LOCUS       NM_178942               2369 bp    mRNA    linear   ROD 13-AUG-2024
DEFINITION  Mus musculus interleukin 17 receptor C (Il17rc), transcript variant
            1, mRNA.
ACCESSION   NM_178942
VERSION     NM_178942.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2369)
  AUTHORS   Subudhi,I., Konieczny,P., Prystupa,A., Castillo,R.L., Sze-Tu,E.,
            Xing,Y., Rosenblum,D., Reznikov,I., Sidhu,I., Loomis,C., Lu,C.P.,
            Anandasabapathy,N., Suarez-Farinas,M., Gudjonsson,J.E.,
            Tsirigos,A., Scher,J.U. and Naik,S.
  TITLE     Metabolic coordination between skin epithelium and type 17 immunity
            sustains chronic skin inflammation
  JOURNAL   Immunity 57 (7), 1665-1680 (2024)
   PUBMED   38772365
REFERENCE   2  (bases 1 to 2369)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 2369)
  AUTHORS   Chandra,V., Li,L., Le Roux,O., Zhang,Y., Howell,R.M., Rupani,D.N.,
            Baydogan,S., Miller,H.D., Riquelme,E., Petrosino,J., Kim,M.P.,
            Bhat,K.P.L., White,J.R., Kolls,J.K., Pylayeva-Gupta,Y. and
            McAllister,F.
  TITLE     Gut epithelial Interleukin-17 receptor A signaling can modulate
            distant tumors growth through microbial regulation
  JOURNAL   Cancer Cell 42 (1), 85-100 (2024)
   PUBMED   38157865
REFERENCE   4  (bases 1 to 2369)
  AUTHORS   Wu,L., Wang,L. and Chai,X.
  TITLE     Interleukin-17 receptor C is essential for the pro-inflammatory
            pathogenicity of granulocyte-macrophage-colony-stimulating
            factor-producing T helper cells in experimental autoimmune uveitis
  JOURNAL   Cell Immunol 390, 104740 (2023)
   PUBMED   37336144
  REMARK    GeneRIF: Interleukin-17 receptor C is essential for the
            pro-inflammatory pathogenicity of
            granulocyte-macrophage-colony-stimulating factor-producing T helper
            cells in experimental autoimmune uveitis.
REFERENCE   5  (bases 1 to 2369)
  AUTHORS   Hirose,S., Wang,S., Jaggi,U., Matundan,H.H., Kato,M., Song,X.Y.,
            Molesworth-Kenyon,S.J., Lausch,R.N. and Ghiasi,H.
  TITLE     IL-17A expression by both T cells and non-T cells contribute to
            HSV-IL-2-induced CNS demyelination
  JOURNAL   Front Immunol 14, 1102486 (2023)
   PUBMED   36817487
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2369)
  AUTHORS   Zheng,Y., Valdez,P.A., Danilenko,D.M., Hu,Y., Sa,S.M., Gong,Q.,
            Abbas,A.R., Modrusan,Z., Ghilardi,N., de Sauvage,F.J. and Ouyang,W.
  TITLE     Interleukin-22 mediates early host defense against attaching and
            effacing bacterial pathogens
  JOURNAL   Nat Med 14 (3), 282-289 (2008)
   PUBMED   18264109
REFERENCE   7  (bases 1 to 2369)
  AUTHORS   Kuestner,R.E., Taft,D.W., Haran,A., Brandt,C.S., Brender,T.,
            Lum,K., Harder,B., Okada,S., Ostrander,C.D., Kreindler,J.L.,
            Aujla,S.J., Reardon,B., Moore,M., Shea,P., Schreckhise,R.,
            Bukowski,T.R., Presnell,S., Guerra-Lewis,P., Parrish-Novak,J.,
            Ellsworth,J.L., Jaspers,S., Lewis,K.E., Appleby,M., Kolls,J.K.,
            Rixon,M., West,J.W., Gao,Z. and Levin,S.D.
  TITLE     Identification of the IL-17 receptor related molecule IL-17RC as
            the receptor for IL-17F
  JOURNAL   J Immunol 179 (8), 5462-5473 (2007)
   PUBMED   17911633
REFERENCE   8  (bases 1 to 2369)
  AUTHORS   Toy,D., Kugler,D., Wolfson,M., Vanden Bos,T., Gurgel,J., Derry,J.,
            Tocker,J. and Peschon,J.
  TITLE     Cutting edge: interleukin 17 signals through a heteromeric receptor
            complex
  JOURNAL   J Immunol 177 (1), 36-39 (2006)
   PUBMED   16785495
  REMARK    GeneRIF: The biologic activity of IL-17 is dependent on a complex
            composed of receptors IL-17RA and IL-17RC.
