LOCUS       NM_008359               3970 bp    mRNA    linear   ROD 31-DEC-2024
DEFINITION  Mus musculus interleukin 17 receptor A (Il17ra), mRNA.
ACCESSION   NM_008359
VERSION     NM_008359.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3970)
  AUTHORS   Rosenzweig,N., Kleemann,K.L., Rust,T., Carpenter,M., Grucci,M.,
            Aronchik,M., Brouwer,N., Valenbreder,I., Cooper-Hohn,J., Iyer,M.,
            Krishnan,R.K., Sivanathan,K.N., Brandao,W., Yahya,T., Durao,A.,
            Yin,Z., Chadarevian,J.P., Properzi,M.J., Nowarski,R., Davtyan,H.,
            Weiner,H.L., Blurton-Jones,M., Yang,H.S., Eggen,B.J.L.,
            Sperling,R.A. and Butovsky,O.
  TITLE     Sex-dependent APOE4 neutrophil-microglia interactions drive
            cognitive impairment in Alzheimer's disease
  JOURNAL   Nat Med 30 (10), 2990-3003 (2024)
   PUBMED   38961225
REFERENCE   2  (bases 1 to 3970)
  AUTHORS   Dey,I., Li,Y., Taylor,T.C., Peroumal,D., Asada,N., Panzer,U.,
            Biswas,P.S., Sterneck,E. and Gaffen,S.L.
  TITLE     C/EBPdelta Mediates Immunity to Renal Autoinflammatory Disorders in
            a Stage-specific Manner
  JOURNAL   J Immunol 213 (6), 767-778 (2024)
   PUBMED   39082925
REFERENCE   3  (bases 1 to 3970)
  AUTHORS   Theune,W.C., Chen,J., Theune,E.V., Ye,X., Menoret,A., Vella,A.T.
            and Wang,K.
  TITLE     Interleukin-17 directly stimulates tumor infiltrating Tregs to
            prevent cancer development
  JOURNAL   Front Immunol 15, 1408710 (2024)
   PUBMED   38947320
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3970)
  AUTHORS   Gallo,R., Teijeiro,A., Angulo-Aguado,M. and Djouder,N.
  TITLE     IL-17A produced by POMC neurons regulates diet-induced obesity
  JOURNAL   iScience 27 (7), 110259 (2024)
   PUBMED   39027371
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3970)
  AUTHORS   Arenas,Y.M., Lopez-Gramaje,A., Montoliu,C., Llansola,M. and
            Felipo,V.
  TITLE     Increased levels and activation of the IL-17 receptor in microglia
            contribute to enhanced neuroinflammation in cerebellum of
            hyperammonemic rats
  JOURNAL   Biol Res 57 (1), 18 (2024)
   PUBMED   38671534
  REMARK    GeneRIF: Increased levels and activation of the IL-17 receptor in
            microglia contribute to enhanced neuroinflammation in cerebellum of
            hyperammonemic rats.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3970)
  AUTHORS   Ye,P., Rodriguez,F.H., Kanaly,S., Stocking,K.L., Schurr,J.,
            Schwarzenberger,P., Oliver,P., Huang,W., Zhang,P., Zhang,J.,
            Shellito,J.E., Bagby,G.J., Nelson,S., Charrier,K., Peschon,J.J. and
            Kolls,J.K.
  TITLE     Requirement of interleukin 17 receptor signaling for lung CXC
            chemokine and granulocyte colony-stimulating factor expression,
            neutrophil recruitment, and host defense
  JOURNAL   J Exp Med 194 (4), 519-527 (2001)
   PUBMED   11514607
REFERENCE   7  (bases 1 to 3970)
  AUTHORS   Footz,T.K., Brinkman-Mills,P., Banting,G.S., Maier,S.A.,
            Riazi,M.A., Bridgland,L., Hu,S., Birren,B., Minoshima,S.,
            Shimizu,N., Pan,H., Nguyen,T., Fang,F., Fu,Y., Ray,L., Wu,H.,
            Shaull,S., Phan,S., Yao,Z., Chen,F., Huan,A., Hu,P., Wang,Q.,
            Loh,P., Qi,S., Roe,B.A. and McDermid,H.E.
