LOCUS       NM_008365               4158 bp    mRNA    linear   ROD 12-NOV-2024
DEFINITION  Mus musculus interleukin 18 receptor 1 (Il18r1), transcript variant
            1, mRNA.
ACCESSION   NM_008365
VERSION     NM_008365.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4158)
  AUTHORS   Oberkircher,L.M., Scheiding,V.M., Rafeld,H.L., Hanssen,E.,
            Hansen,J.N., Fleischmann,M.J., Kessler,N., Pitsch,D., Wachten,D.,
            Kastenmuller,W., Brown,A.S., Hartland,E.L., van Driel,I.R., Ng,G.Z.
            and Garbi,N.
  TITLE     Opposing roles of resident and infiltrating immune cells in the
            defense against Legionella longbeachae via IL-18R/IFN-gamma/ROS
            axis in mice
  JOURNAL   Mucosal Immunol 17 (5), 777-792 (2024)
   PUBMED   38750967
REFERENCE   2  (bases 1 to 4158)
  AUTHORS   Mertens,R.T., Misra,A., Xiao,P., Baek,S., Rone,J.M., Mangani,D.,
            Sivanathan,K.N., Arojojoye,A.S., Awuah,S.G., Lee,I., Shi,G.P.,
            Petrova,B., Brook,J.R., Anderson,A.C., Flavell,R.A., Kanarek,N.,
            Hemberg,M. and Nowarski,R.
  TITLE     A metabolic switch orchestrated by IL-18 and the cyclic
            dinucleotide cGAMP programs intestinal tolerance
  JOURNAL   Immunity 57 (9), 2077-2094 (2024)
   PUBMED   38906145
REFERENCE   3  (bases 1 to 4158)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 4158)
  AUTHORS   Medina Sanchez,L., Siller,M., Zeng,Y., Brigleb,P.H., Sangani,K.A.,
            Soto,A.S., Engl,C., Laughlin,C.R., Rana,M., Van Der Kraak,L.,
            Pandey,S.P., Bender,M.J., Fitzgerald,B., Hedden,L., Fiske,K.,
            Taylor,G.M., Wright,A.P., Mehta,I.D., Rahman,S.A., Galipeau,H.J.,
            Mullett,S.J., Gelhaus,S.L., Watkins,S.C., Bercik,P., Nice,T.J.,
            Jabri,B., Meisel,M., Das,J., Dermody,T.S., Verdu,E.F. and
            Hinterleitner,R.
  TITLE     The gut protist Tritrichomonas arnold restrains virus-mediated loss
            of oral tolerance by modulating dietary antigen-presenting
            dendritic cells
  JOURNAL   Immunity 56 (8), 1862-1875 (2023)
   PUBMED   37478853
REFERENCE   5  (bases 1 to 4158)
  AUTHORS   Song,X., Zhang,H., Zhang,Y., Goh,B., Bao,B., Mello,S.S., Sun,X.,
            Zheng,W., Gazzaniga,F.S., Wu,M., Qu,F., Yin,Q., Gilmore,M.S.,
            Oh,S.F. and Kasper,D.L.
  TITLE     Gut microbial fatty acid isomerization modulates intraepithelial T
            cells
  JOURNAL   Nature 619 (7971), 837-843 (2023)
   PUBMED   37380774
REFERENCE   6  (bases 1 to 4158)
  AUTHORS   Sergi,B. and Penttila,I.
  TITLE     Interleukin 18 receptor
  JOURNAL   J Biol Regul Homeost Agents 18 (1), 55-61 (2004)
   PUBMED   15323361
  REMARK    GeneRIF: review of structure, function and tissue distribution of
            IL-18R [review]
            Review article
REFERENCE   7  (bases 1 to 4158)
  AUTHORS   Seki,E., Tsutsui,H., Tsuji,N.M., Hayashi,N., Adachi,K., Nakano,H.,
            Futatsugi-Yumikura,S., Takeuchi,O., Hoshino,K., Akira,S.,
            Fujimoto,J. and Nakanishi,K.
