LOCUS       NM_019583               2061 bp    mRNA    linear   ROD 13-AUG-2024
DEFINITION  Mus musculus interleukin 17 receptor B (Il17rb), mRNA.
ACCESSION   NM_019583
VERSION     NM_019583.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2061)
  AUTHORS   Huang,Y., Wu,L., Zhao,Y., Guo,J., Li,R., Ma,S. and Ying,Z.
  TITLE     Schwann cell promotes macrophage recruitment through IL-17B/IL-17RB
            pathway in injured peripheral nerves
  JOURNAL   Cell Rep 43 (2), 113753 (2024)
   PUBMED   38341853
REFERENCE   2  (bases 1 to 2061)
  AUTHORS   Chandra,V., Li,L., Le Roux,O., Zhang,Y., Howell,R.M., Rupani,D.N.,
            Baydogan,S., Miller,H.D., Riquelme,E., Petrosino,J., Kim,M.P.,
            Bhat,K.P.L., White,J.R., Kolls,J.K., Pylayeva-Gupta,Y. and
            McAllister,F.
  TITLE     Gut epithelial Interleukin-17 receptor A signaling can modulate
            distant tumors growth through microbial regulation
  JOURNAL   Cancer Cell 42 (1), 85-100 (2024)
   PUBMED   38157865
REFERENCE   3  (bases 1 to 2061)
  AUTHORS   Jeerawattanawart,S., Hansakon,A., Roytrakul,S. and Angkasekwinai,P.
  TITLE     Regulation and function of adiponectin in the intestinal epithelial
            cells in response to Trichinella spiralis infection
  JOURNAL   Sci Rep 13 (1), 14004 (2023)
   PUBMED   37635188
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2061)
  AUTHORS   Cui,W., Nagano,Y., Morita,S., Tanoue,T., Yamane,H., Ishikawa,K.,
            Sato,T., Kubo,M., Hori,S., Taniguchi,T., Hatakeyama,M., Atarashi,K.
            and Honda,K.
  TITLE     Diet-mediated constitutive induction of novel IL-4+ ILC2 cells
            maintains intestinal homeostasis in mice
  JOURNAL   J Exp Med 220 (8) (2023)
   PUBMED   37163450
REFERENCE   5  (bases 1 to 2061)
  AUTHORS   Ignacio,A., Shah,K., Bernier-Latmani,J., Koller,Y., Coakley,G.,
            Moyat,M., Hamelin,R., Armand,F., Wong,N.C., Ramay,H., Thomson,C.A.,
            Burkhard,R., Wang,H., Dufour,A., Geuking,M.B., McDonald,B.,
            Petrova,T.V., Harris,N.L. and McCoy,K.D.
  TITLE     Small intestinal resident eosinophils maintain gut homeostasis
            following microbial colonization
  JOURNAL   Immunity 55 (7), 1250-1267 (2022)
   PUBMED   35709757
REFERENCE   6  (bases 1 to 2061)
  AUTHORS   Rickel,E.A., Siegel,L.A., Yoon,B.R., Rottman,J.B., Kugler,D.G.,
            Swart,D.A., Anders,P.M., Tocker,J.E., Comeau,M.R. and Budelsky,A.L.
  TITLE     Identification of functional roles for both IL-17RB and IL-17RA in
            mediating IL-25-induced activities
  JOURNAL   J Immunol 181 (6), 4299-4310 (2008)
   PUBMED   18768888
  REMARK    GeneRIF: IL-25-mediated activities require both IL-17RB and IL-17RA
            in this example of an IL-17 family ligand that utilizes a
            heteromeric receptor complex.
REFERENCE   7  (bases 1 to 2061)
  AUTHORS   Maezawa,Y., Nakajima,H., Suzuki,K., Tamachi,T., Ikeda,K., Inoue,J.,
            Saito,Y. and Iwamoto,I.
  TITLE     Involvement of TNF receptor-associated factor 6 in IL-25 receptor
            signaling
  JOURNAL   J Immunol 176 (2), 1013-1018 (2006)
   PUBMED   16393988
  REMARK    GeneRIF: TRAF6 plays a critical role in IL-25R-mediated NF-kappaB
            activation and gene expression.
REFERENCE   8  (bases 1 to 2061)
  AUTHORS   Pan,G., French,D., Mao,W., Maruoka,M., Risser,P., Lee,J.,
            Foster,J., Aggarwal,S., Nicholes,K., Guillet,S., Schow,P. and
            Gurney,A.L.
  TITLE     Forced expression of murine IL-17E induces growth retardation,
            jaundice, a Th2-biased response, and multiorgan inflammation in
            mice
  JOURNAL   J Immunol 167 (11), 6559-6567 (2001)
   PUBMED   11714825
REFERENCE   9  (bases 1 to 2061)
  AUTHORS   Tian,E., Sawyer,J.R., Largaespada,D.A., Jenkins,N.A., Copeland,N.G.
            and Shaughnessy,J.D. Jr.
