LOCUS       NM_010531               1482 bp    mRNA    linear   ROD 28-AUG-2024
DEFINITION  Mus musculus interleukin 18 binding protein (Il18bp), transcript
            variant 1, mRNA.
ACCESSION   NM_010531
VERSION     NM_010531.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1482)
  AUTHORS   Mertens,R.T., Misra,A., Xiao,P., Baek,S., Rone,J.M., Mangani,D.,
            Sivanathan,K.N., Arojojoye,A.S., Awuah,S.G., Lee,I., Shi,G.P.,
            Petrova,B., Brook,J.R., Anderson,A.C., Flavell,R.A., Kanarek,N.,
            Hemberg,M. and Nowarski,R.
  TITLE     A metabolic switch orchestrated by IL-18 and the cyclic
            dinucleotide cGAMP programs intestinal tolerance
  JOURNAL   Immunity (2024) In press
   PUBMED   38906145
  REMARK    Publication Status: Available-Online prior to print
REFERENCE   2  (bases 1 to 1482)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 1482)
  AUTHORS   Fauteux-Daniel,S., Merlo Pich,L.M., Girard-Guyonvarc'h,C.,
            Caruso,A., Rodriguez,E. and Gabay,C.
  TITLE     The role of interleukin-18 and interleukin-18 binding protein in
            K/BxN serum transfer-induced arthritis
  JOURNAL   Front Immunol 14, 1215364 (2023)
   PUBMED   37415987
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1482)
  AUTHORS   Harel,M., Fauteux-Daniel,S., Rodriguez,E., Palmer,G. and Gabay,C.
  TITLE     IL-18 Binding Protein-Producing Cells Attenuate Anemia in Murine
            Macrophage Activation Syndrome
  JOURNAL   J Immunol 210 (11), 1790-1803 (2023)
   PUBMED   37074208
  REMARK    GeneRIF: IL-18 Binding Protein-Producing Cells Attenuate Anemia in
            Murine Macrophage Activation Syndrome.
REFERENCE   5  (bases 1 to 1482)
  AUTHORS   Harel,M., Girard-Guyonvarc'h,C., Rodriguez,E., Palmer,G. and
            Gabay,C.
  TITLE     Production of IL-18 Binding Protein by Radiosensitive and
            Radioresistant Cells in CpG-Induced Macrophage Activation Syndrome
  JOURNAL   J Immunol 205 (4), 1167-1175 (2020)
   PUBMED   32651219
  REMARK    GeneRIF: Production of IL-18 Binding Protein by Radiosensitive and
            Radioresistant Cells in CpG-Induced Macrophage Activation Syndrome.
REFERENCE   6  (bases 1 to 1482)
  AUTHORS   Banda,N.K., Vondracek,A., Kraus,D., Dinarello,C.A., Kim,S.H.,
            Bendele,A., Senaldi,G. and Arend,W.P.
  TITLE     Mechanisms of inhibition of collagen-induced arthritis by murine
            IL-18 binding protein
  JOURNAL   J Immunol 170 (4), 2100-2105 (2003)
   PUBMED   12574381
  REMARK    GeneRIF: Administratioan of murine IL-18BP at the time of the
            booster injection of bovine CII reduces the progressive severity of
            collagen-induced arthritis; both clinical disease activity and
            histological scores are decreased by 50%.
REFERENCE   7  (bases 1 to 1482)
  AUTHORS   Kim,S.H., Eisenstein,M., Reznikov,L., Fantuzzi,G., Novick,D.,
            Rubinstein,M. and Dinarello,C.A.
  TITLE     Structural requirements of six naturally occurring isoforms of the
            IL-18 binding protein to inhibit IL-18
  JOURNAL   Proc Natl Acad Sci U S A 97 (3), 1190-1195 (2000)
   PUBMED   10655506
REFERENCE   8  (bases 1 to 1482)
  AUTHORS   Xiang,Y. and Moss,B.
  TITLE     Identification of human and mouse homologs of the MC51L-53L-54L
            family of secreted glycoproteins encoded by the Molluscum
            contagiosum poxvirus
  JOURNAL   Virology 257 (2), 297-302 (1999)
   PUBMED   10329540
REFERENCE   9  (bases 1 to 1482)
  AUTHORS   Aizawa,Y., Akita,K., Taniai,M., Torigoe,K., Mori,T., Nishida,Y.,
            Ushio,S., Nukada,Y., Tanimoto,T., Ikegami,H., Ikeda,M. and
            Kurimoto,M.
  TITLE     Cloning and expression of interleukin-18 binding protein
  JOURNAL   FEBS Lett 445 (2-3), 338-342 (1999)
   PUBMED   10094485
REFERENCE   10 (bases 1 to 1482)
  AUTHORS   Novick,D., Kim,S.H., Fantuzzi,G., Reznikov,L.L., Dinarello,C.A. and
            Rubinstein,M.
  TITLE     Interleukin-18 binding protein: a novel modulator of the Th1
            cytokine response
  JOURNAL   Immunity 10 (1), 127-136 (1999)
   PUBMED   10023777
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC167240.5 and AF122907.1.