  TITLE     Critical roles of myeloid differentiation factor 88-dependent
            proinflammatory cytokine release in early phase clearance of
            Listeria monocytogenes in mice
  JOURNAL   J Immunol 169 (7), 3863-3868 (2002)
   PUBMED   12244183
REFERENCE   8  (bases 1 to 4158)
  AUTHORS   Okamoto,M., Kato,S., Oizumi,K., Kinoshita,M., Inoue,Y., Hoshino,K.,
            Akira,S., McKenzie,A.N., Young,H.A. and Hoshino,T.
  TITLE     Interleukin 18 (IL-18) in synergy with IL-2 induces lethal lung
            injury in mice: a potential role for cytokines, chemokines, and
            natural killer cells in the pathogenesis of interstitial pneumonia
  JOURNAL   Blood 99 (4), 1289-1298 (2002)
   PUBMED   11830478
REFERENCE   9  (bases 1 to 4158)
  AUTHORS   Hoshino,K., Tsutsui,H., Kawai,T., Takeda,K., Nakanishi,K.,
            Takeda,Y. and Akira,S.
  TITLE     Cutting edge: generation of IL-18 receptor-deficient mice: evidence
            for IL-1 receptor-related protein as an essential IL-18 binding
            receptor
  JOURNAL   J Immunol 162 (9), 5041-5044 (1999)
   PUBMED   10227969
REFERENCE   10 (bases 1 to 4158)
  AUTHORS   Parnet,P., Garka,K.E., Bonnert,T.P., Dower,S.K. and Sims,J.E.
  TITLE     IL-1Rrp is a novel receptor-like molecule similar to the type I
            interleukin-1 receptor and its homologues T1/ST2 and IL-1R AcP
  JOURNAL   J Biol Chem 271 (8), 3967-3970 (1996)
   PUBMED   8626725
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC167126.6.
            
            On Jun 19, 2009 this sequence version replaced NM_008365.1.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (a).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments and are consistent with Northern
            analyses.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN00849383,
                              SAMN00849387 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-352               AC167126.6         75381-75732
            353-438             AC167126.6         81104-81189
            439-685             AC167126.6         84069-84315
            686-851             AC167126.6         87760-87925
            852-996             AC167126.6         90297-90441
            997-1059            AC167126.6         93656-93718
            1060-1183           AC167126.6         96350-96473
            1184-1323           AC167126.6         98976-99115
            1324-1482           AC167126.6         100433-100591
            1483-1641           AC167126.6         105124-105282
            1642-4158           AC167126.6         107713-110229
FEATURES             Location/Qualifiers
     source          1..4158
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 19.27 cM"
     gene            1..4158
                     /gene="Il18r1"
                     /gene_synonym="Il18ralpha; Il1rrp"
                     /note="interleukin 18 receptor 1"
                     /db_xref="GeneID:16182"
                     /db_xref="MGI:MGI:105383"
     exon            1..352
                     /gene="Il18r1"
                     /gene_synonym="Il18ralpha; Il1rrp"
                     /inference="alignment:Splign:2.1.0"
     exon            353..438
                     /gene="Il18r1"
                     /gene_synonym="Il18ralpha; Il1rrp"
                     /inference="alignment:Splign:2.1.0"
     exon            439..685
                     /gene="Il18r1"
                     /gene_synonym="Il18ralpha; Il1rrp"
                     /inference="alignment:Splign:2.1.0"
