LOCUS       NM_001357221            1147 bp    mRNA    linear   ROD 11-FEB-2025
DEFINITION  Mus musculus interleukin 18 (Il18), transcript variant 2, mRNA.
ACCESSION   NM_001357221 XM_006510026
VERSION     NM_001357221.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1147)
  AUTHORS   Zhao,C., Zhao,J.W., Zhang,Y.H., Zhu,Y.D., Yang,Z.Y., Liu,S.L.,
            Tang,Q.Y., Yang,Y., Wang,H.K., Shu,Y.J., Dong,P., Wu,X.S. and
            Gong,W.
  TITLE     PTBP3 Mediates IL-18 Exon Skipping to Promote Immune Escape in
            Gallbladder Cancer
  JOURNAL   Adv Sci (Weinh) 11 (38), e2406633 (2024)
   PUBMED   39116343
  REMARK    GeneRIF: PTBP3 Mediates IL-18 Exon Skipping to Promote Immune
            Escape in Gallbladder Cancer.
REFERENCE   2  (bases 1 to 1147)
  AUTHORS   Mertens,R.T., Misra,A., Xiao,P., Baek,S., Rone,J.M., Mangani,D.,
            Sivanathan,K.N., Arojojoye,A.S., Awuah,S.G., Lee,I., Shi,G.P.,
            Petrova,B., Brook,J.R., Anderson,A.C., Flavell,R.A., Kanarek,N.,
            Hemberg,M. and Nowarski,R.
  TITLE     A metabolic switch orchestrated by IL-18 and the cyclic
            dinucleotide cGAMP programs intestinal tolerance
  JOURNAL   Immunity 57 (9), 2077-2094 (2024)
   PUBMED   38906145
  REMARK    GeneRIF: A metabolic switch orchestrated by IL-18 and the cyclic
            dinucleotide cGAMP programs intestinal tolerance.
REFERENCE   3  (bases 1 to 1147)
  AUTHORS   Lana,J.P., de Oliveira,M.C., Silveira,A.L.M., Yamada,L.T.P.,
            Costa,K.A., da Silva,S.V., de Assis-Ferreira,A., Gautier,E.L.,
            Dussaud,S., Pinho,V., Teixeira,M.M., Marcelin,G., Clement,K. and
            Ferreira,A.V.M.
  TITLE     Role of IL-18 in adipose tissue remodeling and metabolic
            dysfunction
  JOURNAL   Int J Obes (Lond) 48 (7), 964-972 (2024)
   PUBMED   38459259
  REMARK    GeneRIF: Role of IL-18 in adipose tissue remodeling and metabolic
            dysfunction.
REFERENCE   4  (bases 1 to 1147)
  AUTHORS   Du,G., Yang,Z., Wen,Y., Li,X., Zhong,W., Li,Z., Zhang,S., Luo,E.,
            Ding,H. and Li,W.
  TITLE     Heat stress induces IL-1beta and IL-18 overproduction via
            ROS-activated NLRP3 inflammasome: implication in neuroinflammation
            in mice with heat stroke
  JOURNAL   Neuroreport 35 (9), 558-567 (2024)
   PUBMED   38687900
  REMARK    GeneRIF: Heat stress induces IL-1beta and IL-18 overproduction via
            ROS-activated NLRP3 inflammasome: implication in neuroinflammation
            in mice with heat stroke.
REFERENCE   5  (bases 1 to 1147)
  AUTHORS   Roman-Dominguez,L., Salazar-Leon,J., Meza-Sosa,K.F.,
            Perez-Martinez,L. and Pedraza-Alva,G.
  TITLE     Adipose tissue IL-18 production is independent of caspase-1 and
            caspase-11
  JOURNAL   Immun Inflamm Dis 12 (4), e1241 (2024)
   PUBMED   38629728
  REMARK    GeneRIF: Adipose tissue IL-18 production is independent of
            caspase-1 and caspase-11.