            
            On Jun 3, 2018 this sequence version replaced NM_010531.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF122907.1, SRR5189682.27629.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164143 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-77                AC167240.5         6975-7051
            78-1479             AF122907.1         1-1402
            1480-1482           AC167240.5         10131-10133
FEATURES             Location/Qualifiers
     source          1..1482
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 54.71 cM"
     gene            1..1482
                     /gene="Il18bp"
                     /gene_synonym="Igifbp; IL-18BP; MC54L"
                     /note="interleukin 18 binding protein"
                     /db_xref="GeneID:16068"
                     /db_xref="MGI:MGI:1333800"
     exon            1..123
                     /gene="Il18bp"
                     /gene_synonym="Igifbp; IL-18BP; MC54L"
                     /inference="alignment:Splign:2.1.0"
     exon            124..191
                     /gene="Il18bp"
                     /gene_synonym="Igifbp; IL-18BP; MC54L"
                     /inference="alignment:Splign:2.1.0"
     exon            192..256
                     /gene="Il18bp"
                     /gene_synonym="Igifbp; IL-18BP; MC54L"
                     /inference="alignment:Splign:2.1.0"
     exon            257..448
                     /gene="Il18bp"
                     /gene_synonym="Igifbp; IL-18BP; MC54L"
                     /inference="alignment:Splign:2.1.0"
     exon            449..572
                     /gene="Il18bp"
                     /gene_synonym="Igifbp; IL-18BP; MC54L"
                     /inference="alignment:Splign:2.1.0"
     exon            573..720
                     /gene="Il18bp"
                     /gene_synonym="Igifbp; IL-18BP; MC54L"
                     /inference="alignment:Splign:2.1.0"
     exon            721..1482
                     /gene="Il18bp"
                     /gene_synonym="Igifbp; IL-18BP; MC54L"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1357..1362
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Il18bp"
                     /gene_synonym="Igifbp; IL-18BP; MC54L"
                     /note="hexamer: CATAAA"
     polyA_site      1377
                     /gene="Il18bp"
                     /gene_synonym="Igifbp; IL-18BP; MC54L"
                     /note="major polyA site"
     regulatory      1459..1464
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Il18bp"
                     /gene_synonym="Igifbp; IL-18BP; MC54L"
                     /note="hexamer: AATAAA"
     polyA_site      1482
                     /gene="Il18bp"
                     /gene_synonym="Igifbp; IL-18BP; MC54L"
                     /note="major polyA site"
ORIGIN      
        1 gagttttgta cacgagccag gcagggaagt tgctccttcc tgtggtgaga ttttcttggg
       61 gccaggcagc tatcctggct gagccttaga gctccaagaa gctattcggg gcttaggagc
      121 cagaagctga ctgctgcctg cccttcccag aaggaggctg gcaagctggc aaacggactg
      181 ttgcttccca gaggaagtca cagacaccag acttgcttgc aagtcatcat gaccatgaga
      241 cactgctgga cagcaggccc cagttcttgg tgggtcctgc ttttgtatgt ccatgtcatt
      301 ttggccagag ccacatctgc acctcagaca actgccactg tcttaactgg aagctcaaaa
      361 gacccatgct cttcctggtc tccagcagtc ccaactaagc agtacccagc actggatgtg
      421 atttggccag aaaaagaagt gccactgaat ggaactctga ccttgtcctg tactgcctgc
      481 agccgcttcc cctacttcag catcctctac tggctgggca atggttcctt cattgagcac
      541 ctcccaggcc ggctgaagga gggccacaca agtcgcgagc acaggaacac aagcacctgg
      601 ctgcacaggg ccttggtgct ggaagaactg agccccaccc tacgaagtac caacttctcc
      661 tgtttgtttg tggatcctgg acaagtggcc cagtatcaca tcattctggc ccagctctgg
      721 gatgggttga agacagctcc gtccccttct caagaaaccc tctctagcca cagcccagta
      781 tccagatcag caggcccagg ggttgcataa agccaaccac accatgacct tgaccagagc
      841 ctggctctca tctacctgga gggtggagtc tacaccatag gctgtgattg cctttctgct
      901 gctgaacctc aaactcaagc ttcacttcta ccctagatta tcatagtaat taagtcctta
      961 gagttcttcc tgtttgtcct cctgtccatc catccagttt accttttctg atgtcttatt
     1021 catcccactg gtgttctgga acctctgaga cctgatgaca ccttagccaa gtgatagctc
     1081 tgcttacact taacgtgaaa ttgagatgcc tatctggcag atttctacat cctgtaccaa
     1141 tcaaaaaggt taacccgaag cctagttgag atataacttt ggcaacatcc actcagctct
     1201 gaccactatc tgcactgact tcaatcttta catgtgattt tgttttccta gtttgcccct
     1261 aatgtactgt ccccaaggca aggacggaac agtggctgcg tcaggtcaca actgtatatg
     1321 tcagtctgtg tctctgcagg gcccacactg agtactcata aagctgcagc agctcaaggt
     1381 ctcattttta tttagaccct ggtactgtcc tcaggaactc tgcctgactc aggcagcatg
     1441 agacactgcc tcttgccaaa taaaaattca gaataacatg aa
//