     exon            686..851
                     /gene="Il18r1"
                     /gene_synonym="Il18ralpha; Il1rrp"
                     /inference="alignment:Splign:2.1.0"
     exon            852..996
                     /gene="Il18r1"
                     /gene_synonym="Il18ralpha; Il1rrp"
                     /inference="alignment:Splign:2.1.0"
     exon            997..1059
                     /gene="Il18r1"
                     /gene_synonym="Il18ralpha; Il1rrp"
                     /inference="alignment:Splign:2.1.0"
     exon            1060..1183
                     /gene="Il18r1"
                     /gene_synonym="Il18ralpha; Il1rrp"
                     /inference="alignment:Splign:2.1.0"
     exon            1184..1323
                     /gene="Il18r1"
                     /gene_synonym="Il18ralpha; Il1rrp"
                     /inference="alignment:Splign:2.1.0"
     exon            1324..1482
                     /gene="Il18r1"
                     /gene_synonym="Il18ralpha; Il1rrp"
                     /inference="alignment:Splign:2.1.0"
     exon            1483..1641
                     /gene="Il18r1"
                     /gene_synonym="Il18ralpha; Il1rrp"
                     /inference="alignment:Splign:2.1.0"
     exon            1642..4158
                     /gene="Il18r1"
                     /gene_synonym="Il18ralpha; Il1rrp"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4126..4131
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Il18r1"
                     /gene_synonym="Il18ralpha; Il1rrp"
                     /note="hexamer: ATTAAA"
     polyA_site      4158
                     /gene="Il18r1"
                     /gene_synonym="Il18ralpha; Il1rrp"
                     /note="major polyA site"
ORIGIN      
        1 tcccagccct ccacctccct acccccggtc gttggcttct tcttcttctt cttctttttt
       61 ttttttcctg cgataattct ctggtttgcc aaatctctct aatcaagctc ctggccttgc
      121 ctcactgtgc cttccctccc tgtctgttgt cacagttgtg gaccaggagg tatttagtct
      181 cacttgctgg gcgaatcctg cttcacagat gtaagtgaag gagaagccac tgcccaggcc
      241 tgtgtgtggg ccacctctct gaaggtaagg gcagactctg atgtccagtc ctcactgtct
      301 tctgctgtct ggagcaagga gaggaaccac ccacaacgat cctgaaaaca agagatacca
      361 ttcaaagtgg aagcctaaac atgcatcatg aagaattaat cttgacactc tgcattctca
      421 ttgttaaaag tgcctcaaaa agttgtattc accgatcaca aattcatgtg gtagagggag
      481 aaccttttta tctgaagcca tgtggcatat ctgcaccagt gcacaggaat gaaacagcca
      541 ccatgagatg gttcaaaggc agtgcttcac atgagtatag agagctgaac aacagaagct
      601 cgcccagagt cacttttcat gatcacacct tggaattctg gccagttgag atggaggatg
      661 agggaacgta catttctcaa gtcggaaatg atcgtcgcaa ttggacctta aatgtcacca
      721 aaagaaacaa acacagctgt ttctctgaca agctcgtgac aagcagagat gttgaagtta
      781 acaaatctct gcatatcact tgtaagaatc ctaactatga agagctgatc caggacacat
      841 ggctgtataa gaactgtaag gaaatatcca aaaccccaag gatcctgaag gatgccgagt
      901 ttggagatga gggctactac tcctgcgtgt tttctgtcca ccataatggg acacggtaca
      961 acatcaccaa gactgtcaat ataacagtta ttgaaggaag gagtaaagta actccagcta
     1021 ttttaggacc aaagtgtgag aaggttggtg tagaactagg aaaggatgtg gagttgaact
     1081 gcagtgcttc attgaataaa gacgatctgt tttattggag catcaggaaa gaggacagct
     1141 cagaccctaa tgtgcaagaa gacaggaagg agacgacaac atggatttct gaaggcaaac
     1201 tgcatgcttc aaaaatactg agatttcaga aaattactga aaactatctc aatgttttat
     1261 ataattgcac cgtggccaac gaagaagcca tagacaccaa gagcttcgtc ttggtgagaa
     1321 aagaaatacc tgatatccca ggccatgtct ttacaggagg agtaactgtg cttgttctcg
