg gtatgtcaaa gaatctacac aggagtggga
     1321 aatgtcagta tttgaggaga aaagaattca atccactttc aagaatgaag tcattgaacg
     1381 taccatcttc ttgagagaag ttacccagag agatctcagc agaaagtttg tttgctttgc
     1441 ccagaactcc attgggaaca caacacggac catacggctg aggaagaagg aagaggtggt
     1501 gtttgtatac atccttctcg gcacggcctt gatgctggtg ggcgttctgg tggcagctgc
     1561 tttcctctac tggtactgga ttgaagttgt cctgctctgt cgaacctaca agaacaaaga
     1621 tgagactctg ggggataaga aggaattcga tgcatttgta tcctactcga attggagctc
     1681 tcctgagact gacgccgtgg gatctctgag tgaggaacac ctggctctga atcttttccc
     1741 ggaagtgcta gaagacacct atgggtacag attgtgtttg cttgaccgag atgtgacccc
     1801 aggaggagtg tatgcagatg acattgtgag catcattaag aaaagccgaa gaggaatatt
     1861 tatcctgagt cccagctacc tcaatggacc ccgtgtcttt gagctacaag cagcagtgaa
     1921 tcttgccttg gttgatcaga cactgaagtt gattttaatt aagttctgtt ccttccaaga
     1981 gccagaatct cttccttacc ttgtcaaaaa ggctctgcgg gttctcccca cagtcacatg
     2041 gaaaggcttg aagtcggtcc acgccagttc caggttctgg acccaaattc gttaccacat
     2101 gcctgtgaag aactccaaca ggtttatgtt caacgggctc agaattttcc tgaagggctt
     2161 ttcccctgaa aaggacctag tgacacagaa acccctggaa ggaatgccca agtctgggaa
     2221 tgaccacgga gctcagaacc tccttctcta cagtgaccag aagaggtgct gatgggtaga
     2281 acttgctgtg tggatcaggc tgatagaaat tgagcctttc tgctctcagt gccaagcaag
     2341 cttgacaggc agtggaatga agcggcatct gtggttttag ggtctgggtt cctggaacag
     2401 acacagagca atactccaga cctctgccgt gtgcttagca cacatttccc tgagagttcc
     2461 caagtagcct gaacagaatc aacagaaata gctccatggg ctgtccaaca ttcatgcacg
     2521 catgcctgtt ttgcactata tatatgaatt tatcatacgt ttgtgtgtgt atatgcattc
     2581 agataaatag gattttattt tgttcgatac gagtgattga aactccatct aaagcccttc
     2641 tgtaaagaaa ttttgctgca tgtttattca tcaattctat agaggagaaa tatagaaggt
     2701 gagacagaac atatgatctc ctgggtccct acaggaccca cttgaaggca tgaactaggt
     2761 atatgtttct agacctgcag gtgaacaaca tgcatggtat ctgttgttgg cagaaaatat
     2821 cacgactcac aaatgaattt agtgagctca tcctgtgtcc aagcttcgaa aggtccaata
     2881 tagaatggtg gtcattcccc ttgtgtctaa ggggctgggt gagagttgtg ctttctttcc
     2941 tactcactac cataagcgaa agtcacatca caagtcacta gtgccagaaa aaaaaaatac
     3001 atcaacactc agagggtcaa aaatttgagt caagttcttc caaattgtat ataacagaga
     3061 ggacagagcc ctcctcttgg ctggaacact ctttacagga ttcagattta ggaatgggat
     3121 agaactaatt acgatatctc cttgtttcct tggctagaga ccttacccga gtctctgcaa
     3181 gtagagacta atttgtccca gatcattagt ccaattaaga caaagaatgg gtttgtagtt
     3241 gtctacaacc tagagaggca gcaattatga agcagagtgt ggggcataag ggcacccatt
     3301 tgttgacaag cagcaagaat acaacagatg ccatagcttt gcatgtcatt tgcctgctga
     3361 gagtggtatc ctgtatggac actgattggc cgagtggtct taggggaagt cttccttagt
     3421 aacaagatga tgtgtttaag ggctgggtcg tcgttttgat taacaaagtg aatttgatgc
     3481 tcatgacttg gtctatagct gaaacagggt ttgagttgat gtggctgttt atgccctttg
     3541 aacaccacct ttcctgatgg aacagggtgg ctcatcatgt gagcagtgaa ggcagcacct
     3601 catgaactgg ctcccacatc atgagtcaca tcccctgaga accaaatgag gtccacaggc
     3661 agagtgggtt atccactgac atctgaccca ttggtgtctg tgtgaattgc tcttctgatc
     3721 ctccttcgca gaagaaccac atcataaaaa ccactttggc tttggcacta accagcatcc
     3781 tggctggaaa tctcaaagct aaagaggaac caaagagcat aaattatccc tggaggaagt
     3841 ttttgtggga aggaccactg tgggatcgca gtggggagga acccacactt gttgaaccac
     3901 tgtgccctgg ctctggccag gcttcctggg tttcttgtta gcctctctca gagatcatag
     3961 actcagaaac ctcttctggc cagtgcagcc aggtttatct tgttccaaga taactgagct
     4021 cccaagcatt tggctttaca gtgcctcaga cttgtacaaa tatgaaagca gaaatagcca
     4081 gtccatgttt atagaatgtc ttcttttcca tagctaggtc cagtgagatg acaggtatgc
     4141 atttgggaca aactgttatt aatatttatg ccttgcatat caactaaaac aagaggaata
     4201 atcaagacaa aattcctgtg tttgcaagac tttggctgag cagctaggct cagcagaatg
     4261 aaagcaaagc cacgttttct ggctgcacca tctagatgag gaggccatgt atcttgtcta
     4321 ttgcttcaca tacattgaac aaatacaatg gtaaccatgc tttatttcgg tataagaaag
     4381 catcaccatt tgagtatgga tggcaccctt ctaggacaca ctgcagacct ttccttatgg
     4441 accctatatg gtctcccaga cagttctcag agagaaagtt ctcaacattc atgttattcc
     4501 aaggtcaata cctcaagtaa tataaaataa atgcccacag tcctgactac tggtttgttt
     4561 tatgccagct taatacaagc taaatcagtt tggaagaagg aacattggca gagagagagc
     4621 ccccactaga ttggactatg gacaagcctg tggtacattg tcttgattca tgatcaatgt
     4681 ggggggtcac agctcactgt gtacagtgtc acccctgggc tggtggccct ggatgctatg
     4741 agtaagcagg gtaaataagc cataaatagg aaaccagtaa gcagcacttt tccatggctc
     4801 tgcttcagtt cctgtgccca gattcctggc ttgtactccc tggacaatgg acctgagaat
     4861 tgtaagactg aataaaccct ttccttctc
//
