LOCUS       NM_008360               1298 bp    mRNA    linear   ROD 11-FEB-2025
DEFINITION  Mus musculus interleukin 18 (Il18), transcript variant 1, mRNA.
ACCESSION   NM_008360 XM_006510027
VERSION     NM_008360.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1298)
  AUTHORS   Zhao,C., Zhao,J.W., Zhang,Y.H., Zhu,Y.D., Yang,Z.Y., Liu,S.L.,
            Tang,Q.Y., Yang,Y., Wang,H.K., Shu,Y.J., Dong,P., Wu,X.S. and
            Gong,W.
  TITLE     PTBP3 Mediates IL-18 Exon Skipping to Promote Immune Escape in
            Gallbladder Cancer
  JOURNAL   Adv Sci (Weinh) 11 (38), e2406633 (2024)
   PUBMED   39116343
  REMARK    GeneRIF: PTBP3 Mediates IL-18 Exon Skipping to Promote Immune
            Escape in Gallbladder Cancer.
REFERENCE   2  (bases 1 to 1298)
  AUTHORS   Mertens,R.T., Misra,A., Xiao,P., Baek,S., Rone,J.M., Mangani,D.,
            Sivanathan,K.N., Arojojoye,A.S., Awuah,S.G., Lee,I., Shi,G.P.,
            Petrova,B., Brook,J.R., Anderson,A.C., Flavell,R.A., Kanarek,N.,
            Hemberg,M. and Nowarski,R.
  TITLE     A metabolic switch orchestrated by IL-18 and the cyclic
            dinucleotide cGAMP programs intestinal tolerance
  JOURNAL   Immunity 57 (9), 2077-2094 (2024)
   PUBMED   38906145
  REMARK    GeneRIF: A metabolic switch orchestrated by IL-18 and the cyclic
            dinucleotide cGAMP programs intestinal tolerance.
REFERENCE   3  (bases 1 to 1298)
  AUTHORS   Lana,J.P., de Oliveira,M.C., Silveira,A.L.M., Yamada,L.T.P.,
            Costa,K.A., da Silva,S.V., de Assis-Ferreira,A., Gautier,E.L.,
            Dussaud,S., Pinho,V., Teixeira,M.M., Marcelin,G., Clement,K. and
            Ferreira,A.V.M.
  TITLE     Role of IL-18 in adipose tissue remodeling and metabolic
            dysfunction
  JOURNAL   Int J Obes (Lond) 48 (7), 964-972 (2024)
   PUBMED   38459259
  REMARK    GeneRIF: Role of IL-18 in adipose tissue remodeling and metabolic
            dysfunction.
REFERENCE   4  (bases 1 to 1298)
  AUTHORS   Du,G., Yang,Z., Wen,Y., Li,X., Zhong,W., Li,Z., Zhang,S., Luo,E.,
            Ding,H. and Li,W.
  TITLE     Heat stress induces IL-1beta and IL-18 overproduction via
            ROS-activated NLRP3 inflammasome: implication in neuroinflammation
            in mice with heat stroke
  JOURNAL   Neuroreport 35 (9), 558-567 (2024)
   PUBMED   38687900
  REMARK    GeneRIF: Heat stress induces IL-1beta and IL-18 overproduction via
            ROS-activated NLRP3 inflammasome: implication in neuroinflammation
            in mice with heat stroke.
REFERENCE   5  (bases 1 to 1298)
  AUTHORS   Roman-Dominguez,L., Salazar-Leon,J., Meza-Sosa,K.F.,
            Perez-Martinez,L. and Pedraza-Alva,G.
  TITLE     Adipose tissue IL-18 production is independent of caspase-1 and
            caspase-11
  JOURNAL   Immun Inflamm Dis 12 (4), e1241 (2024)
   PUBMED   38629728
  REMARK    GeneRIF: Adipose tissue IL-18 production is independent of
            caspase-1 and caspase-11.
            Erratum:[Immun Inflamm Dis. 2024 Dec;12(12):e70095. doi:
            10.1002/iid3.70095.. PMID: 39724276]
REFERENCE   6  (bases 1 to 1298)
  AUTHORS   Conti,B., Jahng,J.W., Tinti,C., Son,J.H. and Joh,T.H.
