LOCUS       NM_145826               2653 bp    mRNA    linear   ROD 08-JUN-2024
DEFINITION  Mus musculus interleukin 17 receptor E (Il17re), transcript variant
            1, mRNA.
ACCESSION   NM_145826
VERSION     NM_145826.6
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2653)
  AUTHORS   Wang,J., Wang,X., Wang,M., Wang,J., Wu,Y. and Qi,X.
  TITLE     Clinical significance of Interleukin 17 receptor E in diabetic
            nephropathy
  JOURNAL   Int Immunopharmacol 120, 110324 (2023)
   PUBMED   37235960
  REMARK    GeneRIF: Clinical significance of Interleukin 17 receptor E in
            diabetic nephropathy.
REFERENCE   2  (bases 1 to 2653)
  AUTHORS   Lin,X., Gaudino,S.J., Jang,K.K., Bahadur,T., Singh,A., Banerjee,A.,
            Beaupre,M., Chu,T., Wong,H.T., Kim,C.K., Kempen,C., Axelrad,J.,
            Huang,H., Khalid,S., Shah,V., Eskiocak,O., Parks,O.B., Berisha,A.,
            McAleer,J.P., Good,M., Hoshino,M., Blumberg,R., Bialkowska,A.B.,
            Gaffen,S.L., Kolls,J.K., Yang,V.W., Beyaz,S., Cadwell,K. and
            Kumar,P.
  TITLE     IL-17RA-signaling in Lgr5+ intestinal stem cells induces expression
            of transcription factor ATOH1 to promote secretory cell lineage
            commitment
  JOURNAL   Immunity 55 (2), 237-253 (2022)
   PUBMED   35081371
REFERENCE   3  (bases 1 to 2653)
  AUTHORS   Wang,J., Gong,J., Yang,Q., Wang,L., Jian,Y. and Wang,P.
  TITLE     Interleukin-17 Receptor E and C-C Motif Chemokine Receptor 10
            Identify Heterogeneous T Helper 17 Subsets in a Mouse Dry Eye
            Disease Model
  JOURNAL   Am J Pathol 192 (2), 332-343 (2022)
   PUBMED   35144761
  REMARK    GeneRIF: Interleukin-17 Receptor E and C-C Motif Chemokine Receptor
            10 Identify Heterogeneous T Helper 17 Subsets in a Mouse Dry Eye
            Disease Model.
REFERENCE   4  (bases 1 to 2653)
  AUTHORS   Hansakon,A., Jeerawattanawart,S., Pattanapanyasat,K. and
            Angkasekwinai,P.
  TITLE     IL-25 Receptor Signaling Modulates Host Defense against
            Cryptococcus neoformans Infection
  JOURNAL   J Immunol 205 (3), 674-685 (2020)
   PUBMED   32561567
  REMARK    GeneRIF: IL-25 Receptor Signaling Modulates Host Defense against
            Cryptococcus neoformans Infection.
REFERENCE   5  (bases 1 to 2653)
  AUTHORS   Vella,G., Lunding,L., Ritzmann,F., Honecker,A., Herr,C.,
            Wegmann,M., Bals,R. and Beisswenger,C.
  TITLE     The IL-17 receptor IL-17RE mediates polyIC-induced exacerbation of
            experimental allergic asthma
  JOURNAL   Respir Res 21 (1), 176 (2020)
   PUBMED   32641167
  REMARK    GeneRIF: The IL-17 receptor IL-17RE mediates polyIC-induced
            exacerbation of experimental allergic asthma.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2653)
  AUTHORS   Chang,S.H., Reynolds,J.M., Pappu,B.P., Chen,G., Martinez,G.J. and
            Dong,C.
  TITLE     Interleukin-17C promotes Th17 cell responses and autoimmune disease
            via interleukin-17 receptor E
  JOURNAL   Immunity 35 (4), 611-621 (2011)
   PUBMED   21982598
  REMARK    GeneRIF: IL-17C-IL-17RE induced the expression of a nuclear IkappaB
            family member, IkappaBzeta, in Th17 cells to potentiate the Th17
            cell response
REFERENCE   7  (bases 1 to 2653)
  AUTHORS   Ramirez-Carrozzi,V., Sambandam,A., Luis,E., Lin,Z., Jeet,S.,
            Lesch,J., Hackney,J., Kim,J., Zhou,M., Lai,J., Modrusan,Z., Sai,T.,
            Lee,W., Xu,M., Caplazi,P., Diehl,L., de Voss,J., Balazs,M.,
            Gonzalez,L. Jr., Singh,H., Ouyang,W. and Pappu,R.