            Erratum:[Immun Inflamm Dis. 2024 Dec;12(12):e70095. doi:
            10.1002/iid3.70095.. PMID: 39724276]
REFERENCE   6  (bases 1 to 1147)
  AUTHORS   Conti,B., Jahng,J.W., Tinti,C., Son,J.H. and Joh,T.H.
  TITLE     Induction of interferon-gamma inducing factor in the adrenal cortex
  JOURNAL   J Biol Chem 272 (4), 2035-2037 (1997)
   PUBMED   8999896
REFERENCE   7  (bases 1 to 1147)
  AUTHORS   Tsutsui,H., Nakanishi,K., Matsui,K., Higashino,K., Okamura,H.,
            Miyazawa,Y. and Kaneda,K.
  TITLE     IFN-gamma-inducing factor up-regulates Fas ligand-mediated
            cytotoxic activity of murine natural killer cell clones
  JOURNAL   J Immunol 157 (9), 3967-3973 (1996)
   PUBMED   8892629
REFERENCE   8  (bases 1 to 1147)
  AUTHORS   Micallef,M.J., Ohtsuki,T., Kohno,K., Tanabe,F., Ushio,S., Namba,M.,
            Tanimoto,T., Torigoe,K., Fujii,M., Ikeda,M., Fukuda,S. and
            Kurimoto,M.
  TITLE     Interferon-gamma-inducing factor enhances T helper 1 cytokine
            production by stimulated human T cells: synergism with
            interleukin-12 for interferon-gamma production
  JOURNAL   Eur J Immunol 26 (7), 1647-1651 (1996)
   PUBMED   8766574
REFERENCE   9  (bases 1 to 1147)
  AUTHORS   Ushio,S., Namba,M., Okura,T., Hattori,K., Nukada,Y., Akita,K.,
            Tanabe,F., Konishi,K., Micallef,M., Fujii,M., Torigoe,K.,
            Tanimoto,T., Fukuda,S., Ikeda,M., Okamura,H. and Kurimoto,M.
  TITLE     Cloning of the cDNA for human IFN-gamma-inducing factor, expression
            in Escherichia coli, and studies on the biologic activities of the
            protein
  JOURNAL   J Immunol 156 (11), 4274-4279 (1996)
   PUBMED   8666798
REFERENCE   10 (bases 1 to 1147)
  AUTHORS   Okamura,H., Tsutsi,H., Komatsu,T., Yutsudo,M., Hakura,A.,
            Tanimoto,T., Torigoe,K., Okura,T., Nukada,Y., Hattori,K. et al.
  TITLE     Cloning of a new cytokine that induces IFN-gamma production by T
            cells
  JOURNAL   Nature 378 (6552), 88-91 (1995)
   PUBMED   7477296
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC127254.3 and AC025500.8.
            
            On Oct 24, 2017 this sequence version replaced XM_006510026.1.
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Variants 1 and 2 both encode the same isoform (a).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CX240735.1, DW712213.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-278               AC127254.3         173924-174201
            279-436             AC127254.3         184593-184750
            437-517             AC025500.8         39551-39631
            518-529             AC025500.8         40977-40988
            530-661             AC025500.8         42044-42175
            662-795             AC025500.8         43570-43703
            796-1147            AC025500.8         45773-46124
FEATURES             Location/Qualifiers
     source          1..1147
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 27.75 cM"
     gene            1..1147
                     /gene="Il18"
                     /gene_synonym="Igif; Il-18"
                     /note="interleukin 18"
                     /db_xref="GeneID:16173"
                     /db_xref="MGI:MGI:107936"
     exon            1..278
                     /gene="Il18"
                     /gene_synonym="Igif; Il-18"
                     /inference="alignment:Splign:2.1.0"
     exon            279..436
                     /gene="Il18"
                     /gene_synonym="Igif; Il-18"
                     /inference="alignment:Splign:2.1.0"