  TITLE     Analysis of the cat eye syndrome critical region in humans and the
            region of conserved synteny in mice: a search for candidate genes
            at or near the human chromosome 22 pericentromere
  JOURNAL   Genome Res 11 (6), 1053-1070 (2001)
   PUBMED   11381032
REFERENCE   8  (bases 1 to 3970)
  AUTHORS   Schwandner,R., Yamaguchi,K. and Cao,Z.
  TITLE     Requirement of tumor necrosis factor receptor-associated factor
            (TRAF)6 in interleukin 17 signal transduction
  JOURNAL   J Exp Med 191 (7), 1233-1240 (2000)
   PUBMED   10748240
REFERENCE   9  (bases 1 to 3970)
  AUTHORS   Balch,S.G., McKnight,A.J., Seldin,M.F. and Gordon,S.
  TITLE     Cloning of a novel C-type lectin expressed by murine macrophages
  JOURNAL   J Biol Chem 273 (29), 18656-18664 (1998)
   PUBMED   9660840
REFERENCE   10 (bases 1 to 3970)
  AUTHORS   Yao,Z., Fanslow,W.C., Seldin,M.F., Rousseau,A.M., Painter,S.L.,
            Comeau,M.R., Cohen,J.I. and Spriggs,M.K.
  TITLE     Herpesvirus Saimiri encodes a new cytokine, IL-17, which binds to a
            novel cytokine receptor
  JOURNAL   Immunity 3 (6), 811-821 (1995)
   PUBMED   8777726
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY267308.1, U31993.1 and AK080226.2.
            
            On Aug 11, 2009 this sequence version replaced NM_008359.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK036587.1, SRR1660821.124537.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-38                BY267308.1         2-39
            39-3275             U31993.1           27-3263
            3276-3970           AK080226.2         4109-4803
FEATURES             Location/Qualifiers
     source          1..3970
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 56.95 cM"
     gene            1..3970
                     /gene="Il17ra"
                     /gene_synonym="Cdw217; Il17r; VDw217"
                     /note="interleukin 17 receptor A"
                     /db_xref="GeneID:16172"
                     /db_xref="MGI:MGI:107399"
     exon            1..270
                     /gene="Il17ra"
                     /gene_synonym="Cdw217; Il17r; VDw217"
                     /inference="alignment:Splign:2.1.0"
     exon            271..295
                     /gene="Il17ra"
                     /gene_synonym="Cdw217; Il17r; VDw217"
                     /inference="alignment:Splign:2.1.0"
     exon            296..442
                     /gene="Il17ra"
                     /gene_synonym="Cdw217; Il17r; VDw217"
                     /inference="alignment:Splign:2.1.0"
     exon            443..555
                     /gene="Il17ra"
                     /gene_synonym="Cdw217; Il17r; VDw217"
                     /inference="alignment:Splign:2.1.0"
     exon            556..682
                     /gene="Il17ra"
                     /gene_synonym="Cdw217; Il17r; VDw217"
                     /inference="alignment:Splign:2.1.0"
     exon            683..730
                     /gene="Il17ra"
                     /gene_synonym="Cdw217; Il17r; VDw217"
                     /inference="alignment:Splign:2.1.0"
     exon            731..894