  TITLE     Induction of interferon-gamma inducing factor in the adrenal cortex
  JOURNAL   J Biol Chem 272 (4), 2035-2037 (1997)
   PUBMED   8999896
REFERENCE   7  (bases 1 to 1298)
  AUTHORS   Tsutsui,H., Nakanishi,K., Matsui,K., Higashino,K., Okamura,H.,
            Miyazawa,Y. and Kaneda,K.
  TITLE     IFN-gamma-inducing factor up-regulates Fas ligand-mediated
            cytotoxic activity of murine natural killer cell clones
  JOURNAL   J Immunol 157 (9), 3967-3973 (1996)
   PUBMED   8892629
REFERENCE   8  (bases 1 to 1298)
  AUTHORS   Micallef,M.J., Ohtsuki,T., Kohno,K., Tanabe,F., Ushio,S., Namba,M.,
            Tanimoto,T., Torigoe,K., Fujii,M., Ikeda,M., Fukuda,S. and
            Kurimoto,M.
  TITLE     Interferon-gamma-inducing factor enhances T helper 1 cytokine
            production by stimulated human T cells: synergism with
            interleukin-12 for interferon-gamma production
  JOURNAL   Eur J Immunol 26 (7), 1647-1651 (1996)
   PUBMED   8766574
REFERENCE   9  (bases 1 to 1298)
  AUTHORS   Ushio,S., Namba,M., Okura,T., Hattori,K., Nukada,Y., Akita,K.,
            Tanabe,F., Konishi,K., Micallef,M., Fujii,M., Torigoe,K.,
            Tanimoto,T., Fukuda,S., Ikeda,M., Okamura,H. and Kurimoto,M.
  TITLE     Cloning of the cDNA for human IFN-gamma-inducing factor, expression
            in Escherichia coli, and studies on the biologic activities of the
            protein
  JOURNAL   J Immunol 156 (11), 4274-4279 (1996)
   PUBMED   8666798
REFERENCE   10 (bases 1 to 1298)
  AUTHORS   Okamura,H., Tsutsi,H., Komatsu,T., Yutsudo,M., Hakura,A.,
            Tanimoto,T., Torigoe,K., Okura,T., Nukada,Y., Hattori,K. et al.
  TITLE     Cloning of a new cytokine that induces IFN-gamma production by T
            cells
  JOURNAL   Nature 378 (6552), 88-91 (1995)
   PUBMED   7477296
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC127254.3, CX123286.1 and AC025500.8.
            
            On or before Oct 24, 2017 this sequence version replaced
            XM_006510027.3, NM_008360.1.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longer isoform (a). Variants 1 and 2
            both encode the same isoform (a).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            CDS exon combination :: BC024384.1, AY157835.1 [ECO:0000331]
            RNAseq introns       :: single sample supports all introns
                                    SAMN00849375, SAMN00849377 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-252               AC127254.3         173924-174175
            253-894             CX123286.1         1-642
            895-946             AC025500.8         43652-43703
            947-1298            AC025500.8         45773-46124
FEATURES             Location/Qualifiers
     source          1..1298
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 27.75 cM"
     gene            1..1298
                     /gene="Il18"
                     /gene_synonym="Igif; Il-18"
                     /note="interleukin 18"
                     /db_xref="GeneID:16173"
                     /db_xref="MGI:MGI:107936"
     exon            1..278
                     /gene="Il18"
                     /gene_synonym="Igif; Il-18"
                     /inference="alignment:Splign:2.1.0"
     exon            279..429
                     /gene="Il18"
                     /gene_synonym="Igif; Il-18"
                     /inference="alignment:Splign:2.1.0"
     exon            430..587
                     /gene="Il18"
                     /gene_synonym="Igif; Il-18"
                     /inference="alignment:Splign:2.1.0"
     exon            588..668
                     /gene="Il18"