     exon            437..517
                     /gene="Il18"
                     /gene_synonym="Igif; Il-18"
                     /inference="alignment:Splign:2.1.0"
     CDS             442..1020
                     /gene="Il18"
                     /gene_synonym="Igif; Il-18"
                     /note="isoform a is encoded by transcript variant 2; IL-1
                     gamma; interleukin-1 gamma; IFN-gamma-inducing factor;
                     interferon gamma-inducing factor"
                     /codon_start=1
                     /product="interleukin-18 isoform a"
                     /protein_id="NP_001344150.1"
                     /db_xref="CCDS:CCDS40622.1"
                     /db_xref="GeneID:16173"
                     /db_xref="MGI:MGI:107936"
                     /translation="MAAMSEDSCVNFKEMMFIDNTLYFIPEENGDLESDNFGRLHCTT
                     AVIRNINDQVLFVDKRQPVFEDMTDIDQSASEPQTRLIIYMYKDSEVRGLAVTLSVKD
                     SKMSTLSCKNKIISFEEMDPPENIDDIQSDLIFFQKRVPGHNKMEFESSLYEGHFLAC
                     QKEDDAFKLILKKKDENGDKSVMFTLTNLHQS"
     exon            518..529
                     /gene="Il18"
                     /gene_synonym="Igif; Il-18"
                     /inference="alignment:Splign:2.1.0"
     exon            530..661
                     /gene="Il18"
                     /gene_synonym="Igif; Il-18"
                     /inference="alignment:Splign:2.1.0"
     exon            662..795
                     /gene="Il18"
                     /gene_synonym="Igif; Il-18"
                     /inference="alignment:Splign:2.1.0"
     exon            796..1147
                     /gene="Il18"
                     /gene_synonym="Igif; Il-18"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1125..1130
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Il18"
                     /gene_synonym="Igif; Il-18"
                     /note="hexamer: AGTAAA"
     polyA_site      1147
                     /gene="Il18"
                     /gene_synonym="Igif; Il-18"
                     /note="major polyA site"
ORIGIN      
        1 aaagcagtgg ttttcagctg ggaaaactca ggatagagaa aaaccctttg aggcatccag
       61 gacaaatcag atctctgggc tgaatcctgc cccagtgcgt cacattagct gactgaacac
      121 tggctgttcc cacaacgatg agtacaccaa tcctgtggtt ggtaaaacaa gcttgctttc
      181 acttctcccc tgtggtgtgc tgcctgcatc acacaaagag gctttggaag cctgctataa
      241 tcctcaggcc ccgggcgcag cagtccaact gcagactggc acagctggac ctggtggggg
      301 ttctctgtgg ttccatgctt tctggactcc tgcctgctgg ctggagctgc tgacaggcct
      361 gacatcttct gcaacctcca gcatcaggac aaagaaagcc gcctcaaacc ttccaaatca
      421 cttcctcttg gcccaggaac aatggctgcc atgtcagaag actcttgcgt caacttcaag
      481 gaaatgatgt ttattgacaa cacgctttac tttatacctg aagaaaatgg agacctggaa
      541 tcagacaact ttggccgact tcactgtaca accgcagtaa tacggaatat aaatgaccaa
      601 gttctcttcg ttgacaaaag acagcctgtg ttcgaggata tgactgatat tgatcaaagt
      661 gccagtgaac cccagaccag actgataata tacatgtaca aagacagtga agtaagagga
      721 ctggctgtga ccctctctgt gaaggatagt aaaatgtcta ccctctcctg taagaacaag
      781 atcatttcct ttgaggaaat ggatccacct gaaaatattg atgatataca aagtgatctc
      841 atattctttc agaaacgtgt tccaggacac aacaagatgg agtttgaatc ttcactgtat
      901 gaaggacact ttcttgcttg ccaaaaggaa gatgatgctt tcaaactcat tctgaaaaaa
      961 aaggatgaaa atggggataa atctgtaatg ttcactctca ctaacttaca tcaaagttag
     1021 gtggggaggg tttgtgttcc agaaagatga ttagcacaca tgcgccttgt gatgacctcg
     1081 cctgtatttc cataacagaa tacccgaggc tgcatgattt atagagtaaa cacgtttatt
     1141 tgtcgca
//