REFERENCE   9  (bases 1 to 2369)
  AUTHORS   VanBuren,V., Piao,Y., Dudekula,D.B., Qian,Y., Carter,M.G.,
            Martin,P.R., Stagg,C.A., Bassey,U.C., Aiba,K., Hamatani,T.,
            Kargul,G.J., Luo,A.G., Kelso,J., Hide,W. and Ko,M.S.
  TITLE     Assembly, verification, and initial annotation of the NIA mouse
            7.4K cDNA clone set
  JOURNAL   Genome Res 12 (12), 1999-2003 (2002)
   PUBMED   12466305
REFERENCE   10 (bases 1 to 2369)
  AUTHORS   Haudenschild,D., Moseley,T., Rose,L. and Reddi,A.H.
  TITLE     Soluble and transmembrane isoforms of novel interleukin-17
            receptor-like protein by RNA splicing and expression in prostate
            cancer
  JOURNAL   J Biol Chem 277 (6), 4309-4316 (2002)
   PUBMED   11706037
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY018830.1, AF458066.1, AI592368.1, AK075634.1 and AK040950.1.
            
            Transcript Variant: This variant (1) represents the longer variant
            and it encodes the longer protein (isoform 1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN00849374,
                              SAMN00849375 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-119               BY018830.1         2-120
            120-474             AF458066.1         1-355
            475-681             AI592368.1         71-277
            682-2344            AK075634.1         100-1762
            2345-2369           AK040950.1         2-26                c
FEATURES             Location/Qualifiers
     source          1..2369
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 52.77 cM"
     gene            1..2369
                     /gene="Il17rc"
                     /gene_synonym="1110025H02Rik; Gm19850; IL-17RC; IL17-RC;
                     IL17-RL; Il17rl"
                     /note="interleukin 17 receptor C"
                     /db_xref="GeneID:171095"
                     /db_xref="MGI:MGI:2159336"
     exon            1..333
                     /gene="Il17rc"
                     /gene_synonym="1110025H02Rik; Gm19850; IL-17RC; IL17-RC;
                     IL17-RL; Il17rl"
                     /inference="alignment:Splign:2.1.0"
     CDS             229..2325
                     /gene="Il17rc"
                     /gene_synonym="1110025H02Rik; Gm19850; IL-17RC; IL17-RC;
                     IL17-RL; Il17rl"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; IL-17RL; zcytoR14; IL-17 receptor C;
                     interleukin-17 receptor-like protein"
                     /codon_start=1
                     /product="interleukin-17 receptor C isoform 1 precursor"
                     /protein_id="NP_849273.1"
                     /db_xref="GeneID:171095"
                     /db_xref="MGI:MGI:2159336"
                     /translation="MPVSWFLLSLALGRNPVVVSLERLMEPQDTARCSLGLSCHLWDG
                     DVLCLPGSLQSAPGPVLVPTRLQTELVLRCPQKTDCALCVRVVVHLAVHGHWAEPEEA
                     GKSDSELQESRNASLQAQVVLSFQAYPIARCALLEVQVPADLVQPGQSVGSAVFDCFE
                     ASLGAEVQIWSYTKPRYQKELNLTQQLPDCRGLEVRDSIQSCWVLPWLNVSTDGDNVL
                     LTLDVSEEQDFSFLLYLRPVPDALKSLWYKNLTGPQNITLNHTDLVPCLCIQVWSLEP
                     DSERVEFCPFREDPGAHRNLWHIARLRVLSPGVWQLDAPCCLPGKVTLCWQAPDQSPC
                     QPLVPPVPQKNATVNEPQDFQLVAGHPNLCVQVSTWEKVQLQACLWADSLGPFKDDML
                     LVEMKTGLNNTSVCALEPSGCTPLPSMASTRAARLGEELLQDFRSHQCMQLWNDDNMG
                     SLWACPMDKYIHRRWVLVWLACLLLAAALFFFLLLKKDRRKAARGSRTALLLHSADGA
                     GYERLVGALASALSQMPLRVAVDLWSRRELSAHGALAWFHHQRRRILQEGGVVILLFS
                     PAAVAQCQQWLQLQTVEPGPHDALAAWLSCVLPDFLQGRATGRYVGVYFDGLLHPDSV
                     PSPFRVAPLFSLPSQLPAFLDALQGGCSTSAGRPADRVERVTQALRSALDSCTSSSEA
                     PGCCEEWDLGPCTTLE"