                     /gene_synonym="Igif; Il-18"
                     /inference="alignment:Splign:2.1.0"
     CDS             593..1171
                     /gene="Il18"
                     /gene_synonym="Igif; Il-18"
                     /note="isoform a is encoded by transcript variant 1; IL-1
                     gamma; interleukin-1 gamma; IFN-gamma-inducing factor;
                     interferon gamma-inducing factor"
                     /codon_start=1
                     /product="interleukin-18 isoform a"
                     /protein_id="NP_032386.1"
                     /db_xref="CCDS:CCDS40622.1"
                     /db_xref="GeneID:16173"
                     /db_xref="MGI:MGI:107936"
                     /translation="MAAMSEDSCVNFKEMMFIDNTLYFIPEENGDLESDNFGRLHCTT
                     AVIRNINDQVLFVDKRQPVFEDMTDIDQSASEPQTRLIIYMYKDSEVRGLAVTLSVKD
                     SKMSTLSCKNKIISFEEMDPPENIDDIQSDLIFFQKRVPGHNKMEFESSLYEGHFLAC
                     QKEDDAFKLILKKKDENGDKSVMFTLTNLHQS"
     exon            669..680
                     /gene="Il18"
                     /gene_synonym="Igif; Il-18"
                     /inference="alignment:Splign:2.1.0"
     exon            681..812
                     /gene="Il18"
                     /gene_synonym="Igif; Il-18"
                     /inference="alignment:Splign:2.1.0"
     exon            813..946
                     /gene="Il18"
                     /gene_synonym="Igif; Il-18"
                     /inference="alignment:Splign:2.1.0"
     exon            947..1298
                     /gene="Il18"
                     /gene_synonym="Igif; Il-18"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1276..1281
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Il18"
                     /gene_synonym="Igif; Il-18"
                     /note="hexamer: AGTAAA"
     polyA_site      1298
                     /gene="Il18"
                     /gene_synonym="Igif; Il-18"
                     /note="major polyA site"
ORIGIN      
        1 aaagcagtgg ttttcagctg ggaaaactca ggatagagaa aaaccctttg aggcatccag
       61 gacaaatcag atctctgggc tgaatcctgc cccagtgcgt cacattagct gactgaacac
      121 tggctgttcc cacaacgatg agtacaccaa tcctgtggtt ggtaaaacaa gcttgctttc
      181 acttctcccc tgtggtgtgc tgcctgcatc acacaaagag gctttggaag cctgctataa
      241 tcctcaggcc ccgggcgcag cagtccaact gcagactgca atctatgcag agcagctgga
      301 attctctgag agcttaagga cagcctggcc tacagagtga gttctaggcc atccagggtt
      361 tcataggtcc tgcctcaaac aaacatgtaa cttgatggaa tgaaaattta caagtttaca
      421 agcatccagg cacagctgga cctggtgggg gttctctgtg gttccatgct ttctggactc
      481 ctgcctgctg gctggagctg ctgacaggcc tgacatcttc tgcaacctcc agcatcagga
      541 caaagaaagc cgcctcaaac cttccaaatc acttcctctt ggcccaggaa caatggctgc
      601 catgtcagaa gactcttgcg tcaacttcaa ggaaatgatg tttattgaca acacgcttta
      661 ctttatacct gaagaaaatg gagacctgga atcagacaac tttggccgac ttcactgtac
      721 aaccgcagta atacggaata taaatgacca agttctcttc gttgacaaaa gacagcctgt
      781 gttcgaggat atgactgata ttgatcaaag tgccagtgaa ccccagacca gactgataat
      841 atacatgtac aaagacagtg aagtaagagg actggctgtg accctctctg tgaaggatag
      901 taaaatgtct accctctcct gtaagaacaa gatcatttcc tttgaggaaa tggatccacc
      961 tgaaaatatt gatgatatac aaagtgatct catattcttt cagaaacgtg ttccaggaca
     1021 caacaagatg gagtttgaat cttcactgta tgaaggacac tttcttgctt gccaaaagga
     1081 agatgatgct ttcaaactca ttctgaaaaa aaaggatgaa aatggggata aatctgtaat
     1141 gttcactctc actaacttac atcaaagtta ggtggggagg gtttgtgttc cagaaagatg
     1201 attagcacac atgcgccttg tgatgacctc gcctgtattt ccataacaga atacccgagg
     1261 ctgcatgatt tatagagtaa acacgtttat ttgtcgca
//
