LOCUS       NM_145856               1178 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus interleukin 17F (Il17f), mRNA.
ACCESSION   NM_145856
VERSION     NM_145856.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1178)
  AUTHORS   Hajam,I.A., Tsai,C.M., Gonzalez,C., Caldera,J.R., Lazaro Diez,M.,
            Du,X., Aralar,A., Lin,B., Duong,W. and Liu,G.Y.
  TITLE     Pathobiont-induced suppressive immune imprints thwart T cell
            vaccine responses
  JOURNAL   Nat Commun 15 (1), 10335 (2024)
   PUBMED   39681568
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1178)
  AUTHORS   Zhang,Y., Li,B., Hong,Y., Luo,P., Hong,Z., Xia,X., Mo,P., Yu,C. and
            Chen,W.
  TITLE     Histone demethylase JMJD2D protects against enteric bacterial
            infection via up-regulating colonic IL-17F to induce beta-defensin
            expression
  JOURNAL   PLoS Pathog 20 (6), e1012316 (2024)
   PUBMED   38905308
  REMARK    GeneRIF: Histone demethylase JMJD2D protects against enteric
            bacterial infection via up-regulating colonic IL-17F to induce
            beta-defensin expression.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1178)
  AUTHORS   Matsuda,K.M., Kotani,H., Hisamoto,T., Kuzumi,A., Fukasawa,T.,
            Yoshizaki-Ogawa,A., Sato,S. and Yoshizaki,A.
  TITLE     Dual blockade of interleukin-17A and interleukin-17F as a
            therapeutic strategy for liver fibrosis: Investigating the
            potential effect and mechanism of brodalumab
  JOURNAL   Cytokine 178, 156587 (2024)
   PUBMED   38531177
  REMARK    GeneRIF: Dual blockade of interleukin-17A and interleukin-17F as a
            therapeutic strategy for liver fibrosis: Investigating the
            potential effect and mechanism of brodalumab.
REFERENCE   4  (bases 1 to 1178)
  AUTHORS   Sinton,M.C., Chandrasegaran,P.R.G., Capewell,P., Cooper,A.,
            Girard,A., Ogunsola,J., Perona-Wright,G., M Ngoyi,D., Kuispond,N.,
            Bucheton,B., Camara,M., Kajimura,S., Benezech,C., Mabbott,N.A.,
            MacLeod,A. and Quintana,J.F.
  TITLE     IL-17 signalling is critical for controlling subcutaneous adipose
            tissue dynamics and parasite burden during chronic murine
            Trypanosoma brucei infection
  JOURNAL   Nat Commun 14 (1), 7070 (2023)
   PUBMED   37923768
  REMARK    Erratum:[Nat Commun. 2024 Feb 28;15(1):1833. doi:
            10.1038/s41467-024-46299-4.. PMID: 38418827]
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1178)
  AUTHORS   Wang,Y., Ahmadi,M.Z., Dikeman,D.A., Youn,C. and Archer,N.K.
  TITLE     gammadelta T cell-intrinsic IL-1R promotes survival during
            Staphylococcus aureus bacteremia
  JOURNAL   Front Immunol 14, 1171934 (2023)
   PUBMED   37483624
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1178)
  AUTHORS   Akimzhanov,A.M., Yang,X.O. and Dong,C.
  TITLE     Chromatin remodeling of interleukin-17 (IL-17)-IL-17F cytokine gene
            locus during inflammatory helper T cell differentiation
  JOURNAL   J Biol Chem 282 (9), 5969-5972 (2007)
   PUBMED   17218320
  REMARK    GeneRIF: THi cell differentiation is associated with epigenetic
            changes in the IL-17-IL-17F locus, which suggests novel mechanisms
            in T cell functional regulation.
REFERENCE   7  (bases 1 to 1178)
  AUTHORS   Liang,S.C., Tan,X.Y., Luxenberg,D.P., Karim,R.,
            Dunussi-Joannopoulos,K., Collins,M. and Fouser,L.A.
  TITLE     Interleukin (IL)-22 and IL-17 are coexpressed by Th17 cells and
            cooperatively enhance expression of antimicrobial peptides
  JOURNAL   J Exp Med 203 (10), 2271-2279 (2006)
   PUBMED   16982811
REFERENCE   8  (bases 1 to 1178)
  AUTHORS   Toy,D., Kugler,D., Wolfson,M., Vanden Bos,T., Gurgel,J., Derry,J.,
            Tocker,J. and Peschon,J.
  TITLE     Cutting edge: interleukin 17 signals through a heteromeric receptor
            complex
  JOURNAL   J Immunol 177 (1), 36-39 (2006)
   PUBMED   16785495
REFERENCE   9  (bases 1 to 1178)
  AUTHORS   Oda,N., Canelos,P.B., Essayan,D.M., Plunkett,B.A., Myers,A.C. and
            Huang,S.K.