                     /gene="Il17ra"
                     /gene_synonym="Cdw217; Il17r; VDw217"
                     /inference="alignment:Splign:2.1.0"
     exon            895..978
                     /gene="Il17ra"
                     /gene_synonym="Cdw217; Il17r; VDw217"
                     /inference="alignment:Splign:2.1.0"
     exon            979..1063
                     /gene="Il17ra"
                     /gene_synonym="Cdw217; Il17r; VDw217"
                     /inference="alignment:Splign:2.1.0"
     exon            1064..1075
                     /gene="Il17ra"
                     /gene_synonym="Cdw217; Il17r; VDw217"
                     /inference="alignment:Splign:2.1.0"
     exon            1076..1183
                     /gene="Il17ra"
                     /gene_synonym="Cdw217; Il17r; VDw217"
                     /inference="alignment:Splign:2.1.0"
     exon            1184..1225
                     /gene="Il17ra"
                     /gene_synonym="Cdw217; Il17r; VDw217"
                     /inference="alignment:Splign:2.1.0"
     exon            1226..3970
                     /gene="Il17ra"
                     /gene_synonym="Cdw217; Il17r; VDw217"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gggggagccg gaagcgggac agaggaggcc gtgtgaagcc gacgagcgcc agtcctcggc
       61 cgggaaagcc atcgcgggcc ctcgctgtcg cgcggagcca gctgcgagcg ctccgcgacc
      121 gggccgaggg ctatggcgat tcggcgctgc tggccacggg tcgtccccgg gcccgcgctg
      181 ggatggctgc ttctgctgct gaacgttctg gccccgggcc gcgcctcccc gcgcctcctc
      241 gacttcccgg ctccggtctg cgcgcaggag gggctgagct gcagagtcaa gaatagtact
      301 tgtctggatg acagctggat ccaccccaaa aacctgaccc cgtcttcccc aaaaaacatc
      361 tatatcaatc ttagtgtttc ctctacccag cacggagaat tagtccctgt gttgcatgtt
      421 gagtggaccc tgcagacaga tgccagcatc ctgtacctcg agggtgcaga gctgtccgtc
      481 ctgcagctga acaccaatga gcggctgtgt gtcaagttcc agtttctgtc catgctgcag
      541 catcaccgta agcggtggcg gttttccttc agccactttg tggtagatcc tggccaggag
      601 tatgaagtga ctgttcacca cctgccgaag cccatccctg atggggaccc aaaccacaaa
      661 tccaagatca tctttgtgcc tgactgtgag gacagcaaga tgaagatgac tacctcatgc
      721 gtgagctcag gcagcctttg ggatcccaac atcactgtgg agaccttgga cacacagcat
      781 ctgcgagtgg acttcaccct gtggaatgaa tccaccccct accaggtcct gctggaaagt
      841 ttctccgact cagagaacca cagctgcttt gatgtcgtta aacaaatatt tgcgcccagg
      901 caagaagaat tccatcagcg agctaatgtc acattcactc taagcaagtt tcactggtgc
      961 tgccatcacc acgtgcaggt ccagcccttc ttcagcagct gcctaaatga ctgtttgaga
     1021 cacgctgtga ctgtgccctg cccagtaatc tcaaatacca cagttcccaa gccagttgca
     1081 gactacattc ccctgtgggt gtatggcctc atcacactca tcgccattct gctggtggga
     1141 tctgtcatcg tgctgatcat ctgtatgacc tggaggcttt ctggcgccga tcaagagaaa
     1201 catggtgatg actccaaaat caatggcatc ttgcccgtag cagacctgac tcccccaccc
     1261 ctgaggccca ggaaggtctg gatcgtctac tcggccgacc accccctcta tgtggaggtg
     1321 gtcctaaagt tcgcccagtt cctgatcact gcctgtggca ctgaagtagc ccttgacctc
     1381 ctggaagagc aggttatctc tgaggtgggg gtcatgacct gggtgagccg acagaagcag
     1441 gagatggtgg agagcaactc caaaatcatc atcctgtgtt cccgaggcac ccaagcaaag