     exon            334..355
                     /gene="Il17rc"
                     /gene_synonym="1110025H02Rik; Gm19850; IL-17RC; IL17-RC;
                     IL17-RL; Il17rl"
                     /inference="alignment:Splign:2.1.0"
     exon            356..508
                     /gene="Il17rc"
                     /gene_synonym="1110025H02Rik; Gm19850; IL-17RC; IL17-RC;
                     IL17-RL; Il17rl"
                     /inference="alignment:Splign:2.1.0"
     exon            509..571
                     /gene="Il17rc"
                     /gene_synonym="1110025H02Rik; Gm19850; IL-17RC; IL17-RC;
                     IL17-RL; Il17rl"
                     /inference="alignment:Splign:2.1.0"
     exon            572..681
                     /gene="Il17rc"
                     /gene_synonym="1110025H02Rik; Gm19850; IL-17RC; IL17-RC;
                     IL17-RL; Il17rl"
                     /inference="alignment:Splign:2.1.0"
     exon            682..793
                     /gene="Il17rc"
                     /gene_synonym="1110025H02Rik; Gm19850; IL-17RC; IL17-RC;
                     IL17-RL; Il17rl"
                     /inference="alignment:Splign:2.1.0"
     exon            794..838
                     /gene="Il17rc"
                     /gene_synonym="1110025H02Rik; Gm19850; IL-17RC; IL17-RC;
                     IL17-RL; Il17rl"
                     /inference="alignment:Splign:2.1.0"
     exon            839..978
                     /gene="Il17rc"
                     /gene_synonym="1110025H02Rik; Gm19850; IL-17RC; IL17-RC;
                     IL17-RL; Il17rl"
                     /inference="alignment:Splign:2.1.0"
     exon            979..1038
                     /gene="Il17rc"
                     /gene_synonym="1110025H02Rik; Gm19850; IL-17RC; IL17-RC;
                     IL17-RL; Il17rl"
                     /inference="alignment:Splign:2.1.0"
     exon            1039..1093
                     /gene="Il17rc"
                     /gene_synonym="1110025H02Rik; Gm19850; IL-17RC; IL17-RC;
                     IL17-RL; Il17rl"
                     /inference="alignment:Splign:2.1.0"
     exon            1094..1275
                     /gene="Il17rc"
                     /gene_synonym="1110025H02Rik; Gm19850; IL-17RC; IL17-RC;
                     IL17-RL; Il17rl"
                     /inference="alignment:Splign:2.1.0"
     exon            1276..1326
                     /gene="Il17rc"
                     /gene_synonym="1110025H02Rik; Gm19850; IL-17RC; IL17-RC;
                     IL17-RL; Il17rl"
                     /inference="alignment:Splign:2.1.0"
     exon            1327..1372
                     /gene="Il17rc"
                     /gene_synonym="1110025H02Rik; Gm19850; IL-17RC; IL17-RC;
                     IL17-RL; Il17rl"
                     /inference="alignment:Splign:2.1.0"
     exon            1373..1494
                     /gene="Il17rc"
                     /gene_synonym="1110025H02Rik; Gm19850; IL-17RC; IL17-RC;
                     IL17-RL; Il17rl"
                     /inference="alignment:Splign:2.1.0"
     exon            1495..1554
                     /gene="Il17rc"
                     /gene_synonym="1110025H02Rik; Gm19850; IL-17RC; IL17-RC;
                     IL17-RL; Il17rl"
                     /inference="alignment:Splign:2.1.0"
     exon            1555..1606
                     /gene="Il17rc"
                     /gene_synonym="1110025H02Rik; Gm19850; IL-17RC; IL17-RC;
                     IL17-RL; Il17rl"
                     /inference="alignment:Splign:2.1.0"
     exon            1607..1702
                     /gene="Il17rc"
                     /gene_synonym="1110025H02Rik; Gm19850; IL-17RC; IL17-RC;
                     IL17-RL; Il17rl"