  TITLE     Evi27 encodes a novel membrane protein with homology to the IL17
            receptor
  JOURNAL   Oncogene 19 (17), 2098-2109 (2000)
   PUBMED   10815801
REFERENCE   10 (bases 1 to 2061)
  AUTHORS   Li,J., Shen,H., Himmel,K.L., Dupuy,A.J., Largaespada,D.A.,
            Nakamura,T., Shaughnessy,J.D. Jr., Jenkins,N.A. and Copeland,N.G.
  TITLE     Leukaemia disease genes: large-scale cloning and pathway
            predictions
  JOURNAL   Nat Genet 23 (3), 348-353 (1999)
   PUBMED   10610183
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AK045627.1.
            
            On Apr 6, 2007 this sequence version replaced NM_019583.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK045627.1, BC026546.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2061              AK045627.1         2-2062
FEATURES             Location/Qualifiers
     source          1..2061
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 18.39 cM"
     gene            1..2061
                     /gene="Il17rb"
                     /gene_synonym="Evi27; IL-17ER; IL-17Rh1; Il17br; IL17RH1"
                     /note="interleukin 17 receptor B"
                     /db_xref="GeneID:50905"
                     /db_xref="MGI:MGI:1355292"
     exon            1..165
                     /gene="Il17rb"
                     /gene_synonym="Evi27; IL-17ER; IL-17Rh1; Il17br; IL17RH1"
                     /inference="alignment:Splign:2.1.0"
     CDS             106..1605
                     /gene="Il17rb"
                     /gene_synonym="Evi27; IL-17ER; IL-17Rh1; Il17br; IL17RH1"
                     /note="IL-17B receptor; interleukin 17B receptor; IL-17RB;
                     IL-17 receptor B; IL-17 receptor homolog 1; ecotropic
                     viral integration site 27"
                     /codon_start=1
                     /product="interleukin-17 receptor B precursor"
                     /protein_id="NP_062529.2"
                     /db_xref="CCDS:CCDS36845.1"
                     /db_xref="GeneID:50905"
                     /db_xref="MGI:MGI:1355292"
                     /translation="MLLVLLILAASCRSALPREPTIQCGSETGPSPEWMVQHTLTPGD
                     LRDLQVELVKTSVAAEEFSILMNISWILRADASIRLLKATKICVSGKNNMNSYSCVRC
                     NYTEAFQSQTRPSGGKWTFSYVGFPVELSTLYLISAHNIPNANMNEDSPSLSVNFTSP
                     GCLNHVMKYKKQCTEAGSLWDPDITACKKNEKMVEVNFTTNPLGNRYTILIQRDTTLG
                     FSRVLENKLMRTSVAIPVTEESEGAVVQLTPYLHTCGNDCIRREGTVVLCSETSAPIP
                     PDDNRRMLGGWLPLFLVLLVAVWVLAAGIYLTWRQGRSTKTSFPISTMLLPLIKVLVV
                     YPSEICFHHTVCRFTDFLQNYCRSEVILEKWQKKKIAEMGPVQWLTTQKQAADKVVFL
                     LPSDVPTLCDSACGHNEGSARENSQDLFPLAFNLFCSDFSSQTHLHKYLVVYLGGADL
                     KGDYNALSVCPQYHLMKDATAFHTELLKATQSMSVKKRSQACHDSCSPL"
     exon            166..190
                     /gene="Il17rb"
                     /gene_synonym="Evi27; IL-17ER; IL-17Rh1; Il17br; IL17RH1"
                     /inference="alignment:Splign:2.1.0"
     exon            191..331
                     /gene="Il17rb"
                     /gene_synonym="Evi27; IL-17ER; IL-17Rh1; Il17br; IL17RH1"
                     /inference="alignment:Splign:2.1.0"
     exon            332..459
                     /gene="Il17rb"
                     /gene_synonym="Evi27; IL-17ER; IL-17Rh1; Il17br; IL17RH1"
                     /inference="alignment:Splign:2.1.0"
     exon            460..586
                     /gene="Il17rb"
                     /gene_synonym="Evi27; IL-17ER; IL-17Rh1; Il17br; IL17RH1"
                     /inference="alignment:Splign:2.1.0"
     exon            587..634
                     /gene="Il17rb"
                     /gene_synonym="Evi27; IL-17ER; IL-17Rh1; Il17br; IL17RH1"
                     /inference="alignment:Splign:2.1.0"
     exon            635..777
                     /gene="Il17rb"
                     /gene_synonym="Evi27; IL-17ER; IL-17Rh1; Il17br; IL17RH1"
                     /inference="alignment:Splign:2.1.0"