  TITLE     IL-17C regulates the innate immune function of epithelial cells in
            an autocrine manner
  JOURNAL   Nat Immunol 12 (12), 1159-1166 (2011)
   PUBMED   21993848
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 2653)
  AUTHORS   Swaidani,S., Bulek,K., Kang,Z., Liu,C., Lu,Y., Yin,W., Aronica,M.
            and Li,X.
  TITLE     The critical role of epithelial-derived Act1 in IL-17- and
            IL-25-mediated pulmonary inflammation
  JOURNAL   J Immunol 182 (3), 1631-1640 (2009)
   PUBMED   19155512
REFERENCE   9  (bases 1 to 2653)
  AUTHORS   Li,T.S., Li,X.N., Chang,Z.J., Fu,X.Y. and Liu,L.
  TITLE     Identification and functional characterization of a novel
            interleukin 17 receptor: a possible mitogenic activation through
            ras/mitogen-activated protein kinase signaling pathway
  JOURNAL   Cell Signal 18 (8), 1287-1298 (2006)
   PUBMED   16310341
REFERENCE   10 (bases 1 to 2653)
  AUTHORS   Maezawa,Y., Nakajima,H., Suzuki,K., Tamachi,T., Ikeda,K., Inoue,J.,
            Saito,Y. and Iwamoto,I.
  TITLE     Involvement of TNF receptor-associated factor 6 in IL-25 receptor
            signaling
  JOURNAL   J Immunol 176 (2), 1013-1018 (2006)
   PUBMED   16393988
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC153910.6.
            
            On Apr 7, 2018 this sequence version replaced NM_145826.5.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK046302.1, AK046713.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-256               AC153910.6         133912-134167
            257-272             AC153910.6         134501-134516
            273-370             AC153910.6         137420-137517
            371-530             AC153910.6         137735-137894
            531-670             AC153910.6         137969-138108
            671-739             AC153910.6         139094-139162
            740-806             AC153910.6         139902-139968
            807-982             AC153910.6         140856-141031
            983-1030            AC153910.6         141121-141168
            1031-1076           AC153910.6         141250-141295
            1077-1231           AC153910.6         141394-141548
            1232-1300           AC153910.6         143578-143646
            1301-1352           AC153910.6         144047-144098
            1353-1451           AC153910.6         144171-144269
            1452-2653           AC153910.6         144698-145899
FEATURES             Location/Qualifiers
     source          1..2653
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 52.76 cM"
     gene            1..2653
                     /gene="Il17re"
                     /gene_synonym="IL-17RE; Il25r"
                     /note="interleukin 17 receptor E"
                     /db_xref="GeneID:57890"
                     /db_xref="MGI:MGI:1889371"
     exon            1..256
                     /gene="Il17re"
                     /gene_synonym="IL-17RE; Il25r"
                     /inference="alignment:Splign:2.1.0"
     CDS             125..2038
                     /gene="Il17re"
                     /gene_synonym="IL-17RE; Il25r"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; IL-17 receptor E"
                     /codon_start=1
                     /product="interleukin-17 receptor E isoform 1 precursor"
                     /protein_id="NP_665825.2"
                     /db_xref="CCDS:CCDS20420.1"
                     /db_xref="GeneID:57890"
                     /db_xref="MGI:MGI:1889371"