                     /inference="alignment:Splign:2.1.0"
     exon            1703..2369
                     /gene="Il17rc"
                     /gene_synonym="1110025H02Rik; Gm19850; IL-17RC; IL17-RC;
                     IL17-RL; Il17rl"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2321..2326
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Il17rc"
                     /gene_synonym="1110025H02Rik; Gm19850; IL-17RC; IL17-RC;
                     IL17-RL; Il17rl"
                     /note="hexamer: AATAAA"
     polyA_site      2346
                     /gene="Il17rc"
                     /gene_synonym="1110025H02Rik; Gm19850; IL-17RC; IL17-RC;
                     IL17-RL; Il17rl"
                     /note="major polyA site"
ORIGIN      
        1 ggggcgggaa cagccactgc ctgctgggag ccaaatcgaa agcactccag ctgaaactgg
       61 gcctggagtc caggctcact ggagtgggga agcatggctg gagaggaatt ctagcccttg
      121 ctctctccca gggacacggg gctgattgtc agcaggggcg aggggtctgc ccccccttgg
      181 gggggcagga cggggcctca ggcctgggtg ctgtccggca cctggaagat gcctgtgtcc
      241 tggttcctgc tgtccttggc actgggccga aaccctgtgg tcgtctctct ggagagactg
      301 atggagcctc aggacactgc acgctgctct ctaggcctct cctgccacct ctgggatggt
      361 gacgtgctct gcctgcctgg aagcctccag tctgccccag gccctgtgct agtgcctacc
      421 cgcctgcaga cggagctggt gctgaggtgt ccacagaaga cagattgcgc cctctgtgtc
      481 cgtgtggtgg tccacttggc cgtgcatggg cactgggcag agcctgaaga agctggaaag
      541 tctgattcag aactccagga gtctaggaac gcctctctcc aggcccaggt ggtgctctcc
      601 ttccaggcct accccatcgc ccgctgtgcc ctgctggagg tccaggtgcc cgctgacctg
      661 gtgcagcctg gtcagtccgt gggttctgcg gtatttgact gtttcgaggc tagtcttggg
      721 gctgaggtac agatctggtc ctacacgaag cccaggtacc agaaagagct caacctcaca
      781 cagcagctgc ctgactgcag gggtcttgaa gtccgggaca gcatccagag ctgctgggtc
      841 ctgccctggc tcaatgtgtc tacagatggt gacaatgtcc ttctgacact ggatgtctct
      901 gaggagcagg actttagctt cttactgtac ctgcgtccag tcccggatgc tctcaaatcc
      961 ttgtggtaca aaaacctgac tggacctcag aacattactt taaaccacac agacctggtt
     1021 ccctgcctct gcattcaggt gtggtcgcta gagccagact ctgagagggt cgaattctgc
     1081 cccttccggg aagatcccgg tgcacacagg aacctctggc acatagccag gctgcgggta
     1141 ctgtccccag gggtatggca gctagatgcg ccttgctgtc tgccgggcaa ggtaacactg
     1201 tgctggcagg caccagacca gagtccctgc cagccacttg tgccaccagt gccccagaag
     1261 aacgccactg tgaatgagcc acaagatttc cagttggtgg caggccaccc caacctctgt
     1321 gtccaggtga gcacctggga gaaggttcag ctgcaagcgt gcttgtgggc tgactccttg
     1381 gggcccttca aggatgatat gctgttagtg gagatgaaaa ccggcctcaa caacacatca
     1441 gtctgtgcct tggaacccag tggctgtaca ccactgccca gcatggcctc cacgagagct
     1501 gctcgcctgg gagaggagtt gctgcaagac ttccgatcac accagtgtat gcagctgtgg
     1561 aacgatgaca acatgggatc gctatgggcc tgccccatgg acaagtacat ccacaggcgc
     1621 tgggtcctag tatggctggc ctgcctactc ttggctgcgg cgcttttctt cttcctcctt
     1681 ctaaaaaagg accgcaggaa agcggcccgt ggctcccgca cggccttgct cctccactcc
     1741 gccgacggag cgggctacga gcgtctggtg ggagcactgg cgtccgcgtt gagccagatg
     1801 ccactgcgcg tggccgtgga cctgtggagc cgccgcgagc tgagcgcgca cggagcccta
     1861 gcctggttcc accaccagcg acgccgtatc ctgcaggagg gtggcgtggt aatccttctc
     1921 ttctcgcccg cggccgtggc gcagtgtcag cagtggctgc agctccagac agtggagccc
     1981 gggccgcatg acgccctcgc cgcctggctc agctgcgtgc tacccgattt cctgcaaggc
     2041 cgggcgaccg gccgctacgt cggggtctac ttcgacgggc tgctgcaccc agactctgtg
     2101 ccctccccgt tccgcgtcgc cccgctcttc tccctgccct cgcagctgcc ggctttcctg
     2161 gatgcactgc agggaggctg ctccacttcc gcggggcgac ccgcggaccg ggtggaacga
     2221 gtgacccagg cgctgcggtc cgccctggac agctgtactt ctagctcgga agccccaggc
     2281 tgctgcgagg aatgggacct gggaccctgc actacactag aataaaagcc gatacagtat
     2341 tcctaaccaa gtagcactcg tgtatctgt
//