     1381 cctctgtggc agcagtgtgt atagtgattt tgtgtgtcat ttataaagtt gacttggttc
     1441 tgttctatag gcgcatagcg gaaagagacg agacactaac agatggtaaa acatatgatg
     1501 cctttgtgtc ttacctgaaa gagtgtcatc ctgagaataa agaagagtat acttttgctg
     1561 tggagacgtt acccagggtc ctggagaaac agtttgggta taagttatgc atatttgaaa
     1621 gagatgtggt gcctggcgga gctgttgtcg aggagatcca ttcactgata gagaaaagcc
     1681 ggaggctaat catcgttctc agccagagtt acctgactaa cggagccagg cgtgagctcg
     1741 agagtggact ccacgaagca ctggtagaga ggaagattaa gatcatctta attgagttta
     1801 ctccagccag caacatcacc tttctccccc cgtcgctgaa actcctgaag tcctacagag
     1861 ttctaaaatg gagggctgac agtccctcca tgaactcaag gttctggaag aatcttgttt
     1921 acctgatgcc cgcaaaagcc gtcaagccat ggagagagga gtcggaggcg cggtctgttc
     1981 tctcagcacc ttgagctcca gacgagcttg atgtcaaaag caagtgaagc gctgctagag
     2041 gtcatgcgtg tgcctattca cagcggtagc tgtggttcaa aaggctgaat tttgtgacta
     2101 taccccccac tcccagttag gagagttgtc atcgggtcat cacagatgaa acagagcctt
     2161 ggttgtgatc ctgaactcgc agagggggcc ttgggattca caagaaatca gtttgttatt
     2221 ctttcttcct ctggagcagt gattcccaac ctgtgggttg tggccccttt ggcaaacctt
     2281 tatctccaaa atagatgtac gctatgattc ataactgtag ccaactcaca gttacaaagt
     2341 agcaacgaaa aaagttttat ggttgggggt ttcaccacag tgtgaagaac tgtattaaag
     2401 ggttgaagca ttaggaaggt tgagaaccgc tggcctagag ctgtctgcat accgttccat
     2461 tcagccaaga tggaggtagg ctggcaaact gatttatgcc cctaaataag gcacctcttc
     2521 agaatttttc aactaacagt ggattccaac tggagaattt tatgcgctcc gaggcatttt
     2581 ctatgagcca atctttactg catctcaagg gtacatggct ctctcccagg cttgggaggt
     2641 gcaagaggtg agagaaaaag ctggaaacac aagagaaatg ggatgagaga aagctccagg
     2701 aacttggctt caggatgagt ttggtgttgc aaggtagttc ttagaaagtc agtcagacgt
     2761 caagcaggac ttccttgttt cttcaacctt ttcgtacatc ctttgaaatg gaacctgcga
     2821 tatcgtttat tgcagacaga agtttaaatt cagagaactc agtgggcctt tcaactttag
     2881 tggctttaag tttttgttgg ctttgtgtaa atgtttatct gtaggatcat actagctgct
     2941 aaactgtagc aaacaatcaa caaatgcttg ctgtttttat gagccaattc tggtgccctg
     3001 ggcatgcagg cagttttggt gtggcagttg acggtgtggt atgtgcagcc aaatttgatg
     3061 gacaatcttg gattttgtga gctctggaat tttatccaac ttctcatact tcagtttact
     3121 catttctaaa atcagagttt aaagtaaata cagctagttc ccaagggcac taaagactac
     3181 tctgtaaaca tggctcttat tgttgatggc agtaactgct ctcattcatt ggctcagtga
     3241 ttccacagta gagggaatgg gagccagaga gcaggttggg aaatgggtct acaaatagga
     3301 gcaacaagtg gagagggcag aggagaaaca tagcagtaga agaaacacaa tatacataag
     3361 catacacaca taaacataca tacatacaaa aacacacata caaacagaaa cacacataaa
     3421 cacaaacata gaaccgcaca cacagaaaca catacaaaca tacatacaca cacatacaca
     3481 cacacacaca cacacacaca cacacacaca cacacacaca acacctcctg ctgaaatatg
     3541 catctctcgg cactggaaga tacttttgtt tctctaaaga gagttgtcac actggggcct
     3601 cctccatggt tcaaaacagt agctgtctgt gggaattgcc ccccgctccc atgtgtgtgt
     3661 gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtctgtctgt ctgtgtgtgt gtaggtgtat
     3721 gctacccttg cataaaaaag aagattcaga gaagcccaaa gcttcttgtg accttgcaag
     3781 tgcctgagtg aagcaagaat attctaggga agtctagagc agagactgtg ctgaacaaac
     3841 acagtagatt ttaggaaaac caaaccaaac caaatgaaag gaaaggaaac agaaaaaaaa
     3901 acaagaagaa tggggattct taagtaattt ttgtaactca tgacttcatg tgctatttga
     3961 ctgacttgag aaaagaaggt aaattcattc aacatctgct gtcacaacag ctgtgtgtga
     4021 aaacctagca tcagaagaga gttgggagag tttgagactt cgctttgttc ttctatcagc
     4081 caagcttcga cacatgaagt ttattttata tgaaatatat tttgtattaa atctgccaaa
     4141 tacatacatt agactgga
//