                     /translation="MGSPRLAALLLSLPLLLIGLAVSARVACPCLRSWTSHCLLAYRV
                     DKRFAGLQWGWFPLLVRKSKSPPKFEDYWRHRTPASFQRKLLGSPSLSEESHRISIPS
                     SAISHRGQRTKRAQPSAAEGREHLPEAGSQKCGGPEFSFDLLPEVQAVRVTIPAGPKA
                     SVRLCYQWALECEDLSSPFDTQKIVSGGHTVDLPYEFLLPCMCIEASYLQEDTVRRKK
                     CPFQSWPEAYGSDFWQSIRFTDYSQHNQMVMALTLRCPLKLEASLCWRQDPLTPCETL
                     PNATAQESEGWYILENVDLHPQLCFKFSFENSSHVECPHQSGSLPSWTVSMDTQAQQL
                     TLHFSSRTYATFSAAWSDPGLGPDTPMPPVYSISQTQGSVPVTLDLIIPFLRQENCIL
                     VWRSDVHFAWKHVLCPDVSHRHLGLLILALLALTALVGVVLVLLGRRLLPGSGRTRPV
                     LLLHAADSEAQRRLVGALAELLRTALGGGRDVIVDLWEGTHVARIGPLPWLWAARERV
                     AREQGTVLLLWNCAGPSTACSGDPQAASLRTLLCAAPRPLLLAYFSRLCAKGDIPRPL
                     RALPRYRLLRDLPRLLRALDAQPATLASSWSHLGAKRCLKNRLEQCHLLELEAAKDDY
                     QGSTNSPCGFSCL"
     exon            257..272
                     /gene="Il17re"
                     /gene_synonym="IL-17RE; Il25r"
                     /inference="alignment:Splign:2.1.0"
     exon            273..370
                     /gene="Il17re"
                     /gene_synonym="IL-17RE; Il25r"
                     /inference="alignment:Splign:2.1.0"
     exon            371..530
                     /gene="Il17re"
                     /gene_synonym="IL-17RE; Il25r"
                     /inference="alignment:Splign:2.1.0"
     exon            531..670
                     /gene="Il17re"
                     /gene_synonym="IL-17RE; Il25r"
                     /inference="alignment:Splign:2.1.0"
     exon            671..739
                     /gene="Il17re"
                     /gene_synonym="IL-17RE; Il25r"
                     /inference="alignment:Splign:2.1.0"
     exon            740..806
                     /gene="Il17re"
                     /gene_synonym="IL-17RE; Il25r"
                     /inference="alignment:Splign:2.1.0"
     exon            807..982
                     /gene="Il17re"
                     /gene_synonym="IL-17RE; Il25r"
                     /inference="alignment:Splign:2.1.0"
     exon            983..1030
                     /gene="Il17re"
                     /gene_synonym="IL-17RE; Il25r"
                     /inference="alignment:Splign:2.1.0"
     exon            1031..1076
                     /gene="Il17re"
                     /gene_synonym="IL-17RE; Il25r"
                     /inference="alignment:Splign:2.1.0"
     exon            1077..1231
                     /gene="Il17re"
                     /gene_synonym="IL-17RE; Il25r"
                     /inference="alignment:Splign:2.1.0"
     exon            1232..1300
                     /gene="Il17re"
                     /gene_synonym="IL-17RE; Il25r"
                     /inference="alignment:Splign:2.1.0"
     exon            1301..1352
                     /gene="Il17re"
                     /gene_synonym="IL-17RE; Il25r"
                     /inference="alignment:Splign:2.1.0"
     exon            1353..1451
                     /gene="Il17re"
                     /gene_synonym="IL-17RE; Il25r"
                     /inference="alignment:Splign:2.1.0"
     exon            1452..2653
                     /gene="Il17re"
                     /gene_synonym="IL-17RE; Il25r"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2625..2630
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Il17re"
                     /gene_synonym="IL-17RE; Il25r"
                     /note="hexamer: AATAAA"