     1501 tggaaagcta tcttgggttg ggctgagcct gctgtccagc tacggtgtga ccactggaag
     1561 cctgctgggg accttttcac tgcagccatg aacatgatcc tgccagactt caagaggcca
     1621 gcctgcttcg gcacctacgt tgtttgctac ttcagtggca tctgtagtga gagggatgtc
     1681 cccgacctct tcaacatcac ctccaggtac ccactcatgg acagatttga ggaggtttac
     1741 ttccggatcc aggacctgga gatgtttgaa cccggccgga tgcaccatgt cagagagctc
     1801 acaggggaca attacctgca gagccctagt ggccggcagc tcaaggaggc tgtgcttagg
     1861 ttccaggagt ggcaaaccca gtgccccgac tggttcgagc gtgagaacct ctgcttagct
     1921 gatggccaag atcttccctc cctggatgaa gaagtgtttg aagacccact gctgccacca
     1981 gggggaggaa ttgtcaaaca gcagcccctg gtgcgggaac tcccatctga cggctgcctt
     2041 gtggtagatg tctgtgtcag tgaggaagaa agtagaatgg caaagctgga ccctcagcta
     2101 tggccacaga gagagctagt ggctcacacc ctccaaagca tggtgctgcc agcagagcag
     2161 gtccctgcag ctcatgtggt ggagcctctc catctcccag acggcagtgg agcagctgcc
     2221 cagctgccca tgacagagga cagcgaggct tgcccgctgc tgggggtcca gaggaacagc
     2281 atcctttgcc tccccgtgga ctcagatgac ttgccactct gtagcacccc aatgatgtca
     2341 cctgaccacc tccaaggcga tgcaagagag cagctagaaa gcctaatgct ctcggtgctg
     2401 cagcagagcc tgagtggaca gcccctggag agctggccga ggccagaggt ggtcctcgag
     2461 ggctgcacac cctctgagga ggagcagcgg cagtcggtgc agtcggacca gggctacatc
     2521 tccaggagct ccccgcagcc ccccgagtgg ctcacggagg aggaagagct agaactgggt
     2581 gagcccgttg agtctctctc tcctgaggaa ctacggagcc tgaggaagct ccagaggcag
     2641 cttttcttct gggagctcga gaagaaccct ggctggaaca gcttggagcc acggagaccc
     2701 accccagaag agcagaatcc ctcctaggcc tcctgagcct gctacttaag agggtgtata
     2761 ttgtactctg tgtgtgcgtg cgtgtgtgtg tgtgtgtgtg tgtgtgtgtg cgtgtgtgtg
     2821 tgtgtgtgtg tgtgtgtgtg tgtgtagtgc ccggcttaga aatgtgaaca tctgaatctg
     2881 acatagtgtt gtatacctga agtcccagca cttgggaact gagacttgat gatctcctga
     2941 agccaggtgt tcagggccag tgtgaaaaca tagcaagacc tcagagaaat caatgcagac
     3001 atcttggtac tgatccctaa acacacccct ttccctgata acccgacatg agcatctggt
     3061 catcattgca caagaatcca cagcccgttc ccagagctca tagccaagtg tgttgctcat
     3121 tccttgaata tttattctgt acctactatt catcagacat ttggaattca aaaacaagtt
     3181 acatgacaca gccttagcca ctaagaagct taaaattcgg taaggatgta aaattagcca
     3241 ggatgaatag agggctgctg ccctggctgc agaagaaccc gagagagcct gcgggtggcg
     3301 tctgggcaag aggggagtgg cctgtggatt gagtattagg aaggagccag agctcagggt
     3361 ggagagagct ctgtggggct agggtgggag cagctgggga ctcctctcat gagtggatct
     3421 gttgccctac gggggaggaa acttcatgcc aaatataccc agaagtcttc tcagatcagt
     3481 tctttagaaa gagctggtat agaaatgggt gatgtaaaac ttgagaagca ggaagaggcg
     3541 tgtgaaatcc tgtgctctct caagtgctgg ctgccagtcc gtgggagggc tgcggcatgt
     3601 gattcttcat gggctgcagc caccagatcc ctggagagct ctacctcggg gtacagtgag
     3661 ggagttgaga aagatgtgag ggtagtgggc atgggggcgt ggcataacag gagaactcgg
     3721 gaggccctca aggtcagagg aaagtatgtc actgtataac tacagtaaga gaggttgttt
     3781 aaagtagctc cagggcgccc tcatggggca gacagcagcc ttgtggcgta ggttctagag
     3841 aatgcacagg tcttcctaga cttaggtgag aaaaggacca tgaaatgctg tgggaagcac
     3901 gaattcagtg attgtgtgtg tgcatatgtg tgtgcagtaa tgaagactta ataaagttgc
     3961 tgtattggta
//