  TITLE     Interleukin-17F induces pulmonary neutrophilia and amplifies
            antigen-induced allergic response
  JOURNAL   Am J Respir Crit Care Med 171 (1), 12-18 (2005)
   PUBMED   15477493
  REMARK    GeneRIF: a role for IL-17F in the induction of neutrophilia in the
            lungs and in the exacerbation of Ag-induced pulmonary inflammation.
REFERENCE   10 (bases 1 to 1178)
  AUTHORS   Hurst,S.D., Muchamuel,T., Gorman,D.M., Gilbert,J.M., Clifford,T.,
            Kwan,S., Menon,S., Seymour,B., Jackson,C., Kung,T.T.,
            Brieland,J.K., Zurawski,S.M., Chapman,R.W., Zurawski,G. and
            Coffman,R.L.
  TITLE     New IL-17 family members promote Th1 or Th2 responses in the lung:
            in vivo function of the novel cytokine IL-25
  JOURNAL   J Immunol 169 (1), 443-453 (2002)
   PUBMED   12077275
  REMARK    GeneRIF: Intranasal administration of adenovirus expressing IL-17F
            results in bronchoalveolar lavage neutrophilia and inflammatory
            gene expression in the lung.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC159614.7.
            
            On Dec 12, 2006 this sequence version replaced NM_145856.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY380822.1, AB116259.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849385
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-98                AC159614.7         126007-126104       c
            99-319              AC159614.7         121125-121345       c
            320-1178            AC159614.7         118980-119838       c
FEATURES             Location/Qualifiers
     source          1..1178
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 6.49 cM"
     gene            1..1178
                     /gene="Il17f"
                     /gene_synonym="IL-17F"
                     /note="interleukin 17F"
                     /db_xref="GeneID:257630"
                     /db_xref="MGI:MGI:2676631"
     exon            1..98
                     /gene="Il17f"
                     /gene_synonym="IL-17F"
                     /inference="alignment:Splign:2.1.0"
     CDS             72..557
                     /gene="Il17f"
                     /gene_synonym="IL-17F"
                     /codon_start=1
                     /product="interleukin-17F precursor"
                     /protein_id="NP_665855.2"
                     /db_xref="CCDS:CCDS35522.1"
                     /db_xref="GeneID:257630"
                     /db_xref="MGI:MGI:2676631"
                     /translation="MKCTRETAMVKSLLLLMLGLAILREVAARKNPKAGVPALQKAGN
                     CPPLEDNTVRVDIRIFNQNQGISVPREFQNRSSSPWDYNITRDPHRFPSEIAEAQCRH
                     SGCINAQGQEDSTMNSVAIQQEILVLRREPQGCSNSFRLEKMLLKVGCTCVKPIVHQA
                     A"
     exon            99..319
                     /gene="Il17f"
                     /gene_synonym="IL-17F"
                     /inference="alignment:Splign:2.1.0"
     exon            320..1178
                     /gene="Il17f"
                     /gene_synonym="IL-17F"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gacataccca ggaagacata cttagaagaa agtacttcct gagggaagaa gcagccattg
       61 gagaaaccag catgaagtgc acccgtgaaa cagccatggt caagtctttg ctactgttga
      121 tgttgggact tgccattctg agggaggtag cagctcggaa gaaccccaaa gcaggggttc
      181 ctgccttgca gaaggctggg aactgtcctc ccctggagga taacactgtg agagttgaca
      241 ttcgaatctt caaccaaaac cagggcattt ctgtcccacg tgaattccag aaccgctcca
      301 gttccccatg ggattacaac atcactcgag acccccaccg gttcccctca gagatcgctg
      361 aggcccagtg cagacactca ggctgcatca atgcccaggg tcaggaagac agcaccatga
      421 actccgtcgc cattcagcaa gaaatcctgg tccttcggag ggagccccag ggctgttcta
      481 attccttcag gttggagaag atgctcctaa aagttggctg cacctgtgtc aagcccattg
      541 tccaccaagc ggcctgacaa cgctgcatac aaaaatcagt tgaagacttc cactgagaaa
      601 aagcctcctt ttatccagag ctctgtgtga agcccgatct ccaagtcttt atgctttcta
      661 ggactctcag taaggtgtgc atggcattct tgcagctctg cagtagatat agcttgaact
      721 ttctggcttg ctttagaatt gttaccagtc ctggtgtgtt cccaatgcct cacttaaact
      781 cctaaaaaca aaggtaaatg aaggcaccct tggcccagtc tctttgtgtt agatgatgac
      841 cacagttctt gtctgtcaag actgtcactt tgatgcagta ccattcttgt agagttcaat
      901 gaaatgctca tatttgtgat ggaaagaaaa caaacataat cagaatgcat gggaggaggc
      961 ctgtgtagca ggggctggac tggcaaggaa gaagcacaca tggtatgtgt gtttttagag
     1021 aaaaatttgg taaatataaa tgaagttggc ataaactatt atatatttat gttggtaggg
     1081 gaactataca tatatttatg acctattgat tatatatcaa tttagtagaa aattaatata
     1141 tccattaatt atataataaa atatttttaa ttcaaaaa
//