     polyA_site      2653
                     /gene="Il17re"
                     /gene_synonym="IL-17RE; Il25r"
                     /note="major polyA site"
ORIGIN      
        1 agggcagggt taggtgagag cgcctgctgg tactgtgtgc ttctcacagc tccagggcca
       61 ggccctgctg ccctcttgca gacaggaaag acatggtctc tgcgcccgga tcctacagaa
      121 gctcatgggg agccccagac tggcagcctt gctcctgtct ctcccgctac tgctcatcgg
      181 cctcgctgtg tctgctcggg ttgcctgccc ctgcctgcgg agttggacca gccactgtct
      241 cctggcctac cgtgtggata aacgttttgc tggccttcag tggggctggt tccctctctt
      301 ggtgaggaaa tctaaaagtc ctcctaaatt tgaagactat tggaggcaca ggacaccagc
      361 atccttccag aggaagctgc taggcagccc ttccctgtct gaggaaagcc atcgaatttc
      421 catcccctcc tcagccatct cccacagagg ccaacgcacc aaaagggccc agccttcagc
      481 tgcagaagga agagaacatc tccctgaagc agggtcacaa aagtgtggag gacctgaatt
      541 ctcctttgat ttgctgcccg aggtgcaggc tgttcgggtg actattcctg caggccccaa
      601 ggccagtgtg cgcctttgtt atcagtgggc actggaatgt gaagacttga gtagcccttt
      661 tgatacccag aaaattgtgt ctggaggcca cactgtagac ctgccttatg aattccttct
      721 gccctgcatg tgcatagagg cctcctacct gcaagaggac actgtgaggc gcaaaaagtg
      781 tcccttccag agctggcctg aagcttatgg ctcagacttc tggcagtcaa tacgcttcac
      841 tgactacagc cagcacaatc agatggtcat ggctctgaca ctccgctgcc cactgaaact
      901 ggaggcctcc ctctgctgga ggcaggaccc actcacaccc tgcgaaaccc ttcccaacgc
      961 cacagcacag gagtcagaag gatggtatat cctggagaat gtggacttgc acccccagct
     1021 ctgctttaag ttctcatttg aaaacagcag ccacgttgaa tgtccccacc agagtggctc
     1081 tctcccatcc tggactgtga gcatggatac ccaggcccag cagctgacgc ttcacttttc
     1141 ttcgaggaca tatgccacct tcagtgctgc ctggagtgac ccaggtttgg ggccggatac
     1201 ccccatgcct cctgtgtaca gcatcagcca gacccagggc tcagtcccag tgacgctaga
     1261 cctcatcatc cccttcctga ggcaggagaa ttgcatcctg gtgtggaggt cagatgtcca
     1321 ttttgcctgg aagcacgtct tgtgtcctga tgtctcccat agacacctcg ggctcttgat
     1381 cctggcactg ctggctctca ccgctctagt gggtgtagtt ctggtcctcc tcggccggcg
     1441 cctactgcca ggctccggtc gaacaaggcc agttttactc ctacatgcag cggactcaga
     1501 ggcacagcga cgcctggtgg gagctttggc cgaactgctg cggacggcgc tgggaggtgg
     1561 acgcgacgtg atcgtggatc tctgggaagg gacgcacgta gcacgcattg gaccactgcc
     1621 gtggctttgg gcagcgcggg agcgcgtggc gcgggagcag ggcacagtgc tgctcctgtg
     1681 gaactgtgcg ggtcccagca ccgcctgcag cggtgacccg caggctgcgt cccttcgcac
     1741 cttgttgtgc gctgctccac gtccgctgct gctcgcctac ttcagtcgcc tctgcgccaa
     1801 aggtgacatc ccccggccgc tgcgcgctct gccacgctac cgcctgcttc gtgacctgcc
     1861 gcgcctgctg agagcactgg atgctcagcc tgccacccta gcctccagct ggagtcacct
     1921 tggggctaag cggtgcttga aaaaccgtct ggagcagtgt cacctgctgg aacttgaggc
     1981 tgccaaagat gactaccaag gctcaaccaa tagtccctgt ggtttcagct gtctgtagcc
     2041 tcagcctgtg tagcaacagc aggaactcca gaatgaggcc tcacacatgt actctttggg
     2101 ggtgcttctt gtcccccaaa ccgtaagact caccttaagt cccacacttg accaacctcc
     2161 ctcacatttg ctccctctta gagttcctga gaggaacttg ggctttcctg ataggtcctc
     2221 agccctttct gagaaggagg gacgattttt ccatttcttt tcaaaactga aaaaaaaaaa
     2281 aaaaaaaaaa aagacaacca tctgcatcga gcactccagt tcaggctgga gggctaggcc
     2341 aggattggaa agcagggcct aagtgtcaag cgcttgaagg gggtgggggc ggggggaggt
     2401 gctctgctcg gcagagttga gagaaacccc gtcagccagg agtccctcac cttccccaga
     2461 gggaggcctc gtccagaggt agtttgattt gtttgtttgt ttgtttgaga ctgaagccca
     2521 ctgtgtagcc cttgatggcc tggaacaaag aggtttatct acctgcctct gtctccggag
     2581 tgctaggatt agaagcctac atcacccaat tggtaagaga gatgaataaa agcaaacgta
     2641 gtagacacat taa
//