     exon            778..843
                     /gene="Il17rb"
                     /gene_synonym="Evi27; IL-17ER; IL-17Rh1; Il17br; IL17RH1"
                     /inference="alignment:Splign:2.1.0"
     exon            844..943
                     /gene="Il17rb"
                     /gene_synonym="Evi27; IL-17ER; IL-17Rh1; Il17br; IL17RH1"
                     /inference="alignment:Splign:2.1.0"
     exon            944..1039
                     /gene="Il17rb"
                     /gene_synonym="Evi27; IL-17ER; IL-17Rh1; Il17br; IL17RH1"
                     /inference="alignment:Splign:2.1.0"
     exon            1040..2061
                     /gene="Il17rb"
                     /gene_synonym="Evi27; IL-17ER; IL-17Rh1; Il17br; IL17RH1"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      1758
                     /gene="Il17rb"
                     /gene_synonym="Evi27; IL-17ER; IL-17Rh1; Il17br; IL17RH1"
                     /note="major polyA site"
     regulatory      2003..2008
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Il17rb"
                     /gene_synonym="Evi27; IL-17ER; IL-17Rh1; Il17br; IL17RH1"
                     /note="hexamer: AATGAA"
     polyA_site      2030
                     /gene="Il17rb"
                     /gene_synonym="Evi27; IL-17ER; IL-17Rh1; Il17br; IL17RH1"
                     /note="major polyA site"
ORIGIN      
        1 gtgggaggcg gagcccggag aactgcggcg ggcgcctgga taagaggacc ctggacctct
       61 ggccccagct ccgcgtggtg gtgggcggtg gccagtggcc gggccatgtt gctagtgttg
      121 ctgatcttgg ctgcatcgtg caggagcgcc ctgcctcgag agccgactat tcagtgtggc
      181 tctgagacag ggccatctcc agagtggatg gtccaacaca cactcactcc aggagacttg
      241 agggacctcc aagtggaact cgtcaagaca agtgtggcag cagaggagtt ttcaattttg
      301 atgaacataa gctggatact ccgggcagac gccagcatcc gcttgttgaa ggccaccaag
      361 atctgcgtga gtggcaaaaa caacatgaat tcatacagct gtgtgaggtg caactacaca
      421 gaggccttcc aaagccagac cagaccttcc ggcggcaaat ggacattctc ctatgtaggc
      481 ttccctgtgg agctgagcac tctctatctc atcagcgccc ataacatccc caatgctaat
      541 atgaatgagg acagcccttc tttgtctgtg aacttcacct cgccaggctg cctaaaccac
      601 gtaatgaaat ataaaaagca gtgcactgag gcgggaagcc tgtgggaccc agacatcact
      661 gcttgtaaaa agaacgagaa gatggttgaa gtgaatttca caaccaatcc ccttggaaac
      721 agatacacga ttctcattca acgggacacg acattggggt tttctagagt gctggagaat
      781 aaactgatga ggacgtctgt agccatcccg gtgactgagg agagtgaagg tgcggtggtt
      841 cagctgaccc catatttaca tacctgcggc aatgactgca tccgacgcga agggacagtt
      901 gtgctttgct cagagacaag tgctcccatc cctccagatg acaacagacg catgctggga
      961 ggctggctgc ctctcttcct ggtgctgctg gtggctgtgt gggtgctggc agctgggatc
     1021 tacctaactt ggaggcaagg aaggagcacg aagacgtcct ttcctatttc caccatgctc
     1081 ctgcccctca ttaaggtcct ggtggtttat ccttctgaga tatgtttcca tcacaccgtc
     1141 tgtcgcttca ctgactttct tcaaaactac tgcagaagtg aggtcatcct tgaaaaatgg
     1201 cagaaaaaga aaatcgccga gatggggccg gtacagtggc tgaccactca gaagcaagcg
     1261 gcagataaag tggtcttcct tcttcccagt gacgtcccga ccctttgtga cagtgcctgt
     1321 ggccacaatg agggcagcgc cagggagaac tctcaggatc tgttccctct tgcctttaac
     1381 ctcttttgta gtgatttcag cagccagacg catctgcaca aatacctggt ggtctatctt
     1441 gggggagcag acctcaaagg cgactataat gccctgagtg tctgccccca atatcatctc
     1501 atgaaggacg ccacagcttt ccacacagaa cttctcaagg ctacgcagag catgtcagtg
     1561 aagaaacgct cacaagcctg ccatgatagc tgttcaccct tgtagtccac ccgggggaat
     1621 agagactctg aagccttcct actctccctt ccagtgacaa atgctgtgtg acgactctga
     1681 aatgtgtggg agaggctgtg tggaggtagt gctatgtaca aacttgcttt aaaactggag
     1741 tttgcaaagt caacctgagc atacacgcct gaggctagtc attggctgga tttatgaaga
     1801 caacacagtt acagacaata atgagtggga cctacatttg ggatataccc aaagctgggt
     1861 aatgattatc actgagaacc acgcactctg gccatgaggt aatacggcac ttccctgtca
     1921 ggctgtctgt caggttgggt ctgtcttgca ctgcccatgc tctatgctgc acgtagaccg
     1981 ttttgtaaca ttttaatctg ttaatgaata atccgtttgg gaggctctca ctaatgtgta
     2041 gcttcctaag agaagaagcc t
//
